SZGR2 - Beplay体育中心

Summary？

基因	995
象征	CDC25C
Synonyms	CDC25 \| PPP1R60
Description	细胞分裂周期25C
Reference	MIM：157680\|HGNC：HGNC：1727\|Ensembl:ENSG00000158402\|HPRD：01146\|Vega：Otthumg00000129203
基因类型	蛋白质编码
Map location	5Q31
Pascal p-value	0.002
胎儿β	1.698
DMG	2(# studies)
主持人	Myers' cis & trans

Gene in Data Sources

基因集名称	Method of gene set	Description	信息
CV:PGCnp	Genome-wide Association Study	GWAS
DMG：JAFFE_2016	全基因组DNA甲基化分析	该数据集包括与SZ患者相关的2,104个探针/CPG（n = 108），而在Bonferroni调整后的P <0.05时，其中136个对照。	2
DMG：Wockner_2014	全基因组DNA甲基化分析	该数据集包括4641个差异甲基化探针，对应于精神分裂症患者（n = 24）和对照组（n = 24）之间的2929个独特基因。	2
GSMA_I	Genome scan meta-analysis	PSR：0.0032

Section I. Genetics and epigenetics annotation

Differentially methylated gene

Probe	染色体	位置	Nearest gene	p（dis）	Beta (dis)	fdr（dis）	学习
CG10909732	5	137667807	CDC25C	4.3E-4	0.545	0.045	DMG：Wockner_2014
CG24098762	5	137667672	CDC25C	9.2e-10	-0.018	1.11E-6	DMG：JAFFE_2016

eQTL annotation

SNP ID	染色体	位置	主持人	Gene Entrez ID	pvalue	QVALUE	TSS距离	EQTL类型
RS10994209	Chr10	61877705	CDC25C	995		0.11		反式

第二节。转录组注释

一般基因表达（GTEX）

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

时间变化的基因表达（brainspan）

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1：胎儿（13-26个概念后周），ST2：婴儿早期至童年（4个月至11年）和ST3：青春期至成年期（13-23年）
所示的栏表示表达分布的较低25％和上层25％。

大脑区域的顶级共表达基因

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	斯皮尔曼的相关性
KHDRBS1	0.96	0.97
SF3B3	0.95	0.97
VPRBP	0.95	0.97
XPO5	0.95	0.96
SP3	0.95	0.96
PAK2	0.95	0.96
FUBP1	0.95	0.97
SLC39A6	0.95	0.98
ATF7IP	0.95	0.97
PBRM1	0.95	0.98

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	斯皮尔曼的相关性
AF347015.31	-0.72	-0.91
HLA-F	-0.72	-0.79
C5orf53	-0.72	-0.77
AF347015.27	-0.71	-0.89
MT-CO2	-0.71	-0.92
FXYD1	-0.70	-0.90
AIFM3	-0.70	-0.77
AF347015.33	-0.70	-0.88
S100B	-0.70	-0.84
IFI27	-0.70	-0.89

第三节。基因本体论注释

分子功能	去学期	证据	神经关键字	PubMed ID
去：0005515	蛋白质结合	IPI		16330544\|17110335\|17349584
GO:0004725	蛋白酪氨酸磷酸酶活性	IEA		-
GO:0004725	蛋白酪氨酸磷酸酶活性	nas		11078813
GO：0016787	水解酶活性	IEA		-
生物过程	去学期	证据	神经关键字	PubMed ID
去：0000079	调节细胞周期蛋白依赖性蛋白激酶活性	TAS		11139144
去：0000087	M phase of mitotic cell cycle	IEA		-
去：0006470	protein amino acid dephosphorylation	IEA		-
GO:0006260	基因复制	经验		12791985
GO:0007049	cell cycle	IEA		-
GO:0007088	有丝分裂的调节	TAS		1828290
GO:0007089	遍历开始控制点of mitotic cell cycle	TAS		2195549
GO:0008283	cell proliferation	TAS		11139144
去：0051301	细胞分裂	IEA		-
GO:0044419	interspecies interaction between organisms	IEA		-
Cellular component	去学期	证据	神经关键字	PubMed ID
GO:0005829	细胞质	经验		10330186\|11063929
去：0005575	cellular_component	nd		-
去：0005622	细胞内	IEA		-
去：0005634	nucleus	IEA		-
去：0005654	核质	经验		1828290\|9278512\|11063929 \|11897663\|12766774
去：0005737	cytoplasm	IEA		-

Section IV. Protein-protein interaction annotation

互动者	别名b	官方全名b	实验	Source	PubMed ID
CCNA2	CCN1 \| CCNA	cyclin A2	-	HPRD,BioGRID	10864927
CCNB1	CCNB	cyclin B1	-	HPRD,BioGRID	1836978\|8402895 \|10864927
CDC2	cdc28a \|CDK1 \|DKFZP686L20222 \|MGC111195	细胞分裂cycle 2, G1 to S and G2 to M	-	HPRD	11836499
CHEK1	CHK1	CHK1checkpoint homolog (S. pombe)	CHEK1（CHK1）磷酸化Cdc25c的未指定同工型。	绑定	15735702
CHEK1	CHK1	CHK1checkpoint homolog (S. pombe)	-	HPRD,BioGRID	9278511
LCK	yt16 \|p56lck \|pp58lck	lymphocyte-specific protein tyrosine kinase	-	HPRD,BioGRID	11389730
MAPK14	CSBP1 \|CSBP2 \|CSPB1 \|Exip \|mxi2 \|PRKM14 \|PRKM15 \|RK \|SAPK2A \|p38 \| p38ALPHA	有丝分裂原激活的蛋白激酶14	-	HPRD,BioGRID	11333986
NEDD4	KIAA0093 \| MGC176705 \| NEDD4-1 \| RPF1	神经前体细胞表达，发育下调4	-	HPRD,BioGRID	10037602
PCNA	MGC8367	增殖细胞核抗原	-	HPRD,BioGRID	11896603
PIN1	国防部\|UBL5	肽基丙基顺式/反式异构酶，NIMA相互作用1	-	HPRD	9482729\|9499405 \|10037602\|9499405\|10037602
PIN1	国防部\|UBL5	肽基丙基顺式/反式异构酶，NIMA相互作用1	-	HPRD,BioGRID	9499405\|10037602
PLK1	PLK \| STPK13	polo样激酶1（果蝇）	-	HPRD,BioGRID	11202906
PLK1	PLK \| STPK13	polo样激酶1（果蝇）	PLK1磷酸化Cdc25c的未指定同工型。这种相互作用是通过人类PLK1从未指定物种中证明Cdc25c的磷酸化建模的。	绑定	15766665
PLK3	CNK \| FNK \| PRK	polo样激酶3（果蝇）	-	HPRD,BioGRID	10557092\|11551930
SP1	-	Sp1 transcription factor	SP1与CDC25C启动子相互作用。	绑定	15574328
TP53	FLJ92943 \| LFS1 \| TRP53 \| p53	肿瘤蛋白p53	-	HPRD	10853038
TP53	FLJ92943 \| LFS1 \| TRP53 \| p53	肿瘤蛋白p53	p53 interacts with the cdc25c promoter.	绑定	15574328
YWHAA	-	酪氨酸3-单加氧酶/色氨酸5-单加氧酶激活蛋白，α多肽	Two-hybrid	Biogrid	15284440
YWHAB	GW128 \|HS1 \|KCIP-1	酪氨酸3-单加氧酶/色氨酸5-单加氧酶激活蛋白，β多肽	-	HPRD	12937170
YWHAE	14-3-3E \| FLJ45465 \| KCIP-1 \| MDCR \| MDS	酪氨酸3-单加氧酶/色氨酸5-单加氧酶激活蛋白，epsilon多肽	亲和力捕获 - 韦斯特恩	Biogrid	10330186
YWHAH	YWHA1	酪氨酸3-单加氧酶/色氨酸5-单加氧酶激活蛋白，ETA多肽	-	HPRD	9278512\|10330186
YWHAH	YWHA1	酪氨酸3-单加氧酶/色氨酸5-单加氧酶激活蛋白，ETA多肽	亲和力捕获 - 韦斯特恩	Biogrid	11969417
YWHAZ	KCIP-1 \|MGC111427 \|MGC126532 \|MGC138156	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	-	HPRD,BioGRID	10864927

Section V. Pathway annotation

路径名	路径大小	# SZGR 2.0 genes in pathway	信息
kegg细胞周期	128	84	All SZGR 2.0 genes in this pathway
Kegg卵母细胞减数分裂	114	79	All SZGR 2.0 genes in this pathway
KEGG孕酮介导的卵母细胞成熟	86	59	All SZGR 2.0 genes in this pathway
BIOCARTA SRCRPTP PATHWAY	11	9	All SZGR 2.0 genes in this pathway
BIOCARTA G2 PATHWAY	24	20	All SZGR 2.0 genes in this pathway
Biocarta MPR途径	34	28	All SZGR 2.0 genes in this pathway
Biocarta RB途径	13	11	All SZGR 2.0 genes in this pathway
Biocarta PTC1途径	11	6	All SZGR 2.0 genes in this pathway
PID ATR途径	39	25	All SZGR 2.0 genes in this pathway
PID ATM路径	34	25	All SZGR 2.0 genes in this pathway
PID PLK1途径	46	25	All SZGR 2.0 genes in this pathway
反应组细胞周期	421	253	All SZGR 2.0 genes in this pathway
反应组细胞周期MITOTIC	325	185	All SZGR 2.0 genes in this pathway
Reactome细胞周期检查点	124	70	All SZGR 2.0 genes in this pathway
REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION	15	8	All SZGR 2.0 genes in this pathway
REACTOME MITOTIC G2 G2 M PHASES	81	50	All SZGR 2.0 genes in this pathway
ATR的反应组激活复制应力	38	18	All SZGR 2.0 genes in this pathway
REACTOME G2 M CHECKPOINTS	45	23	All SZGR 2.0 genes in this pathway
REACTOME G2 M DNA DAMAGE CHECKPOINT	12	8	All SZGR 2.0 genes in this pathway
ZERBINI RESPONSE TO SULINDAC DN	6	5	All SZGR 2.0 genes in this pathway
CASORELLI ACUTE PROMYELOCYTIC LEUKEMIA DN	663	425	All SZGR 2.0 genes in this pathway
gal白血病干细胞DN	244	153	All SZGR 2.0 genes in this pathway
Lopez中端瘤的生存时间上升	14	8	All SZGR 2.0 genes in this pathway
洛佩兹间皮瘤生存最差与最好的	14	10	All SZGR 2.0 genes in this pathway
SENESE HDAC1 TARGETS DN	260	143	All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION UP	1278	748	All SZGR 2.0 genes in this pathway
多德鼻咽癌DN	1375	806	All SZGR 2.0 genes in this pathway
MARKEY RB1 ACUTE LOF DN	228	137	All SZGR 2.0 genes in this pathway
berenjeno由Rhoa Up Troment	536	340	All SZGR 2.0 genes in this pathway
受甲基化DN调节的Missiaglia	122	67	All SZGR 2.0 genes in this pathway
NUNODA RESPONSE TO DASATINIB IMATINIB UP	29	20	All SZGR 2.0 genes in this pathway
EGUCHI CELL CYCLE RB1 TARGETS	23	13	All SZGR 2.0 genes in this pathway
Heidenblad Amplicon 8Q24 UP	40	23	All SZGR 2.0 genes in this pathway
Dairkee Tert目标	380	213	All SZGR 2.0 genes in this pathway
Pujana乳腺癌点燃int网络	101	73	All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC网络	1652	1023	All SZGR 2.0 genes in this pathway
Pujana BRCA2 PCC网络	423	265	All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS DN	1024	594	All SZGR 2.0 genes in this pathway
TP53和TP73 DN的SCIAN细胞周期目标	22	14	All SZGR 2.0 genes in this pathway
里克曼肿瘤分化中等程度与不良	121	71	All SZGR 2.0 genes in this pathway
Benporath循环基因	648	385	All SZGR 2.0 genes in this pathway
MORI MATURE B LYMPHOCYTE DN	75	43	All SZGR 2.0 genes in this pathway
彭谷氨酰胺剥夺	38	25	All SZGR 2.0 genes in this pathway
Peart HDAC增殖集群	57	35	All SZGR 2.0 genes in this pathway
LI WILMS TUMOR VS FETAL KIDNEY 1 DN	163	115	All SZGR 2.0 genes in this pathway
Affar YY1靶向DN	234	137	All SZGR 2.0 genes in this pathway
ALCALAY AML BY NPM1 LOCALIZATION DN	184	132	All SZGR 2.0 genes in this pathway
TBH和H2O2的Weigel氧化应激	36	24	All SZGR 2.0 genes in this pathway
PAL PRMT5靶向	203	135	All SZGR 2.0 genes in this pathway
BURTON ADIPOGENESIS PEAK AT 24HR	43	30	All SZGR 2.0 genes in this pathway
CUI TCF21目标2向上	428	266	All SZGR 2.0 genes in this pathway
SATO SILENCED BY METHYLATION IN PANCREATIC CANCER 1	419	273	All SZGR 2.0 genes in this pathway
HU遗传毒性损伤4小时	35	28	All SZGR 2.0 genes in this pathway
马丁内斯对trabectedin dn的反应	271	175	All SZGR 2.0 genes in this pathway
由E2F4绑定的Marson未刺激	728	415	All SZGR 2.0 genes in this pathway
AMUNDSON GAMMA RADIATION RESPONSE	40	25	All SZGR 2.0 genes in this pathway
FUJII YBX1 TARGETS DN	202	132	All SZGR 2.0 genes in this pathway
西部肾上腺皮质肿瘤	294	199	All SZGR 2.0 genes in this pathway
对Salirasib dn的Blum响应	342	220	All SZGR 2.0 genes in this pathway
Mueller Plurinet	299	189	All SZGR 2.0 genes in this pathway
REICHERT G1S REGULATORS AS PI3K TARGETS	8	6	All SZGR 2.0 genes in this pathway
GOLDRATH ANTIGEN RESPONSE	346	192	All SZGR 2.0 genes in this pathway
CHANG CYCLING GENES	148	83	All SZGR 2.0 genes in this pathway
霍夫曼大到小淋巴细胞向上	163	102	All SZGR 2.0 genes in this pathway
SHEDDEN LUNG CANCER POOR SURVIVAL A6	456	285	All SZGR 2.0 genes in this pathway
CROONQUIST NRAS SIGNALING DN	72	47	All SZGR 2.0 genes in this pathway
CAIRO HEPATOBLASTOMA CLASSES UP	605	377	All SZGR 2.0 genes in this pathway
DANG MYC TARGETS UP	143	100	All SZGR 2.0 genes in this pathway
由MYC约束	1103	714	All SZGR 2.0 genes in this pathway
惠特菲尔德细胞周期文献	44	25	All SZGR 2.0 genes in this pathway
WHITFIELD CELL CYCLE G2	182	102	All SZGR 2.0 genes in this pathway
Thillainadesan Znf217靶向	44	22	All SZGR 2.0 genes in this pathway
FEVR CTNNB1靶向DN	553	343	All SZGR 2.0 genes in this pathway
GOBERT OLIGODENDROCYTE DIFFERENTIATION UP	570	339	All SZGR 2.0 genes in this pathway
LE神经元分化DN	19	16	All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 1ST EGF PULSE ONLY	1839	928	All SZGR 2.0 genes in this pathway

Gene Page:CDC25C