Gene Page:EPHX2

Summary?
GeneID 2053
Symbol EPHX2
Synonyms CEH|SEH
Description epoxide hydrolase 2
Reference MIM:132811|HGNC:HGNC:3402|Ensembl:ENSG00000120915|HPRD:00582|Vega:OTTHUMG00000102115
Gene type protein-coding
Map location 8p21
Pascal p-value 8.982E-5
Sherlock p-value 0.262
Fetal beta -1.162
eGene Caudate basal ganglia
Cerebellar Hemisphere
Cerebellum
Cortex
Frontal Cortex BA9
Hypothalamus
Myers' cis & trans
元

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:GWAScat Genome-wide Association Studies 这个数据集包括560 SNPs associated with schizophrenia. A total of 486 genes were mapped to these SNPs within 50kb.
CV:GWASdb Genome-wide Association Studies GWASdb records for schizophrenia
CV:PGC128 Genome-wide Association Study A multi-stage schizophrenia GWAS of up to 36,989 cases and 113,075 controls. Reported by the Schizophrenia Working Group of PGC. 128 independent associations spanning 108 loci
CV:PGCnp Genome-wide Association Study GWAS
GSMA_I Genome scan meta-analysis Psr: 0.031
GSMA_IIE Genome scan meta-analysis (European-ancestry samples) Psr: 0.00057
GSMA_IIA Genome scan meta-analysis (All samples) Psr: 0.03086

Section I. Genetics and epigenetics annotation

@CV:PGC128

SNP ID Chromosome Position Allele P Function Gene Up/Down Distance
rs73229090 chr8 27442127 AC 1.952E-8 intergenic EPHX2,CLU dist=39688;dist=12307

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs10958899 chr9 10128700 EPHX2 2053 0.11 trans
rs10958907 chr9 10131580 EPHX2 2053 0.09 trans
rs1322159 chr9 10132695 EPHX2 2053 0.17 trans
rs192069 chrX 76053555 EPHX2 2053 0.07 trans
rs16983508 chrX 99747940 EPHX2 2053 0.12 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26页ostconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
AAMP 0.90 0.88
GRK6 0.89 0.88
COBRA1 0.89 0.88
ATG4B 0.89 0.87
STK25 0.89 0.86
BBS1 0.89 0.88
THAP4 0.89 0.85
RIC8A 0.89 0.88
B4GALT7 0.88 0.87
TMUB2 0.88 0.86
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
MT-CO2 -0.75 -0.70
AF347015.21 -0.75 -0.74
AF347015.8 -0.74 -0.71
AF347015.31 -0.74 -0.70
AF347015.27 -0.73 -0.72
MT-CYB -0.72 -0.69
AF347015.33 -0.72 -0.68
AF347015.2 -0.71 -0.68
AF347015.15 -0.70 -0.67
AF347015.26 -0.69 -0.66

Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0000287 magnesium ion binding IEA -
GO:0004301 epoxide hydrolase activity IDA 10862610
GO:0016787 hydrolase activity IEA -
GO:0042803 protein homodimerization activity NAS 10862610
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0008217 regulation of blood pressure NAS 10862610
GO:0008152 metabolic process IEA -
GO:0009636 response to toxin NAS 10862610
GO:0017144 drug metabolic process NAS 10862610
GO:0006805 xenobiotic metabolic process NAS 10862610
GO:0006800 oxygen and reactive oxygen species metabolic process NAS 10862610
GO:0006954 inflammatory response NAS 10862610
GO:0006874 cellular calcium ion homeostasis NAS 10862610
GO:0019439 aromatic compound catabolic process IEA -
GO:0045909 positive regulation of vasodilation NAS 10862610
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0005829 cytosol NAS 10862610
GO:0005625 soluble fraction NAS 10862610
GO:0005737 cytoplasm IEA -
GO:0005777 peroxisome IEA -

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG ARACHIDONIC ACID METABOLISM 58 36 All SZGR 2.0 genes in this pathway
KEGG PEROXISOME 78 47 All SZGR 2.0 genes in this pathway
MULLIGHAN NPM1 MUTATED SIGNATURE 1 DN 126 86 All SZGR 2.0 genes in this pathway
MULLIGHAN NPM1 SIGNATURE 3 DN 162 116 All SZGR 2.0 genes in this pathway
ENK UV RESPONSE EPIDERMIS DN 508 354 All SZGR 2.0 genes in this pathway
LANDIS BREAST CANCER PROGRESSION DN 70 43 All SZGR 2.0 genes in this pathway
LANDIS ERBB2 BREAST TUMORS 324 DN 149 93 All SZGR 2.0 genes in this pathway
MARTORIATI MDM4 TARGETS NEUROEPITHELIUM UP 176 111 All SZGR 2.0 genes in this pathway
GRUETZMANN PANCREATIC CANCER DN 203 134 All SZGR 2.0 genes in this pathway
SHETH LIVER CANCER VS TXNIP LOSS PAM4 261 153 All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 48HR UP 487 286 All SZGR 2.0 genes in this pathway
LEE LIVER CANCER MYC TGFA DN 65 44 All SZGR 2.0 genes in this pathway
LEE LIVER CANCER MYC E2F1 DN 64 38 All SZGR 2.0 genes in this pathway
LEE LIVER CANCER DENA DN 74 45 All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT REJECTED VS OK DN 546 351 All SZGR 2.0 genes in this pathway
SANSOM APC TARGETS DN 366 238 All SZGR 2.0 genes in this pathway
SESTO RESPONSE TO UV C7 68 44 All SZGR 2.0 genes in this pathway
YANG MUC2 TARGETS DUODENUM 3MO DN 23 14 All SZGR 2.0 genes in this pathway
YANG MUC2 TARGETS DUODENUM 6MO DN 21 12 All SZGR 2.0 genes in this pathway
HELLER SILENCED BY METHYLATION UP 282 183 All SZGR 2.0 genes in this pathway
MARTINEZ RB1 TARGETS UP 673 430 All SZGR 2.0 genes in this pathway
MARTINEZ TP53 TARGETS DN 593 372 All SZGR 2.0 genes in this pathway
MARTINEZ RB1 AND TP53 TARGETS UP 601 369 All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER DN 540 340 All SZGR 2.0 genes in this pathway
ACEVEDO LIVER TUMOR VS NORMAL ADJACENT TISSUE DN 274 165 All SZGR 2.0 genes in this pathway
SMID BREAST CANCER BASAL DN 701 446 All SZGR 2.0 genes in this pathway
WEST ADRENOCORTICAL TUMOR DN 546 362 All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305 895 All SZGR 2.0 genes in this pathway
BOYAULT LIVER CANCER SUBCLASS G123 DN 51 30 All SZGR 2.0 genes in this pathway
卡波济肝癌DN 6 5 All SZGR 2.0 genes in this pathway
WOO LIVER CANCER RECURRENCE DN 80 54 All SZGR 2.0 genes in this pathway
NAKAYAMA SOFT TISSUE TUMORS PCA1 DN 74 47 All SZGR 2.0 genes in this pathway
NIELSEN LEIOMYOSARCOMA DN 18 11 All SZGR 2.0 genes in this pathway
BAE BRCA1 TARGETS UP 75 47 All SZGR 2.0 genes in this pathway
NOUSHMEHR GBM SILENCED BY METHYLATION 50 32 All SZGR 2.0 genes in this pathway
MARTENS TRETINOIN RESPONSE UP 857 456 All SZGR 2.0 genes in this pathway
WANG CLASSIC ADIPOGENIC TARGETS OF PPARG 26 15 All SZGR 2.0 genes in this pathway
WIERENGA STAT5A TARGETS DN 213 127 All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG RXRA BOUND 36HR 152 88 All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG RXRA BOUND 8D 882 506 All SZGR 2.0 genes in this pathway
RAO BOUND BY SALL4 227 149 All SZGR 2.0 genes in this pathway