Gene Page:MED12
概括?
| 基因 | 9968 |
| 象征 | MED12 |
| Synonyms | ARC240|CAGH45|FGS1|HOPA|MED12S|OHDOX|OKS|OPA1|TNRC11|TRAP230 |
| Description | mediator complex subunit 12 |
| Reference | MIM:300188|HGNC:HGNC:11957|Ensembl:ENSG00000184634|HPRD:02176|Vega:OTTHUMG00000021788 |
| Gene type | protein-coding |
| Map location | Xq13 |
| Sherlock p-value | 0.953 |
| 度p-value | DEG：ZHAO_2015：P = 3.07E-04：Q = 0.0924 |
| Fetal beta | 0.162 |
| Support | Ascano FMRP targets |
数据源中的基因
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DEG：Zhao_2015 | RNA测序分析 | 转录组测序和全基因组的关联分析揭示了精神分裂症和躁郁症中的溶酶体功能和肌动蛋白细胞骨架重塑。 | |
| PMID:cooccur | High-throughput literature-search | Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included. | |
| Association | A combined odds ratio method (Sun et al. 2008），协会研究 | 2 | Link to SZGene |
| 文学 | High-throughput literature-search | Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenias | 点击to show details |
第一节遗传学和表观遗传学注释
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
脚注：
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
脚注：
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| ERAL1 | 0.88 | 0.85 |
| MCRS1 | 0.87 | 0.84 |
| TBRG4 | 0.87 | 0.85 |
| C11orf49 | 0.86 | 0.83 |
| SLC35B1 | 0.86 | 0.82 |
| jagn1 | 0.86 | 0.83 |
| TMEM203 | 0.85 | 0.85 |
| ZDHHC16 | 0.85 | 0.82 |
| APEH | 0.85 | 0.83 |
| C7orf20 | 0.85 | 0.83 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| AF347015.8 | -0.68 | -0.62 |
| AF347015.18 | -0.65 | -0.68 |
| MT-CO2 | -0.65 | -0.58 |
| AF347015.26 | -0.65 | -0.62 |
| AF347015.33 | -0.63 | -0.58 |
| MT-CYB | -0.63 | -0.59 |
| AF347015.31 | -0.63 | -0.58 |
| AF347015.27 | -0.63 | -0.60 |
| MT-ATP8 | -0.63 | -0.66 |
| AF347015.21 | -0.63 | -0.58 |
Section III. Gene Ontology annotation
| 分子功能 | GO term | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| 去：0004872 | receptor activity | IDA | 12218053 | |
| GO:0005515 | protein binding | 新闻学会 | 16109376 | |
| GO:0019904 | protein domain specific binding | 新闻学会 | 11984006 | |
| GO:0016455 | RNA polymerase II transcription mediator activity | IDA | 10198638 | |
| GO:0030374 | 配体依赖性核受体转录共激活因子活性 | NAS | 10235266 | |
| GO:0042809 | 维生素D受体结合 | NAS | 10235266 | |
| GO:0046966 | thyroid hormone receptor binding | IDA | 10198638 | |
| 生物过程 | GO term | Evidence | Neuro keywords | PubMed ID |
| 去：0006355 | regulation of transcription, DNA-dependent | IEA | - | |
| GO:0006367 | transcription initiation from RNA polymerase II promoter | IDA | 12218053 | |
| 去：0006350 | transcription | IEA | - | |
| GO:0030521 | 雄激素受体信号通路 | IDA | 12218053 | |
| GO:0045944 | positive regulation of transcription from RNA polymerase II promoter | IDA | 12037571 | |
| Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
| 去：0000119 | mediator complex | IDA | 10198638 | |
| 去：0005813 | centrosome | IDA | 18029348 | |
| GO:0005634 | nucleus | IDA | 10235267 | |
| GO:0005730 | nucleolus | IDA | 18029348 | |
| GO:0005730 | nucleolus | IDA | 18029348 |
第四节。蛋白质蛋白相互作用注释
| Interactors | Aliases B | Official full name B | Experimental | 资源 | PubMed ID |
|---|---|---|---|---|---|
| CDK8 | K35 | MGC126074 | MGC126075 | cyclin-dependent kinase 8 | 亲和力捕获ms | BioGRID | 10198638 |
| LYST | CHS | CHS1 | 溶酶体贩运调节剂 | - | HPRD,BioGRID | 11984006 |
| MED10 | L6 |MGC5309 |nut2 |TRG20 | mediator complex subunit 10 | 亲和力捕获ms Affinity Capture-Western |
BioGRID | 15175163 |
| MED19 | DT2P1G7 | LCMR1 | mediator complex subunit 19 | 亲和力捕获ms | BioGRID | 15175163 |
| MED26 | CRSP7 | CRSP70 | mediator complex subunit 26 | 亲和力捕获ms Affinity Capture-Western |
BioGRID | 15175163 |
| MED28 | 1500003d12rik |DKFZP434N185 |EG1 |魔术 | mediator complex subunit 28 | 亲和力捕获ms | BioGRID | 15175163 |
| MED29 | DKFZp434H247 | IXL | mediator complex subunit 29 | - | HPRD | 14576168 |
| MED29 | DKFZp434H247 | IXL | mediator complex subunit 29 | 亲和力捕获ms | BioGRID | 15175163 |
| MED9 | FLJ10193 |Med25 |MGC138234 | mediator complex subunit 9 | - | HPRD | 14638676 |
| MED9 | FLJ10193 |Med25 |MGC138234 | mediator complex subunit 9 | 亲和力捕获ms | BioGRID | 15175163 |
| MYC | bHLHe39 | c-Myc | v-myc myelocytomatosis viral oncogene homolog (avian) | Reconstituted Complex | BioGRID | 12660246 |
| PPARGC1A | LEM6 | PGC-1(alpha) | PGC-1v | PGC1 | PGC1A | PPARGC1 | peroxisome proliferator-activated receptor gamma, coactivator 1 alpha | Affinity Capture-Western Reconstituted Complex |
BioGRID | 14636573 |
| SOX9 | CMD1 | CMPD1 | SRA1 | SRY (sex determining region Y)-box 9 | Affinity Capture-Western Reconstituted Complex 两个杂交 |
BioGRID | 12136106 |
| THRA | AR7 | EAR7 | ERB-T-1 | ERBA | ERBA1 | MGC000261 | MGC43240 | NR1A1 | THRA1 | THRA2 | c-ERBA-1 | 甲状腺激素受体，α（红细胞性白血病病毒（V-ERB-A）癌基因同源物，Avian） | 亲和力捕获ms Affinity Capture-Western |
BioGRID | 10198638 |
| VDR | NR1I1 | vitamin D (1,25- dihydroxyvitamin D3) receptor | 亲和力捕获ms | BioGRID | 10198638|12837248 |
V.途径注释
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| PID BETA CATENIN NUC PATHWAY | 80 | 60 | 该途径中的所有SZGR 2.0基因 |
| REACTOME DEVELOPMENTAL BIOLOGY | 396 | 292 | 该途径中的所有SZGR 2.0基因 |
| Reactome Ppara激活基因表达 | 104 | 72 | 该途径中的所有SZGR 2.0基因 |
| REACTOME GENERIC TRANSCRIPTION PATHWAY | 352 | 181 | 该途径中的所有SZGR 2.0基因 |
| 脂质和脂蛋白的反应组代谢 | 478 | 302 | 该途径中的所有SZGR 2.0基因 |
| REACTOME FATTY ACID TRIACYLGLYCEROL AND KETONE BODY METABOLISM | 168 | 115 | 该途径中的所有SZGR 2.0基因 |
| REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | 72 | 53 | 该途径中的所有SZGR 2.0基因 |
| DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP | 1382 | 904 | 该途径中的所有SZGR 2.0基因 |
| DEURIG T细胞PROLYMPHOCYTIC白血病 | 368 | 234 | 该途径中的所有SZGR 2.0基因 |
| DOANE RESPONSE TO ANDROGEN UP | 184 | 125 | 该途径中的所有SZGR 2.0基因 |
| LAIHO COLORECTAL CANCER SERRATED DN | 86 | 47 | 该途径中的所有SZGR 2.0基因 |
| MAYBURD RESPONSE TO L663536 UP | 29 | 18 | 该途径中的所有SZGR 2.0基因 |
| GRAESSMANN APOPTOSIS BY DOXORUBICIN DN | 1781 | 1082 | 该途径中的所有SZGR 2.0基因 |
| RICKMAN TUMOR DIFFERENTIATED WELL VS POORLY UP | 236 | 139 | 该途径中的所有SZGR 2.0基因 |
| Benporath Nanog目标 | 988 | 594 | 该途径中的所有SZGR 2.0基因 |
| BENPORATH OCT4 TARGETS | 290 | 172 | 该途径中的所有SZGR 2.0基因 |
| BENPORATH SOX2 TARGETS | 734 | 436 | 该途径中的所有SZGR 2.0基因 |
| BENPORATH NOS TARGETS | 179 | 105 | 该途径中的所有SZGR 2.0基因 |
| PENG GLUTAMINE DEPRIVATION DN | 337 | 230 | 该途径中的所有SZGR 2.0基因 |
| Kayo衰老肌肉DN | 123 | 76 | 该途径中的所有SZGR 2.0基因 |
| RIZKI TUMOR INVASIVENESS 3D DN | 270 | 181 | 该途径中的所有SZGR 2.0基因 |
| Ambrosini Flavopiridol处理TP53 | 109 | 63 | 该途径中的所有SZGR 2.0基因 |
| YAGI AML WITH T 8 21 TRANSLOCATION | 368 | 247 | 该途径中的所有SZGR 2.0基因 |
Section VI. microRNA annotation
| mirna家族 | Target position | mirna id | miRNA seq | ||
|---|---|---|---|---|---|
| UTR start | UTR end | Match method | |||
| miR-23 | 143 | 149 | m8 | hsa-miR-23abrain | aucacauugccagggauucc |
| hsa-miR-23bbrain | AUCACAUUGCCAGGGAUUACC | ||||
| miR-323 | 142 | 149 | 1A,m8 | HSA-MIR-323brain | gcacauuacggucgaccucu |
| mir-381 | 169 | 175 | 1A | hsa-miR-381 | uauacaagggcaagcucucugu |
| miR-410 | 180 | 186 | 1A | hsa-miR-410 | aauauaacacagauggcugu |
| mir-495 | 137 | 143 | 1A | hsa-miR-495brain | AAACAAACAUGGUGCACUUCUUU |