Gene Page:DPP4

Summary?
GeneID 1803
Symbol DPP4
Synonyms ADABP|ADCP2|CD26|DPPIV|TP103
Description dipeptidyl peptidase 4
Reference 米IM:102720|HGNC:HGNC:3009|Ensembl:ENSG00000197635|HPRD:02187|Vega:OTTHUMG00000132056
Gene type protein-coding
米ap location 2q24.3
帕斯卡假定值 2.019E-6
Fetal beta 1.306

Gene in Data Sources
Gene set name 米ethod of gene set Description Info
CV:GWAScat Genome-wide Association Studies This data set includes 560 SNPs associated with schizophrenia. A total of 486 genes were mapped to these SNPs within 50kb.
CV:PGC128 Genome-wide Association Study A multi-stage schizophrenia GWAS of up to 36,989 cases and 113,075 controls. Reported by the Schizophrenia Working Group of PGC. 128 independent associations spanning 108 loci
CV:PGCnp Genome-wide Association Study GWAS
PMID:cooccur High-throughput literature-search Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
GSMA_IIA Genome scan meta-analysis (All samples) Psr: 0.02395
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias Click to show details
GO_Annotation 米apping neuro-related keywords to Gene Ontology annotations Hits with neuro-related keywords: 1

Section I. Genetics and epigenetics annotation

@CV:PGC128

SNP ID Chromosome Position Allele P Function Gene Up/Down Distance
rs2909457 chr2 162845855 AG 4.375E-8 intergenic SLC4A10,DPP4 dist=4069;dist=2900


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
DMPK 0.60 0.69
AC004410.1 0.57 0.67
SLC12A9 0.57 0.67
PRX 0.56 0.66
AC006028.3 0.56 0.63
CCDC37 0.54 0.48
ZNF296 0.53 0.65
AMIGO3 0.53 0.68
PCSK4 0.53 0.58
AP006284.2 0.53 0.53
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
KBTBD3 -0.43 -0.58
UGP2 -0.41 -0.46
ATP6V1E1 -0.40 -0.40
FAM162A -0.39 -0.49
HIGD1A -0.39 -0.49
CHN1 -0.39 -0.39
米DH1 -0.38 -0.39
C12orf29 -0.38 -0.45
TMEM70 -0.38 -0.41
C1orf43 -0.38 -0.40

Section III. Gene Ontology annotation

米olecular function GO term Evidence Neuro keywords PubMed ID
GO:0004252 serine-type endopeptidase activity IEA glutamate (GO term level: 7) -
GO:0004177 aminopeptidase activity IEA -
GO:0005515 protein binding 新闻学会 7594462|14684150
GO:0008239 dipeptidyl-peptidase activity IDA 14684150
GO:0008233 peptidase activity IEA -
GO:0042803 protein homodimerization activity 新闻学会 14684150
Biological process GO term Evidence Neuro keywords PubMed ID
GO:0001666 response to hypoxia IDA 16670267
GO:0006508 proteolysis IEA -
GO:0042110 T细胞激活 IDA 7594462
GO:0033632 regulation of cell-cell adhesion mediated by integrin IDA 11772392
Cellular component GO term Evidence Neuro keywords PubMed ID
GO:0005576 extracellular region IEA -
GO:0016021 integral to membrane IEA -
GO:0009986 cell surface IDA 7594462|11772392
GO:0005886 plasma membrane IDA 16670267
GO:0046581 intercellular canaliculus IEA -

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
REACTOMEINTEGRATION OF ENERGY METABOLISM 120 84 All SZGR 2.0 genes in this pathway
REACTOMEREGULATION OF INSULIN SECRETION 93 65 All SZGR 2.0 genes in this pathway
REACTOMESYNTHESIS SECRETION AND INACTIVATION OF GIP 14 8 All SZGR 2.0 genes in this pathway
REACTOMEINCRETIN SYNTHESIS SECRETION AND INACTIVATION 22 14 All SZGR 2.0 genes in this pathway
REACTOMESYNTHESIS SECRETION AND INACTIVATION OF GLP1 19 12 All SZGR 2.0 genes in this pathway
CASORELLI ACUTE PROMYELOCYTIC LEUKEMIA DN 663 425 All SZGR 2.0 genes in this pathway
CORRE MULTIPLE MYELOMA UP 74 45 All SZGR 2.0 genes in this pathway
BASAKI YBX1 TARGETS DN 384 230 All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 16D DN 143 83 All SZGR 2.0 genes in this pathway
DELYS THYROID CANCER UP 443 294 All SZGR 2.0 genes in this pathway
HAMAI APOPTOSIS VIA TRAIL UP 584 356 All SZGR 2.0 genes in this pathway
CAVARD LIVER CANCER MALIGNANT VS BENIGN 32 19 All SZGR 2.0 genes in this pathway
米URATA VIRULENCE OF H PILORI 24 16 All SZGR 2.0 genes in this pathway
LEE LIVER CANCER CIPROFIBRATE DN 66 43 All SZGR 2.0 genes in this pathway
LEE LIVER CANCER ACOX1 DN 65 39 All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT REJECTED VS OK DN 546 351 All SZGR 2.0 genes in this pathway
LENAOUR DENDRITIC CELL MATURATION UP 114 84 All SZGR 2.0 genes in this pathway
TRAYNOR RETT SYNDROM UP 45 33 All SZGR 2.0 genes in this pathway
CUI TCF21 TARGETS 2 DN 830 547 All SZGR 2.0 genes in this pathway
KAYO AGING MUSCLE DN 123 76 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 48HR DN 504 323 All SZGR 2.0 genes in this pathway
JIANG HYPOXIA NORMAL 311 205 All SZGR 2.0 genes in this pathway
米CDOWELL ACUTE LUNG INJURY DN 48 33 All SZGR 2.0 genes in this pathway
HOWLIN CITED1 TARGETS 1 UP 35 25 All SZGR 2.0 genes in this pathway
ACEVEDO NORMAL TISSUE ADJACENT TO LIVER TUMOR UP 174 96 All SZGR 2.0 genes in this pathway
ACEVEDO METHYLATED IN LIVER CANCER DN 940 425 All SZGR 2.0 genes in this pathway
SMID BREAST CANCER NORMAL LIKE UP 476 285 All SZGR 2.0 genes in this pathway
QI PLASMACYTOMA UP 259 185 All SZGR 2.0 genes in this pathway
BOYLAN MULTIPLE MYELOMA C CLUSTER UP 38 26 All SZGR 2.0 genes in this pathway
BOYLAN MULTIPLE MYELOMA C UP 47 29 All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305 895 All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS DN 366 257 All SZGR 2.0 genes in this pathway
VALK AML CLUSTER 1 28 19 All SZGR 2.0 genes in this pathway
BOYAULT LIVER CANCER SUBCLASS G56 UP 12 9 All SZGR 2.0 genes in this pathway
CHIANG LIVER CANCER SUBCLASS CTNNB1 UP 176 110 All SZGR 2.0 genes in this pathway
YAGI AML WITH 11Q23 REARRANGED 351 238 All SZGR 2.0 genes in this pathway
FONTAINE FOLLICULAR THYROID ADENOMA DN 68 45 All SZGR 2.0 genes in this pathway
FONTAINE PAPILLARY THYROID CARCINOMA UP 66 38 All SZGR 2.0 genes in this pathway
CHANDRAN METASTASIS DN 306 191 All SZGR 2.0 genes in this pathway
LI INDUCED T TO NATURAL KILLER DN 116 83 All SZGR 2.0 genes in this pathway
米IYAGAWA TARGETS OF EWSR1 ETS FUSIONS UP 259 159 All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS UP 745 475 All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS UP 682 433 All SZGR 2.0 genes in this pathway
SERVITJA ISLET HNF1A TARGETS DN 109 71 All SZGR 2.0 genes in this pathway
SERVITJA LIVER HNF1A TARGETS DN 157 105 All SZGR 2.0 genes in this pathway
KOHOUTEK CCNT2 TARGETS 58 35 All SZGR 2.0 genes in this pathway
BOSCO ALLERGEN INDUCED TH2 ASSOCIATED MODULE 151 86 All SZGR 2.0 genes in this pathway
ZWANG CLASS 3 TRANSIENTLY INDUCED BY EGF 222 159 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end 米atch method
miR-140 602 609 1A,m8 hsa-miR-140brain AGUGGUUUUACCCUAUGGUAG
miR-148/152 585 591 1A hsa-miR-148a UCAGUGCACUACAGAACUUUGU
hsa-miR-152brain UCAGUGCAUGACAGAACUUGGG
hsa-miR-148b UCAGUGCAUCACAGAACUUUGU
miR-153 577 583 1A hsa-miR-153 UUGCAUAGUCACAAAAGUGA
miR-205 848 854 1A hsa-miR-205 UCCUUCAUUCCACCGGAGUCUG
miR-22 770 776 m8 hsa-miR-22brain AAGCUGCCAGUUGAAGAACUGU
miR-29 686 692 1A hsa-miR-29aSZ UAGCACCAUCUGAAAUCGGUU
hsa-miR-29bSZ UAGCACCAUUUGAAAUCAGUGUU
hsa-miR-29cSZ UAGCACCAUUUGAAAUCGGU
miR-378 564 570 1A hsa-miR-378 CUCCUGACUCCAGGUCCUGUGU
miR-448 576 583 1A,m8 hsa-miR-448 UUGCAUAUGUAGGAUGUCCCAU
miR-9 625 631 1A hsa-miR-9SZ UCUUUGGUUAUCUAGCUGUAUGA