Data Source for Linkage Study

The linkage datasets are collected based on two genome scan meta-analyses (GSMA). The first GSMA was applied to data from 20 schizophrenia genome-wide linkage scans (Lewis et al. 2003). We selected 12 bins whoseP_AvgRnkandP_ordare both <0.05, identified their corresponding physical locations on chromosomes, and extracted genes within these regions. These genes are then defined as "GSMA_I" in our database. The second GSMA was applied to 32 schizophrenia genome scans (Ng et al. 2009). We obtained genes from 10 bins whoseP_SRare <0.05 for all the samples and 6 bins only for European samples. These two lists are defined as "GSMA_IIA" and "GSMA_IIE". ThePvalue of each linkage bin was assigned to the genes within the bin.

• Lewis, C.M., Levinson, D.F., Wise, L.H., DeLisi, L.E., Straub, R.E., Hovatta, I., Williams, N.M., Schwab, S.G., Pulver, A.E., Faraone, S.V., et al. (2003) Genome scan meta-analysis of schizophrenia and bipolar disorder, part II: Schizophrenia.Am. J. Hum. Genet.73(1): 34 - 48PubMed
• Ng, M.Y.M., Levinson, D.F., Faraone, S.V., Suarez, B.K., DeLisi, L.E., Arinami, T., Riley, B., Paunio, T., Pulver, A.E., Irmansyah, et al. (2009) Meta-analysis of 32 genome-wide linkage studies of schizophrenia.Mol. PsychiatryEpub ahead of print