Gene Page:RBM8A

Summary?
GeneID 9939
Symbol RBM8A
Synonyms BOV-1A|BOV-1B|BOV-1C|C1DELq21.1|DEL1q21.1|MDS014|RBM8|RBM8B|TAR|Y14|ZNRP|ZRNP1
Description RNA binding motif protein 8A
Reference MIM:605313|HGNC:HGNC:9905|Ensembl:ENSG00000265241|HPRD:05609|Vega:OTTHUMG00000013736
Gene type protein-coding
Map location 1q21.1
Fetal beta 0.869

Gene in Data Sources
Gene set name Method of gene set Description Info
CNV:YES Copy number variation studies Manual curation
PMID:cooccur High-throughput literature-search 系统搜索PubMed的基因co-occurring with SCZ keywords. A total of 3027 genes were included.
GSMA_I Genome scan meta-analysis Psr: 0.0235
GSMA_IIA Genome scan meta-analysis (All samples) Psr: 0.00814
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias Click to show details

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
C19orf43 0.93 0.91
C17orf49 0.93 0.94
EIF3G 0.92 0.94
EIF6 0.92 0.94
RPL8 0.92 0.89
ALKBH2 0.92 0.91
PSMB7 0.92 0.93
LSM7 0.91 0.89
UBXN1 0.91 0.91
RPL10A 0.91 0.85
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
AF347015.27 -0.67 -0.78
MT-CYB -0.66 -0.77
AF347015.33 -0.66 -0.76
MT-CO2 -0.66 -0.74
AF347015.15 -0.66 -0.78
AF347015.8 -0.66 -0.76
AF347015.31 -0.64 -0.73
AF347015.2 -0.64 -0.77
AF347015.26 -0.64 -0.78
AF347015.9 -0.62 -0.76

Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0000166 nucleotide binding IEA -
GO:0003729 mRNA binding NAS 11030346
GO:0005515 protein binding 新闻学会 10662555|14730019
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IEA -
GO:0000398 nuclear mRNA splicing, via spliceosome EXP 12226669
GO:0008380 RNA splicing IEA -
GO:0008150 biological_process ND -
GO:0006810 transport IEA -
GO:0051028 mRNA transport IEA -
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0005634 nucleus NAS 11013075|11030346
GO:0005681 spliceosome IEA -
GO:0005737 cytoplasm NAS 11030346

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG SPLICEOSOME 128 72 All SZGR 2.0 genes in this pathway
REACTOME PROCESSING OF CAPPED INTRON CONTAINING PRE MRNA 140 77 All SZGR 2.0 genes in this pathway
REACTOME TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM 54 34 All SZGR 2.0 genes in this pathway
REACTOME RNA POL II TRANSCRIPTION 105 54 All SZGR 2.0 genes in this pathway
REACTOME MRNA PROCESSING 161 86 All SZGR 2.0 genes in this pathway
REACTOME MRNA SPLICING 111 58 All SZGR 2.0 genes in this pathway
REACTOME TRANSCRIPTION 210 127 All SZGR 2.0 genes in this pathway
REACTOME MRNA 3 END PROCESSING 35 18 All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF MRNA 284 128 All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF RNA 330 155 All SZGR 2.0 genes in this pathway
REACTOME CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION 44 22 All SZGR 2.0 genes in this pathway
REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX 176 57 All SZGR 2.0 genes in this pathway
ZHONG RESPONSE TO AZACITIDINE AND TSA DN 70 38 All SZGR 2.0 genes in this pathway
DAVICIONI MOLECULAR ARMS VS ERMS UP 332 228 All SZGR 2.0 genes in this pathway
GARY CD5 TARGETS DN 431 263 All SZGR 2.0 genes in this pathway
RHEIN ALL GLUCOCORTICOID THERAPY DN 362 238 All SZGR 2.0 genes in this pathway
TIEN INTESTINE PROBIOTICS 24HR UP 557 331 All SZGR 2.0 genes in this pathway
KIM WT1 TARGETS 8HR UP 164 122 All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA POORLY DIFFERENTIATED DN 805 505 All SZGR 2.0 genes in this pathway
HAHTOLA MYCOSIS FUNGOIDES CD4 DN 116 71 All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE DN 485 334 All SZGR 2.0 genes in this pathway
EBAUER TARGETS OF PAX3 FOXO1 FUSION UP 207 128 All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK 1442 892 All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS DN 1024 594 All SZGR 2.0 genes in this pathway
BUYTAERT PHOTODYNAMIC THERAPY STRESS DN 637 377 All SZGR 2.0 genes in this pathway
FERREIRA EWINGS SARCOMA UNSTABLE VS STABLE DN 98 59 All SZGR 2.0 genes in this pathway
BENPORATH CYCLING GENES 648 385 All SZGR 2.0 genes in this pathway
BENPORATH PROLIFERATION 147 80 All SZGR 2.0 genes in this pathway
PETRETTO BLOOD PRESSURE DN 7 6 All SZGR 2.0 genes in this pathway
SAKAI TUMOR INFILTRATING MONOCYTES DN 81 51 All SZGR 2.0 genes in this pathway
ASTON MAJOR DEPRESSIVE DISORDER DN 160 110 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE INCIPIENT UP 390 242 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 1691 1088 All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 1 528 324 All SZGR 2.0 genes in this pathway
BOYAULT LIVER CANCER SUBCLASS G1 UP 113 70 All SZGR 2.0 genes in this pathway
DANG BOUND BY MYC 1103 714 All SZGR 2.0 genes in this pathway
WHITFIELD CELL CYCLE G2 M 216 124 All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN 1972 1213 All SZGR 2.0 genes in this pathway
DORMOY ELAVL1 TARGETS 17 10 All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 1ST EGF PULSE ONLY 1839 928 All SZGR 2.0 genes in this pathway