Gene Page:SLC12A6

Summary?
GeneID 9990
Symbol SLC12A6
Synonyms ACCPN|KCC3|KCC3A|KCC3B
Description solute carrier family 12 member 6
Reference MIM:604878|HGNC:HGNC:10914|Ensembl:ENSG00000140199|HPRD:09220|Vega:OTTHUMG00000129441
Gene type protein-coding
Map location 15q13
Pascal p-value 0.115
Support CompositeSet
Darnell FMRP targets

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
PMID:cooccur High-throughput literature-search Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias Click to show details
GO_Annotation Mapping neuro-related keywords to Gene Ontology annotations Hits with neuro-related keywords: 1

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
DCUN1D1 0.87 0.85
STX12 0.86 0.85
CHMP2B 0.85 0.85
ACSL4 0.84 0.86
OTUD6B 0.84 0.84
ATAD1 0.83 0.84
RAB18 0.83 0.83
TRNT1 0.83 0.84
RAB23 0.83 0.83
RAB2A 0.83 0.83
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
FXYD1 -0.58 -0.55
EIF4EBP3 -0.57 -0.60
MT-CO2 -0.56 -0.55
PTPRCAP -0.56 -0.58
AC018755.7 -0.55 -0.58
AF347015.21 -0.53 -0.45
HSD17B14 -0.53 -0.53
HIGD1B -0.53 -0.54
METRN -0.52 -0.58
AF347015.31 -0.52 -0.53

Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0005515 protein binding IEA -
GO:0005215 transporter activity IEA -
GO:0015377 cation:chloride symporter activity IEA -
GO:0015379 potassium:chloride symporter activity NAS -
GO:0015293 symporter activity IEA -
GO:0030955 potassium ion binding IEA -
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0008217 regulation of blood pressure NAS -
GO:0006821 chloride transport IEA -
GO:0006814 sodium ion transport IEA -
GO:0006811 ion transport IEA -
GO:0006813 potassium ion transport IEA -
GO:0006884 cell volume homeostasis NAS -
GO:0006873 cellular ion homeostasis IC -
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0030424 axon IEA neuron, axon, Neurotransmitter (GO term level: 6) -
GO:0005624 membrane fraction TAS 10187864
GO:0016020 membrane IEA -
GO:0016021 integral to membrane IEA -
GO:0005887 integral to plasma membrane TAS 10187864
GO:0016323 basolateral plasma membrane IEA -

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
REACTOME TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 413 270 All SZGR 2.0 genes in this pathway
REACTOME SLC MEDIATED TRANSMEMBRANE TRANSPORT 241 157 All SZGR 2.0 genes in this pathway
REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES 94 65 All SZGR 2.0 genes in this pathway
PARENT MTOR SIGNALING DN 46 29 All SZGR 2.0 genes in this pathway
CHEMNITZ RESPONSE TO PROSTAGLANDIN E2 DN 391 222 All SZGR 2.0 genes in this pathway
ZHONG RESPONSE TO AZACITIDINE AND TSA UP 183 119 All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP 1382 904 All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA UP 1821 933 All SZGR 2.0 genes in this pathway
GOZGIT ESR1 TARGETS DN 781 465 All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN 1781 1082 All SZGR 2.0 genes in this pathway
GAUSSMANN MLL AF4融合目标C 170 114 All SZGR 2.0 genes in this pathway
NUYTTEN NIPP1 TARGETS DN 848 527 All SZGR 2.0 genes in this pathway
RICKMAN TUMOR DIFFERENTIATED MODERATELY VS POORLY UP 121 71 All SZGR 2.0 genes in this pathway
LIN SILENCED BY TUMOR MICROENVIRONMENT 108 73 All SZGR 2.0 genes in this pathway
PEART HDAC PROLIFERATION CLUSTER UP 57 35 All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS EARLY PROGENITOR 532 309 All SZGR 2.0 genes in this pathway
CUI TCF21 TARGETS 2 DN 830 547 All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 6HR UP 953 554 All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 24HR UP 783 442 All SZGR 2.0 genes in this pathway
SANSOM APC TARGETS REQUIRE MYC 210 123 All SZGR 2.0 genes in this pathway
阿塞维多活R CANCER WITH H3K27ME3 UP 295 149 All SZGR 2.0 genes in this pathway
MIKKELSEN ES ICP WITH H3K4ME3 718 401 All SZGR 2.0 genes in this pathway
MIKKELSEN NPC ICP WITH H3K4ME3 445 257 All SZGR 2.0 genes in this pathway
MIYAGAWA TARGETS OF EWSR1 ETS FUSIONS UP 259 159 All SZGR 2.0 genes in this pathway
BAKKER FOXO3 TARGETS UP 61 41 All SZGR 2.0 genes in this pathway
PEDERSEN METASTASIS BY ERBB2 ISOFORM 7 403 240 All SZGR 2.0 genes in this pathway
皮德森的目标611年周大福ERBB同种型2 76 45 All SZGR 2.0 genes in this pathway
HUANG GATA2 TARGETS UP 149 96 All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 1ST EGF PULSE ONLY 1839 928 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-135 1195 1202 1A,m8 hsa-miR-135a UAUGGCUUUUUAUUCCUAUGUGA
hsa-miR-135b UAUGGCUUUUCAUUCCUAUGUG
miR-137 3182 3189 1A,m8 hsa-miR-137 UAUUGCUUAAGAAUACGCGUAG
miR-151 3101 3107 1A hsa-miR-151brain ACUAGACUGAAGCUCCUUGAGG
miR-18 3208 3215 1A,m8 hsa-miR-18a UAAGGUGCAUCUAGUGCAGAUA
hsa-miR-18b UAAGGUGCAUCUAGUGCAGUUA
miR-24 136 142 m8 hsa-miR-24SZ UGGCUCAGUUCAGCAGGAACAG
miR-30-3p 3189 3196 1A,m8 hsa-miR-30a-3p CUUUCAGUCGGAUGUUUGCAGC
hsa-miR-30e-3p CUUUCAGUCGGAUGUUUACAGC
miR-30-5p 3808 3815 1A,m8 hsa-miR-30a-5p UGUAAACAUCCUCGACUGGAAG
hsa-miR-30cbrain UGUAAACAUCCUACACUCUCAGC
hsa-miR-30dSZ UGUAAACAUCCCCGACUGGAAG
hsa-miR-30bSZ UGUAAACAUCCUACACUCAGCU
hsa-miR-30e-5p UGUAAACAUCCUUGACUGGA
miR-96 1080 1086 m8 hsa-miR-96brain UUUGGCACUAGCACAUUUUUGC