基因Page:HS3ST2

概括?
基因ID 9956
Symbol HS3ST2
同义词 30ST2|3OST2
描述 heparan sulfate-glucosamine 3-sulfotransferase 2
参考 MIM:604056|HGNC:HGNC:5195|ENSEMBL：ENSG00000122254|HPRD:04957|Vega:OTTHUMG00000094785
基因type protein-coding
地图位置 16p12
Pascal p-value 0.754
Sherlock P值 0.544
Fetal beta -1.961
DMG 1（＃研究）
eGene 迈尔斯的顺式和跨性别

数据源中的基因
基因set name 基因组方法 描述 Info
CV：GWASDB 全基因组关联研究 gwasdbrecords for schizophrenia
CV:PGCnp Genome-wide Association Study GWAS
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1
PMID:cooccur 高通量文献搜索 Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
GSMA_IIE 基因组扫描荟萃分析（欧洲官方样品） PSR：0.01775
文学 高通量文献搜索 与精神分裂症Co-occurance关键词:schizophrenia,schizophrenic,schizophrenias Click to show details

第一节遗传学和表观遗传学注释

@Differentially methylated gene

探测 Chromosome Position Nearest gene P (dis) beta（dis） FDR (dis) Study
cg27403265 16 22825621 HS3ST2 5.26E-5 -0.186 0.022 DMG:Wockner_2014

@eQTL annotation

SNP ID Chromosome Position eGene 基因Entrez ID pvalue qvalue TSS distance eQTL type
RS2239335 chr16 22897794 HS3ST2 9956 0.01 cis
rs2369690 chr16 22920851 HS3ST2 9956 0 cis
rs6669846 chr1 9650570 HS3ST2 9956 0.1 trans
RS11127467 chr2 12993 HS3ST2 9956 0.02 trans
rs921163 chr2 205337399 HS3ST2 9956 0 trans
rs13003798 chr2 205355767 HS3ST2 9956 0 trans
RS6746267 chr2 205612604 HS3ST2 9956 0.17 trans
rs16863576 chr2 223120977 HS3ST2 9956 0.11 trans
rs17635521 chr3 27813669 HS3ST2 9956 0.15 trans
rs9882574 chr3 56944018 HS3ST2 9956 0.14 trans
rs9862967 chr3 56944181 HS3ST2 9956 0.14 trans
rs9825359 chr3 56944297 HS3ST2 9956 0.14 trans
RS9828029 chr3 56949706 HS3ST2 9956 0.12 trans
rs1392700 chr3 56952899 HS3ST2 9956 0.14 trans
RS12489848 chr3 60399321 HS3ST2 9956 0.18 trans
rs16827037 chr3 117203284 HS3ST2 9956 1.087E-4 trans
rs6834153 chr4 8606484 HS3ST2 9956 0.01 trans
rs17511050 chr4 133842650 HS3ST2 9956 0.06 trans
RS7664027 chr4 169121200 HS3ST2 9956 0.02 trans
rs17053782 chr4 169127022 HS3ST2 9956 0.02 trans
rs11722969 chr4 169133757 HS3ST2 9956 0.02 trans
rs6846811 chr4 169234535 HS3ST2 9956 0.02 trans
rs6894161 chr5 91098032 HS3ST2 9956 0.02 trans
rs3861862 chr5 141842691 HS3ST2 9956 0.12 trans
rs17109939 chr5 148694416 HS3ST2 9956 0.04 trans
RS9397453 chr6 152236878 HS3ST2 9956 0.2 trans
rs887719 chr7 21184272 HS3ST2 9956 1.015E-4 trans
rs320082 chr7 29105404 HS3ST2 9956 3.005E-6 trans
rs317720 chr7 29110633 HS3ST2 9956 3.807E-4 trans
rs317714 chr7 29115553 HS3ST2 9956 1.935E-7 trans
rs317724 chr7 29120565 HS3ST2 9956 3.807E-4 trans
rs1419793 chr7 34697630 HS3ST2 9956 0.05 trans
rs6942437 chr7 146798442 HS3ST2 9956 0.09 trans
rs10099022 chr8 24510800 HS3ST2 9956 0.1 trans
RS4242415 chr8 24597175 HS3ST2 9956 0.03 trans
RS16886605 chr8 115894398 HS3ST2 9956 3.725E-4 trans
rs1494750 chr8 116094224 HS3ST2 9956 0.01 trans
rs7029518 chr9 37782560 HS3ST2 9956 0.09 trans
RS1020772 chr9 76532511 HS3ST2 9956 0.07 trans
rs11203077 chr10 91097084 HS3ST2 9956 0.03 trans
rs16933545 chr11 7918293 HS3ST2 9956 0.19 trans
rs10834670 chr11 25404015 HS3ST2 9956 0.05 trans
rs11019015 chr11 90157517 HS3ST2 9956 0.04 trans
rs17127472 chr11 123448587 HS3ST2 9956 0.16 trans
rs12312877 chr12 79751818 HS3ST2 9956 0.06 trans
rs17627481 chr12 111777481 HS3ST2 9956 0.16 trans
rs11066476 chr12 113465366 HS3ST2 9956 0.03 trans
RS11043285 chr12 122443533 HS3ST2 9956 0.07 trans
RS7971538 chr12 122473662 HS3ST2 9956 0.07 trans
rs2993290 chr13 113647189 HS3ST2 9956 0.02 trans
rs1307687 0 HS3ST2 9956 0.01 trans
rs11158850 chr14 70757171 HS3ST2 9956 9.826E-4 trans
rs9302779 chr16 3933344 HS3ST2 9956 0.06 trans
rs2369690 chr16 22920851 HS3ST2 9956 0.13 trans
rs12452652 chr17 72235560 HS3ST2 9956 0 trans
rs1230712 chr18 54992531 HS3ST2 9956 0.04 trans
rs862699 chr19 57863551 HS3ST2 9956 0.18 trans
rs12276 chr19 58154091 HS3ST2 9956 0.05 trans
rs6119412 chr20 32470871 HS3ST2 9956 0.08 trans
rs6121844 chr20 60489981 HS3ST2 9956 0.06 trans

Section II. Transcriptome annotation

基因ral gene expression (GTEx)

Not available

基因expression during devlopment (BrainCloud)

脚注：
总共绘制了269个时间点，n = 38个胎儿样品（x = 1：38）。每个三角形代表一个时间点。

基因expression of temporal and spatial changes (BrainSpan)

脚注：
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
基因 Pearson's Correlation Spearman's Correlation
应付 0.91 0.91
nosip 0.91 0.89
EXOSC4 0.91 0.91
TIMM17B 0.91 0.92
SCAND1 0.90 0.89
FAM96B 0.90 0.89
MRPS34 0.90 0.89
ALKBH7 0.89 0.91
SF3B5 0.89 0.91
DCTN3 0.88 0.88
Top 10 negatively co-expressed genes
基因 Pearson's Correlation Spearman's Correlation
AF347015.15 -0.57 -0.70
AF347015.26 -0.57 -0.70
MT-CYB -0.57 -0.69
AF347015.27 -0.57 -0.68
AF347015.8 -0.57 -0.68
AF347015.33 -0.56 -0.68
EPB41L2 -0.55 -0.58
AF347015.2 -0.55 -0.67
ABCB1 -0.54 -0.58
MT-CO2 -0.53 -0.64

Section III. Gene Ontology annotation

Molecular function GO term Evidence Neuro keywords PubMed ID
GO:0016740 transferase activity IEA -
GO:0008146 sulfotransferase activity IEA -
GO:0008146 sulfotransferase activity 塔斯 9988767
GO:0033871 [heparan sulfate]-glucosamine 3-sulfotransferase 2 activity IEA -
细胞分量 GO term Evidence Neuro keywords PubMed ID
去：0000139 高尔基膜 IEA -
GO:0005794 Golgi apparatus IEA -
GO:0016020 膜 IEA -
GO:0016021 integral to membrane 塔斯 9988767

V.途径注释

Pathway name Pathway size ＃szgr 2.0基因 Info
KEGG GLYCOSAMINOGLYCAN BIOSYNTHESIS HEPARAN SULFATE 26 16 该途径中的所有SZGR 2.0基因
REACTOME HS GAG BIOSYNTHESIS 31 17 该途径中的所有SZGR 2.0基因
REACTOME HEPARAN SULFATE HEPARIN HS GAG METABOLISM 52 33 该途径中的所有SZGR 2.0基因
REACTOME GLYCOSAMINOGLYCAN METABOLISM 111 69 该途径中的所有SZGR 2.0基因
REACTOME METABOLISM OF CARBOHYDRATES 247 154 该途径中的所有SZGR 2.0基因
FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS DN 463 290 该途径中的所有SZGR 2.0基因
NUP98 HOXA9 Fusion 10D DN的Takeda目标 142 90 该途径中的所有SZGR 2.0基因
Schlesinger H3K27me3在正常状态下甲基化的癌症 28 21 该途径中的所有SZGR 2.0基因
BENPORATH SUZ12 TARGETS 1038 678 该途径中的所有SZGR 2.0基因
BENPORATH ES WITH H3K27ME3 1118 744 该途径中的所有SZGR 2.0基因
BENPORATH MYC MAX TARGETS 775 494 该途径中的所有SZGR 2.0基因
ONDER CDH1 TARGETS 2 DN 464 276 该途径中的所有SZGR 2.0基因
ONDER CDH1 TARGETS 1 DN 169 102 该途径中的所有SZGR 2.0基因
ONDER CDH1 TARGETS 3 DN 59 32 该途径中的所有SZGR 2.0基因
Taci的Moreaux多发性骨髓瘤 412 249 该途径中的所有SZGR 2.0基因
MOREAUX B LYMPHOCYTE MATURATION BY TACI UP 92 58 该途径中的所有SZGR 2.0基因
BLALOCK ALZHEIMERS DISEASE DN 1237 837 该途径中的所有SZGR 2.0基因
WALLACE PROSTATE CANCER RACE DN 88 42 该途径中的所有SZGR 2.0基因
Meissner NPC HCP，含H3未甲基化 536 296 该途径中的所有SZGR 2.0基因
MEISSNER BRAIN HCP WITH H3K4ME3 AND H3K27ME3 1069 729 该途径中的所有SZGR 2.0基因
MIKKELSEN MCV6 HCP WITH H3K27ME3 435 318 该途径中的所有SZGR 2.0基因
DANG BOUND BY MYC 1103 714 该途径中的所有SZGR 2.0基因
MIKKELSEN MEF HCP WITH H3K27ME3 590 403 该途径中的所有SZGR 2.0基因
KOINUMA TARGETS OF SMAD2 OR SMAD3 824 528 该途径中的所有SZGR 2.0基因

Section VI. microRNA annotation

miRNA family Target position mirna id miRNA seq
UTR start UTR end Match method
mir-194 666 672 m8 hsa-miR-194 UGUAACAGCAACUCCAUGUGGA
miR-218 651 657 m8 HSA-MIR-218脑 uugugcuugaucuaaccaugu
miR-23 730 736 1A hsa-miR-23a脑 aucacauugccagggauucc
hsa-miR-23b脑 AUCACAUUGCCAGGGAUUACC
mir-99/100 670 677 1A,m8 HSA-MIR-99A脑 AACCCGUAGAUCCGAUCUUGUG
HSA-MIR-100脑 AACCCGUAGAUCCGAACUUGUG
HSA-MIR-99B脑 cacccguagaaccgaccuugcg