SZGR2 - Beplay体育中心

Summary？

基因	4137
Symbol	mapt
同义词	ddpac \| ftdp-17 \| maptl \| mstd \| mtbt1 \| mtbt2 \| ppnd \| ppp1r103 \| tau
描述	microtubule associated protein tau
参考	MIM：157140\|HGNC：HGNC：6893\|Ensembl:ENSG00000186868\|HPRD:01142\|Vega：Otthumg00000168833
基因type	蛋白质编码
地图位置	17q21.1
Sherlock p-value	0.004
胎儿β	-2.487
主持人	小脑半球 Cerebellum Cortex Frontal Cortex BA9 Myers' cis & trans 元
支持	STRUCTURAL PLASTICITY g2cdb.humanpsd G2CDB.HUMANPSP COMPOSITESET potential synaptic genes

基因in Data Sources

基因set name	基因组方法	描述	信息
简历：PGCNP	全基因组协会研究	GWAS
CV:PheWAS	全球整个关联研究（PHEWAS）	157个与精神分裂症相关的SNP	1
PMID：cooccur	高通量文献搜索	Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
文学	高通量文献搜索	Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenias	点击显示详细信息
go_annotation	Mapping neuro-related keywords to Gene Ontology annotations	Hits with neuro-related keywords: 8
网络	Shortest path distance of core genes in the Human protein-protein interaction network	PPI网络中最短路径的贡献：3.6916

Section I. Genetics and epigenetics annotation

CV:PheWAS

SNP ID	Chromosome	position	等位基因	p	功能	基因	Up/Down Distance
RS242557	17	0	null	1.576	mapt	null

EQTL注释

SNP ID	Chromosome	position	主持人	Gene Entrez ID	QVALUE	EQTL类型
rs12947718	CHR17	43493100	mapt	4137	0	顺式
RS17631303	CHR17	43516401	mapt	4137	0	顺式
RS3946526	CHR17	43541655	mapt	4137	1.764E-4	顺式
RS2696425	CHR17	43666905	mapt	4137	8.37E-4	顺式
RS418891	CHR17	43693537	mapt	4137	0	顺式
rs413778	CHR17	43716884	mapt	4137	0	顺式
RS453997	CHR17	43727060	mapt	4137	5.899E-4	顺式
RS422112	CHR17	43728136	mapt	4137	0	顺式
RS241033	CHR17	43733982	mapt	4137	5.899E-4	顺式
RS241032	CHR17	43734144	mapt	4137	0	顺式
RS241031	CHR17	43734303	mapt	4137	5.899E-4	顺式
RS17760733	CHR17	43746275	mapt	4137	0.01	顺式
RS17687571	CHR17	43750009	mapt	4137	0	顺式
rs17687667	CHR17	43754098	mapt	4137	6.42E-4	顺式
RS17688002	CHR17	43762593	mapt	4137	5.899E-4	顺式
rs17688068	CHR17	43763934	mapt	4137	0.02	顺式
rs17688391	CHR17	43772108	mapt	4137	9.156E-4	顺式
RS17688434	CHR17	43772539	mapt	4137	0	顺式
rs12150610	CHR17	43775478	mapt	4137	0	顺式
rs12150547	CHR17	43775545	mapt	4137	5.899E-4	顺式
rs17762165	CHR17	43778601	mapt	4137	8.734e-4	顺式
RS17688922	CHR17	43779350	mapt	4137	0	顺式
RS17688944	CHR17	43779418	mapt	4137	5.878E-4	顺式
rs1526128	CHR17	43779623	mapt	4137	7.6e-4	顺式
rs1526129	CHR17	43779656	mapt	4137	0	顺式
rs1724425	CHR17	43781746	mapt	4137	0.01	顺式
RS17563501	CHR17	43801694	mapt	4137	7.043E-4	顺式
RS2902662	CHR17	43806924	mapt	4137	0	顺式
RS17563787	CHR17	43813251	mapt	4137	5.878E-4	顺式
rs17563827	CHR17	43818221	mapt	4137	7.176E-4	顺式
RS12150672	CHR17	43826636	mapt	4137	0.01	顺式
RS17426106	CHR17	43828934	mapt	4137	5.452E-4	顺式
RS17426195	CHR17	43832366	mapt	4137	7.513E-4	顺式
rs6503447	CHR17	43834911	mapt	4137	0.06	顺式
rs4074462	CHR17	43855227	mapt	4137	0	顺式
rs17689471	CHR17	43892972	mapt	4137	7.043E-4	顺式
rs17762769	CHR17	43893402	mapt	4137	0	顺式
RS171440	CHR17	43893486	mapt	4137	0.08	顺式
rs8072451	CHR17	43893715	mapt	4137	0	顺式
rs4277389	CHR17	43895652	mapt	4137	5.878E-4	顺式
rs17689824	CHR17	43904396	mapt	4137	6.987E-4	顺式
rs17763086	CHR17	43905480	mapt	4137	0.02	顺式
rs17689882	CHR17	43906827	mapt	4137	5.878E-4	顺式
RS17769552	CHR17	43927289	mapt	4137	9.779E-4	顺式
RS916793	CHR17	43954685	mapt	4137	7.043E-4	顺式
RS17649553	CHR17	43994647	mapt	4137	0	顺式
RS17649641	CHR17	43997371	mapt	4137	0	顺式
RS17564223	CHR17	43997519	mapt	4137	0	顺式
RS17649954	CHR17	44001660	mapt	4137	5.441E-4	顺式
RS17564619	CHR17	44002137	mapt	4137	9.354e-4	顺式
RS17650063	CHR17	44002554	mapt	4137	7.043E-4	顺式
rs17564780	CHR17	44005412	mapt	4137	7.043E-4	顺式
rs17650381	CHR17	44013023	mapt	4137	0	顺式
rs12150111	CHR17	44013937	mapt	4137	7.043E-4	顺式
rs2316784	CHR17	44021698	mapt	4137	8.505E-4	顺式
RS4327091	CHR17	44021716	mapt	4137	5.878E-4	顺式
RS242559	CHR17	44025887	mapt	4137	0	顺式
RS17571718	CHR17	44032767	mapt	4137	4.555e-4	顺式
RS17571739	CHR17	44032914	mapt	4137	5.878E-4	顺式
RS17650872	CHR17	44039515	mapt	4137	7.043E-4	顺式
rs17572169	CHR17	44045973	mapt	4137	5.878E-4	顺式
rs17651213	CHR17	44051923	mapt	4137	0.01	顺式
rs17572361	CHR17	44052008	mapt	4137	0	顺式
RS17572851	CHR17	44063765	mapt	4137	0	顺式
RS17572893	CHR17	44064207	mapt	4137	5.878E-4	顺式
RS17573175	CHR17	44071088	mapt	4137	8.2E-4	顺式
RS1078268	CHR17	44075900	mapt	4137	0	顺式
rs8070723	CHR17	44081063	mapt	4137	5.878E-4	顺式
RS17652449	CHR17	44088936	mapt	4137	0	顺式
RS17652502	CHR17	44094470	mapt	4137	7.043E-4	顺式
RS17574228	CHR17	44104508	mapt	4137	5.878E-4	顺式
rs1076222	CHR17	44109768	mapt	4137	0	顺式
rs7350980	CHR17	44110270	mapt	4137	0	顺式
RS4597358	CHR17	44110669	mapt	4137	5.878E-4	顺式
RS17653162	CHR17	44111826	mapt	4137	3.466E-4	顺式
RS17574824	CHR17	44115106	mapt	4137	0	顺式
RS12150090	CHR17	44115885	mapt	4137	7.043E-4	顺式
RS7221390	CHR17	44116949	mapt	4137	7.043E-4	顺式
RS17575556	CHR17	44135826	mapt	4137	8.802E-4	顺式
RS17659881	CHR17	44157596	mapt	4137	7.043E-4	顺式
RS17660132	CHR17	44165802	mapt	4137	3.611E-4	顺式
RS17577094	CHR17	44187491	mapt	4137	0	顺式
RS17660907	CHR17	44191084	mapt	4137	0	顺式
rs8070942	CHR17	44208673	mapt	4137	5.515E-4	顺式
rs2532316	CHR17	44213711	mapt	4137	5.878E-4	顺式
RS2696600	CHR17	44216225	mapt	4137	0	顺式
RS1406068	CHR17	44234525	mapt	4137	5.878E-4	顺式
rs2532292	CHR17	44237067	mapt	4137	7.043E-4	顺式
rs2532286	CHR17	44241663	mapt	4137	7.544E-4	顺式
rs2532276	CHR17	44246623	mapt	4137	0	顺式
rs2532275	CHR17	44246996	mapt	4137	7.043E-4	顺式
RS2532259	CHR17	44253363	mapt	4137	7.043E-4	顺式
rs2732646	CHR17	44254378	mapt	4137	5.878E-4	顺式
rs2732589	CHR17	44266021	mapt	4137	0	顺式
RS1918788	CHR17	44267616	mapt	4137	7.043E-4	顺式
rs2732596	CHR17	44269545	mapt	4137	0.01	顺式
RS2732675	CHR17	44280187	mapt	4137	0	顺式
RS2732674	CHR17	44280696	mapt	4137	0.01	顺式
RS2668695	CHR17	44292125	mapt	4137	6.7E-4	顺式
rs2532332	CHR17	44347726	mapt	4137	0.08	顺式
RS2732706	CHR17	44351685	mapt	4137	0	顺式
RS2668624	CHR17	44352871	mapt	4137	0.01	顺式
RS199436	CHR17	44789284	mapt	4137	0.17	顺式
RS142167	CHR17	44795233	mapt	4137	0.12	顺式
RS199452	CHR17	44801339	mapt	4137	0.13	顺式
RS199449	CHR17	44808901	mapt	4137	0.15	顺式
RS199535	CHR17	44822661	mapt	4137	0.04	顺式
rs199515	CHR17	44856640	mapt	4137	0.1	顺式
rs12947718	CHR17	43493100	mapt	4137	0.17	trans
RS17631303	CHR17	43516401	mapt	4137	0.1	trans
RS3946526	CHR17	43541655	mapt	4137	0.02	trans
RS2696425	CHR17	43666905	mapt	4137	0.06	trans
RS418891	CHR17	43693537	mapt	4137	0.17	trans
rs413778	CHR17	43716884	mapt	4137	0.13	trans
RS453997	CHR17	43727060	mapt	4137	0.05	trans
RS422112	CHR17	43728136	mapt	4137	0.13	trans
RS241033	CHR17	43733982	mapt	4137	0.05	trans
RS241031	CHR17	43734303	mapt	4137	0.05	trans
RS17687571	CHR17	43750009	mapt	4137	0.18	trans
rs17687667	CHR17	43754098	mapt	4137	0.05	trans
RS17688002	CHR17	43762593	mapt	4137	0.05	trans
rs17688391	CHR17	43772108	mapt	4137	0.07	trans
RS17688434	CHR17	43772539	mapt	4137	0.11	trans
rs12150610	CHR17	43775478	mapt	4137	0.1	trans
rs12150547	CHR17	43775545	mapt	4137	0.05	trans
rs17762165	CHR17	43778601	mapt	4137	0.06	trans
RS17688922	CHR17	43779350	mapt	4137	0.07	trans
RS17688944	CHR17	43779418	mapt	4137	0.05	trans
rs1526128	CHR17	43779623	mapt	4137	0.06	trans
rs1526129	CHR17	43779656	mapt	4137	0.08	trans
RS17563501	CHR17	43801694	mapt	4137	0.05	trans
RS2902662	CHR17	43806924	mapt	4137	0.1	trans
RS17563787	CHR17	43813251	mapt	4137	0.05	trans
rs17563827	CHR17	43818221	mapt	4137	0.05	trans
RS17426106	CHR17	43828934	mapt	4137	0.04	trans
RS17426195	CHR17	43832366	mapt	4137	0.06	trans
rs4074462	CHR17	43855227	mapt	4137	0.09	trans
rs17689471	CHR17	43892972	mapt	4137	0.05	trans
rs17762769	CHR17	43893402	mapt	4137	0.1	trans
rs8072451	CHR17	43893715	mapt	4137	0.08	trans
rs4277389	CHR17	43895652	mapt	4137	0.05	trans
rs17689824	CHR17	43904396	mapt	4137	0.05	trans
RS17769552	CHR17	43927289	mapt	4137	0.07	trans
SNP_A-2150382		0	mapt	4137	0.04	trans
RS916793	CHR17	43954685	mapt	4137	0.05	trans
RS17649553	CHR17	43994647	mapt	4137	0.09	trans
RS17649641	CHR17	43997371	mapt	4137	0.17	trans
RS17564223	CHR17	43997519	mapt	4137	0.09	trans
RS17649954	CHR17	44001660	mapt	4137	0.04	trans
RS17564619	CHR17	44002137	mapt	4137	0.07	trans
RS17650063	CHR17	44002554	mapt	4137	0.05	trans
rs17564780	CHR17	44005412	mapt	4137	0.05	trans
rs17650381	CHR17	44013023	mapt	4137	0.11	trans
rs12150111	CHR17	44013937	mapt	4137	0.05	trans
rs2316784	CHR17	44021698	mapt	4137	0.06	trans
RS4327091	CHR17	44021716	mapt	4137	0.05	trans
RS242559	CHR17	44025887	mapt	4137	0.08	trans
RS17571718	CHR17	44032767	mapt	4137	0.04	trans
RS17571739	CHR17	44032914	mapt	4137	0.05	trans
RS17650872	CHR17	44039515	mapt	4137	0.05	trans
rs17572169	CHR17	44045973	mapt	4137	0.05	trans
rs17572361	CHR17	44052008	mapt	4137	0.18	trans
RS17572851	CHR17	44063765	mapt	4137	0.1	trans
RS17572893	CHR17	44064207	mapt	4137	0.05	trans
RS17573175	CHR17	44071088	mapt	4137	0.06	trans
RS1078268	CHR17	44075900	mapt	4137	0.09	trans
rs8070723	CHR17	44081063	mapt	4137	0.05	trans
RS17652449	CHR17	44088936	mapt	4137	0.15	trans
RS17652502	CHR17	44094470	mapt	4137	0.05	trans
RS17574228	CHR17	44104508	mapt	4137	0.05	trans
rs1076222	CHR17	44109768	mapt	4137	0.09	trans
rs7350980	CHR17	44110270	mapt	4137	0.08	trans
RS4597358	CHR17	44110669	mapt	4137	0.05	trans
RS17653162	CHR17	44111826	mapt	4137	0.03	trans
RS17574824	CHR17	44115106	mapt	4137	0.2	trans
RS12150090	CHR17	44115885	mapt	4137	0.05	trans
snp_a-1855473		0	mapt	4137	0.05	trans
RS7221390	CHR17	44116949	mapt	4137	0.05	trans
snp_a-1823652		0	mapt	4137	0.18	trans
RS17575556	CHR17	44135826	mapt	4137	0.06	trans
RS17659881	CHR17	44157596	mapt	4137	0.05	trans
RS17660132	CHR17	44165802	mapt	4137	0.03	trans
RS17577094	CHR17	44187491	mapt	4137	0.15	trans
RS17660907	CHR17	44191084	mapt	4137	0.07	trans
rs8070942	CHR17	44208673	mapt	4137	0.04	trans
rs2532316	CHR17	44213711	mapt	4137	0.05	trans
RS2696600	CHR17	44216225	mapt	4137	0.13	trans
RS1406068	CHR17	44234525	mapt	4137	0.05	trans
rs2532292	CHR17	44237067	mapt	4137	0.05	trans
rs2532286	CHR17	44241663	mapt	4137	0.06	trans
rs2532276	CHR17	44246623	mapt	4137	0.07	trans
rs2532275	CHR17	44246996	mapt	4137	0.05	trans
RS2532259	CHR17	44253363	mapt	4137	0.05	trans
rs2732646	CHR17	44254378	mapt	4137	0.05	trans
rs2732589	CHR17	44266021	mapt	4137	0.16	trans
RS1918788	CHR17	44267616	mapt	4137	0.05	trans
RS2732675	CHR17	44280187	mapt	4137	0.14	trans
RS2668695	CHR17	44292125	mapt	4137	0.05	trans
RS2732706	CHR17	44351685	mapt	4137	0.11	trans
RS2668622		0	mapt	4137	0.04	trans

第二节。转录组注释

一般基因表达（GTEX）

基因expression during devlopment (BrainCloud)

脚注：
总共绘制了269个时间点，n = 38个胎儿样品（x = 1：38）。每个三角形代表一个时间点。

基因expression of temporal and spatial changes (BrainSpan)

脚注：
SC：亚皮质区域；SM：感觉运动区域；FC：额叶皮层；和TP：颞顶皮层
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

前10个积极共表达的基因
基因	皮尔逊的相关性	Spearman's Correlation
TNS1	0.83	0.86
TLN1	0.80	0.81
RRBP1	0.79	0.83
SLC20A2	0.78	0.82
GSN	0.77	0.78
ANGPTL2	0.77	0.79
TJP2	0.77	0.82
UNC5B	0.77	0.80
mylk	0.77	0.79
ERBB3	0.77	0.77

前10个负共表达基因
基因	皮尔逊的相关性	Spearman's Correlation
NR2C2AP	-0.53	-0.56
RPL27	-0.52	-0.67
RPL31	-0.52	-0.66
polb	-0.52	-0.58
RPS23	-0.52	-0.66
FRG1	-0.52	-0.61
RPL24	-0.52	-0.68
CYP2R1	-0.52	-0.57
RPS18	-0.52	-0.64
RPL32	-0.51	-0.64

第三节。基因本体论注释

分子功能	去学期	证据	神经关键字	pubMed ID
GO:0005200	细胞骨架的结构成分	TAS		2498079
去：0008034	lipoprotein binding	IPI		7972031
GO：0017124	SH3 domain binding	IPI		9763511
去：0008017	microtubule binding	艾达		1918161
去：0008017	microtubule binding	ISS		-
GO:0019899	酶结合	IPI		9736630\|12888622
GO:0034187	载脂蛋白E结合	IPI		7566652
生物过程	去学期	证据	神经关键字	pubMed ID
GO：0048699	神经元的产生	NAS	神经元，神经发生（GO期限：7）	8522593
GO：0045773	轴突延伸的正调节	艾达	Axon（GO术语级别：15）	1389180
GO：0045773	轴突延伸的正调节	ISS	Axon（GO术语级别：15）	-
去:0000226	微管细胞骨架组织	艾达		1057175
去:0000226	微管细胞骨架组织	ISS		-
去：0007026	微管解聚的负调节	IEA		-
去：0031116	微管聚合的阳性调节	艾达		1421571
去：0031116	微管聚合的阳性调节	ISS		-
细胞分量	去学期	证据	神经关键字	pubMed ID
GO：0042995	细胞投影	IEA	轴突(GO term level: 4)	-
GO:0030426	growth cone	艾达	Axon，Dendrite（GO期限：5）	8642405
GO:0030426	growth cone	ISS	Axon，Dendrite（GO期限：5）	-
GO:0030424	轴突	艾达	神经元，轴突，神经递质（GO期限：6）	8642405
GO:0030424	轴突	ISS	神经元，轴突，神经递质（GO期限：6）	-
去：0005829	cytosol	TAS		10747907
GO:0005856	细胞骨架	IEA		-
GO:0005875	微管相关的复合物	TAS		10747907
去：0005737	细胞质	IEA		-
GO:0005886	质膜	艾达		8522593
GO:0005886	质膜	ISS		-
GO:0045298	微管蛋白复合物	艾达		8642405
GO:0045298	微管蛋白复合物	ISS		-

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	实验	资源	pubMed ID
AATF	CHE-1 \| CHE1 \| DED	凋亡拮抗转录因子	-	HPRD，Biogrid	14697667
apoe	AD2 \| LPG \| MGC1571 \| apoprotein	apolipoprotein E	重构的复合物	Biogrid	8620924
apoe	AD2 \| LPG \| MGC1571 \| apoprotein	apolipoprotein E	-	HPRD	7566652\|9147408
平静1	Calml2 \|CAMI \|DD132 \|PHKD	calmodulin 1 (phosphorylase kinase, delta)	-	HPRD，Biogrid	2123288
Fyn	MGC45350 \|SLK \|syn	Fynoncogene related to SRC, FGR, YES	-	HPRD，Biogrid	11826099
GSK3B	-	糖原合酶激酶3β	GSK3BETA磷酸化FTAU。这种相互作用是在兔GSK3Beta和人FTAU之间的相互作用上建模的。	BIND	14636947
标记4	FLJ90097 \|KIAA1860 \|markl1 \|NBLA00650	MAP/microtubule affinity-regulating kinase 4	-	HPRD，Biogrid	14594945
OGT	FLJ23071 \| HRNT1 \| MGC22921 \| O-GLCNAC	O连接的N-乙酰葡萄糖胺（GlcNAC）转移酶（UDP-N-乙酰葡萄糖：多肽-N-乙酰葡萄糖苷转移酶）	-	HPRD，Biogrid	8910513\|12911634
PIN1	DOD \| UBL5	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	-	HPRD，Biogrid	10391244
PSEN1	ad3 \|时尚\|PS1 \|S182	presenilin 1	-	HPRD，Biogrid	9689133
S100B	NEF \| S100 \| S100beta	S100钙结合蛋白B	-	HPRD	11264299
S100B	NEF \| S100 \| S100beta	S100钙结合蛋白B	-	HPRD，Biogrid	2833519
SNCA	MGC110988 \| NACP \| PARK1 \| PARK4 \| PD1	突触核蛋白，α（淀粉样蛋白前体的非A4成分）	-	HPRD，Biogrid	10464279
SPTB	HSPTB1	spectrin, beta, erythrocytic	-	HPRD，Biogrid	6743699
STXBP1	EIEE4 \|munc18-1 \|UNC18 \|Hunc18 \|RBSEC1	语法素结合蛋白1	-	HPRD，Biogrid	12963086
TUBB2A	tubb \|tubb2 \|DJ40E16.7	微管蛋白，β2A	-	HPRD	9922135
USP9Y	AZF \|AZF1 \|azfa \|dffry \|FLJ33043 \|SP3	泛素特异性肽酶9，Y连锁（类似脂肪的果蝇）	-	HPRD，Biogrid	1723470
YWHAA	-	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, alpha polypeptide	亲和力捕获 - 韦斯特恩	Biogrid	12176984
YWHAB	GW128 \|HS1 \|KCIP-1	酪氨酸3-单加氧酶/色氨酸5-单加氧酶激活蛋白，β多肽	-	HPRD，Biogrid	10840038
YWHAZ	KCIP-1\|MGC111427 \| MGC126532 \| MGC138156	酪氨酸3-单加氧酶/色氨酸5-单加氧酶激活蛋白，Zeta多肽	Tau与14-3-3-Zeta相互作用。	BIND	12176984
YWHAZ	KCIP-1\|MGC111427 \| MGC126532 \| MGC138156	酪氨酸3-单加氧酶/色氨酸5-单加氧酶激活蛋白，Zeta多肽	-	HPRD，Biogrid	10840038

Section V. Pathway annotation

pathway name	路径大小	＃szgr 2.0基因	信息
kegg mapk信号通路	267	205	All SZGR 2.0 genes in this pathway
Kegg阿尔茨海默氏病	169	110	All SZGR 2.0 genes in this pathway
生物卡丁生物肽途径	45	35	All SZGR 2.0 genes in this pathway
Biocarta P35alzheimers途径	11	9	All SZGR 2.0 genes in this pathway
pID LYSOPHOSPHOLIPID PATHWAY	66	53	All SZGR 2.0 genes in this pathway
pid reelin途径	29	29	All SZGR 2.0 genes in this pathway
PID LKB1途径	47	37	All SZGR 2.0 genes in this pathway
pID P38 GAMMA DELTA PATHWAY	11	9	All SZGR 2.0 genes in this pathway
反应组凋亡的细胞蛋白裂解	40	26	All SZGR 2.0 genes in this pathway
Reactome caspase介导的细胞骨架蛋白的切割	13	11	All SZGR 2.0 genes in this pathway
反应组凋亡	148	94	All SZGR 2.0 genes in this pathway
REACTOME APOPTOTIC EXECUTION PHASE	54	37	All SZGR 2.0 genes in this pathway
Liu Sox4靶向DN	309	191	All SZGR 2.0 genes in this pathway
THUM收缩心力衰竭DN	244	147	All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER LUMINAL VS BASAL UP	380	215	All SZGR 2.0 genes in this pathway
Doane对雄激素的反应	184	125	All SZGR 2.0 genes in this pathway
Doane乳腺癌ESR1 UP	112	72	All SZGR 2.0 genes in this pathway
GINESTIER BREAST CANCER 20Q13 AMPLIFICATION UP	119	66	All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN	1781	1082	All SZGR 2.0 genes in this pathway
GAUSSMANN MLL AF4 FUSION TARGETS G UP	238	135	All SZGR 2.0 genes in this pathway
FARMER BREAST CANCER APOCRINE VS BASAL	330	217	All SZGR 2.0 genes in this pathway
农民乳腺癌基础与仙女	330	215	All SZGR 2.0 genes in this pathway
SCHLOSSER SERUM RESPONSE UP	134	93	All SZGR 2.0 genes in this pathway
Teramoto OPN目标集群8	8	7	All SZGR 2.0 genes in this pathway
YANG乳腺癌ESR1 UP	36	22	All SZGR 2.0 genes in this pathway
Pujana ATM PCC网络	1442	892	All SZGR 2.0 genes in this pathway
Benporath Suz12目标	1038	678	All SZGR 2.0 genes in this pathway
BENPORATH EED TARGETS	1062	725	All SZGR 2.0 genes in this pathway
与H3K27me3的Benporath ES	1118	744	All SZGR 2.0 genes in this pathway
BENPORATH PRC2 TARGETS	652	441	All SZGR 2.0 genes in this pathway
阿斯顿主要抑郁症DN	160	110	All SZGR 2.0 genes in this pathway
FRASOR RESPONSE TO ESTRADIOL UP	37	28	All SZGR 2.0 genes in this pathway
EWSR1 FLI1融合的Zhang目标	88	68	All SZGR 2.0 genes in this pathway
Browne HCMV感染20小时	240	152	All SZGR 2.0 genes in this pathway
lu衰老的脑dn	153	120	All SZGR 2.0 genes in this pathway
伊万诺娃造血干细胞长期	302	191	All SZGR 2.0 genes in this pathway
CUI TCF21目标2 DN	830	547	All SZGR 2.0 genes in this pathway
CUI TCF21 TARGETS DN	31	23	All SZGR 2.0 genes in this pathway
kayo卡路里限制肌肉	95	64	All SZGR 2.0 genes in this pathway
MCDOWELL ACUTE LUNG INJURY DN	48	33	All SZGR 2.0 genes in this pathway
Creighton内分泌疗法抗性1	528	324	All SZGR 2.0 genes in this pathway
Creighton内分泌疗法抗性4	307	185	All SZGR 2.0 genes in this pathway
H3K27me3	97	72	All SZGR 2.0 genes in this pathway
Heller HDAC靶向被甲基化的沉默	461	298	All SZGR 2.0 genes in this pathway
Lee转移和替代剪接DN	45	31	All SZGR 2.0 genes in this pathway
Massarweh他莫昔芬抵抗DN	258	160	All SZGR 2.0 genes in this pathway
Massarweh对雌二醇的反应	61	47	All SZGR 2.0 genes in this pathway
OUILLETTE CLL 13Q14删除DN	60	38	All SZGR 2.0 genes in this pathway
RIGGI EWING SARCOMA PROGENITOR UP	430	288	All SZGR 2.0 genes in this pathway
脑DN中的乳腺癌复发	85	58	All SZGR 2.0 genes in this pathway
SMID乳腺癌腔内B	172	109	All SZGR 2.0 genes in this pathway
Smid乳腺癌基础DN	701	446	All SZGR 2.0 genes in this pathway
Mir34b和Mir34C的丰田目标	463	262	All SZGR 2.0 genes in this pathway
Zheng胶质母细胞瘤可塑性DN	58	39	All SZGR 2.0 genes in this pathway
HUANG DASATINIB RESISTANCE DN	69	44	All SZGR 2.0 genes in this pathway
Yoshimura mapk8靶向	1305	895	All SZGR 2.0 genes in this pathway
SWEET LUNG CANCER KRAS DN	435	289	All SZGR 2.0 genes in this pathway
霍夫曼（Hoffmann	36	24	All SZGR 2.0 genes in this pathway
肌肉中的罗马胰岛素靶标	442	263	All SZGR 2.0 genes in this pathway
Poola侵入性乳腺癌DN	134	83	All SZGR 2.0 genes in this pathway
金双相情感障碍少突胶质细胞密度相关	682	440	All SZGR 2.0 genes in this pathway
Kim所有疾病Calb1 Corr Up	548	370	All SZGR 2.0 genes in this pathway
verhaak胶质母细胞瘤pro	177	132	All SZGR 2.0 genes in this pathway
DUTERTRE ESTRADIOL RESPONSE 6HR UP	229	149	All SZGR 2.0 genes in this pathway
BHAT ESR1通过AKT1 UP目标	281	183	All SZGR 2.0 genes in this pathway
FARDIN HYPOXIA 11	32	29	All SZGR 2.0 genes in this pathway
TORCHIA TARGETS OF EWSR1 FLI1 FUSION UP	271	165	All SZGR 2.0 genes in this pathway
GOBERT OLIGODENDROCYTE DIFFERENTIATION DN	1080	713	All SZGR 2.0 genes in this pathway
由SALL4同工型绑定的RAO A	182	108	All SZGR 2.0 genes in this pathway
ghandhi旁观者辐射DN	12	10	All SZGR 2.0 genes in this pathway
Zwang仅通过第二EGF脉冲瞬时向上	1725年	838	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	目标位置			mirna id	mirna seq
miRNA family	UTR开始	UTR结束	匹配方法	mirna id	mirna seq
mir-181	4068	4074	m8	HSA-MIR-181A^脑	aacauucaacgcugucggugagu
				HSA-MIR-181B^SZ	aacauucauugcugucggggg
				HSA-MIR-181C^脑	aacauucaaccugucggugagu
				HSA-MIR-181D^脑	AACAUUCAUUGUUGUCGGUGGGUU
miR-214	2039	2045	m8	hsa-miR-214^脑	acagcaggcacagacaggcag
miR-219	3175	3181	m8	hsa-miR-219^脑	UGAUUGUCCAAACGCAAUUCU
mir-27	4065	4071	1A	hsa-miR-27a^脑	uucacaguggcuaaguuccgc
mir-27	4065	4071	1A	hsa-miR-27b^脑	uucacaguggcuaaguucugc
mir-34/449	1187	1193	m8	HSA-MIR-34A^脑	uggcaguguuaguguguuuu
				HSA-MIR-34C	AGGCAGUGUAGUUAGCUGAUUGC
				hsa-miR-449	UGGCAGUGUAUUGUUAGCUGGU
				HSA-MIR-449B	Aggcaguguauuguuagcuggc

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click这里to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click这里查看与大脑相关的miRNA列表。

基因页：mapt