Gene Page:GRIA1

Summary?
GeneID 2890
Symbol GRIA1
Synonyms GLUH1|GLUR1|GLURA|GluA1|HBGR1
Description glutamate ionotropic receptor AMPA type subunit 1
Reference MIM: 138248|HGNC:HGNC:4571|Ensembl:ENSG00000155511|HPRD:00695|Vega:OTTHUMG00000130148
Gene type protein-coding
Map location 5q31.1
Pascal p-value 0.197
Fetal beta -0.218
eGene Myers' cis & trans
Support LIGAND GATED ION SIGNALING
G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-CONSENSUS
G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-FULL
G2Cdb.human_BAYES-COLLINS-MOUSE-PSD-CONSENSUS
G2Cdb.human_TAP-PSD-95-CORE
G2Cdb.humanARC
G2Cdb.humanPSD
G2Cdb.humanPSP
Potential synaptic genes

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
PMID:cooccur High-throughput literature-search Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Association A combined odds ratio method (Sun et al. 2008), association studies 1 Link to SZGene
GSMA_I Genome scan meta-analysis Psr: 0.0032
GSMA_IIE Genome scan meta-analysis (European-ancestry samples) Psr: 0.01718
GSMA_IIA Genome scan meta-analysis (All samples) Psr: 0.00459
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenics,schizophrenias Click to show details
GO_Annotation Mapping neuro-related keywords to Gene Ontology annotations Hits with neuro-related keywords: 5
Network Shortest path distance of core genes in the Human protein-protein interaction network Contribution to shortest path in PPI network: 0.4005

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs4958734 chr5 153789504 GRIA1 2890 0.1 cis
rs6712415 chr2 133868796 GRIA1 2890 0.05 trans
rs10184338 chr2 133868936 GRIA1 2890 0.07 trans
rs10172235 chr2 133869155 GRIA1 2890 0.17 trans
rs17029291 chr3 32402138 GRIA1 2890 8.566E-5 trans
rs3988303 chr8 19776538 GRIA1 2890 0.15 trans
rs11793484 chr9 317239 GRIA1 2890 0.03 trans
rs10970457 chr9 326183 GRIA1 2890 0.03 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
PORCN 0.90 0.87
C3orf39 0.89 0.88
SCYL1 0.89 0.87
FAM127A 0.88 0.86
ATP6AP1 0.88 0.87
RNF123 0.87 0.83
ACP2 0.86 0.85
SLC45A1 0.86 0.87
CDIPT 0.86 0.86
C17orf28 0.85 0.82
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
AF347015.21 -0.58 -0.44
AF347015.18 -0.56 -0.48
NSBP1 -0.56 -0.55
AL139819.3 -0.53 -0.51
MT-ATP8 -0.52 -0.42
AF347015.8 -0.52 -0.39
GNG11 -0.52 -0.45
MT-CO2 -0.50 -0.37
NOSTRIN -0.50 -0.39
AF347015.31 -0.50 -0.37

Section III. Gene Ontology annotation

Molecular function 去term Evidence Neuro keywords PubMed ID
GO:0005234 extracellular-glutamate-gated ion channel activity IEA glutamate (GO term level: 11) -
GO:0015277 kainate selective glutamate receptor activity TAS glutamate (GO term level: 8) 1311100
GO:0004872 receptor activity IEA -
GO:0005515 protein binding IEA -
GO:0005216 ion channel activity IEA -
Biological process 去term Evidence Neuro keywords PubMed ID
GO:0007268 synaptic transmission TAS neuron, Synap, Neurotransmitter (GO term level: 6) 1311100
GO:0007165 signal transduction TAS 1311100
GO:0007616 long-term memory IEA -
GO:0006811 ion transport IEA -
GO:0031623 receptor internalization IEA -
Cellular component 去term Evidence Neuro keywords PubMed ID
GO:0014069 postsynaptic density IEA Synap (GO term level: 10) -
GO:0045211 postsynaptic membrane IEA Synap, Neurotransmitter (GO term level: 5) -
GO:0045202 synapse IEA neuron, Synap, Neurotransmitter, Glial (GO term level: 2) -
GO:0005789 endoplasmic reticulum membrane IEA -
GO:0005624 membrane fraction IEA -
GO:0005783 endoplasmic reticulum IEA -
GO:0016021 integral to membrane IEA -
GO:0005886 plasma membrane TAS 1311100
GO:0030054 cell junction IEA -

Section IV. Protein-protein interaction annotation

Interactors Aliases B Official full name B Experimental Source PubMed ID
CACNG2 MGC138502 | MGC138504 calcium channel, voltage-dependent, gamma subunit 2 - HPRD,BioGRID 11140673
CANX CNX | FLJ26570 | IP90 | P90 calnexin - HPRD 10461883
DLG1 DKFZp761P0818 | DKFZp781B0426 | DLGH1 | SAP97 | dJ1061C18.1.1 | hdlg discs, large homolog 1 (Drosophila) - HPRD,BioGRID 9677374|11567040
EPB41L1 4.1N | DKFZp686H17242 | KIAA0338 | MGC11072 erythrocyte membrane protein band 4.1-like 1 - HPRD,BioGRID 11050113
EPB41L2 4.1-G | DKFZp781D1972 | DKFZp781H1755 erythrocyte membrane protein band 4.1-like 2 - HPRD,BioGRID 11050113
GRIA2 GLUR2 | GLURB | GluR-K2 | HBGR2 glutamate receptor, ionotropic, AMPA 2 Affinity Capture-Western BioGRID 10358037
GRIA4 GLUR4 | GLUR4C | GLURD 谷氨酸受体,ionotrophic, AMPA 4 - HPRD,BioGRID 9466455
GRID2 MGC117022 | MGC117023 | MGC117024 glutamate receptor, ionotropic, delta 2 Affinity Capture-Western BioGRID 12573530
GRID2 MGC117022 | MGC117023 | MGC117024 glutamate receptor, ionotropic, delta 2 GluR1 interacts with GluR-delta-2 BIND 12573530
GRIK2 EAA4 | GLR6 | GLUK6 | GLUR6 | MGC74427 | MRT6 glutamate receptor, ionotropic, kainate 2 Affinity Capture-Western BioGRID 8288598
GRIK2 EAA4 | GLR6 | GLUK6 | GLUR6 | MGC74427 | MRT6 glutamate receptor, ionotropic, kainate 2 - HPRD 10358037
GRIP1 GRIP glutamate receptor interacting protein 1 Reconstituted Complex BioGRID 11891216
HOMER1 HOMER | HOMER1A | HOMER1B | HOMER1C | SYN47 | Ves-1 homer homolog 1 (Drosophila) - HPRD,BioGRID 9069287|9808458
|11418862
HSPA5 毕普| FLJ26106 | GRP78 | MIF2 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) - HPRD 10461883
PICK1 MGC15204 | PICK | PRKCABP protein interacting with PRKCA 1 - HPRD,BioGRID 11891216
SDCBP MDA-9 | ST1 | SYCL | TACIP18 syndecan binding protein (syntenin) - HPRD,BioGRID 11891216
TANC1 KIAA1728 | ROLSB | TANC tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 - HPRD 15673434
TRPC1 HTRP-1 | MGC133334 | MGC133335 | TRP1 transient receptor potential cation channel, subfamily C, member 1 - HPRD 14614461


Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG NEUROACTIVE LIGAND RECEPTOR INTERACTION 272 195 All SZGR 2.0 genes in this pathway
KEGG LONG TERM POTENTIATION 70 57 All SZGR 2.0 genes in this pathway
KEGG LONG TERM DEPRESSION 70 53 All SZGR 2.0 genes in this pathway
KEGG AMYOTROPHIC LATERAL SCLEROSIS ALS 53 43 All SZGR 2.0 genes in this pathway
PID EPHB FWD PATHWAY 40 38 All SZGR 2.0 genes in this pathway
REACTOME TRANSMISSION ACROSS CHEMICAL SYNAPSES 186 155 All SZGR 2.0 genes in this pathway
REACTOME NEURONAL SYSTEM 279 221 All SZGR 2.0 genes in this pathway
REACTOME NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL 137 110 All SZGR 2.0 genes in this pathway
REACTOME TRAFFICKING OF AMPA RECEPTORS 28 23 All SZGR 2.0 genes in this pathway
REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS 16 11 All SZGR 2.0 genes in this pathway
REACTOME ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS 37 32 All SZGR 2.0 genes in this pathway
REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION 15 14 All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE LPS UP 431 237 All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK 1442 892 All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 48HR DN 428 306 All SZGR 2.0 genes in this pathway
STARK PREFRONTAL CORTEX 22Q11 DELETION UP 195 138 All SZGR 2.0 genes in this pathway
LEE TARGETS OF PTCH1 AND SUFU DN 83 69 All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS 882 572 All SZGR 2.0 genes in this pathway
MODY HIPPOCAMPUS POSTNATAL 63 50 All SZGR 2.0 genes in this pathway
LU AGING BRAIN DN 153 120 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE DN 1237 837 All SZGR 2.0 genes in this pathway
JIANG AGING HYPOTHALAMUS DN 40 31 All SZGR 2.0 genes in this pathway
MCCLUNG COCAINE REWARD 5D 79 62 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 8HR UP 105 73 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 48HR UP 180 125 All SZGR 2.0 genes in this pathway
XU GH1 AUTOCRINE TARGETS UP 268 157 All SZGR 2.0 genes in this pathway
YAUCH HEDGEHOG SIGNALING PARACRINE DN 264 159 All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305 895 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 1HR UP 61 44 All SZGR 2.0 genes in this pathway
MIYAGAWA TARGETS OF EWSR1 ETS FUSIONS DN 229 135 All SZGR 2.0 genes in this pathway
ACEVEDO FGFR1 TARGETS IN PROSTATE CANCER MODEL DN 308 187 All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 2ND EGF PULSE ONLY 1725 838 All SZGR 2.0 genes in this pathway