Gene Page:RCE1
Summary?
| GeneID | 9986 |
| Symbol | RCE1 |
| Synonyms | FACE2|RCE1A|RCE1B |
| Description | Ras converting CAAX endopeptidase 1 |
| Reference | MIM:605385|HGNC:HGNC:13721|Ensembl:ENSG00000173653|HPRD: 07289|Vega:OTTHUMG00000167098 |
| Gene type | protein-coding |
| Map location | 11q13 |
| Pascal p-value | 0.002 |
| Sherlock p-value | 0.649 |
| eGene | Myers' cis & trans |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS |
Section I. Genetics and epigenetics annotation
eQTL annotation
eQTL annotation| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs16829545 | chr2 | 151977407 | RCE1 | 9986 | 2.618E-8 | trans | ||
| rs7584986 | chr2 | 184111432 | RCE1 | 9986 | 0.02 | trans | ||
| rs4565419 | chr8 | 32540035 | RCE1 | 9986 | 0.19 | trans | ||
| rs3765543 | chr9 | 134458323 | RCE1 | 9986 | 0.08 | trans | ||
| rs10786479 | chr10 | 100602355 | RCE1 | 9986 | 0.19 | trans | ||
| rs16955618 | chr15 | 29937543 | RCE1 | 9986 | 6.017E-8 | trans | ||
| rs16993189 | chrX | 144666166 | RCE1 | 9986 | 0.06 | trans |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| PPP2R1A | 0.95 | 0.95 |
| PSMD3 | 0.93 | 0.93 |
| KAT5 | 0.91 | 0.90 |
| ALAS1 | 0.91 | 0.88 |
| PSMF1 | 0.91 | 0.89 |
| TCF25 | 0.91 | 0.89 |
| DHX30 | 0.91 | 0.89 |
| TBRG4 | 0.91 | 0.87 |
| KLHL22 | 0.91 | 0.90 |
| YIPF3 | 0.90 | 0.90 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| MT-CO2 | -0.82 | -0.79 |
| AF347015.8 | -0.82 | -0.81 |
| AF347015.31 | -0.81 | -0.80 |
| AF347015.33 | -0.81 | -0.82 |
| AF347015.2 | -0.80 | -0.81 |
| MT-CYB | -0.80 | -0.79 |
| AF347015.27 | -0.79 | -0.82 |
| AF347015.21 | -0.79 | -0.81 |
| AF347015.15 | -0.78 | -0.79 |
| AF347015.26 | -0.77 | -0.79 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| PARENT MTOR SIGNALING UP | 567 | 375 | All SZGR 2.0 genes in this pathway |
| BORCZUK MALIGNANT MESOTHELIOMA DN | 104 | 59 | All SZGR 2.0 genes in this pathway |
| MULLIGHAN NPM1 MUTATED SIGNATURE 2 UP | 139 | 83 | All SZGR 2.0 genes in this pathway |
| GRAESSMANN APOPTOSIS BY DOXORUBICIN DN | 1781 | 1082 | All SZGR 2.0 genes in this pathway |
| GRAESSMANN RESPONSE TO MC AND DOXORUBICIN DN | 770 | 415 | All SZGR 2.0 genes in this pathway |
| LOPEZ MBD TARGETS | 957 | 597 | All SZGR 2.0 genes in this pathway |
| NIKOLSKY BREAST CANCER 11Q12 Q14 AMPLICON | 158 | 93 | All SZGR 2.0 genes in this pathway |
| NIKOLSKY MUTATED AND AMPLIFIED IN BREAST CANCER | 94 | 60 | All SZGR 2.0 genes in this pathway |
| PANGAS TUMOR SUPPRESSION BY SMAD1 AND SMAD5 DN | 157 | 106 | All SZGR 2.0 genes in this pathway |
| LINSLEY MIR16 TARGETS | 206 | 127 | All SZGR 2.0 genes in this pathway |
| PURBEY TARGETS OF CTBP1 NOT SATB1 DN | 448 | 282 | All SZGR 2.0 genes in this pathway |