Summary
基因 8626
象征 TP63
同义词 AIS|B(p51A)|B(p51B)|EEC3|KET|LMS|NBP|OFC8|RHS|SHFM4|TP53CP|TP53L|TP73L|p40|p51|p53CP|p63|p73H|p73L
描述 肿瘤蛋白p63
Reference MIM:603273|HGNC:HGNC:15979|Ensembl:ENSG0000000073282|HPRD:04469|Vega:Otthumg00000156313
基因类型 蛋白质编码
地图位置 3Q28
Pascal P值 0.429
主持人

基因in Data Sources
基因集名称 基因组方法 描述 信息
简历:PGCNP 全基因组协会研究 GWAS
简历:Phewas phenome-wide association studies (PheWAS) 157个与精神分裂症相关的SNP 1
网络 Shortest path distance of core genes in the Human protein-protein interaction network PPI网络中最短路径的贡献:0.0143

Section I. Genetics and epigenetics annotation

@简历:Phewas

SNP ID 染色体 位置 等位基因 p 功能 基因 向上/向下距离
RS10937405 3 189383183 无效的 1.465 TP63 无效的


第二节。转录组注释

一般基因表达(GTEX)

无法使用

时间变化的基因表达(brainspan)

Footnote:
SC:亚皮质区域;SM:感觉运动区域;FC:额叶皮层;和TP:颞顶皮层
ST1:胎儿(13-26个概念后周),ST2:婴儿早期至童年(4个月至11年)和ST3:青春期至成年期(13-23年)
所示的栏表示表达分布的较低25%和上层25%。

No co-expressed genes in brain regions


第三节。基因本体论注释

分子功能 去学期 证据 神经关键字 PubMed ID
去:0003700 transcription factor activity IEA -
去:0008270 锌离子结合 IEA -
GO:0016564 transcription repressor activity 艾达 12446784
GO:0016563 transcription activator activity 艾达 12446784
GO:0016563 transcription activator activity nas 9774969
GO:0042802 相同的蛋白质结合 IPI 12446779
GO:0046872 金属离子结合 IEA -
生物过程 去学期 证据 神经关键字 PubMed ID
去:0002347 对肿瘤细胞的反应 IEA -
GO:0006917 诱导凋亡 TAS 9662378
GO:0006915 凋亡 艾达 9774969
去:0007275 多细胞生物发育 IEA -
GO:0051289 蛋白质同质化 IPI 10373484
去:0030308 细胞生长的负调控 IEA -
GO:0045747 positive regulation of Notch signaling pathway 艾达 11641404
GO:0045892 转录,DNA依赖性的负调控 艾达 12446784
GO:0045893 转录,DNA依赖性的阳性调节 艾达 12446784
细胞分量 去学期 证据 神经关键字 PubMed ID
去:0005856 细胞骨架 艾达 18029348
去:0005634 nucleus 艾达 12446779
去:0005634 nucleus nas 9774969
去:0005737 cytoplasm 艾达 10657951
GO:0005925 局灶性粘附 艾达 18029348

Section V. Pathway annotation

路径名 路径大小 # SZGR 2.0基因通路 信息
PID P73Pathway 79 59 All SZGR 2.0 genes in this pathway
pID P53 DOWNSTREAM PATHWAY 137 94 All SZGR 2.0 genes in this pathway
PID Delta NP63途径 47 34 All SZGR 2.0 genes in this pathway
PID TAP63途径 54 40 All SZGR 2.0 genes in this pathway
刘前列腺癌DN 481 290 All SZGR 2.0 genes in this pathway
Schuetz乳腺癌导管侵入性DN 84 53 All SZGR 2.0 genes in this pathway
DAVICIONI MOLECULAR ARMS VS ERMS DN 182 111 All SZGR 2.0 genes in this pathway
deurig t细胞促进性白血病 368 234 All SZGR 2.0 genes in this pathway
乳腺癌腔与基础DN 455 304 All SZGR 2.0 genes in this pathway
王攀登目标 269 146 All SZGR 2.0 genes in this pathway
Jaeger转移DN 258 141 All SZGR 2.0 genes in this pathway
Odonnell TFRC靶向DN 139 76 All SZGR 2.0 genes in this pathway
多德鼻咽癌DN 1375 806 All SZGR 2.0 genes in this pathway
ENK UV响应角质形成细胞DN 485 334 All SZGR 2.0 genes in this pathway
McBryan Pubertal乳房4 5WK 271 175 All SZGR 2.0 genes in this pathway
EBAUER TARGETS OF PAX3 FOXO1 FUSION UP 207 128 All SZGR 2.0 genes in this pathway
XU HGF TARGETS REPRESSED BY AKT1 DN 95 58 All SZGR 2.0 genes in this pathway
SIMBULAN UV RESPONSE NORMAL DN 33 27 All SZGR 2.0 genes in this pathway
里克曼肿瘤分化了井和DN不良 382 224 All SZGR 2.0 genes in this pathway
Schaeffer前列腺开发12小时 116 79 All SZGR 2.0 genes in this pathway
Amit EGF响应60 MCF10A 39 24 All SZGR 2.0 genes in this pathway
AMIT SERUM RESPONSE 40 MCF10A 32 21 All SZGR 2.0 genes in this pathway
Kauffmann DNA修复基因 230 137 All SZGR 2.0 genes in this pathway
Onder CDH1目标2 DN 464 276 All SZGR 2.0 genes in this pathway
Onder CDH1目标1 DN 169 102 All SZGR 2.0 genes in this pathway
Onder CDH1目标3 DN 59 32 All SZGR 2.0 genes in this pathway
MATSUDA NATURAL KILLER DIFFERENTIATION 475 313 All SZGR 2.0 genes in this pathway
NGUYEN NOTCH1 TARGETS DN 86 67 All SZGR 2.0 genes in this pathway
Cromer转移DN 81 58 All SZGR 2.0 genes in this pathway
dazard对UV SCC DN的响应 123 86 All SZGR 2.0 genes in this pathway
Dazard对UV NHEK DN的反应 318 220 All SZGR 2.0 genes in this pathway
dazard UV响应集群G6 153 112 All SZGR 2.0 genes in this pathway
霁CARCINOGENESIS BY KRAS AND STK11 UP 12 7 All SZGR 2.0 genes in this pathway
马丁内斯RB1靶向 673 430 All SZGR 2.0 genes in this pathway
Martinez TP53靶向 602 364 All SZGR 2.0 genes in this pathway
Martinez RB1和TP53靶向 601 369 All SZGR 2.0 genes in this pathway
Sarrio上皮间质转变DN 154 101 All SZGR 2.0 genes in this pathway
iwanaga癌变由Kras Pten Up 181 112 All SZGR 2.0 genes in this pathway
Smid乳腺癌正常 476 285 All SZGR 2.0 genes in this pathway
张乳腺癌祖细胞 425 253 All SZGR 2.0 genes in this pathway
huper乳房基础与腔内 54 29 All SZGR 2.0 genes in this pathway
Hofmann骨髓发育异常综合症高风险DN 20 13 All SZGR 2.0 genes in this pathway
Hofmann骨髓增生综合征风险DN 23 12 All SZGR 2.0 genes in this pathway
Shedden肺癌良好生存A12 317 177 All SZGR 2.0 genes in this pathway
DUTERTRE ESTRADIOL RESPONSE 24HR DN 505 328 All SZGR 2.0 genes in this pathway
Smad1和Smad5抑制Pangas肿瘤 134 85 All SZGR 2.0 genes in this pathway
STAT3的Azare肿瘤转化 121 70 All SZGR 2.0 genes in this pathway
Azare STAT3目标 24 12 All SZGR 2.0 genes in this pathway
Rattenbacher由Celf1绑定 467 251 All SZGR 2.0 genes in this pathway
前列腺癌模型DN中的Acevedo FGFR1靶标 308 187 All SZGR 2.0 genes in this pathway
林乳腺干细胞向上 489 314 All SZGR 2.0 genes in this pathway
Zwang 3类由EGF瞬时诱导 222 159 All SZGR 2.0 genes in this pathway

第六节。microRNA注释

mirna家族 目标位置 miRNA ID mirna seq
UTR开始 UTR结束 匹配方法
mir-101 2211 2217 M8 hsa-miR-101 uacaguacugauaacugaag
mir-130/301 422 428 M8 HSA-MIR-130Abrain cagugcaauguaaaaggggau
hsa-miR-301 cagugcaauaugucaaagc
HSA-MIR-130bbrain Cagugcaaugaagggauggau
HSA-MIR-454-3P uagugcaauauugcuuauaggguuu
mir-19 1656 1662 1a HSA-MIR-19A ugugcaaauaugauaugaaaacuga
HSA-MIR-19B UGUGCAAAUCCAUGCAAAACUGA
mir-25/32/92/363/367 2734 2740 1a hsa-miR-25brain Cauugcacuugucucggucuga
HSA-MIR-32 uauugcacauacuaaguugc
HSA-MIR-92 uauugcacuugucccgcgcug
HSA-MIR-367 Aauugcacuuuagcaaugga
HSA-MIR-92BSZ uauugcacucgucccgcgcuc
miR-363 1686 1692 1a HSA-MIR-363 auugcacgguauccaucuguaa
miR-377 1754年 1761 1A,M8 HSA-MIR-377 aucacacaaaggaacuuuuugu
miR-493-5p 2561 2567 1a HSA-MIR-493-5p uuguacaugguaggcuuucauu
mir-93.hd/291-3p/294/295/302/372/373/520 424 430 1a HSA-MIR-93brain aaagugcuguucgugcagguag
hsa-miR-302a uaagugcuugcauguuuguga
hsa-miR-302b uaagugcuuccauguuuaguag
hsa-miR-302c uaagugcuuccauguucagugg
hsa-miR-302d Uaagugcuauguugugugu
HSA-MIR-372 aaagugcugcgacauuugagcgu
HSA-MIR-373 Gaagugcuucgauuuggggugu
HSA-MIR-520E Aaagugcuuuuuugaggg
hsa-miR-520a aaagugcuucccuuguggugu
hsa-miR-520b aaagugcuuuuuuagaggg
hsa-miR-520c aaagugcuuuuuuaggggug
hsa-miR-520d aaaguguuugugggguggguu