Gene Page:MMP16

Summary?
GeneID 4325
Symbol MMP16
Synonyms C8orf57|MMP-X2|MT-MMP2|MT-MMP3|MT3-MMP
Description matrix metallopeptidase 16
Reference MIM:602262|HGNC:HGNC:7162|Ensembl:ENSG00000156103|HPRD:03776|Vega:OTTHUMG00000163769
Gene type protein-coding
Map location 8q21.3
Pascal p-value 5.134E-7
Sherlock p-value 0.581
Fetal beta 1.586
DMG 1 (# studies)

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:GWASdb Genome-wide Association Studies GWASdb records for schizophrenia
CV:PGCnp Genome-wide Association Study GWAS
DMG:Jaffe_2016 Genome-wide DNA methylation analysis This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 1
LK:YES Genome-wide Association Study This data set included 99 genes mapped to the 22 regions. The 24 leading SNPs were also included in CV:Ripke_2013
PMID:cooccur High-throughput literature-search 系统的搜索PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias Click to show details

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg07609388 8 89341103 MMP16 3.9E-9 -0.023 2.43E-6 DMG:Jaffe_2016


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
DRG2 0.85 0.83
WDR45 0.85 0.82
NIT1 0.85 0.82
PHKG2 0.85 0.81
ATP6V0D1 0.84 0.82
TRUB2 0.84 0.86
FOXRED1 0.83 0.81
GRINA 0.83 0.82
MED29 0.83 0.83
SLC25A11 0.82 0.81
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
AF347015.18 -0.55 -0.36
AF347015.21 -0.50 -0.27
AC010300.1 -0.49 -0.50
MT-ATP8 -0.48 -0.28
AF347015.2 -0.45 -0.22
AF347015.8 -0.45 -0.23
NSBP1 -0.44 -0.36
FAM159B -0.43 -0.52
AL139819.3 -0.43 -0.35
AC100783.1 -0.43 -0.27

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX 29 11 All SZGR 2.0 genes in this pathway
REACTOME EXTRACELLULAR MATRIX ORGANIZATION 87 42 All SZGR 2.0 genes in this pathway
DAVICIONI TARGETS OF PAX FOXO1 FUSIONS UP 255 177 All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER BASAL VS MESENCHYMAL DN 50 36 All SZGR 2.0 genes in this pathway
王FORSKOLIN反应 23 17 All SZGR 2.0 genes in this pathway
SENESE HDAC3 TARGETS UP 501 327 All SZGR 2.0 genes in this pathway
GOZGIT ESR1 TARGETS DN 781 465 All SZGR 2.0 genes in this pathway
LIEN BREAST CARCINOMA METAPLASTIC 35 25 All SZGR 2.0 genes in this pathway
ROPERO HDAC2 TARGETS 114 71 All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 48HR DN 428 306 All SZGR 2.0 genes in this pathway
NIKOLSKY BREAST CANCER 8Q12 Q22 AMPLICON 132 82 All SZGR 2.0 genes in this pathway
CERVERA SDHB TARGETS 1 DN 38 22 All SZGR 2.0 genes in this pathway
NELSON RESPONSE TO ANDROGEN DN 19 14 All SZGR 2.0 genes in this pathway
STANELLE E2F1 TARGETS 29 20 All SZGR 2.0 genes in this pathway
TARTE PLASMA CELL VS PLASMABLAST UP 398 262 All SZGR 2.0 genes in this pathway
NOUZOVA METHYLATED IN APL 68 39 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 14HR DN 298 200 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 1691 1088 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 48HR DN 504 323 All SZGR 2.0 genes in this pathway
VERRECCHIA RESPONSE TO TGFB1 C2 25 18 All SZGR 2.0 genes in this pathway
VERRECCHIA EARLY RESPONSE TO TGFB1 58 43 All SZGR 2.0 genes in this pathway
MCCLUNG CREB1 TARGETS UP 100 72 All SZGR 2.0 genes in this pathway
CUI TCF21 TARGETS 2 UP 428 266 All SZGR 2.0 genes in this pathway
RIGGINS TAMOXIFEN RESISTANCE DN 220 147 All SZGR 2.0 genes in this pathway
HELLER SILENCED BY METHYLATION DN 105 67 All SZGR 2.0 genes in this pathway
RIGGI EWING SARCOMA PROGENITOR DN 191 123 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 1HR DN 222 147 All SZGR 2.0 genes in this pathway
VERHAAK GLIOBLASTOMA PRONEURAL 177 132 All SZGR 2.0 genes in this pathway
HOELZEL NF1 TARGETS DN 115 73 All SZGR 2.0 genes in this pathway
DUTERTRE ESTRADIOL RESPONSE 6HR DN 91 56 All SZGR 2.0 genes in this pathway
DUTERTRE ESTRADIOL RESPONSE 24HR DN 505 328 All SZGR 2.0 genes in this pathway
ZHU SKIL TARGETS UP 20 14 All SZGR 2.0 genes in this pathway
LOPEZ TRANSLATION VIA FN1 SIGNALING 35 21 All SZGR 2.0 genes in this pathway
PLASARI TGFB1 TARGETS 10HR DN 244 157 All SZGR 2.0 genes in this pathway
PEDRIOLI MIR31 TARGETS DN 418 245 All SZGR 2.0 genes in this pathway
RATTENBACHER BOUND BY CELF1 467 251 All SZGR 2.0 genes in this pathway
NABA ECM REGULATORS 238 125 All SZGR 2.0 genes in this pathway
NABA MATRISOME ASSOCIATED 753 411 All SZGR 2.0 genes in this pathway
NABA MATRISOME 1028 559 All SZGR 2.0 genes in this pathway