| Abstract |
Oxidative-stress, genetic regions of interest (1p13 and 22q11), and common copy number variations (CNVs) may play roles in the pathophysiology of精神分裂症. In the present study, we confirmed associations between精神分裂症and the common CNVs in the glutathione (GSH)-related genes GSTT1,DDTL, and GSTM1 using quantitative real-time polymerase chain reaction analyses of 620 patients with精神分裂症and in 622 controls. No significant differences in GSTT1 copy number distributions were found between patient groups. However, frequencies of characterized CNVs and assumed gain alleles ofDDTLand GSTM1 were significantly higher in patients with精神分裂症. In agreement with a previous report, the present data indicate that gains in the CNV allelesDDTLand GSTM1 are genetic risk factors in Japanese patients with精神分裂症, and suggest involvement of micro-inflammation and oxidative stress in the pathophysiology of精神分裂症. |