Gene Page:TYR

Summary?
GeneID 7299
Symbol TYR
Synonyms ATN|CMM8|OCA1|OCA1A|OCAIA|SHEP3
Description tyrosinase
Reference MIM:606933|HGNC:HGNC:12442|Ensembl:ENSG00000077498|HPRD:06086|Vega:OTTHUMG00000167294
Gene type protein-coding
Map location 11q14.3
Pascal p-value 0.057
Fetal beta -0.124

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
CV:PheWAS Phenome-wide association studies (PheWAS) 157 SNPs associated with schizophrenia 2
PMID:cooccur High-throughput literature-search Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenics,schizophrenias Click to show details

Section I. Genetics and epigenetics annotation

@CV:PheWAS

SNP ID Chromosome Position Allele P Function Gene Up/Down Distance
rs1393350 11 89011046 null 1.741 TYR null
rs1847134 11 89005253 null 1.683 TYR null


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
USP7 0.96 0.95
ZRANB1 0.93 0.94
YTHDC2 0.93 0.93
NUP50 0.92 0.93
C4orf41 0.92 0.92
HECTD1 0.92 0.93
RABGEF1 0.92 0.92
AFTPH 0.92 0.92
OSBP 0.91 0.92
ANKRD17 0.91 0.92
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
FXYD1 -0.80 -0.81
MT-CO2 -0.78 -0.79
AF347015.31 -0.78 -0.79
HIGD1B -0.78 -0.82
HSD17B14 -0.76 -0.78
AF347015.21 -0.76 -0.80
TLCD1 -0.76 -0.80
IFI27 -0.75 -0.79
CST3 -0.75 -0.81
S100A16 -0.75 -0.79

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG TYROSINE METABOLISM 42 30 All SZGR 2.0 genes in this pathway
KEGG RIBOFLAVIN METABOLISM 16 11 All SZGR 2.0 genes in this pathway
KEGG MELANOGENESIS 102 80 All SZGR 2.0 genes in this pathway
ONKEN UVEAL MELANOMA DN 526 357 All SZGR 2.0 genes in this pathway
MCBRYAN发育期的沥青ST 5 6WK DN 137 97 All SZGR 2.0 genes in this pathway
MCBRYAN发育期的沥青ST 6 7WK UP 197 135 All SZGR 2.0 genes in this pathway
MCBRYAN PUBERTAL TGFB1 TARGETS DN 62 44 All SZGR 2.0 genes in this pathway
HERNANDEZ ABERRANT MITOSIS BY DOCETACEL 2NM UP 81 57 All SZGR 2.0 genes in this pathway
HERNANDEZ MITOTIC ARREST BY DOCETAXEL 2 UP 64 45 All SZGR 2.0 genes in this pathway
SHEN SMARCA2 TARGETS DN 357 212 All SZGR 2.0 genes in this pathway
KAAB FAILED HEART ATRIUM UP 38 30 All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER WITH H3K27ME3 UP 295 149 All SZGR 2.0 genes in this pathway
ACEVEDO METHYLATED IN LIVER CANCER DN 940 425 All SZGR 2.0 genes in this pathway
SWEET KRAS ONCOGENIC SIGNATURE 89 56 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 4HR DN 254 158 All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 2ND EGF PULSE ONLY 1725 838 All SZGR 2.0 genes in this pathway