Gene Page:DMTF1
Summary?
| GeneID | 9988 |
| Symbol | DMTF1 |
| Synonyms | DMP1|DMTF|MRUL|hDMP1 |
| Description | cyclin D binding myb like transcription factor 1 |
| Reference | MIM:608491|HGNC:HGNC:14603|Ensembl:ENSG00000135164|HPRD:09770|Vega:OTTHUMG00000154135 |
| Gene type | protein-coding |
| Map location | 7q21 |
| Pascal p-value | 0.128 |
| Sherlock p-value | 0.222 |
| Fetal beta | 1.074 |
| DMG | 1 (# studies) |
| eGene | Myers' cis & trans |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DMG:Wockner_2014 | Genome-wide DNA methylation analysis | This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). | 2 |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
Differentially methylated gene| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg00659421 | 7 | 86781760 | DMTF1 | 1.03E-6 | -0.71 | 0.007 | DMG:Wockner_2014 |
| cg08689931 | 7 | 86781758 | DMTF1 | 2.887E-4 | -0.232 | 0.039 | DMG:Wockner_2014 |
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs7972594 | chr12 | 11724913 | DMTF1 | 9988 | 0.07 | trans | ||
| rs10491979 | chr12 | 11727969 | DMTF1 | 9988 | 0.07 | trans | ||
| rs7882576 | chrX | 38501487 | DMTF1 | 9988 | 0.14 | trans |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconception周),ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| C14orf153 | 0.85 | 0.85 |
| PANK2 | 0.85 | 0.85 |
| ARMCX2 | 0.84 | 0.84 |
| KLRAQ1 | 0.84 | 0.81 |
| PPFIA2 | 0.83 | 0.84 |
| NDEL1 | 0.83 | 0.83 |
| C16orf45 | 0.82 | 0.80 |
| TPM1 | 0.82 | 0.84 |
| VPS41 | 0.82 | 0.82 |
| KCTD2 | 0.82 | 0.84 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| AF347015.21 | -0.66 | -0.53 |
| MT-CO2 | -0.63 | -0.54 |
| AF347015.31 | -0.63 | -0.55 |
| AF347015.8 | -0.63 | -0.52 |
| AF347015.2 | -0.62 | -0.51 |
| MT-CYB | -0.61 | -0.51 |
| AF347015.15 | -0.60 | -0.51 |
| AF347015.26 | -0.59 | -0.48 |
| AF347015.27 | -0.59 | -0.51 |
| METRN | -0.59 | -0.59 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| PID FRA PATHWAY | 37 | 28 | All SZGR 2.0 genes in this pathway |
| PID AP1 PATHWAY | 70 | 60 | All SZGR 2.0 genes in this pathway |
| CHEMNITZ RESPONSE TO PROSTAGLANDIN E2 DN | 391 | 222 | All SZGR 2.0 genes in this pathway |
| WANG LMO4 TARGETS UP | 372 | 227 | All SZGR 2.0 genes in this pathway |
| NUYTTEN NIPP1 TARGETS UP | 769 | 437 | All SZGR 2.0 genes in this pathway |
| BUYTAERT PHOTODYNAMIC THERAPY STRESS UP | 811 | 508 | All SZGR 2.0 genes in this pathway |
| BENPORATH MYC MAX TARGETS | 775 | 494 | All SZGR 2.0 genes in this pathway |
| BENPORATH CYCLING GENES | 648 | 385 | All SZGR 2.0 genes in this pathway |
| BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS | 882 | 572 | All SZGR 2.0 genes in this pathway |
| DAZARD RESPONSE TO UV NHEK DN | 318 | 220 | All SZGR 2.0 genes in this pathway |
| BROWNE HCMV INFECTION 6HR DN | 160 | 101 | All SZGR 2.0 genes in this pathway |
| BILD SRC ONCOGENIC SIGNATURE | 62 | 38 | All SZGR 2.0 genes in this pathway |
| ACEVEDO LIVER CANCER UP | 973 | 570 | All SZGR 2.0 genes in this pathway |
| MITSIADES RESPONSE TO APLIDIN UP | 439 | 257 | All SZGR 2.0 genes in this pathway |
| BOCHKIS FOXA2 TARGETS | 425 | 261 | All SZGR 2.0 genes in this pathway |
| CHEN HOXA5 TARGETS 9HR UP | 223 | 132 | All SZGR 2.0 genes in this pathway |
| DANG BOUND BY MYC | 1103 | 714 | All SZGR 2.0 genes in this pathway |
| KOINUMA TARGETS OF SMAD2 OR SMAD3 | 824 | 528 | All SZGR 2.0 genes in this pathway |