Gene Page:NDST3

Summary?
GeneID 9348
Symbol NDST3
Synonyms HSST3
Description N-deacetylase/N-sulfotransferase 3
Reference MIM:603950|HGNC:HGNC:7682|Ensembl:ENSG00000164100|Vega:OTTHUMG00000132959
Gene type protein-coding
Map location 4q26
Pascal p-value 3.839E-4
Sherlock p-value 0.785
Fetal beta -0.434
eGene Myers' cis & trans

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:GWAScat Genome-wide Association Studies This data set includes 560 SNPs associated with schizophrenia. A total of 486 genes were mapped to these SNPs within 50kb.
CV:GWASdb Genome-wide Association Studies GWASdb records for schizophrenia
CV:PGCnp Genome-wide Association Study GWAS
PMID:cooccur High-throughput literature-search 系统搜索PubMed co-o基因ccurring with SCZ keywords. A total of 3027 genes were included.
Expression Meta-analysis of gene expression Pvalue: 1.959
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias Click to show details

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs17029291 chr3 32402138 NDST3 9348 8.465E-6 trans
rs830202 chr3 165654796 NDST3 9348 0.19 trans
rs7894597 chr10 9384581 NDST3 9348 0.13 trans
rs1324669 chr13 107872446 NDST3 9348 0.07 trans
rs17145698 chrX 40218345 NDST3 9348 0.14 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
LPAR6 0.74 0.68
LY96 0.74 0.60
AL050337.1 0.71 0.52
AL138743.2 0.70 0.57
CGRRF1 0.70 0.68
SPDYA 0.69 0.34
ACOT13 0.69 0.70
IMMP1L 0.68 0.69
MTCP1NB 0.68 0.66
SCRG1 0.68 0.59
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
TNKS1BP1 -0.54 -0.55
MYO18A -0.52 -0.48
FAM129B -0.52 -0.61
CLIP2 -0.52 -0.53
CADM4 -0.51 -0.52
SMG6 -0.51 -0.49
PHACTR3 -0.50 -0.48
DHX37 -0.50 -0.51
WDR81 -0.50 -0.47
SUPT6H -0.50 -0.47

Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0016787 hydrolase activity IEA -
GO:0016740 transferase activity IEA -
GO:0008146 sulfotransferase activity IEA -
GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity IEA -
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0000139 Golgi membrane IEA -
GO:0005794 Golgi apparatus IEA -
GO:0016020 membrane IEA -
GO:0016021 integral to membrane IEA -

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG GLYCOSAMINOGLYCAN BIOSYNTHESIS HEPARAN SULFATE 26 16 All SZGR 2.0 genes in this pathway
REACTOME HS GAG BIOSYNTHESIS 31 17 All SZGR 2.0 genes in this pathway
REACTOME HEPARAN SULFATE HEPARIN HS GAG METABOLISM 52 33 All SZGR 2.0 genes in this pathway
REACTOME GLYCOSAMINOGLYCAN METABOLISM 111 69 All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF CARBOHYDRATES 247 154 All SZGR 2.0 genes in this pathway
IWANAGA CARCINOGENESIS BY KRAS PTEN DN 353 226 All SZGR 2.0 genes in this pathway