Gene Page:MAD1L1

概括?
基因 8379
象征 MAD1L1
Synonyms MAD1|PIG9|TP53I9|TXBP181
Description MAD1有丝分裂逮捕不足1（酵母）
Reference MIM:602686|HGNC:HGNC:6762|ENSEMBL：ENSG00000002822|HPRD:04065|Vega:OTTHUMG00000151493
Gene type protein-coding
Map location 7p22
Pascal p-value 5.049e-11
Fetal beta -0.594
DMG 3（＃研究）

数据源中的基因
Gene set name Method of gene set Description Info
CV:GWAScat Genome-wide Association Studies 该数据集包括与精神分裂症相关的560个SNP。总共将486个基因映射到50kb内的这些SNP。
CV：GWASDB Genome-wide Association Studies GWASdb records for schizophrenia
CV:PGC128 Genome-wide Association Study A multi-stage schizophrenia GWAS of up to 36,989 cases and 113,075 controls. Reported by the Schizophrenia Working Group of PGC. 128 independent associations spanning 108 loci
CV:PGCnp Genome-wide Association Study GWAS
CV:Ripke_2013 Genome-wide Association Study 多阶段GWA，瑞典人口和PGC2。24个领先的SNP
DMG:Jaffe_2016 Genome-wide DNA methylation analysis This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 4
DMG:Montano_2016 Genome-wide DNA methylation analysis This dataset includes 172 replicated associations between CpGs with schizophrenia. 4
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 4
LK：是的 Genome-wide Association Study 该数据集包括映射到22个区域的99个基因。CV：RIPKE_2013中还包括24个领先的SNP
PMID:cooccur High-throughput literature-search Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
文学 High-throughput literature-search 有限公司-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenias Click to show details

第一节遗传学和表观遗传学注释

@CV:PGC128

SNP ID Chromosome Position Allele P 功能 Gene Up/Down Distance

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg25323444 7 2111060 MAD1L1 1.07E-6 0.011 0.016 DMG:Montano_2016
cg23997168 7 1984831 MAD1L1 8.11E-5 0.323 0.026 DMG:Wockner_2014
CG04395498 7 2017437 MAD1L1 2.208E-4 0.465 0.036 DMG:Wockner_2014
cg20935553 7 2272059 MAD1L1 7.53E-9 -0.015 3.72E-6 DMG:Jaffe_2016


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

脚注：
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

脚注：
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

大脑区域的顶级共表达基因

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
RBM5 0.91 0.92
ZC3H11A 0.90 0.91
EXOSC10 0.90 0.90
SFRS14 0.89 0.91
ZNF509 0.89 0.90
WDR59 0.89 0.89
INTS3 0.89 0.92
HARS2 0.89 0.89
ZNF862 0.88 0.89
TCERG1 0.88 0.91
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
AF347015.31 -0.75 -0.82
MT-CO2 -0.74 -0.81
AF347015.27 -0.73 -0.79
AF347015.33 -0.71 -0.77
IFI27 -0.71 -0.78
mt-cyb -0.70 -0.77
AF347015.21 -0.70 -0.84
FXYD1 -0.70 -0.78
AF347015.8 -0.70 -0.79
HIGD1B -0.70 -0.80

第四节。蛋白质蛋白相互作用注释

互动者 Aliases B Official full name B Experimental 资源 PubMed ID
AMOTL2 LCCP angiomotin like 2 两个杂交 BioGRID 16189514
FAM131C C1orf117 |FLJ36766 |RP11-5P18.9 family with sequence similarity 131, member C 两个杂交 BioGRID 16189514
HDAC1 DKFZp686H12203 | GON-10 | HD1 | RPD3 | RPD3L1 histone deacetylase 1 Affinity Capture-Western
共纯化		 BioGRID 15388328
HDAC2 RPD3 |yaf1 histone deacetylase 2 Affinity Capture-Western
共纯化		 BioGRID 15388328
MAD1L1 HsMAD1 | MAD1 | PIG9 | TP53I9 | TXBP181 MAD1有丝分裂逮捕不足1（酵母） 两个杂交 BioGRID 16189514
MAD2L1 HSMAD2 | MAD2 MAD2 mitotic arrest deficient-like 1 (yeast) - HPRD 11804586
MAD2L1 HSMAD2 | MAD2 MAD2 mitotic arrest deficient-like 1 (yeast) MAD1L1 (Mad1) interacts with MAD2L1 (Mad2). BIND 15694304
MAD2L1 HSMAD2 | MAD2 MAD2 mitotic arrest deficient-like 1 (yeast) Reconstituted Complex
两个杂交		 BioGRID 10660610|11707408
|16189514
MAD2L1 HSMAD2 | MAD2 MAD2 mitotic arrest deficient-like 1 (yeast) TXBP181 interacts with HsMAD2. BIND 9546394
NDC80 Hec |Hec1 |kntc2 |tid3 |HSNDC80 NDC80 homolog, kinetochore complex component (S. cerevisiae) - HPRD 12351790
NONO NMT55 | NRB54 | P54 | P54NRB 非POU域含有八聚体结合 两个杂交 BioGRID 16189514
RP4-691N24.1 FLJ11792 |KIAA0980 |NLP |DJ691N24.1 ninein-like 两个杂交 BioGRID 16189514
sin3a DKFZp434K2235 | FLJ90319 | KIAA0700 SIN3 homolog A, transcription regulator (yeast) - HPRD 11106735
SIN3B KIAA0700 SIN3 homolog B, transcription regulator (yeast) - HPRD 11101889|11370785
TEX11 TGC1 | TSGA3 testis expressed 11 两个杂交 BioGRID 16189514
TRIM29 ATDC |FLJ36085 tripartite motif-containing 29 两个杂交 BioGRID 16189514
TUBGCP4 76P | FLJ14797 | GCP4 tubulin, gamma complex associated protein 4 两个杂交 BioGRID 16189514


V.途径注释

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG CELL CYCLE 128 84 该途径中的所有SZGR 2.0基因
PID CMYB PATHWAY 84 61 该途径中的所有SZGR 2.0基因
REACTOME CELL CYCLE 421 253 该途径中的所有SZGR 2.0基因
REACTOME CELL CYCLE MITOTIC 325 185 该途径中的所有SZGR 2.0基因
Reactome细胞周期检查点 124 70 该途径中的所有SZGR 2.0基因
REACTOME MITOTIC M M G1 PHASES 172 98 该途径中的所有SZGR 2.0基因
REACTOME DNA REPLICATION 192 110 该途径中的所有SZGR 2.0基因
REACTOME MITOTIC PROMETAPHASE 87 51 该途径中的所有SZGR 2.0基因
ONKEN UVEAL MELANOMA UP 783 507 该途径中的所有SZGR 2.0基因
CASORELLI ACUTE PROMYELOCYTIC LEUKEMIA DN 663 425 该途径中的所有SZGR 2.0基因
Huttmann B Cll生存不佳 276 187 该途径中的所有SZGR 2.0基因
DEURIG T细胞PROLYMPHOCYTIC白血病 368 234 该途径中的所有SZGR 2.0基因
UDAYAKUMAR MED1 TARGETS UP 135 82 该途径中的所有SZGR 2.0基因
ENK UV响应角质形成细胞 530 342 该途径中的所有SZGR 2.0基因
LANG MYB FAMILY TARGETS 29 16 该途径中的所有SZGR 2.0基因
Perez TP53目标 1174 695 该途径中的所有SZGR 2.0基因
DACOSTA UV RESPONSE VIA ERCC3 TTD DN 84 63 该途径中的所有SZGR 2.0基因
DACOSTA UV RESPONSE VIA ERCC3 DN 855 609 该途径中的所有SZGR 2.0基因
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN UP 479 299 该途径中的所有SZGR 2.0基因
AMIT EGF RESPONSE 480 HELA 164 118 该途径中的所有SZGR 2.0基因
KAUFFMANN DNA REPAIR GENES 230 137 该途径中的所有SZGR 2.0基因
NIKOLSKY BREAST CANCER 7P22 AMPLICON 38 27 该途径中的所有SZGR 2.0基因
SANSOM APC TARGETS UP 126 84 该途径中的所有SZGR 2.0基因
FERRANDO T ALL WITH MLL ENL FUSION UP 87 67 该途径中的所有SZGR 2.0基因
HOFMANN CELL LYMPHOMA DN 39 29 该途径中的所有SZGR 2.0基因
XU对维甲酸DN的响应 13 8 该途径中的所有SZGR 2.0基因
BANDRES RESPONSE TO CARMUSTIN MGMT 48HR DN 161 105 该途径中的所有SZGR 2.0基因
由Foxp3绑定的Marson未刺激 1229 713 该途径中的所有SZGR 2.0基因
SANSOM APC TARGETS 212 121 该途径中的所有SZGR 2.0基因
CHENG IMPRINTED BY ESTRADIOL 110 68 该途径中的所有SZGR 2.0基因
WEST ADRENOCORTICAL TUMOR UP 294 199 该途径中的所有SZGR 2.0基因
AGUIRRE PANCREATIC CANCER COPY NUMBER UP 298 174 该途径中的所有SZGR 2.0基因
Ferrando Hox11邻居 23 13 该途径中的所有SZGR 2.0基因
CHIANG LIVER CANCER SUBCLASS CTNNB1 DN 170 105 该途径中的所有SZGR 2.0基因
清肝癌亚类polymomy7 79 50 该途径中的所有SZGR 2.0基因
开罗肝母细胞瘤上课 605 377 该途径中的所有SZGR 2.0基因
BROWNE HCMV INFECTION 1HR DN 222 147 该途径中的所有SZGR 2.0基因
figueroa aml甲基化簇3 170 97 该途径中的所有SZGR 2.0基因
FIGUEROA AML METHYLATION CLUSTER 6 UP 140 81 该途径中的所有SZGR 2.0基因
FIGUEROA AML METHYLATION CLUSTER 7 UP 118 68 该途径中的所有SZGR 2.0基因
KIM TIAL1 TARGETS 32 22 该途径中的所有SZGR 2.0基因
GOBERT OLIGODENDROCYTE DIFFERENTIATION UP 570 339 该途径中的所有SZGR 2.0基因
SERVITJA LIVER HNF1A TARGETS DN 157 105 该途径中的所有SZGR 2.0基因
SMIRNOV RESPONSE TO IR 6HR UP 166 97 该途径中的所有SZGR 2.0基因