Gene Page:RPS6KA3

概括?
GeneID 6197
Symbol RPS6KA3
Synonyms CLS|HU-3|ISPK-1|MAPKAPK1B|MRX19|RSK|RSK2|S6K-alpha3|p90-RSK2|pp90RSK2
Description ribosomal protein S6 kinase A3
Reference MIM:300075|HGNC:HGNC:10432|Ensembl:ENSG00000177189|HPRD:02092|Vega:OTTHUMG00000021231
Gene type protein-coding
Map location Xp22.2-p22.1
Fetal beta -0.28
Support G2Cdb.humanNRC
G2Cdb.humanPSD
G2Cdb.humanPSP
Potential synaptic genes

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:GWAScat Genome-wide Association Studies This data set includes 560 SNPs associated with schizophrenia. A total of 486 genes were mapped to these SNPs within 50kb.
CV:PGC128 Genome-wide Association Study A multi-stage schizophrenia GWAS of up to 36,989 cases and 113,075 controls. Reported by the Schizophrenia Working Group of PGC. 128 independent associations spanning 108 loci
CV:PGCnp Genome-wide Association Study GWAS
Expression Meta-analysis of gene expression Pvalue: 1.889
GO_Annotation Mapping neuro-related keywords to Gene Ontology annotations Hits with neuro-related keywords: 1
Network Shortest path distance of core genes in the Human protein-protein interaction network Contribution to shortest path in PPI network: 1.2387

Section I. Genetics and epigenetics annotation

@CV:PGC128

SNP ID Chromosome Position Allele P Function Gene Up/Down Distance
rs1378559 chrX 21380266 TC 1.679E-11 intergenic RPS6KA3,CNKSR2 dist=1095516;dist=12270


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
RPL38 0.96 0.93
RPL27A 0.96 0.96
RPL30 0.96 0.95
RPL23 0.95 0.95
RPL35A 0.95 0.93
RPL6P10 0.95 0.90
RPS20 0.95 0.93
RPL37A 0.95 0.93
RPS8 0.94 0.93
RPL24 0.94 0.93
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
ATP10A -0.61 -0.81
EDN3 -0.58 -0.73
PTPRB -0.57 -0.74
BCL2L2 -0.57 -0.78
ABCB1 -0.56 -0.73
SYNM -0.56 -0.77
MAP3K5 -0.56 -0.73
SLC6A12 -0.56 -0.76
EHD2 -0.56 -0.78
APOL1 -0.56 -0.73

Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0000166 nucleotide binding IEA -
GO:0000287 magnesium ion binding IEA -
GO:0004867 serine-type endopeptidase inhibitor activity IEA -
GO:0005524 ATP binding IEA -
GO:0004674 蛋白质丝氨酸/苏氨酸激酶活性 EXP 9770464
GO:0004674 蛋白质丝氨酸/苏氨酸激酶活性 TAS 8141249
GO:0016740 transferase activity IEA -
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0007417 central nervous system development TAS Brain (GO term level: 6) 10319851
GO:0001501 skeletal system development TAS 8955270
GO:0006468 protein amino acid phosphorylation IEA -
GO:0007243 protein kinase cascade IEA -
GO:0007165 signal transduction TAS 10436156
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0005634 nucleus IDA 18029348
GO:0005654 nucleoplasm EXP 9770464|16626623
GO:0005737 cytoplasm IDA 18029348

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG MAPK SIGNALING PATHWAY 267 205 All SZGR 2.0 genes in this pathway
KEGG OOCYTE MEIOSIS 114 79 All SZGR 2.0 genes in this pathway
KEGG MTOR SIGNALING PATHWAY 52 40 All SZGR 2.0 genes in this pathway
KEGG LONG TERM POTENTIATION 70 57 All SZGR 2.0 genes in this pathway
KEGG NEUROTROPHIN SIGNALING PATHWAY 126 103 All SZGR 2.0 genes in this pathway
KEGG PROGESTERONE MEDIATED OOCYTE MATURATION 86 59 All SZGR 2.0 genes in this pathway
BIOCARTA MAPK PATHWAY 87 68 All SZGR 2.0 genes in this pathway
BIOCARTA GPCR PATHWAY 37 31 All SZGR 2.0 genes in this pathway
ST DIFFERENTIATION PATHWAY IN PC12 CELLS 45 35 All SZGR 2.0 genes in this pathway
SA B CELL RECEPTOR COMPLEXES 24 20 All SZGR 2.0 genes in this pathway
ST ERK1 ERK2 MAPK PATHWAY 32 25 All SZGR 2.0 genes in this pathway
SIG PIP3 SIGNALING IN CARDIAC MYOCTES 67 54 All SZGR 2.0 genes in this pathway
SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES 51 41 All SZGR 2.0 genes in this pathway
SIG PIP3 SIGNALING IN B LYMPHOCYTES 36 31 All SZGR 2.0 genes in this pathway
ST PHOSPHOINOSITIDE 3 KINASE PATHWAY 37 29 All SZGR 2.0 genes in this pathway
PID AR PATHWAY 61 46 All SZGR 2.0 genes in this pathway
PID ERBB1 DOWNSTREAM PATHWAY 105 78 All SZGR 2.0 genes in this pathway
PID PDGFRB PATHWAY 129 103 All SZGR 2.0 genes in this pathway
REACTOME SIGNALLING BY NGF 217 167 All SZGR 2.0 genes in this pathway
REACTOME DEVELOPMENTAL BIOLOGY 396 292 All SZGR 2.0 genes in this pathway
REACTOME TRIF MEDIATED TLR3 SIGNALING 74 54 All SZGR 2.0 genes in this pathway
REACTOME NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE 137 105 All SZGR 2.0 genes in this pathway
REACTOME GASTRIN CREB SIGNALLING PATHWAY VIA PKC AND MAPK 205 136 All SZGR 2.0 genes in this pathway
REACTOME NUCLEAR EVENTS KINASE AND TRANSCRIPTION FACTOR ACTIVATION 24 20 All SZGR 2.0 genes in this pathway
REACTOME ERK MAPK TARGETS 21 17 All SZGR 2.0 genes in this pathway
REACTOME TRANSMISSION ACROSS CHEMICAL SYNAPSES 186 155 All SZGR 2.0 genes in this pathway
REACTOME NEURONAL SYSTEM 279 221 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY GPCR 920 449 All SZGR 2.0 genes in this pathway
REACTOME NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL 137 110 All SZGR 2.0 genes in this pathway
REACTOME AXON GUIDANCE 251 188 All SZGR 2.0 genes in this pathway
REACTOME ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS 37 32 All SZGR 2.0 genes in this pathway
REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS 27 23 All SZGR 2.0 genes in this pathway
REACTOME POST NMDA RECEPTOR ACTIVATION EVENTS 33 28 All SZGR 2.0 genes in this pathway
REACTOME MAP KINASE ACTIVATION IN TLR CASCADE 50 37 All SZGR 2.0 genes in this pathway
REACTOME MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES 30 24 All SZGR 2.0 genes in this pathway
REACTOME L1CAM INTERACTIONS 86 62 All SZGR 2.0 genes in this pathway
REACTOME SIGNAL TRANSDUCTION BY L1 34 25 All SZGR 2.0 genes in this pathway
REACTOME RECYCLING PATHWAY OF L1 27 15 All SZGR 2.0 genes in this pathway
REACTOME TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION 77 57 All SZGR 2.0 genes in this pathway
REACTOME NFKB AND MAP KINASES ACTIVATION MEDIATED BY TLR4 SIGNALING REPERTOIRE 72 53 All SZGR 2.0 genes in this pathway
REACTOME MYD88 MAL CASCADE INITIATED ON PLASMA MEMBRANE 83 63 All SZGR 2.0 genes in this pathway
REACTOME INNATE IMMUNE SYSTEM 279 178 All SZGR 2.0 genes in this pathway
REACTOME ACTIVATED TLR4 SIGNALLING 93 69 All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM 933 616 All SZGR 2.0 genes in this pathway
REACTOME TOLL RECEPTOR CASCADES 118 84 All SZGR 2.0 genes in this pathway
IGARASHI ATF4 TARGETS DN 90 65 All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP 1382 904 All SZGR 2.0 genes in this pathway
BORCZUK MALIGNANT MESOTHELIOMA UP 305 185 All SZGR 2.0 genes in this pathway
GRABARCZYK BCL11B TARGETS UP 81 40 All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA UP 1821 933 All SZGR 2.0 genes in this pathway
ENK UV RESPONSE EPIDERMIS DN 508 354 All SZGR 2.0 genes in this pathway
MCBRYAN PUBERTAL BREAST 4 5WK DN 196 131 All SZGR 2.0 genes in this pathway
MCBRYAN PUBERTAL TGFB1 TARGETS UP 169 127 All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 XPCS DN 88 71 All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 DN 855 609 All SZGR 2.0 genes in this pathway
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN DN 584 395 All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS UP 1037 673 All SZGR 2.0 genes in this pathway
KOYAMA SEMA3B TARGETS UP 292 168 All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT REJECTED VS OK DN 546 351 All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT OK VS DONOR UP 555 346 All SZGR 2.0 genes in this pathway
LU AGING BRAIN DN 153 120 All SZGR 2.0 genes in this pathway
WELCSH BRCA1 TARGETS UP 198 132 All SZGR 2.0 genes in this pathway
XU GH1 AUTOCRINE TARGETS UP 268 157 All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 4 307 185 All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 UNSTIMULATED 1229 713 All SZGR 2.0 genes in this pathway
KYNG DNA DAMAGE BY GAMMA AND UV RADIATION 88 65 All SZGR 2.0 genes in this pathway
KYNG DNA DAMAGE UP 226 164 All SZGR 2.0 genes in this pathway
LIN NPAS4 TARGETS UP 163 100 All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA HAPTOTAXIS UP 518 299 All SZGR 2.0 genes in this pathway
YAGI AML WITH 11Q23 REARRANGED 351 238 All SZGR 2.0 genes in this pathway
HOELZEL NF1 TARGETS UP 139 93 All SZGR 2.0 genes in this pathway
GABRIELY MIR21 TARGETS 289 187 All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS UP 504 321 All SZGR 2.0 genes in this pathway
LINSLEY MIR16 TARGETS 206 127 All SZGR 2.0 genes in this pathway
PASINI SUZ12 TARGETS DN 315 215 All SZGR 2.0 genes in this pathway
ZWANG CLASS 1 TRANSIENTLY INDUCED BY EGF 516 308 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
let-7/98 4432 4438 m8 海关a-let-7abrain UGAGGUAGUAGGUUGUAUAGUU
海关a-let-7bbrain UGAGGUAGUAGGUUGUGUGGUU
海关a-let-7cbrain UGAGGUAGUAGGUUGUAUGGUU
海关a-let-7dbrain agagguaguagguugcauagu
海关a-let-7ebrain UGAGGUAGGAGGUUGUAUAGU
海关a-let-7fbrain UGAGGUAGUAGAUUGUAUAGUU
海关a-miR-98brain UGAGGUAGUAAGUUGUAUUGUU
海关a-let-7gSZ UGAGGUAGUAGUUUGUACAGU
海关a-let-7ibrain UGAGGUAGUAGUUUGUGCUGU
miR-142-5p 5136 5142 1A 海关a-miR-142-5p CAUAAAGUAGAAAGCACUAC
miR-15/16/195/424/497 120 126 m8 海关a-miR-15abrain UAGCAGCACAUAAUGGUUUGUG
海关a-miR-16brain UAGCAGCACGUAAAUAUUGGCG
海关a-miR-15bbrain UAGCAGCACAUCAUGGUUUACA
海关a-miR-195SZ UAGCAGCACAGAAAUAUUGGC
海关a-miR-424 CAGCAGCAAUUCAUGUUUUGAA
海关a-miR-497 CAGCAGCACACUGUGGUUUGU
miR-155 312 318 m8 海关a-miR-155 UUAAUGCUAAUCGUGAUAGGGG
miR-17-5p/20/93.mr/106/519.d 4444 4450 m8 海关a-miR-17-5p CAAAGUGCUUACAGUGCAGGUAGU
海关a-miR-20abrain UAAAGUGCUUAUAGUGCAGGUAG
海关a-miR-106a AAAAGUGCUUACAGUGCAGGUAGC
海关a-miR-106bSZ UAAAGUGCUGACAGUGCAGAU
海关a-miR-20bSZ CAAAGUGCUCAUAGUGCAGGUAG
海关a-miR-519d CAAAGUGCCUCCCUUUAGAGUGU
miR-181 636 643 1A,m8 海关a-miR-181abrain AACAUUCAACGCUGUCGGUGAGU
海关a-miR-181bSZ AACAUUCAUUGCUGUCGGUGGG
海关a-miR-181cbrain AACAUUCAACCUGUCGGUGAGU
海关a-miR-181dbrain AACAUUCAUUGUUGUCGGUGGGUU
miR-183 4462 4468 1A 海关a-miR-183 UAUGGCACUGGUAGAAUUCACUG
海关a-miR-183 UAUGGCACUGGUAGAAUUCACUG
miR-186 496 502 1A 海关a-miR-186 CAAAGAAUUCUCCUUUUGGGCUU
海关a-miR-186 CAAAGAAUUCUCCUUUUGGGCUU
miR-190 5184 5190 1A 海关a-miR-190 UGAUAUGUUUGAUAUAUUAGGU
海关a-miR-190 UGAUAUGUUUGAUAUAUUAGGU
miR-200bc/429 588 594 m8 海关a-miR-200b UAAUACUGCCUGGUAAUGAUGAC
海关a-miR-200c UAAUACUGCCGGGUAAUGAUGG
海关a-miR-429 UAAUACUGUCUGGUAAAACCGU
miR-203.1 3101 3107 1A 海关a-miR-203 UGAAAUGUUUAGGACCACUAG
海关a-miR-203 UGAAAUGUUUAGGACCACUAG
miR-204/211 4998 5005 1A,m8 海关a-miR-204brain UUCCCUUUGUCAUCCUAUGCCU
海关a-miR-211 UUCCCUUUGUCAUCCUUCGCCU
miR-205 4082 4089 1A,m8 海关a-miR-205 UCCUUCAUUCCACCGGAGUCUG
miR-21 4486 4492 m8 海关a-miR-21brain UAGCUUAUCAGACUGAUGUUGA
海关a-miR-590 GAGCUUAUUCAUAAAAGUGCAG
miR-216 4551 4557 1A 海关a-miR-216 UAAUCUCAGCUGGCAACUGUG
miR-218 43 49 1A 海关a-miR-218brain UUGUGCUUGAUCUAACCAUGU
海关a-miR-218brain UUGUGCUUGAUCUAACCAUGU
miR-224 3972 3978 1A 海关a-miR-224 CAAGUCACUAGUGGUUCCGUUUA
miR-323 5352 5358 m8 海关a-miR-323brain GCACAUUACACGGUCGACCUCU
miR-326 4514 4520 m8 海关a-miR-326 CCUCUGGGCCCUUCCUCCAG
mir-376 799 805 1A 海关a-miR-376a AUCAUAGAGGAAAAUCCACGU
海关a-miR-376b AUCAUAGAGGAAAAUCCAUGUU
miR-381 5408 5414 m8 hsa - mir - 381 UAUACAAGGGCAAGCUCUCUGU
miR-384 325 331 1A 海关a-miR-384 AUUCCUAGAAAUUGUUCAUA
miR-410 5460 5466 1A 海关a-miR-410 AAUAUAACACAGAUGGCCUGU
mir-494 678 684 1A 海关a-miR-494brain UGAAACAUACACGGGAAACCUCUU
miR-93.hd/291-3p/294/295/302/372/373/520 388 395 1A,m8 海关a-miR-93brain AAAGUGCUGUUCGUGCAGGUAG
海关a-miR-302a UAAGUGCUUCCAUGUUUUGGUGA
海关a-miR-302b UAAGUGCUUCCAUGUUUUAGUAG
海关a-miR-302c UAAGUGCUUCCAUGUUUCAGUGG
海关a-miR-302d UAAGUGCUUCCAUGUUUGAGUGU
海关a-miR-372 AAAGUGCUGCGACAUUUGAGCGU
海关a-miR-373 GAAGUGCUUCGAUUUUGGGGUGU
海关a-miR-520e AAAGUGCUUCCUUUUUGAGGG
海关a-miR-520a AAAGUGCUUCCCUUUGGACUGU
海关a-miR-520b AAAGUGCUUCCUUUUAGAGGG
海关a-miR-520c AAAGUGCUUCCUUUUAGAGGGUU
海关a-miR-520d AAAGUGCUUCUCUUUGGUGGGUU