Gene Page:RORA
概括?
| 基因 | 6095 |
| Symbol | RORA |
| Synonyms | nr1f1 | ror1 | ror2 | ror3 | rzr-alpha | rzra |
| Description | RAR related orphan receptor A |
| Reference | MIM:600825|HGNC:HGNC:10258|Ensembl:ENSG00000069667|HPRD:02896|Vega:OTTHUMG00000132769 |
| Gene type | protein-coding |
| Map location | 15q22.2 |
| Pascal p-value | 0.005 |
| Sherlock p-value | 0.589 |
| Fetal beta | -1.839 |
| eGene | Myers' cis & trans |
数据源中的基因
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:GWAScat | Genome-wide Association Studies | 该数据集包括与精神分裂症相关的560个SNP。总共将486个基因映射到50kb内的这些SNP。 | |
| CV:GWASdb | Genome-wide Association Studies | GWASdb records for schizophrenia | |
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| PMID:cooccur | High-throughput literature-search | Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included. | |
| Expression | Meta-analysis of gene expression | P价值：1.745 | |
| Literature | High-throughput literature-search | Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias | Click to show details |
Section I. Genetics and epigenetics annotation
eQTL annotation
eQTL annotation| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs16869851 | chr4 | 20690056 | RORA | 6095 | 0.15 | trans |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section III. Gene Ontology annotation
| Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0003700 | transcription factor activity | IDA | 17545671 | |
| GO:0003700 | transcription factor activity | IEA | - | |
| GO:0003707 | steroid hormone receptor activity | IEA | - | |
| GO:0005515 | protein binding | IPI | 16713569 | |
| GO:0008270 | zinc ion binding | IEA | - | |
| GO:0046872 | metal ion binding | IEA | - | |
| GO:0043565 | sequence-specific DNA binding | IEA | - | |
| Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
| 去：0006355 | regulation of transcription, DNA-dependent | IEA | - | |
| GO:0006350 | transcription | IEA | - | |
| GO:0007165 | signal transduction | NAS | 7926749 | |
| GO:0045944 | positive regulation of transcription from RNA polymerase II promoter | IDA | 17545671 | |
| Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0005634 | nucleus | IEA | - |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| PID HIF1 TFPATHWAY | 66 | 52 | 该途径中的所有SZGR 2.0基因 |
| NPAS2 ACTIVA REACTOME BMAL1时钟TES CIRCADIAN EXPRESSION | 36 | 27 | 该途径中的所有SZGR 2.0基因 |
| REACTOME PPARA ACTIVATES GENE EXPRESSION | 104 | 72 | 该途径中的所有SZGR 2.0基因 |
| REACTOME RORA ACTIVATES CIRCADIAN EXPRESSION | 24 | 17 | 该途径中的所有SZGR 2.0基因 |
| REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA | 23 | 16 | 该途径中的所有SZGR 2.0基因 |
| REACTOME GENERIC TRANSCRIPTION PATHWAY | 352 | 181 | 该途径中的所有SZGR 2.0基因 |
| REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | 49 | 36 | 该途径中的所有SZGR 2.0基因 |
| REACTOME METABOLISM OF LIPIDS AND LIPOPROTEINS | 478 | 302 | 该途径中的所有SZGR 2.0基因 |
| REACTOME FATTY ACID TRIACYLGLYCEROL AND KETONE BODY METABOLISM | 168 | 115 | 该途径中的所有SZGR 2.0基因 |
| Reactome昼夜节律 | 53 | 40 | 该途径中的所有SZGR 2.0基因 |
| PARENT MTOR SIGNALING UP | 567 | 375 | 该途径中的所有SZGR 2.0基因 |
| NAKAMURA TUMOR ZONE PERIPHERAL VS CENTRAL DN | 634 | 384 | 该途径中的所有SZGR 2.0基因 |
| TURASHVILI BREAST DUCTAL CARCINOMA VS LOBULAR NORMAL UP | 73 | 50 | 该途径中的所有SZGR 2.0基因 |
| DEURIG T CELL PROLYMPHOCYTIC LEUKEMIA DN | 320 | 184 | 该途径中的所有SZGR 2.0基因 |
| HORIUCHI WTAP TARGETS UP | 306 | 188 | 该途径中的所有SZGR 2.0基因 |
| VECCHI GASTRIC CANCER EARLY DN | 367 | 220 | 该途径中的所有SZGR 2.0基因 |
| JAEGER METASTASIS DN | 258 | 141 | 该途径中的所有SZGR 2.0基因 |
| GARGALOVIC RESPONSE TO OXIDIZED PHOSPHOLIPIDS TURQUOISE UP | 79 | 50 | 该途径中的所有SZGR 2.0基因 |
| GARGALOVIC RESPONSE TO OXIDIZED PHOSPHOLIPIDS BLUE UP | 136 | 80 | 该途径中的所有SZGR 2.0基因 |
| GARGALOVIC RESPONSE TO OXIDIZED PHOSPHOLIPIDS GREY UP | 18 | 10 | 该途径中的所有SZGR 2.0基因 |
| ODONNELL TFRC TARGETS UP | 456 | 228 | 该途径中的所有SZGR 2.0基因 |
| ZHOU INFLAMMATORY RESPONSE FIMA UP | 544 | 308 | 该途径中的所有SZGR 2.0基因 |
| ZHOU INFLAMMATORY RESPONSE LPS UP | 431 | 237 | 该途径中的所有SZGR 2.0基因 |
| JAATINEN HEMATOPOIETIC STEM CELL DN | 226 | 132 | 该途径中的所有SZGR 2.0基因 |
| DODD NASOPHARYNGEAL CARCINOMA UP | 1821 | 933 | 该途径中的所有SZGR 2.0基因 |
| ENK UV RESPONSE EPIDERMIS DN | 508 | 354 | 该途径中的所有SZGR 2.0基因 |
| GAUSSMANN MLL AF4 FUSION TARGETS C UP | 170 | 114 | 该途径中的所有SZGR 2.0基因 |
| HAMAI APOPTOSIS VIA TRAIL UP | 584 | 356 | 该途径中的所有SZGR 2.0基因 |
| PEREZ TP53 TARGETS | 1174 | 695 | 该途径中的所有SZGR 2.0基因 |
| PEREZ TP63 TARGETS | 355 | 243 | 该途径中的所有SZGR 2.0基因 |
| PEREZ TP53 AND TP63 TARGETS | 205 | 145 | 该途径中的所有SZGR 2.0基因 |
| KIM MYC AMPLIFICATION TARGETS DN | 97 | 51 | 该途径中的所有SZGR 2.0基因 |
| KIM MYCN AMPLIFICATION TARGETS DN | 103 | 59 | 该途径中的所有SZGR 2.0基因 |
| TSAI对电离辐射的响应 | 149 | 101 | 该途径中的所有SZGR 2.0基因 |
| GROSS HYPOXIA VIA ELK3 AND HIF1A UP | 142 | 104 | 该途径中的所有SZGR 2.0基因 |
| INGRAM SHH TARGETS UP | 127 | 79 | 该途径中的所有SZGR 2.0基因 |
| MANTOVANI VIRAL GPCR SIGNALING UP | 86 | 54 | 该途径中的所有SZGR 2.0基因 |
| KIM GERMINAL CENTER T HELPER DN | 24 | 15 | 该途径中的所有SZGR 2.0基因 |
| SHIPP DLBCL CURED VS FATAL UP | 39 | 22 | 该途径中的所有SZGR 2.0基因 |
| HOFMANN CELL LYMPHOMA DN | 39 | 29 | 该途径中的所有SZGR 2.0基因 |
| NUMATA CSF3 SIGNALING VIA STAT3 | 22 | 17 | 该途径中的所有SZGR 2.0基因 |
| MENSE缺氧了 | 98 | 71 | 该途径中的所有SZGR 2.0基因 |
| BROWNE HCMV INFECTION 16HR UP | 225 | 139 | 该途径中的所有SZGR 2.0基因 |
| BROWNE HCMV INFECTION 12HR UP | 111 | 68 | 该途径中的所有SZGR 2.0基因 |
| BROWNE HCMV INFECTION 24HR UP | 148 | 96 | 该途径中的所有SZGR 2.0基因 |
| CREIGHTON ENDOCRINE THERAPY RESISTANCE 3 | 720 | 440 | 该途径中的所有SZGR 2.0基因 |
| GAVIN FOXP3 TARGETS CLUSTER T4 | 94 | 69 | 该途径中的所有SZGR 2.0基因 |
| HELLER HDAC TARGETS DN | 292 | 189 | 该途径中的所有SZGR 2.0基因 |
| MITSIADES RESPONSE TO APLIDIN UP | 439 | 257 | 该途径中的所有SZGR 2.0基因 |
| BOQUEST STEM CELL CULTURED VS FRESH UP | 425 | 298 | 该途径中的所有SZGR 2.0基因 |
| WEST ADRENOCORTICAL TUMOR DN | 546 | 362 | 该途径中的所有SZGR 2.0基因 |
| BOHN PRIMARY IMMUNODEFICIENCY SYNDROM UP | 47 | 30 | 该途径中的所有SZGR 2.0基因 |
| CHIANG LIVER CANCER SUBCLASS UNANNOTATED UP | 85 | 50 | 该途径中的所有SZGR 2.0基因 |
| QI HYPOXIA | 140 | 96 | 该途径中的所有SZGR 2.0基因 |
| BRUINS UVC RESPONSE EARLY LATE | 317 | 190 | 该途径中的所有SZGR 2.0基因 |
| FEVR CTNNB1 TARGETS UP | 682 | 433 | 该途径中的所有SZGR 2.0基因 |
| PURBEY TARGETS OF CTBP1 NOT SATB1 DN | 448 | 282 | 该途径中的所有SZGR 2.0基因 |
| ZWANG CLASS 3 TRANSIENTLY INDUCED BY EGF | 222 | 159 | 该途径中的所有SZGR 2.0基因 |