SZGR2 - Beplay体育中心

概括?

基因	27257
Symbol	LSM1
Synonyms	CASM\|YJL124C
Description	LSM1 homolog, mRNA degradation associated
Reference	MIM:607281\|HGNC:HGNC:20472\|Ensembl:ENSG00000175324\|HPRD:06281\|Vega:OTTHUMG00000164051
Gene type	protein-coding
Map location	8p11.2
Pascal p-value	1.673E-5
Sherlock p-value	0.204
Fetal beta	0.033
DMG	1 (# studies)

数据源中的基因

Gene set name	Method of gene set	Description	Info
CV:GWAScat	Genome-wide Association Studies	该数据集包括与精神分裂症相关的560个SNP。总共将486个基因映射到50kb内的这些SNP。
CV:GWASdb	Genome-wide Association Studies	GWASdb records for schizophrenia
CV:PGCnp	Genome-wide Association Study	GWAS
DMG:Jaffe_2016	Genome-wide DNA methylation analysis	This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05.	1
PMID:cooccur	High-throughput literature-search	系统搜索PubMed的共病的基因with SCZ keywords. A total of 3027 genes were included.
Literature	High-throughput literature-search	Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias	Click to show details

Section I. Genetics and epigenetics annotation

Differentially methylated gene

Probe	Chromosome	Position	Nearest gene	P (dis)	Beta (dis)	FDR (dis)	Study
cg23409476	8	38034180	LSM1	1.71E-8	-0.009	6.22E-6	DMG:Jaffe_2016

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
C3orf60	2P1 \| DKFZp564J0123 \| E3-3 \| MGC10527	chromosome 3 open reading frame 60	两个杂交	BioGRID	15231747
CLIC1	G6 \| NCC27	chloride intracellular channel 1	两个杂交	BioGRID	14667819
EXOSC6	EAP4 \| MTR3 \| Mtr3p \| hMtr3p \| p11	exosome component 6	两个杂交	BioGRID	15231747
EXOSC8	CIP3 \| EAP2 \| OIP2 \| RP11-421P11.3 \| RRP43 \| Rrp43p \| bA421P11.3 \| p9	exosome component 8	-	HPRD,BioGRID	15231747
GRHPR	GLXR \| GLYD \| PH2	glyoxylate reductase/hydroxypyruvate reductase	-	HPRD,BioGRID	15231747
HSP90AA1	FLJ31884 \|HSP86 \|HSP89A \|HSP90A \|HSP90N \|HSPC1 \|HSPCA \|HSPCAL1 \|HSPCAL4 \|HSPN \| Hsp89 \| Hsp90 \| LAP2	heat shock protein 90kDa alpha (cytosolic), class A member 1	-	HPRD,BioGRID	15231747
LSM2	C6orf28 \| G7b \| YBL026W \| snRNP	LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae)	-	HPRD,BioGRID	11920408\|15231747
LSM3	SMX4 \| USS2 \| YLR438C	LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae)	-	HPRD	11920408
LSM4	YER112W	LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)	-	HPRD,BioGRID	11920408
LSM5	FLJ12710 \| YER146W	LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)	-	HPRD	11920408
LSM6	YDR378C	LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)	-	HPRD	11920408
LSM7	YNL147W	LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae)	-	HPRD	11920408
N4BP1	FLJ31821 \| KIAA0615 \| MGC176730	NEDD4 binding protein 1	两个杂交	BioGRID	15231747
NARS	ASNRS \| NARS1	asparaginyl-tRNA synthetase	-	HPRD,BioGRID	15231747
PSMB5	LMPX \| MB1 \| MGC104214 \| X	proteasome (prosome, macropain) subunit, beta type, 5	-	HPRD,BioGRID	15231747
PSMB8	D6S216 \| D6S216E \| LMP7 \| MGC1491 \| PSMB5i \| RING10 \| beta5i	proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)	-	HPRD,BioGRID	15231747
PTPRC	B220 \| CD45 \| CD45R \| GP180 \| LCA \| LY5 \| T200	protein tyrosine phosphatase, receptor type, C	-	HPRD	8980254
SMN1	BCD541 \| SMA \| SMA1 \| SMA2 \| SMA3 \| SMA4 \| SMA@ \| SMN \| SMNT \| T-BCD541	survival of motor neuron 1, telomeric	-	HPRD	10851237
TMEM214	FLJ20254 \| FLJ39682	transmembrane protein 214	-	HPRD,BioGRID	15231747
UPF2	DKFZp434D222 \| HUPF2 \| KIAA1408 \| MGC138834 \| MGC138835 \| RENT2 \| smg-3	UPF2 regulator of nonsense transcripts homolog (yeast)	两个杂交	BioGRID	15231747
UXT	ART-27	ubiquitously-expressed transcript	-	HPRD,BioGRID	15231747
VPS11	END1 \| PEP5 \| RNF108 \| hVPS11	vacuolar protein sorting 11 homolog (S. cerevisiae)	两个杂交	BioGRID	15231747

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG RNA DEGRADATION	59	37	该途径中的所有SZGR 2.0基因
REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE	15	10	该途径中的所有SZGR 2.0基因
REACTOME METABOLISM OF MRNA	284	128	该途径中的所有SZGR 2.0基因
REACTOME DEADENYLATION DEPENDENT MRNA DECAY	48	29	该途径中的所有SZGR 2.0基因
REACTOME METABOLISM OF RNA	330	155	该途径中的所有SZGR 2.0基因
HOLLMANN APOPTOSIS VIA CD40 UP	201	125	该途径中的所有SZGR 2.0基因
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP	1382	904	该途径中的所有SZGR 2.0基因
JAERVINEN AMPLIFIED IN LARYNGEAL CANCER	40	24	该途径中的所有SZGR 2.0基因
PUJANA BRCA1 PCC NETWORK	1652	1023	该途径中的所有SZGR 2.0基因
PUJANA ATM PCC NETWORK	1442	892	该途径中的所有SZGR 2.0基因
PUJANA CHEK2 PCC NETWORK	779	480	该途径中的所有SZGR 2.0基因
BENPORATH MYC MAX TARGETS	775	494	该途径中的所有SZGR 2.0基因
NIKOLSKY BREAST CANCER 8P12 P11 AMPLICON	57	32	该途径中的所有SZGR 2.0基因
DING LUNG CANCER EXPRESSION BY COPY NUMBER	100	62	该途径中的所有SZGR 2.0基因
ACEVEDO LIVER CANCER UP	973	570	该途径中的所有SZGR 2.0基因
MUELLER PLURINET	299	189	该途径中的所有SZGR 2.0基因
MOOTHA PGC	420	269	该途径中的所有SZGR 2.0基因
AGUIRRE PANCREATIC CANCER COPY NUMBER UP	298	174	该途径中的所有SZGR 2.0基因
DANG BOUND BY MYC	1103	714	该途径中的所有SZGR 2.0基因
BAE BRCA1 TARGETS UP	75	47	该途径中的所有SZGR 2.0基因
PILON KLF1 TARGETS DN	1972	1213	该途径中的所有SZGR 2.0基因
BRUINS UVC RESPONSE EARLY LATE	317	190	该途径中的所有SZGR 2.0基因

Gene Page:LSM1