Gene Page:ETF1

Summary?
GeneID 2107
Symbol ETF1
Synonyms D5S1995|ERF|ERF1|RF1|SUP45L1|TB3-1
Description eukaryotic translation termination factor 1
Reference MIM:600285|HGNC:HGNC:3477|Ensembl:ENSG00000120705|HPRD:02616|Vega:OTTHUMG00000129199
Gene type protein-coding
Map location 5q31.1
Pascal p-value 2.412E-7
Sherlock p-value 0.373
Fetal beta -0.811

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:GWAScat Genome-wide Association Studies This data set includes 560 SNPs associated with schizophrenia. A total of 486 genes were mapped to these SNPs within 50kb.
CV:PGC128 全基因组关联研究 A multi-stage schizophrenia GWAS of up to 36,989 cases and 113,075 controls. Reported by the Schizophrenia Working Group of PGC. 128 independent associations spanning 108 loci
CV:PGCnp 全基因组关联研究 GWAS
GSMA_I Genome scan meta-analysis Psr: 0.0032
Expression Meta-analysis of gene expression Pvalue: 1.79
Network Shortest path distance of core genes in the Human protein-protein interaction network Contribution to shortest path in PPI network: 0.0278

Section I. Genetics and epigenetics annotation

@CV:PGC128

SNP ID Chromosome Position Allele P Function Gene Up/Down Distance
rs3849046 chr5 137851192 TC 4.833E-9 intronic ETF1


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
MDS1 1.00 1.00
FLI1 0.82 0.80
ITGA1 0.81 0.82
COBLL1 0.77 0.78
OCLN 0.76 0.78
FGD5 0.75 0.78
ETS1 0.75 0.80
TEK 0.75 0.77
TGFBR2 0.73 0.79
CDH5 0.73 0.73
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
RPS21 -0.38 -0.45
FAM128A -0.37 -0.35
MRPL52 -0.37 -0.38
SNHG12 -0.36 -0.36
RPL31 -0.36 -0.43
C12orf45 -0.36 -0.37
ATP5E -0.36 -0.41
BLOC1S1 -0.36 -0.35
ST20 -0.36 -0.36
AC008763.1 -0.35 -0.40

Section III. Gene Ontology annotation

Molecular function GO term Evidence Neuro keywords PubMed ID
GO:0003723 RNA binding TAS 7990965
GO:0005515 protein binding 新闻学会 9620853|9712840
GO:0016149 translation release factor activity, codon specific IEA -
GO:0043022 ribosome binding TAS 12867083
Biological process GO term Evidence Neuro keywords PubMed ID
GO:0006449 regulation of translational termination TAS 7990965
Cellular component GO term Evidence Neuro keywords PubMed ID
GO:0005737 cytoplasm TAS 7990965

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
REACTOME TRANSLATION 222 75 All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF PROTEINS 518 242 All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF MRNA 284 128 All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF RNA 330 155 All SZGR 2.0 genes in this pathway
REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX 176 57 All SZGR 2.0 genes in this pathway
GARY CD5 TARGETS DN 431 263 All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP 1382 904 All SZGR 2.0 genes in this pathway
轮藻FE BREAST CANCER LUMINAL VS BASAL DN 455 304 All SZGR 2.0 genes in this pathway
TIEN INTESTINE PROBIOTICS 6HR DN 167 100 All SZGR 2.0 genes in this pathway
TIEN INTESTINE PROBIOTICS 24HR UP 557 331 All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION UP 1278 748 All SZGR 2.0 genes in this pathway
ELVIDGE HYPOXIA DN 146 94 All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY SERUM DEPRIVATION UP 552 347 All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN 1781 1082 All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND DOXORUBICIN DN 770 415 All SZGR 2.0 genes in this pathway
BERENJENO TRANSFORMED BY RHOA UP 536 340 All SZGR 2.0 genes in this pathway
SCHLOSSER MYC TARGETS REPRESSED BY SERUM 159 93 All SZGR 2.0 genes in this pathway
DIRMEIER LMP1 RESPONSE LATE UP 57 41 All SZGR 2.0 genes in this pathway
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN DN 584 395 All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK 1652 1023 All SZGR 2.0 genes in this pathway
WEI MYCN TARGETS WITH E BOX 795 478 All SZGR 2.0 genes in this pathway
SCIAN INVERSED TARGETS OF TP53 AND TP73 DN 31 23 All SZGR 2.0 genes in this pathway
BENPORATH MYC MAX TARGETS 775 494 All SZGR 2.0 genes in this pathway
SHEPARD CRUSH AND BURN MUTANT UP 197 110 All SZGR 2.0 genes in this pathway
PENG LEUCINE DEPRIVATION DN 187 122 All SZGR 2.0 genes in this pathway
BYSTROEM CORRELATED WITH IL5 UP 51 30 All SZGR 2.0 genes in this pathway
TARTE PLASMA CELL VS PLASMABLAST DN 309 206 All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS 882 572 All SZGR 2.0 genes in this pathway
PENG RAPAMYCIN RESPONSE DN 245 154 All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT OK VS DONOR UP 555 346 All SZGR 2.0 genes in this pathway
NEMETH INFLAMMATORY RESPONSE LPS UP 88 64 All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS LATE PROGENITOR 544 307 All SZGR 2.0 genes in this pathway
SESTO RESPONSE TO UV C1 72 45 All SZGR 2.0 genes in this pathway
MONNIER POSTRADIATION TUMOR ESCAPE UP 393 244 All SZGR 2.0 genes in this pathway
HOWLIN CITED1 TARGETS 2 DN 17 11 All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 STIMULATED 1022 619 All SZGR 2.0 genes in this pathway
FOSTER TOLERANT MACROPHAGE UP 156 92 All SZGR 2.0 genes in this pathway
ACEVEDO LIVER TUMOR VS NORMAL ADJACENT TISSUE UP 863 514 All SZGR 2.0 genes in this pathway
YAGI AML WITH INV 16 TRANSLOCATION 422 277 All SZGR 2.0 genes in this pathway
MARSON FOXP3 TARGETS DN 54 38 All SZGR 2.0 genes in this pathway
GUTIERREZ MULTIPLE MYELOMA UP 35 24 All SZGR 2.0 genes in this pathway
DANG BOUND BY MYC 1103 714 All SZGR 2.0 genes in this pathway
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 7 76 46 All SZGR 2.0 genes in this pathway
THILLAINADESAN ZNF217 TARGETS UP 44 22 All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP C 92 60 All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS DN 882 538 All SZGR 2.0 genes in this pathway
HUANG GATA2 TARGETS DN 72 52 All SZGR 2.0 genes in this pathway
RAO BOUND BY SALL4 ISOFORM B 517 302 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-124.1 88 94 m8 hsa-miR-124a UUAAGGCACGCGGUGAAUGCCA
miR-124/506 88 94 1A hsa-miR-506 UAAGGCACCCUUCUGAGUAGA
hsa-miR-124brain UAAGGCACGCGGUGAAUGCC
miR-134 1481 1487 m8 hsa-miR-134brain UGUGACUGGUUGACCAGAGGG
miR-136 2177 2184 1A,m8 hsa-miR-136 ACUCCAUUUGUUUUGAUGAUGGA
miR-150 832 839 1A,m8 hsa-miR-150 UCUCCCAACCCUUGUACCAGUG
miR-17-5p/20/93.mr/106/519.d 1442 1448 1A hsa-miR-17-5p CAAAGUGCUUACAGUGCAGGUAGU
hsa-miR-20abrain UAAAGUGCUUAUAGUGCAGGUAG
hsa-miR-106a AAAAGUGCUUACAGUGCAGGUAGC
hsa-miR-106bSZ UAAAGUGCUGACAGUGCAGAU
hsa-miR-20bSZ CAAAGUGCUCAUAGUGCAGGUAG
hsa-miR-519d CAAAGUGCCUCCCUUUAGAGUGU
miR-181 962 968 m8 hsa-miR-181abrain AACAUUCAACGCUGUCGGUGAGU
hsa-miR-181bSZ AACAUUCAUUGCUGUCGGUGGG
hsa-miR-181cbrain AACAUUCAACCUGUCGGUGAGU
hsa-miR-181dbrain AACAUUCAUUGUUGUCGGUGGGUU
miR-182 1966 1972 1A hsa-miR-182 UUUGGCAAUGGUAGAACUCACA
miR-186 1982 1988 1A hsa-miR-186 CAAAGAAUUCUCCUUUUGGGCUU
miR-200bc/429 2187 2193 1A hsa-miR-200b UAAUACUGCCUGGUAAUGAUGAC
hsa-miR-200c UAAUACUGCCGGGUAAUGAUGG
hsa-miR-429 UAAUACUGUCUGGUAAAACCGU
miR-205 1349 1355 1A hsa-miR-205 UCCUUCAUUCCACCGGAGUCUG
hsa-miR-205 UCCUUCAUUCCACCGGAGUCUG
miR-216 952 959 1A,m8 hsa-miR-216 UAAUCUCAGCUGGCAACUGUG
miR-23 959 965 1A hsa-miR-23abrain AUCACAUUGCCAGGGAUUUCC
hsa-miR-23bbrain AUCACAUUGCCAGGGAUUACC
miR-26 1564 1570 1A hsa-miR-26abrain UUCAAGUAAUCCAGGAUAGGC
hsa-miR-26bSZ UUCAAGUAAUUCAGGAUAGGUU
miR-299-5p 2192 2198 1A hsa-miR-299-5p UGGUUUACCGUCCCACAUACAU
hsa-miR-299-5p UGGUUUACCGUCCCACAUACAU
miR-320 1492 1498 1A hsa-miR-320 AAAAGCUGGGUUGAGAGGGCGAA
miR-324-3p 447 453 1A hsa-miR-324-3p CCACUGCCCCAGGUGCUGCUGG
miR-326 1849 1855 1A hsa-miR-326 CCUCUGGGCCCUUCCUCCAG
miR-329 2034 2040 1A hsa-miR-329brain AACACACCUGGUUAACCUCUUU
miR-330 1733 1739 m8 hsa-miR-330brain GCAAAGCACACGGCCUGCAGAGA
miR-335 292 298 m8 hsa-miR-335brain UCAAGAGCAAUAACGAAAAAUGU
miR-34b 1536 1542 1A hsa-miR-34b UAGGCAGUGUCAUUAGCUGAUUG
miR-381 295 301 m8 hsa-miR-381 UAUACAAGGGCAAGCUCUCUGU
miR-410 2022 2028 1A hsa-miR-410 AAUAUAACACAGAUGGCCUGU
miR-490 1523 1530 1A,m8 hsa-miR-490 CAACCUGGAGGACUCCAUGCUG
miR-493-5p 2168 2174 m8 hsa-miR-493-5p UUGUACAUGGUAGGCUUUCAUU
miR-496 1590 1596 1A hsa-miR-496 AUUACAUGGCCAAUCUC
hsa-miR-496 AUUACAUGGCCAAUCUC
miR-505 545 551 1A hsa-miR-505 GUCAACACUUGCUGGUUUCCUC
miR-543 963 969 m8 hsa-miR-543 AAACAUUCGCGGUGCACUUCU
miR-544 1756 1762 m8 hsa-miR-544 AUUCUGCAUUUUUAGCAAGU
miR-96 1966 1972 1A hsa-miR-96brain UUUGGCACUAGCACAUUUUUGC