基因页：CDC42

Summary?
基因 998
Symbol CDC42
Synonyms CDC42Hs|G25K|TKS
Description cell division cycle 42
Reference MIM：116952|HGNC:HGNC:1736|ENSEMBL：ENSG00000070831|HPRD：00309|Vega：Otthumg00000002753
Gene type protein-coding
地图位置 1p36.1
Pascal p-value 0.002
Sherlock P值 0.982
Fetal beta 0.824
eGene 尾状基底神经节
迈尔斯的顺式和跨性别
元
支持 STRUCTURAL PLASTICITY

Gene in Data Sources
Gene set name Method of gene set Description Info
CV：GWASDB 全基因组关联研究 GWASdb records for schizophrenia
CV:PGCnp 全基因组协会研究 GWAS
PMID:cooccur High-throughput literature-search Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature High-throughput literature-search 与精神分裂症关键词共同存在：精神分裂症，精神分裂症 Click to show details
go_annotation Mapping neuro-related keywords to Gene Ontology annotations Hits with neuro-related keywords: 3
网络 人蛋白蛋白质相互作用网络中核心基因的最短路径距离 Contribution to shortest path in PPI network: 1.1845

第一节遗传学和表观遗传学注释

@EQTL注释

SNP ID Chromosome Position eGene Gene Entrez ID PVALUE qvalue TSS distance eQTL type
rs10994209 Chr10 61877705 CDC42 998 0.15 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

无法使用

Gene expression during devlopment (BrainCloud)

Footnote:
总共绘制了269个时间点，n = 38个胎儿样品（x = 1：38）。每个三角形代表一个时间点。

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC：亚皮质区域；SM：感觉运动区域；FC：额叶皮层；和TP：颞顶皮层
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

前10个积极共表达的基因
Gene Pearson's Correlation Spearman's Correlation
ROBO4 0.84 0.83
mmrn2 0.81 0.83
领带1 0.81 0.80
CXorf36 0.79 0.81
ENG 0.79 0.82
FLI1 0.77 0.77
GPR124 0.77 0.80
TNFRSF1B 0.76 0.79
FGD5 0.76 0.81
NOS3 0.76 0.78
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
MTIF3 -0.51 -0.53
TIMM10 -0.50 -0.51
C8orf59 -0.46 -0.55
TMEM126A -0.46 -0.51
COX7C -0.45 -0.50
USMG5 -0.45 -0.58
ST20 -0.45 -0.50
MRPL21 -0.45 -0.48
ZBTB8OS -0.45 -0.47
MRPS18C -0.45 -0.50

Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0000166 核苷酸结合 IEA -
去：0003924 GTPase activity IEA -
去：0003924 GTPase activity 塔斯 11035016
GO:0005515 protein binding IPI 10587647|10816584|11035016
GO:0005525 GTP结合 IEA -
GO:0030742 GTP-dependent protein binding IEA -
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO：0046847 filopodium formation IEA axon (GO term level: 10) -
GO:0007163 establishment or maintenance of cell polarity 塔斯 11260256
去：0007097 nuclear migration IEA -
去：0007264 small GTPase mediated signal transduction IEA -
去：0030036 actin cytoskeleton organization 艾达 11035016
GO：0031333 negative regulation of protein complex assembly IPI 11584266
GO:0031274 positive regulation of pseudopodium formation 艾达 11035016
GO:0051301 cell division IEA -
GO:0030225 macrophage differentiation 塔斯 11260256
GO：0043552 positive regulation of phosphoinositide 3-kinase activity IEA -
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0030175 filopodium 艾达 axon (GO term level: 5) 11035016
GO:0042995 cell projection IEA axon (GO term level: 4) -
GO:0005829 cytosol EXP 14505571|16407834
GO:0005622 intracellular IEA -
GO:0005737 cytoplasm 艾达 11260256
GO:0005886 质膜 艾达 11260256

第四节。蛋白质蛋白相互作用注释

Interactors Aliases B Official full name B Experimental Source PubMed ID
ACTR3 ARP3 ARP3 actin-related protein 3 homolog (yeast) - HPRD 9860974
ARHGAP1 CDC42GAP | RHOGAP | RHOGAP1 | p50rhoGAP Rho GTPase activating protein 1 - HPRD，Biogrid 9268338
ARHGAP1 CDC42GAP | RHOGAP | RHOGAP1 | p50rhoGAP Rho GTPase activating protein 1 Cdc42GAP interacts with Cdc42. This interaction was modelled on a demonstrated interaction between human Cdc42GAP and Cdc42 from an unspecified species. BIND 10799524
ARHGAP10 FLJ20896 | FLJ41791 | GRAF2 | PS-GAP Rho GTPase激活蛋白10 Biochemical Activity BioGRID 11432776
ARHGAP17 DKFZP564A1363 |FLJ37567 |FLJ43368 |MGC87805 |MST066 |MST110 |MSTP038 |MSTP066 |MSTP110 |纳德林| RICH1 | WBP15 Rho GTPase激活蛋白17 Biochemical Activity BioGRID 11431473
ARHGAP26 FLJ42530 | GRAF | KIAA0621 | OPHN1L | OPHN1L1 Rho GTPase activating protein 26 Biochemical Activity BioGRID 11432776
ARHGAP27 CAMGAP1 |FLJ43547 |MGC120624 Rho GTPase activating protein 27 Biochemical Activity BioGRID 15147912
ARHGAP29 parg1 |RP11-255E17.1 Rho GTPase activating protein 29 Two-hybrid BioGRID 14749388
ARHGAP8 BPGAP1 | FLJ20185 | PP610 Rho GTPase activating protein 8 BPGAP1与CDC42相互作用。 BIND 12944407
ARHGDIA GDIA1 |MGC117248 |Rhogdi |Rhogdi-1 Rho GDP dissociation inhibitor (GDI) alpha - HPRD 10676816
ARHGDIA GDIA1 |MGC117248 |Rhogdi |Rhogdi-1 Rho GDP dissociation inhibitor (GDI) alpha 亲和力捕获ms BioGRID 17353931
ARHGDIB D4 | GDIA2 | GDID4 | LYGDI | Ly-GDI | RAP1GN1 | RhoGDI2 RHO GDP解离抑制剂（GDI）β - HPRD，Biogrid 9799233
ARHGDIG RHOGDI-3 Rho GDP dissociation inhibitor (GDI) gamma - HPRD，Biogrid 9113980
Arhgef6 COOL2 | Cool-2 | KIAA0006 | MRX46 | PIXA | alpha-PIX | alphaPIX Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6 ARHGEF6（Cool-2）与CDC42相互作用。 BIND 15649357
Arhgef7 BETA-PIX | COOL1 | DKFZp686C12170 | DKFZp761K1021 | KIAA0142 | KIAA0412 | Nbla10314 | P50 | P50BP | P85 | P85COOL1 | P85SPR | PAK3 | PIXB Rho鸟嘌呤核苷酸交换因子（GEF）7 Arhgef7(p85Cool-1) interacts with Cdc42. BIND 15649357
BAIAP2 bap2 |IRSP53 BAI1-associated protein 2 - HPRD，Biogrid 11696321
BNIP2 BNIP-2 | NIP2 BCL2/adenovirus E1B 19kDa interacting protein 2 BNIP-2与CDC42的未指定同工型相互作用。This interaction was modeled on a demonstrated interaction between human BNIP-2 and Cdc42 from an unspecified species. BIND 10954711
BNIP2 BNIP-2 | NIP2 BCL2/adenovirus E1B 19kDa interacting protein 2 BNIP-2与CDC42的未指定同工型相互作用。 BIND 15652341
BNIP2 BNIP-2 | NIP2 BCL2/adenovirus E1B 19kDa interacting protein 2 BNIP-2 interacts with Cdc42. This interaction was modelled on a demonstrated interaction between human BNIP-2 and Cdc42 from an unspecified species. BIND 10799524
BNIP2 BNIP-2 | NIP2 BCL2/adenovirus E1B 19kDa interacting protein 2 - HPRD，Biogrid 10551883|10799524
|10954711
BNIPL BNIP-S | BNIPL-1 | BNIPL-2 | BNIPL1 | BNIPL2 | PP753 BCL2/adenovirus E1B 19kD interacting protein like Affinity Capture-Western
Two-hybrid		 BioGRID 12901880
C14orf1 ERG28 | NET51 chromosome 14 open reading frame 1 Two-hybrid BioGRID 16169070
C1orf103 FLJ11269 | RIF1 | RP11-96K19.1 chromosome 1 open reading frame 103 Two-hybrid BioGRID 16169070
CDC42 cdc42hs |G25K cell division cycle 42 (GTP binding protein, 25kDa) - HPRD，Biogrid 10211824
CDC42BPG DMPK2 | HSMDPKIN | KAPPA-200 | MRCKgamma Cdc42结合蛋白激酶γ（类似DMPK） - HPRD，Biogrid 15194684
CDC42EP1 BORG5 | CEP1 | MGC15316 | MSE55 CDC42 effector protein (Rho GTPase binding) 1 Two-hybrid BioGRID 16189514
CDC42EP2 BORG1 | CEP2 CDC42 effector protein (Rho GTPase binding) 2 - HPRD，Biogrid 11035016
CDC42EP2 BORG1 | CEP2 CDC42 effector protein (Rho GTPase binding) 2 Activated Cdc42 interacts with Borg1. This interaction was modeled on a demonstrated interaction between Cdc42 from an unspecified species and Borg1 from human. BIND 10490598
CDC42EP3 BORG2 | CEP3 | FLJ46903 | UB1 CDC42 effector protein (Rho GTPase binding) 3 活化的CDC42与BORG2相互作用。这种相互作用是基于未指定物种的Cdc42与人类BORG2之间的相互作用进行建模的。 BIND 10490598
CDC42EP3 BORG2 | CEP3 | FLJ46903 | UB1 CDC42 effector protein (Rho GTPase binding) 3 - HPRD，Biogrid 10490598
CDC42EP5 Borg3 | CEP5 | MGC21945 | MGC71153 CDC42 effector protein (Rho GTPase binding) 5 - HPRD，Biogrid 10490598|11035016
|11584266 | 11035016
CDC42SE1 SCIP1 | SPEC1 CDC42 small effector 1 - HPRD，Biogrid 10816584
CDC42SE2 FLJ21967 |规格2 CDC42 small effector 2 Two-hybrid BioGRID 10816584
CDGAP KIAA1204 | MGC138368 | MGC138370 Cdc42 GTPase激活蛋白 - HPRD 9786927
CLIP1 剪辑| CLIP-170 | CLIP170 | CYLN1 | MGC131604 | RSN CAP-GLY domain containing linker protein 1 Affinity Capture-Western BioGRID 12110184
CSPG4 HMW-MAA |MCSP |MCSPG |mel-cspg |MSK16 |NG2 chondroitin sulfate proteoglycan 4 - HPRD，Biogrid 10587647
DEF6 IBP | SLAT differentially expressed in FDCP 6 homolog (mouse) - HPRD，Biogrid 15023524
DEF6 IBP | SLAT differentially expressed in FDCP 6 homolog (mouse) DEF6 interacts with Cdc42. This interaction was modelled on a demonstrated interaction between human DEF6 and Cdc42 from an unspecified species. BIND 15023524
DOCK7 KIAA1771 |ZIR2 dedicator of cytokinesis 7 - HPRD 12432077
DOCK8 FLJ00026 | FLJ00152 | FLJ00346 | MRD2 | ZIR8 dedicator of cytokinesis 8 - HPRD，Biogrid 15304341
DOCK9 DKFZp686C11110 | DKFZp686D2047 | DKFZp686N04132 | FLJ11949 | FLJ16744 | FLJ44528 | FLJ45282 | FLJ45601 | KIAA1058 | KIAA1085 | ZIZ1 | ZIZIMIN1 dedicator of cytokinesis 9 - HPRD，Biogrid 12172552
EEF1G EF1G |GIG35 eukaryotic translation elongation factor 1 gamma Two-hybrid BioGRID 16169070
EIF2AK2 EIF2AK1 | MGC126524 | PKR | PRKR eukaryotic translation initiation factor 2-alpha kinase 2 - HPRD 7738010
errfi1 GENE-33 | MIG-6 | MIG6 | RALT ERBB受体反馈抑制剂1 Affinity Capture-Western
Reconstituted Complex		 BioGRID 10749885
FGD1 AAS | FGDY | ZFYVE3 FYVE, RhoGEF and PH domain containing 1 - HPRD，Biogrid 8969170
FLNA ABP-280 | ABPX | DKFZp434P031 | FLN | FLN1 | FMD | MNS | NHBP | OPD | OPD1 | OPD2 filamin A, alpha (actin binding protein 280) - HPRD 10051605
FNBP1L C1orf39 |TOCA1 formin binding protein 1-like Affinity Capture-Western BioGRID 15260990
GDI1 FLJ41411 | GDIL | MRX41 | MRX48 | OPHN2 | RABGD1A| RABGDIA | XAP-4 GDP dissociation inhibitor 1 - HPRD，Biogrid 11583574
geft p63RhoGEF RhoA/RAC/CDC42 exchange factor - HPRD，Biogrid 12547822
GOPC CAL | FIG | GOPC1 | PIST | dJ94G16.2 golgi associated PDZ and coiled-coil motif containing Reconstituted Complex BioGRID 11162552
IQGAP1 humorfa01 |KIAA0051 |sar1 |P195 IQ motif containing GTPase activating protein 1 - HPRD 8670801|12900413|8798539
|9182573
IQGAP1 humorfa01 |KIAA0051 |sar1 |P195 IQ motif containing GTPase activating protein 1 Affinity Capture-Western
in vitro
in vivo
Reconstituted Complex		 BioGRID 8670801|8798539
|9182573|12110184
IQGAP2 - IQ motif containing GTPase activating protein 2 - HPRD 8756646
IQGAP2 - IQ motif containing GTPase activating protein 2 - HPRD，Biogrid 8702968|8756646 | 8756646
ITSN1 ITSN | MGC134948 | MGC134949 | SH3D1A | SH3P17 相交1（SH3结构蛋白） Cdc42 specifically interacts with Dbl-homology and pleckstrin-homology domains of the nucleotide exchange factor ITSN1. BIND 12006984
ITSN1 ITSN | MGC134948 | MGC134949 | SH3D1A | SH3P17 相交1（SH3结构蛋白） - HPRD，Biogrid 11584276
KAT5 ESA1 | HTATIP | HTATIP1 | PLIP | TIP | TIP60 | cPLA2 K(lysine) acetyltransferase 5 Two-hybrid BioGRID 16169070
KTN1 CG1 | KIAA0004 | KNT | MGC133337 | MU-RMS-40.19 kinectin 1 (kinesin receptor) - HPRD 9535835
MAP3K10 MLK2 | MST mitogen-activated protein kinase kinase kinase 10 - HPRD，Biogrid 9427749
MAP3K11 MGC17114 |MLK-3 |MLK3 |ptk1 |泉水 mitogen-activated protein kinase kinase kinase 11 - HPRD，Biogrid 10799501
MAP3K4 FLJ42439 | KIAA0213 | MAPKKK4 | MEKK4 | MTK1 | PRO0412 mitogen-activated protein kinase kinase kinase 4 - HPRD，Biogrid 9079650
MCF2 DBL MCF.2细胞系导出转换序列 Reconstituted Complex BioGRID 10854437
MCF2L ARHGEF14 | DBS | FLJ12122 | KIAA0362 | OST MCF.2细胞系导出的转化序列样 Cdc42 specifically interacts with Dbl-homology and pleckstrin-homology domains of the nucleotide exchange factor Dbs. This interaction is modelled on a demonstrated interaction between mouse Dbs and human Cdc42. BIND 11889037
MCF2L ARHGEF14 | DBS | FLJ12122 | KIAA0362 | OST MCF.2细胞系导出的转化序列样 - HPRD，Biogrid 14701795
METAP2 MAP2 | MNPEP | p67 | p67eIF2 methionyl aminopeptidase 2 - HPRD 7738010
NCF2 FLJ93058 | NCF-2 | NOXA2 | P67-PHOX | P67PHOX neutrophil cytosolic factor 2 - HPRD，Biogrid 7738010|9642115|9642115
NCF2 FLJ93058 | NCF-2 | NOXA2 | P67-PHOX | P67PHOX neutrophil cytosolic factor 2 - HPRD 9642115
OPHN1 MRX60 | OPN1 oligophrenin 1 - HPRD，Biogrid 9582072|11998687
PAK1 MGC130000 | MGC130001 | PAKalpha P21蛋白（CDC42/RAC）激活激酶1 Reconstituted Complex BioGRID 12650940
PAK1 MGC130000 | MGC130001 | PAKalpha P21蛋白（CDC42/RAC）激活激酶1 PAK1interacts with an unspecified isoform of Cdc42. This interaction was modeled on a demonstrated interaction between PAK1 from an unspecified species and human Cdc42. BIND 15864311
PAK1 MGC130000 | MGC130001 | PAKalpha P21蛋白（CDC42/RAC）激活激酶1 - HPRD 7744004|8107774
|9705280 | 9705280
PAK1 MGC130000 | MGC130001 | PAKalpha P21蛋白（CDC42/RAC）激活激酶1 Cdc42 interacts with Pak1. This interaction was modelled on a demonstrated interaction between Cdc42 from an unspecified species and human Pak1. BIND 12944407
PAK2 PAK65 | PAKgamma P21蛋白（CDC42/RAC）激活激酶2 - HPRD，Biogrid 10320322
PAK4 - p21 protein (Cdc42/Rac)-activated kinase 4 - HPRD，Biogrid 9822598
PAK6 PAK5 p21 protein (Cdc42/Rac)-activated kinase 6 - HPRD，Biogrid 11773441
PAK7 KIAA1264 | MGC26232 | PAK5 p21 protein (Cdc42/Rac)-activated kinase 7 - HPRD，Biogrid 11756552|12032833
PARD3 ASIP |巴兹|火箭筒|FLJ21015 |PAR3 |par3alpha |pard3a |SE2-5L16 |SE2-5LT1 |SE2-5T2 par-3 partitioning defective 3 homolog (C. elegans) - HPRD 10934474
PARD6A PAR-6A | PAR6 | PAR6C | PAR6alpha | TAX40 | TIP-40 par-6 partitioning defective 6 homolog alpha (C. elegans) Affinity Capture-Western
in vitro
in vivo
Reconstituted Complex
Two-hybrid		 BioGRID 10873802|10934474
|11260256
PARD6A PAR-6A | PAR6 | PAR6C | PAR6alpha | TAX40 | TIP-40 par-6 partitioning defective 6 homolog alpha (C. elegans) - HPRD 10873802|11260256
PARD6B PAR6B PAR-6分区有缺陷的6个同源β（C. elegans） Affinity Capture-Western
Reconstituted Complex
Two-hybrid		 BioGRID 10934474|11162552
PARD6G FLJ45701 | PAR-6G | PAR6gamma par-6 partitioning defective 6 homolog gamma (C. elegans) - HPRD，Biogrid 11260256
PDE6D PDED 磷酸二酯酶6D，CGMP特异性，杆，三角洲 Two-hybrid BioGRID 16169070
PIK3R1 GRB1 | p85 | p85-ALPHA phosphoinositide-3-kinase, regulatory subunit 1 (alpha) - HPRD，Biogrid 7629060|8034624
|9381982
PIK3R1 GRB1 | p85 | p85-ALPHA phosphoinositide-3-kinase, regulatory subunit 1 (alpha) - HPRD 9381982
PLD1 - phospholipase D1, phosphatidylcholine-specific - HPRD，Biogrid 10747870
PLEKHG2 CLG | DKFZp667J2325 | FLJ00018 | FLJ22458 | FLJ38638 PLECKSTRIN同源域包含family G（带有Rhogef域）成员2 - HPRD，Biogrid 11839748
PRKCA AAG6 | MGC129900 | MGC129901 | PKC-alpha | PKCA | PRKACA protein kinase C, alpha - HPRD，Biogrid 11284700
PRKCZ PKC-ZETA | PKC2 protein kinase C, zeta - HPRD 10733591
Rac1 MGC111543 | MIG5 | TC-25 | p21-Rac1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) Two-hybrid BioGRID 9427749
Rac2 EN-7 | Gx | HSPC022 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) - HPRD，Biogrid 9748241
RHOJ ARHJ | FLJ14445 | MGC34777 | RASL7B | TC10B | TCL ras homolog gene family, member J - HPRD，Biogrid 10967094
RICH2 KIAA0672 |NPC-A-10 Rho-type GTPase-activating protein RICH2 Biochemical Activity BioGRID 11431473
RICS GC-GAP | |毅力KIAA0712 | MGC1892 | p200RhoGAP |p250GAP Rho GTPase-activating protein Biochemical Activity BioGRID 12446789|12819203
|12857875
RPS6KB1 PS6K |S6K |S6K1 |STK14A |P70（S6K）-Alpha |P70-S6K |P70-Alpha ribosomal protein S6 kinase, 70kDa, polypeptide 1 - HPRD 11438723
SRGAP1 ARHGAP13 | FLJ22166 | KIAA1304 缝隙 - robo rho gtpase激活蛋白1 - HPRD 11672528
TBC1D3 TBC1D3A | TRE17 TBC1 domain family, member 3 - HPRD，Biogrid 12612085
TNK2 ACK | ACK1 | FLJ44758 | FLJ45547 | p21cdc42Hs tyrosine kinase, non-receptor, 2 - HPRD，Biogrid 11394904
TP53 FLJ92943 | LFS1 | TRP53 | p53 tumor protein p53 Two-hybrid BioGRID 16169070
TRIP10 CIP4 | HSTP | STOT | STP 甲状腺激素受体相互作用10 - HPRD，Biogrid 9210375|10713100
UBR1 JBS |MGC142065 |MGC142067 ubiquitin protein ligase E3 component n-recognin 1 Two-hybrid BioGRID 16169070
UNC119 HRG4 UNC-119同源物（秀丽隐杆线虫） Two-hybrid BioGRID 16169070
VAV1 VAV VAV 1鸟嘌呤核苷酸交换因子 - HPRD，Biogrid 11287617
WAS IMD2 |THC |黄蜂 Wiskott-Aldrich综合征（湿疹 - 肉毒细胞减少症） CDC42 interacts with WASP. This interaction was modeled on a demonstrated interaction between CDC42 and WASP from an unspecified species. BIND 15652748
WAS IMD2 |THC |黄蜂 Wiskott-Aldrich综合征（湿疹 - 肉毒细胞减少症） Active GTP-bound CDC42 interacts with WAS (WASP). This interaction was modelled on a demonstrated interaction between chicken CDC42 and human WAS. BIND 15735674
WAS IMD2 |THC |黄蜂 Wiskott-Aldrich综合征（湿疹 - 肉毒细胞减少症） CDC42与黄蜂相互作用。 BIND 15361624
WAS IMD2 |THC |黄蜂 Wiskott-Aldrich综合征（湿疹 - 肉毒细胞减少症） - HPRD 8625410|10724160
WAS IMD2 |THC |黄蜂 Wiskott-Aldrich综合征（湿疹 - 肉毒细胞减少症） in vitro
in vivo
Reconstituted Complex		 BioGRID 8625410|8643625
|10713100|10724160
WASF1 FLJ31482 | KIAA0269 | SCAR1 | WAVE | WAVE1 WAS protein family, member 1 - HPRD 12181570
WASF2 scar2 |Wave2 |DJ393P12.2 WAS protein family, member 2 - HPRD 12181570
Wasl DKFZp779G0847 | MGC48327 | N-WASP | NWASP Wiskott-Aldrich syndrome-like in vitro
Reconstituted Complex		 BioGRID 9422512|10781580
Wasl DKFZp779G0847 | MGC48327 | N-WASP | NWASP Wiskott-Aldrich syndrome-like - HPRD 9422512|10724160


V.途径注释

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG MAPK SIGNALING PATHWAY 267 205 All SZGR 2.0 genes in this pathway
KEGG CHEMOKINE SIGNALING PATHWAY 190 128 All SZGR 2.0 genes in this pathway
KEGG ENDOCYTOSIS 183 132 All SZGR 2.0 genes in this pathway
KEGG AXON GUIDANCE 129 103 All SZGR 2.0 genes in this pathway
kegg vegf信号通路 76 53 All SZGR 2.0 genes in this pathway
KEGG FOCAL ADHESION 201 138 All SZGR 2.0 genes in this pathway
KEGG ADHERENS JUNCTION 75 53 All SZGR 2.0 genes in this pathway
KEGG TIGHT JUNCTION 134 86 All SZGR 2.0 genes in this pathway
KEGG T CELL RECEPTOR SIGNALING PATHWAY 108 89 All SZGR 2.0 genes in this pathway
KEGG FC GAMMA R MEDIATED PHAGOCYTOSIS 97 71 All SZGR 2.0 genes in this pathway
KEGG LEUKOCYTE TRANSENDOTHELIAL MIGRATION 118 78 All SZGR 2.0 genes in this pathway
KEGG NEUROTROPHIN SIGNALING PATHWAY 126 103 All SZGR 2.0 genes in this pathway
KEGG REGULATION OF ACTIN CYTOSKELETON 216 144 All SZGR 2.0 genes in this pathway
KEGG GNRH SIGNALING PATHWAY 101 77 All SZGR 2.0 genes in this pathway
KEGG EPITHELIAL CELL SIGNALING IN HELICOBACTER PYLORI INFECTION 68 44 All SZGR 2.0 genes in this pathway
KEGG PATHOGENIC ESCHERICHIA COLI INFECTION 59 36 All SZGR 2.0 genes in this pathway
KEGG PATHWAYS IN CANCER 328 259 All SZGR 2.0 genes in this pathway
KEGG RENAL CELL CARCINOMA 70 60 All SZGR 2.0 genes in this pathway
kegg胰腺癌 70 56 All SZGR 2.0 genes in this pathway
BIOCARTA AGR PATHWAY 36 31 All SZGR 2.0 genes in this pathway
BIOCARTA SALMONELLA PATHWAY 13 10 All SZGR 2.0 genes in this pathway
BIOCARTA P38MAPK PATHWAY 40 31 All SZGR 2.0 genes in this pathway
BIOCARTA RAS PATHWAY 23 20 All SZGR 2.0 genes in this pathway
BIOCARTA MAL PATHWAY 19 17 All SZGR 2.0 genes in this pathway
BIOCARTA CDC42RAC PATHWAY 16 13 All SZGR 2.0 genes in this pathway
SIG PIP3 SIGNALING IN CARDIAC MYOCTES 67 54 All SZGR 2.0 genes in this pathway
SIG CHEMOTAXIS 45 37 All SZGR 2.0 genes in this pathway
ST P38 MAPK途径 37 28 All SZGR 2.0 genes in this pathway
SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES 35 25 All SZGR 2.0 genes in this pathway
ST INTEGRIN SIGNALING PATHWAY 82 62 All SZGR 2.0 genes in this pathway
St GA13途径 37 32 All SZGR 2.0 genes in this pathway
SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES 51 41 All SZGR 2.0 genes in this pathway
ST JNK MAPK PATHWAY 40 30 All SZGR 2.0 genes in this pathway
PID ENDOTHELIN PATHWAY 63 52 All SZGR 2.0 genes in this pathway
PID RHOA PATHWAY 45 33 All SZGR 2.0 genes in this pathway
PID WNT NONCANONICAL PATHWAY 32 26 All SZGR 2.0 genes in this pathway
PID TCR PATHWAY 66 51 All SZGR 2.0 genes in this pathway
PID遇到了路径 80 60 All SZGR 2.0 genes in this pathway
PID EPHB FWD PATHWAY 40 38 All SZGR 2.0 genes in this pathway
PID AVB3 OPN途径 31 29 All SZGR 2.0 genes in this pathway
PID S1P S1P4途径 14 11 All SZGR 2.0 genes in this pathway
PID ILK PATHWAY 45 32 All SZGR 2.0 genes in this pathway
PID NECTIN PATHWAY 30 20 All SZGR 2.0 genes in this pathway
PID P38 ALPHA BETA PATHWAY 31 25 All SZGR 2.0 genes in this pathway
PID CDC42 PATHWAY 70 51 All SZGR 2.0 genes in this pathway
PID CDC42 REG PATHWAY 30 22 All SZGR 2.0 genes in this pathway
PID NETRIN PATHWAY 32 27 All SZGR 2.0 genes in this pathway
PID CXCR4 PATHWAY 102 78 All SZGR 2.0 genes in this pathway
PID AJDISS 2PATHWAY 48 38 All SZGR 2.0 genes in this pathway
PID Ecadherin新生AJ途径 39 33 All SZGR 2.0 genes in this pathway
PID LIS1 PATHWAY 28 22 All SZGR 2.0 genes in this pathway
PID ERBB1 DOWNSTREAM PATHWAY 105 78 All SZGR 2.0 genes in this pathway
PID ERBB2 ERBB3 PATHWAY 44 35 All SZGR 2.0 genes in this pathway
PID TRKR途径 62 48 All SZGR 2.0 genes in this pathway
PID AR NONGENOMIC PATHWAY 31 27 All SZGR 2.0 genes in this pathway
PID ERBB1内部化途径 41 35 All SZGR 2.0 genes in this pathway
PID VEGFR1 2途径 69 57 All SZGR 2.0 genes in this pathway
PID NCADHERIN途径 33 32 All SZGR 2.0 genes in this pathway
Rho GTPases的Reactome信号传导 113 81 All SZGR 2.0 genes in this pathway
Reactome发育生物学 396 292 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY EGFR IN CANCER 109 80 All SZGR 2.0 genes in this pathway
REACTOME EGFR DOWNREGULATION 25 14 All SZGR 2.0 genes in this pathway
GPCR的反应组信号传导 920 449 All SZGR 2.0 genes in this pathway
REACTOME GPVI MEDIATED ACTIVATION CASCADE 31 25 All SZGR 2.0 genes in this pathway
REACTOME AXON GUIDANCE 251 188 All SZGR 2.0 genes in this pathway
Reactome G alpha1213信号传导事件 74 56 All SZGR 2.0 genes in this pathway
REACTOME CD28 CO STIMULATION 32 26 All SZGR 2.0 genes in this pathway
Reactome GPCR下游信号传导 805 368 All SZGR 2.0 genes in this pathway
REACTOME CD28 DEPENDENT VAV1 PATHWAY 11 10 All SZGR 2.0 genes in this pathway
REACTOME SEMA4D IN SEMAPHORIN SIGNALING 32 22 All SZGR 2.0 genes in this pathway
REACTOME SEMAPHORIN INTERACTIONS 68 53 All SZGR 2.0 genes in this pathway
REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE 27 21 All SZGR 2.0 genes in this pathway
REACTOME COSTIMULATION BY THE CD28 FAMILY 63 48 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY ROBO RECEPTOR 30 26 All SZGR 2.0 genes in this pathway
REACTOME MYOGENESIS 28 20 All SZGR 2.0 genes in this pathway
REACTOME NETRIN1 SIGNALING 41 30 All SZGR 2.0 genes in this pathway
REACTOME DCC MEDIATED ATTRACTIVE SIGNALING 13 11 All SZGR 2.0 genes in this pathway
巨核细胞发育和血小板产生涉及的反应组因素 132 101 All SZGR 2.0 genes in this pathway
反应组止血 466 331 All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM 933 616 All SZGR 2.0 genes in this pathway
Reactome适应性免疫系统 539 350 All SZGR 2.0 genes in this pathway
REACTOME PLATELET ACTIVATION SIGNALING AND AGGREGATION 208 138 All SZGR 2.0 genes in this pathway
WATANABE COLON CANCER MSI VS MSS DN 81 42 All SZGR 2.0 genes in this pathway
GAZDA DIAMOND BLACKFAN ANEMIA ERYTHROID DN 493 298 All SZGR 2.0 genes in this pathway
GARY CD5 TARGETS UP 473 314 All SZGR 2.0 genes in this pathway
Deurig t细胞促进性白血病DN 320 184 All SZGR 2.0 genes in this pathway
Doane对雄激素DN的反应 241 146 All SZGR 2.0 genes in this pathway
Wang LMO4靶向DN 352 225 All SZGR 2.0 genes in this pathway
GINESTIER BREAST CANCER ZNF217 AMPLIFIED UP 78 48 All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 8D DN 205 127 All SZGR 2.0 genes in this pathway
Senese HDAC1靶向DN 260 143 All SZGR 2.0 genes in this pathway
SENESE HDAC3 TARGETS DN 536 332 All SZGR 2.0 genes in this pathway
TIEN INTESTINE PROBIOTICS 24HR UP 557 331 All SZGR 2.0 genes in this pathway
HAHTOLA MYCOSIS FUNGOIDES CD4 DN 116 71 All SZGR 2.0 genes in this pathway
HAHTOLA MYCOSIS FUNGOIDES DN 16 10 All SZGR 2.0 genes in this pathway
COLDREN GEFITINIB RESISTANCE DN 230 115 All SZGR 2.0 genes in this pathway
kokkinakis甲硫氨酸剥夺48小时DN 64 39 All SZGR 2.0 genes in this pathway
KOKKINAKIS METHIONINE DEPRIVATION 96HR DN 75 50 All SZGR 2.0 genes in this pathway
lastowska神经母细胞瘤副本编号dn 800 473 All SZGR 2.0 genes in this pathway
LI LUNG CANCER 41 30 All SZGR 2.0 genes in this pathway
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN UP 479 299 All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS UP 1037 673 All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS DN 1024 594 All SZGR 2.0 genes in this pathway
BUYTAERT PHOTODYNAMIC THERAPY STRESS UP 811 508 All SZGR 2.0 genes in this pathway
LOPEZ MBD TARGETS 957 597 All SZGR 2.0 genes in this pathway
WEI MYCN TARGETS WITH E BOX 795 478 All SZGR 2.0 genes in this pathway
CAFFAREL RESPONSE TO THC 24HR 3 DN 13 8 All SZGR 2.0 genes in this pathway
CAFFAREL RESPONSE TO THC 24HR 5 DN 59 35 All SZGR 2.0 genes in this pathway
BENPORATH CYCLING GENES 648 385 All SZGR 2.0 genes in this pathway
SAKAI TUMOR INFILTRATING MONOCYTES DN 81 51 All SZGR 2.0 genes in this pathway
ROZANOV MMP14 TARGETS UP 266 171 All SZGR 2.0 genes in this pathway
IGLESIAS E2F TARGETS UP 151 103 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 20HR UP 240 152 All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS LATE PROGENITOR 544 307 All SZGR 2.0 genes in this pathway
阿尔茨海默氏病dn 1237 837 All SZGR 2.0 genes in this pathway
WANG SMARCE1 TARGETS DN 371 218 All SZGR 2.0 genes in this pathway
YIH RESPONSE TO ARSENITE C4 18 12 All SZGR 2.0 genes in this pathway
JIANG HYPOXIA NORMAL 311 205 All SZGR 2.0 genes in this pathway
Lee衰老的肌肉 45 33 All SZGR 2.0 genes in this pathway
RIZKI TUMOR INVASIVENESS 3D DN 270 181 All SZGR 2.0 genes in this pathway
Ouyang前列腺癌的进展 20 14 All SZGR 2.0 genes in this pathway
BONCI TARGETS OF MIR15A AND MIR16 1 91 75 All SZGR 2.0 genes in this pathway
王肿瘤的侵入性 374 247 All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS DN 366 257 All SZGR 2.0 genes in this pathway
CHEN METABOLIC SYNDROM NETWORK 1210 725 All SZGR 2.0 genes in this pathway
HAHTOLA CTCL CUTANEOUS 26 19 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 30MIN DN 150 99 All SZGR 2.0 genes in this pathway
WHITFIELD CELL CYCLE M G1 148 95 All SZGR 2.0 genes in this pathway
Verhaak胶质母细胞瘤神经 129 85 All SZGR 2.0 genes in this pathway
CHICAS RB1 TARGETS SENESCENT 572 352 All SZGR 2.0 genes in this pathway
Pilon KLF1靶向DN 1972年 1213 All SZGR 2.0 genes in this pathway
ikeda mir133靶向 43 27 All SZGR 2.0 genes in this pathway
Krieg KDM3A靶向缺氧 208 107 All SZGR 2.0 genes in this pathway
刘IL13内存模型 17 12 All SZGR 2.0 genes in this pathway
ABDELMOHSEN ELAVL4 TARGETS 16 13 All SZGR 2.0 genes in this pathway
Smirnov对IR 6小时的回应 166 97 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-1/206 534 541 1A,m8 HSA-MIR-1 Uggaauguaaagaaguaugua
HSA-MIR-206SZ UGGAAUGUAAGGAAGUGUGUGG
HSA-MIR-613 AGGAAUGUUCCUUCUUUGCC
miR-128 744 750 1A HSA-MIR-128a UCACAGUGAACCGGUCUCUUUU
HSA-MIR-128b UCACAGUGAACCGGUCUCUUUC
miR-133 1117 1123 m8 HSA-MIR-133A UUGGUCCCCUUCAACCAGCUGU
HSA-MIR-133B uguguccccuucaaccagcua
miR-137 50 56 m8 HSA-MIR-137 UAUUGCUUAAGAAUACGCGUAG
mir-141/200a 1237 1243 1A HSA-MIR-141 UAACACUGUCUGGUAAAGAUGG
HSA-MIR-200A uaacacugucuguguguguaaacgaugu
mir-18 837 843 m8 HSA-MIR-18a UAAGGUGCAUCUAGUGCAGAUA
HSA-MIR-18b uaaggugcaucuagugcagua
mir-185 647 654 1A,m8 HSA-MIR-185brain Uggagaaaggcaguuc
mir-186 1389 1395 m8 HSA-MIR-186 caaagaauuuugggcuu
miR-224 747 753 m8 hsa-miR-224 CAAGUCACUAGUGGUUCCGUUUA
miR-25/32/92/363/367 97 103 1A HSA-MIR-25brain CAUUGCACUUGUCUCGGUCUGA
HSA-MIR-32 UAUUGCACAUUACUAAGUUGC
HSA-MIR-92 UAUUGCACUUGUCCCGGCCUG
hsa-miR-367 AAUUGCACUUUAGCAAUGGUGA
HSA-MIR-92bSZ UAUUGCACUCGUCCCGGCCUC
mir-27 744 750 m8 hsa-miR-27abrain UUCACAGUGGCUAAGUUCCGC
hsa-miR-27bbrain uucacaguggcuaaguucugc
mir-29 578 584 m8 hsa-miR-29aSZ UAGCACCAUCUGAAAUCGGUU
hsa-miR-29bSZ UAGCACCAUUUGAAAUCAGUGUU
hsa-miR-29cSZ UAGCACCAUUUGAAAUCGGU
mir-299-3p 125 131 m8 HSA-MIR-299-3P uauggggaugguaaaaCcgcuu
miR-342 138 145 1A,m8 hsa-miR-342brain UCUCACACAGAAAUCGCACCCGUC
mir-381 1379 1385 1A hsa - mir - 381 UAUACAAGGGCAAGCUCUCUGU