Gene Page:MED13

Summary?
GeneID 9969
Symbol MED13
Synonyms ARC250|DRIP250|HSPC221|THRAP1|TRAP240
Description mediator complex subunit 13
Reference MIM:603808|HGNC:HGNC:22474|Ensembl:ENSG00000108510|HPRD:07229|Vega:OTTHUMG00000179251
Gene type protein-coding
Map location 17q23.2
Pascal p-value 0.079
Fetal beta 1.795
DMG 1 (# studies)
eGene Myers' cis & trans
Support CompositeSet
Darnell FMRP targets

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Jaffe_2016 Genome-wide DNA methylation analysis This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 1
Expression Meta-analysis of gene expression Pvalue: 1.38

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg20376447 17 60143446 MED13 1.18E-9 -0.029 1.28E-6 DMG:Jaffe_2016

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs12620093 chr2 69393712 MED13 9969 0.1 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
DMXL1 0.93 0.95
NF1 0.93 0.95
GARNL1 0.92 0.92
ATG2B 0.92 0.93
CXorf39 0.92 0.92
DMXL2 0.91 0.92
AC010896.1 0.91 0.95
APPL1 0.91 0.92
SEL1L 0.91 0.94
C9orf5 0.91 0.92
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
FXYD1 -0.59 -0.58
AF347015.21 -0.58 -0.56
C1orf61 -0.57 -0.70
C1orf54 -0.57 -0.62
HIGD1B -0.57 -0.59
MT-CO2 -0.55 -0.56
CSAG1 -0.55 -0.55
VAMP5 -0.55 -0.53
AC098691.2 -0.55 -0.59
EIF4EBP3 -0.54 -0.57

Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0004872 receptor activity IDA 12218053
GO:0016455 RNA polymerase II transcription mediator activity IDA 10198638
GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity NAS 10235266
GO:0042809 vitamin D receptor binding NAS 10235266
GO:0046966 thyroid hormone receptor binding IDA 10198638
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0006355 regulation of transcription, DNA-dependent IEA -
GO:0006367 transcription initiation from RNA polymerase II promoter IDA 12218053
GO:0006350 transcription IEA -
GO:0030521 androgen receptor signaling pathway IDA 12218053
GO:0045944 积极的监管of transcription from RNA polymerase II promoter IDA 12037571
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0000119 mediator complex IDA 10198638
GO:0005634 nucleus IDA 10235267

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP 1382 904 All SZGR 2.0 genes in this pathway
HAHTOLA MYCOSIS FUNGOIDES SKIN UP 177 113 All SZGR 2.0 genes in this pathway
DELYS THYROID CANCER UP 443 294 All SZGR 2.0 genes in this pathway
GAUSSMANN MLL AF4 FUSION TARGETS D UP 38 23 All SZGR 2.0 genes in this pathway
LASTOWSKA NEUROBLASTOMA COPY NUMBER UP 181 108 All SZGR 2.0 genes in this pathway
乳腺癌顶浆分泌与腔的农民 326 213 All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 DN 855 609 All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 COMMON DN 483 336 All SZGR 2.0 genes in this pathway
LOPEZ MBD TARGETS 957 597 All SZGR 2.0 genes in this pathway
NIKOLSKY BREAST CANCER 17Q21 Q25 AMPLICON 335 181 All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT OK VS DONOR UP 555 346 All SZGR 2.0 genes in this pathway
CUI TCF21 TARGETS 2 DN 830 547 All SZGR 2.0 genes in this pathway
WANG CISPLATIN RESPONSE AND XPC DN 228 146 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 1691 1088 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 18HR UP 178 111 All SZGR 2.0 genes in this pathway
DURCHDEWALD SKIN CARCINOGENESIS DN 264 168 All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS UP 504 321 All SZGR 2.0 genes in this pathway
FARMER BREAST CANCER CLUSTER 5 18 11 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-101 3084 3090 1A hsa-miR-101 UACAGUACUGUGAUAACUGAAG
miR-128 760 766 m8 hsa-miR-128a UCACAGUGAACCGGUCUCUUUU
hsa-miR-128b UCACAGUGAACCGGUCUCUUUC
hsa-miR-128a UCACAGUGAACCGGUCUCUUUU
hsa-miR-128b UCACAGUGAACCGGUCUCUUUC
miR-129-5p 3818 3824 1A hsa-miR-129brain CUUUUUGCGGUCUGGGCUUGC
hsa-miR-129-5p CUUUUUGCGGUCUGGGCUUGCU
miR-134 263 270 1A,m8 hsa-miR-134brain UGUGACUGGUUGACCAGAGGG
miR-135 2742 2748 m8 hsa-miR-135a UAUGGCUUUUUAUUCCUAUGUGA
hsa-miR-135b UAUGGCUUUUCAUUCCUAUGUG
hsa-miR-135a UAUGGCUUUUUAUUCCUAUGUGA
hsa-miR-135b UAUGGCUUUUCAUUCCUAUGUG
hsa-miR-135a UAUGGCUUUUUAUUCCUAUGUGA
hsa-miR-135b UAUGGCUUUUCAUUCCUAUGUG
hsa-miR-135a UAUGGCUUUUUAUUCCUAUGUGA
hsa-miR-135b UAUGGCUUUUCAUUCCUAUGUG
miR-136 329 335 1A hsa-miR-136 ACUCCAUUUGUUUUGAUGAUGGA
miR-137 538 544 m8 hsa-miR-137 UAUUGCUUAAGAAUACGCGUAG
miR-140 2893 2899 m8 hsa-miR-140brain AGUGGUUUUACCCUAUGGUAG
miR-142-5p 3623 3629 m8 hsa-miR-142-5p CAUAAAGUAGAAAGCACUAC
miR-144 3083 3090 1A,m8 hsa-miR-144 UACAGUAUAGAUGAUGUACUAG
miR-145 3525 3531 m8 hsa-miR-145 GUCCAGUUUUCCCAGGAAUCCCUU
hsa-miR-145 GUCCAGUUUUCCCAGGAAUCCCUU
miR-146 1450 1456 1A hsa-miR-146a UGAGAACUGAAUUCCAUGGGUU
hsa-miR-146bbrain UGAGAACUGAAUUCCAUAGGCU
miR-15/16/195/424/497 1595 1601 m8 hsa-miR-15abrain UAGCAGCACAUAAUGGUUUGUG
hsa-miR-16brain UAGCAGCACGUAAAUAUUGGCG
hsa-miR-15bbrain UAGCAGCACAUCAUGGUUUACA
hsa-miR-195SZ UAGCAGCACAGAAAUAUUGGC
hsa-miR-424 CAGCAGCAAUUCAUGUUUUGAA
hsa-miR-497 CAGCAGCACACUGUGGUUUGU
miR-153 2737 2743 1A hsa-miR-153 UUGCAUAGUCACAAAAGUGA
miR-17-5p/20/93.mr/106/519.d 3622 3628 1A hsa-miR-17-5p CAAAGUGCUUACAGUGCAGGUAGU
hsa-miR-20abrain UAAAGUGCUUAUAGUGCAGGUAG
hsa-miR-106a AAAAGUGCUUACAGUGCAGGUAGC
hsa-miR-106bSZ UAAAGUGCUGACAGUGCAGAU
hsa-miR-20bSZ CAAAGUGCUCAUAGUGCAGGUAG
hsa-miR-519d CAAAGUGCCUCCCUUUAGAGUGU
miR-18 2796 2802 1A hsa-miR-18a UAAGGUGCAUCUAGUGCAGAUA
hsa-miR-18b UAAGGUGCAUCUAGUGCAGUUA
miR-183 3740 3746 1A hsa-miR-183 UAUGGCACUGGUAGAAUUCACUG
miR-19 1531 1538 1A,m8 hsa-miR-19a UGUGCAAAUCUAUGCAAAACUGA
hsa-miR-19b UGUGCAAAUCCAUGCAAAACUGA
miR-194 1017 1023 1A hsa-miR-194 UGUAACAGCAACUCCAUGUGGA
miR-196 1664 1670 1A hsa-miR-196a UAGGUAGUUUCAUGUUGUUGG
hsa-miR-196b UAGGUAGUUUCCUGUUGUUGG
miR-200bc/429 2659 2665 m8 hsa-miR-200b UAAUACUGCCUGGUAAUGAUGAC
hsa-miR-200c UAAUACUGCCGGGUAAUGAUGG
hsa-miR-429 UAAUACUGUCUGGUAAAACCGU
hsa-miR-200b UAAUACUGCCUGGUAAUGAUGAC
hsa-miR-200c UAAUACUGCCGGGUAAUGAUGG
hsa-miR-429 UAAUACUGUCUGGUAAAACCGU
hsa-miR-200b UAAUACUGCCUGGUAAUGAUGAC
hsa-miR-200c UAAUACUGCCGGGUAAUGAUGG
hsa-miR-429 UAAUACUGUCUGGUAAAACCGU
miR-205 3628 3634 m8 hsa-miR-205 UCCUUCAUUCCACCGGAGUCUG
miR-208 565 572 1A,m8 hsa-miR-208 AUAAGACGAGCAAAAAGCUUGU
miR-217 582 588 1A hsa-miR-217 UACUGCAUCAGGAACUGAUUGGAU
miR-24 288 294 1A hsa-miR-24SZ UGGCUCAGUUCAGCAGGAACAG
miR-26 1641 1647 1A hsa-miR-26abrain UUCAAGUAAUCCAGGAUAGGC
hsa-miR-26bSZ UUCAAGUAAUUCAGGAUAGGUU
hsa-miR-26abrain UUCAAGUAAUCCAGGAUAGGC
hsa-miR-26bSZ UUCAAGUAAUUCAGGAUAGGUU
miR-27 2761 2768 1A,m8 hsa-miR-27abrain UUCACAGUGGCUAAGUUCCGC
hsa-miR-27bbrain UUCACAGUGGCUAAGUUCUGC
miR-299-5p 2892 2898 1A hsa-miR-299-5p UGGUUUACCGUCCCACAUACAU
miR-323 3034 3040 m8 hsa-miR-323brain GCACAUUACACGGUCGACCUCU
miR-324-3p 3657 3663 1A hsa-miR-324-3p CCACUGCCCCAGGUGCUGCUGG
miR-34b 521 527 m8 hsa-miR-34b UAGGCAGUGUCAUUAGCUGAUUG
miR-369-3p 603 609 m8 hsa-miR-369-3p AAUAAUACAUGGUUGAUCUUU
hsa-miR-369-3p AAUAAUACAUGGUUGAUCUUU
miR-374 222 229 1A,m8 hsa-miR-374 UUAUAAUACAACCUGAUAAGUG
miR-375 3717 3723 1A hsa-miR-375 UUUGUUCGUUCGGCUCGCGUGA
miR-379 1662 1668 m8 hsa-miR-379brain UGGUAGACUAUGGAACGUA
miR-381 390 396 m8 hsa-miR-381 UAUACAAGGGCAAGCUCUCUGU
miR-410 894 900 m8 hsa-miR-410 AAUAUAACACAGAUGGCCUGU
hsa-miR-410 AAUAUAACACAGAUGGCCUGU
hsa-miR-410 AAUAUAACACAGAUGGCCUGU
miR-433-3p 3850 3856 1A hsa-miR-433brain AUCAUGAUGGGCUCCUCGGUGU
miR-448 2737 2743 1A hsa-miR-448 UUGCAUAUGUAGGAUGUCCCAU
miR-485-3p 2776 2783 1A,m8 hsa-miR-485-3p GUCAUACACGGCUCUCCUCUCU
miR-493-5p 742 748 m8 hsa-miR-493-5p UUGUACAUGGUAGGCUUUCAUU
hsa-miR-493-5p UUGUACAUGGUAGGCUUUCAUU
hsa-miR-493-5p UUGUACAUGGUAGGCUUUCAUU
miR-499 566 572 1A hsa-miR-499 UUAAGACUUGCAGUGAUGUUUAA
miR-543 1015 1021 1A hsa-miR-543 AAACAUUCGCGGUGCACUUCU