| 1 | 是。J. Med。基因。B Neuropsychiatr。基因。2007年4月144b：341-3 |
|---|---|
| PMID | 17034020 |
| 标题 | No association between ADRA2A polymorphisms and schizophrenia. |
| Abstract | There is evidence to suggest that the alpha(2A)-adrenergic receptor may be involved in精神分裂症。With attention directed at the upstream regulatory region of the gene which codes for this receptor (adra2a），我们提出，该区域内的单核苷酸多态性（SNP）会影响对精神分裂症通过改变该受体的表达。我们选择使用112来测试通过关联研究对易感性的影响精神分裂症/schizoaffective disorder patients and 159 controls. The region of interest was screened for SNPs using a combination of bioinformatic searches and sequencing. A total of nine SNPs were discovered, of which four (-5972-G/A, -2211-A/T, -1291-C/G and -261-G/A) were genotyped in the entire clinical sample. No associations were evident, suggesting no influence for these SNPs in susceptibility to精神分裂症。 |
| SCZ关键字 | 精神分裂症，精神分裂症，精神分裂症患者 |
| 2 | 是。J. Med。基因。B Neuropsychiatr。基因。2007年4月144b：341-3 |
| PMID | 17034020 |
| 标题 | No association between ADRA2A polymorphisms and schizophrenia. |
| Abstract | There is evidence to suggest that the alpha(2A)-adrenergic receptor may be involved in精神分裂症。With attention directed at the upstream regulatory region of the gene which codes for this receptor (adra2a），我们提出，该区域内的单核苷酸多态性（SNP）会影响对精神分裂症通过改变该受体的表达。我们选择使用112来测试通过关联研究对易感性的影响精神分裂症/schizoaffective disorder patients and 159 controls. The region of interest was screened for SNPs using a combination of bioinformatic searches and sequencing. A total of nine SNPs were discovered, of which four (-5972-G/A, -2211-A/T, -1291-C/G and -261-G/A) were genotyped in the entire clinical sample. No associations were evident, suggesting no influence for these SNPs in susceptibility to精神分裂症。 |
| SCZ关键字 | 精神分裂症，精神分裂症，精神分裂症患者 |
| 3 | prog。神经心理药物。生物。精神病学2009年4月33日：499-502 |
| PMID | 19439247 |
| 标题 | 肾上腺素能α2A受体基因的启动子区域中C-1291G多态性与精神分裂症中的多次二虫之间的关联分析。 |
| Abstract | 几项研究表明，存在一种重要的抑制性机制，用于控制涉及肾上腺素能α2A受体的水摄入量（adra2a). A human study using patients with精神分裂症demonstrated an exacerbation of polydipsia by the administration of clonidine, anadra2a- 激动人心的，以及迈亚林（Mianserin）的polydipsia，adra2a-Antagonist，建议中央肾上腺素能参与患者的饮酒行为精神分裂症。根据这些发现，我们检查了C-1291G多态性之间可能的关联adra2a基因和多次生精神分裂症使用日本的情况对照样本。我们的样本包括348例患者精神分裂症（DSM-IV）（84个多二手菌和264个没有多磷酸的）。没有显着关联adra2aC-1291G polymorphism and polydipsia was found. Our result suggests that theadra2aC-1291g多态性可能无法赋予多次敏感精神分裂症在我们的样本中。有必要对较大样品进行进一步的研究。 |
| SCZ关键字 | 精神分裂症，精神分裂症，精神分裂症患者 |
| 4 | J Clin Psychopharmacol 2010 12月30日：667-71 |
| PMID | 21105277 |
| 标题 | 肾上腺素能？-2A受体中的1291-C/G多态性与代谢综合征之间的关联。 |
| Abstract | The prevalence of the metabolic syndrome is increased in patients with精神分裂症compared with the general population. The strong interindividual differences in susceptibility to developing the metabolic syndrome suggests that the genetic makeup is a modulating factor. Part of the genetic puzzle can possibly be explained by variations in the gene coding for the adrenergic ?-2a receptor (adra2a），因为该受体在脂解中起重要作用。三项研究发现？-2a 1291-C/g多态性与抗精神病药诱导的体重增加之间存在关联，白人和亚洲人之间的结果矛盾。尚未发表研究研究1291-C/G多态性与代谢综合征之间的关联。这项横断研究的主要目的是研究adra2a1291-C/G polymorphism and the metabolic syndrome in 470 patients using antipsychotic drugs. There was no significant association between carriership of the variant 1291-G allele and prevalence of the metabolic syndrome (odds ratio, 0.73; 95% confidence interval, 0.49-1.15). Exploratory analysis showed an association between carriership of the variant 1291-G allele and a reduced prevalence of the metabolic syndrome in patients not currently using antipsychotics (odds ratio, 0.05; 95% confidence interval, 0.003-0.97; P = 0.048). In conclusion, this study shows that theadra2a1291-C/g多态性似乎不是使用患者在抗精神病药中长期发生代谢综合征的强大预测因子。有必要使用前瞻性或回顾性设计研究这种关联的研究，以及在非精神病学人群中调查这种关联的研究。 |
| SCZ关键字 | 精神分裂症，精神分裂症，精神分裂症患者 |
| 5 | Hum Psychopharmacol 2011 Aug 26: 386-91 |
| PMID | 21823169 |
| 标题 | 肾上腺素能系统基因中的遗传相互作用：抗精神病药诱导的体重增加的分析。 |
| Abstract | 非典型抗精神病药（AP）对许多神经递质受体具有很高的亲和力。在这些受体中，AP是对肾上腺素能和肾上腺素能受体的拮抗剂，并且已经假定该药理特性与这些药物在临床反应和不良反应方面的作用机理有关。 We tested the hypotheses that AP-induced weight gain is associated with genetic variation in adrenergic receptors and pathway enzymes. We analyzed nine genetic polymorphisms across seven adrenergic genes (ADRA1A,adra2a，Adra2c，Adrb3，DBH，MAOA和COMT）。 One hundred thirty-nine patients with精神分裂症是前瞻性评估AP-induced体重吗gain. The HelixTree software (Golden Helix, Bozeman, MT, USA) was employed to detect differences in genotypic distribution between weight gainer and non-weight gainer groups. Furthermore, for the dopamine ?-hydroxylase haplotype, we were able to obtain both the molecular and the statistical phases, analyzing the phenotype considering both phases. Weight gain was not associated with any adrenergic gene. Our results suggest that genetic polymorphisms in the adrenergic system may not play a major role in AP-induced weight gain; however, adrenergic 2A receptor gene that produced previously the most consistent associations with this phenotype showed a significant interaction with the monoamine oxidase A in weight gainers. |
| SCZ关键字 | 精神分裂症，精神分裂症，精神分裂症患者 |
| 6 | prog。神经心理药物。生物。精神病学2012年1月36日：205-10 |
| PMID | 22037178 |
| 标题 | 精神分裂症患者的ADRA1A基因的关联和代谢异常的严重程度。 |
| Abstract | Patients with精神分裂症患有代谢异常及其相关疾病的风险更高。一些研究发现，代谢综合征成分的积累数与代谢异常的严重程度有关。这项研究的目的是检查ADRA1A的作用，adra2a，ADRB3和5HT2A基因的风险有更严重的代谢异常精神分裂症。我们研究了232个慢性住院患者的样本精神分裂症（120名男性和112名女性）探索四个候选基因与成分的积累数量之间的相关性和代谢综合征的严重程度。对候选基因中的四个单核苷酸多态性进行了基因分型，包括ADRA1A中的ARG347CYS，C1291G，IN中的C1291Gadra2a, the Try64Arg in ADRB3, and the T102C in 5HT2A. An association between the accumulative number of metabolic syndrome components and the ADRA1A gene was found after adjusting age, sex, and other related variables (p-value=0.036). Presence of the Arg347 allele in the ADRA1A gene is a risk factor for having more severe metabolic abnormalities. These findings suggest a medical attention of closely monitoring metabolic risks for精神分裂症patients with high-risk genotypes. |
| SCZ关键字 | 精神分裂症，精神分裂症，精神分裂症患者 |
| 7 | 神经内分泌。Lett。2013 -1 34：792-7 |
| PMID | 24522021 |
| 标题 | Interactive effect of MTHFR and ADRA2A gene polymorphisms on pathogenesis of schizophrenia. |
| Abstract | Increasing evidences support the importance of epigenetic control in精神分裂症发病。通过同型半胱氨酸代谢参与DNA甲基化过程的一种酶是甲基苯甲酸叶酸还原酶（MTHFR）。MTHFR基因中研究最广泛的变体是C677T多态性，导致酶活性降低和同型半胱氨酸水平升高。 In sample of 192精神分裂症S和213健康控制的风险增加精神分裂症associated with MTHFR 677 CT+TT genotype was found (OR=1.6, p=0.021). Association was also evaluated by considering the C677T polymorphism as an interaction with COMT Val158Met andadra2aC-1291G polymorphisms previously associated with精神分裂症risk using a logistic regression analysis. MTHFR*COMT（C677T*Val158met）相互作用的先前研究精神分裂症resulted in inconsistent results. In our sample this interaction did not significantly differ between精神分裂症s and control subjects. On the other hand analysis of MTHFR*adra2a(C677T*C-1291G) interaction revealed significant association betweenadra2aMTHFR TC+TT载体中的CC+CG基因型（P = 0.008）。 我们的结果支持去甲肾上腺素功能的作用以及先前提出的表观遗传控制在发病机理中的作用精神分裂症。进一步的相关研究包括更大的样本size and more markers are needed to prove our results. |
| SCZ关键字 | 精神分裂症，精神分裂症，精神分裂症患者 |
| 8 | 神经内分泌。Lett。2013 -1 34：792-7 |
| PMID | 24522021 |
| 标题 | Interactive effect of MTHFR and ADRA2A gene polymorphisms on pathogenesis of schizophrenia. |
| Abstract | Increasing evidences support the importance of epigenetic control in精神分裂症发病。通过同型半胱氨酸代谢参与DNA甲基化过程的一种酶是甲基苯甲酸叶酸还原酶（MTHFR）。MTHFR基因中研究最广泛的变体是C677T多态性，导致酶活性降低和同型半胱氨酸水平升高。 In sample of 192精神分裂症S和213健康控制的风险增加精神分裂症associated with MTHFR 677 CT+TT genotype was found (OR=1.6, p=0.021). Association was also evaluated by considering the C677T polymorphism as an interaction with COMT Val158Met andadra2aC-1291G polymorphisms previously associated with精神分裂症risk using a logistic regression analysis. MTHFR*COMT（C677T*Val158met）相互作用的先前研究精神分裂症resulted in inconsistent results. In our sample this interaction did not significantly differ between精神分裂症s and control subjects. On the other hand analysis of MTHFR*adra2a(C677T*C-1291G) interaction revealed significant association betweenadra2aMTHFR TC+TT载体中的CC+CG基因型（P = 0.008）。 我们的结果支持去甲肾上腺素功能的作用以及先前提出的表观遗传控制在发病机理中的作用精神分裂症。进一步的相关研究包括更大的样本size and more markers are needed to prove our results. |
| SCZ关键字 | 精神分裂症，精神分裂症，精神分裂症患者 |
| 9 | 精神病学水库2013年1月205日：7-12 |
| PMID | 22940547 |
| 标题 | 精神分裂症和多态性之间的关联的初步证据，在ADRA2A，DRD3和SNAP-25基因的调节区域中。 |
| Abstract | The results of linkage and candidate gene association studies have led to a range of hypotheses about the pathogenesis of精神分裂症。我们将研究限于与多巴胺能和去甲肾上腺素能系统的候选基因的多态性，以及与神经递质胞吐作用有关的25KDA突触体相关蛋白（SNAP-25）基因。八个单核苷酸多态性（SNP）在调节α-2A肾上腺素能受体的基因或编码区域（SNP）（SNP）（adra2a），多巴胺受体D1和D3（DRD1和DRD3），多巴胺？ - 羟化酶（DBH）和SNAP-25是男性患者的基因型精神分裂症（n = 192）和健康对照（n = 213）。这些多态性以前与精神分裂症。The allelic association between精神分裂症和adra2ars1800544 polymorphism, SNAP-25 rs1503112 polymorphism, and DRD3 rs6280 polymorphism was found in our study. However, only observations for rs1503112 survived correction for multiple testing. Association was also evaluated by considering the polymorphisms as interactions; in this case, a likelihood ratio test (LRT) revealed evidence for association with精神分裂症in four polymorphism combinations: two DRD3*SNAP-25 combinations (rs6280*rs3746544 and rs6280*rs3746544, P=0.02), oneadra2a*SNAP25 combination (rs1800544*rs3746544) and oneadra2a*DBH组合（RS1800544*RS2519152）。我们的结果与先前提出的DNA多态性在多巴胺能，去甲肾上腺素能和突触功能中涉及的DNA多态性的作用一致。精神分裂症。需要进一步的相关研究，包括更大的样本量和更多标记来确认我们的结果。 |
| SCZ关键字 | 精神分裂症，精神分裂症，精神分裂症患者 |
| 10 | Front Behav Neurosci 2014 -1 8: 388 |
| PMID | 25414651 |
| 标题 | 成瘾和与奖励相关的基因在产后核核中显示出改变的表达。 |
| Abstract | Motherhood involves a switch in natural rewards, whereby offspring become highly rewarding. Nucleus accumbens (NAC) is a key CNS region for natural rewards and addictions, but to date no study has evaluated on a large scale the events in NAC that underlie the maternal change in natural rewards. In this study we utilized microarray and bioinformatics approaches to evaluate postpartum NAC gene expression changes in mice. Modular Single-set Enrichment Test (MSET) indicated that postpartum (relative to virgin) NAC gene expression profile was significantly enriched for genes related to addiction and reward in five of five independently curated databases (e.g., Malacards, Phenopedia). Over 100 addiction/reward related genes were identified and these included: Per1, Per2, Arc, Homer2, Creb1, Grm3, Fosb, Gabrb3,adra2a, Ntrk2, Cry1, Penk, Cartpt, Adcy1, Npy1r, Htr1a, Drd1a, Gria1, and Pdyn. ToppCluster analysis found maternal NAC expression profile to be significantly enriched for genes related to the drug action of nicotine, ketamine, and dronabinol. Pathway analysis indicated postpartum NAC as enriched for RNA processing, CNS development/differentiation, and transcriptional regulation. Weighted Gene Coexpression Network Analysis (WGCNA) identified possible networks for transcription factors, including Nr1d1, Per2, Fosb, Egr1, and Nr4a1. The postpartum state involves increased risk for mental health disorders and MSET analysis indicated postpartum NAC to be enriched for genes related to depression, bipolar disorder (BPD), and精神分裂症。与心理健康有关的基因包括：FABP7，GRM3，PENK和NR1D1。我们通过定量PCR NR1D1，PER2，GRM3，PENK，DRD1A和PDYN确认。这项研究首次表明产后NAC涉及与成瘾和奖励有关的大规模基因表达改变。由于产后状态也涉及对药物的反应减少，因此这些发现可以提供有关如何减轻成瘾的见解。 |
| SCZ关键字 | 精神分裂症，精神分裂症，精神分裂症患者 |
| 11 | Hum Psychopharmacol 2014 Jan 29: 38-45 |
| PMID | 24424705 |
| 标题 | ADRA2A和MTHFR基因多态性与抗精神病药转换为阿立哌唑或Ziprasidone后的体重减轻。 |
| Abstract | 据报道，各种遗传多态性与抗精神病药诱导的体重增加有关。在这项研究中，我们旨在确定在将抗精神病药转换为阿ipiprazole或Ziprasidone后，12种候选基因中的风险多态性是否与患者体重指数（BMI）的减少有关。 We recruited 115精神分裂症具有代谢异常的患者，谁至少接受其他抗精神病药的治疗。然后将它们切换到阿立哌唑或Ziprasidone。它们是基因型的，其BMI监测了6个月。 Significant associations with reduction in BMI at 6?months following switching were found in two of these genes: with rs1800544 of theadra2agene (CC?+?CG [-0.32?�?1.41?kg/m�] vs GG [-1.04?�?1.63?kg/m�], p?=?0.013) and with rs1801131 of the MTHFR gene (AA [-0.36?�?1.53] vs AC?+?CC [-1.07?�?1.53], p?=?0.015). 研究数据表明，运输adra2aRS1800544 GG基因型和MTHFR RS1801131 C等位基因与该人群的BMI减少有关，因为将抗精神病药切换为阿拉哌唑和Ziprasidone。 |
| SCZ关键字 | 精神分裂症，精神分裂症，精神分裂症患者 |
| 12 | Hum Psychopharmacol 2014年7月29日：336-41 |
| PMID | 25163438 |
| 标题 | alpha 2a肾上腺素能受体基因的多态性与氯氮平治疗的精神分裂症患者的唾液性有关。 |
| Abstract | Clozapine-induced sialorrhea (CIS) is a common, inconvenient and socially stigmatizing adverse effect. The pathophysiology of CIS may be related to the effect of clozapine on the muscarinic and adrenergic receptors as well as the disruption of the circadian rhythms. The aim of this study was to find out if polymorphisms in muscarinic M1 and M3 receptor genes (CHRM1 and CHRM3), adrenoceptor alpha 2A gene (adra2a) or clock circadian regulator gene (CLOCK) are associated with CIS. 二十七十七十的氯氮平治疗的芬兰人精神分裂症将患者用于CHRM1，CHRM3，时钟和adra2apolymorphisms, and their salivary dysfunction was assessed with two questions. Twenty-six of these patients had previously been on medication to treat CIS. Comparisons of the genotypes between patients with excessive versus non-excessive salivation were analysed. Genotype distributions between patients and control group and haplotypes were also studied. CHRM1，CHRM3和时钟多态性和单倍型与CI无关。adra2a（RS1800544）基因型与CIS相关（P？=？0.029）。在CIS患者中，CC基因型（N？=？103）比G-Allele载体（N？=？79）（P？=？0.013或2.13，95％CI：1.17-3.88）更常见。在患者和对照组之间的基因型分布中没有发现差异。 adra2agenotype was associated with CIS. |
| SCZ关键字 | 精神分裂症，精神分裂症，精神分裂症患者 |
| 13 | Brain Behav. Immun. 2015 May 46: 60-9 |
| PMID | 25728234 |
| 标题 | GADD45B是青少年社会行为的表观遗传调节剂，并改变了啮齿动物杏仁核中局部促炎性细胞因子的产生。 |
| Abstract | 围产期发育过程中表观基因组的精确调节对于以后生活中物种典型行为的形成至关重要。最近的数据表明，GADD45B通过募集参与碱基切除修复（BER）的蛋白质促进活性DNA脱甲基化，这将催化5-甲基 - 胞嘧啶（5MC）用于未修饰的胞嘧啶。尽管GADD45B的角色与海马和杏仁核学习任务有关，但据我们所知，尚未进行研究，研究了GADD45B参与社会行为的神经发育计划。为了解决这个问题，我们使用了靶向的siRNA递送方法来瞬时击倒新生大鼠杏仁核中的GADD45B表达。我们选择在少年时期检查社会行为，因为与神经发育障碍相关的社会缺陷往往会在同等年龄的人类中出现。我们发现，新生儿GADD45B敲低的敲除导致少年社会行为改变，并降低了与精神疾病有关的几种基因的表达，包括甲基CPG结合蛋白2（MECP2），reelin和脑衍生的神经营养因子（BDNF）。我们此外还报告了GADD45B在编程表达中的新作用。adra2a). Consistent with Gadd45b's role in the periphery, we also observed changes in the expression of pro-inflammatory cytokines interleukin-6 (Il-6) and interleukin-1beta (Il-1beta) in the amygdala, which could potentially mediate or exacerbate effects of Gadd45b knockdown on the organization of social behavior. These data suggest a prominent role for Gadd45b in the epigenetic programming of complex juvenile social interactions, and may provide insight into the etiology of juvenile behavioral disorders such as ADHD, autism, and/or精神分裂症。 |
| SCZ关键字 | 精神分裂症，精神分裂症，精神分裂症患者 |
| 14 | Schizophr Bull 2016 5月1日：-1 |
| PMID | 27217270 |
| 标题 | 抗精神病药相关体重增加的药物遗传学关联：系统评价和荟萃分析。 |
| Abstract | Although weight gain is a serious but variable adverse effect of antipsychotics that has genetic underpinnings, a comprehensive meta-analysis of pharmacogenetics of antipsychotic-related weight gain is missing. In this review, random effects meta-analyses were conducted for dominant and recessive models on associations of specific single nucleotide polymorphisms (SNP) with prospectively assessed antipsychotic-related weight or body mass index (BMI) changes (primary outcome), or categorical increases in weight or BMI (?7%; secondary outcome). Published studies, identified via systematic database search (last search: December 31, 2014), plus 3 additional cohorts, including 222 antipsychotic-na�ve youth, and 81 and 141 first-episode精神分裂症将每个人在3或4个月治疗时都有患者级数据的成年人进行荟萃分析。总共将72篇报道的文章报道了46个未置换样品（n = 6700，平均随访= 25.1WK），分别是来自20个基因/基因组区域的38个SNP，进行了荟萃分析（对于每次荟萃分析，研究= 2-20，研究= 2-20，n = 81-2082）。来自8个基因的11个SNP与重量或BMI变化显着相关，来自2个基因的4个SNP与分类重量或BMI的增加显着相关。联合来自9个基因的13个SNP（adrenoceptor alpha-2a [adra2a], Adrenoceptor Beta 3 [ADRB3], Brain-Derived Neurotrophic Factor [BDNF], Dopamine Receptor D2 [DRD2], Guanine Nucleotide Binding Protein [GNB3], 5-Hydroxytryptamine (Serotonin) Receptor 2C [HTR2C], Insulin-induced gene 2 [INSIG2], Melanocortin-4 Receptor [MC4R], and Synaptosomal-associated protein, 25kDa [SNAP25]) were significantly associated with antipsychotic-related weight gain (P-values < .05-.001). SNPs inadra2a，DRD2，HTR2C和MC4R的效应尺寸最大（Hedges'G = 0.30-0.80，ORS = 1.47-1.96）。较少先前的抗精神病药物暴露（小儿或第一事件患者）和短随访（1-2 mo）与较大的效应大小相关。单个抗精神病药并未显着适度的效应大小。总之，与抗精神病药相关的体重增加是多基因的，并且与特定的遗传变异型有关，尤其是在编码抗精神病药物药效目标的基因中。 |
| SCZ关键字 | 精神分裂症，精神分裂症，精神分裂症患者 |
| 15 | prog。神经心理药物。生物。精神病学2016年1月64日：87-95 |
| PMID | 26234518 |
| 标题 | 面部刺激中情绪的感知：ADRA2A与COMT基因型的相互作用以及性别。 |
| Abstract | 情感面部刺激是重要的社会信号，为了在日常交流中做出适当的决定和反应，必须被感知和认可。自愿引导注意感知和识别情绪并对情绪做出反应的能力在很大程度上各不相同，并且具有很强的遗传成分（Friedman等，2008）。儿茶酚胺系统的两个关键遗传变异与情绪感知和注意有关的是儿茶酚-O-甲基转移酶遗传变异（COMT Val158met）和？2A受体基因启动子多态性（adra2aC-1291G) accordingly. So far, the interaction of the two with sex in emotion perception has not been studied. Multilevel modeling method was applied to study how COMT Val158Met,adra2aC-1291G和性别与大量年轻人样本中的情绪感知量有关。参与者（n = 506）完成了情感识别和行为情绪检测任务。发现COMT Val158MET基因型与adra2aC-1291G和性别可预测情绪检测以及对价和唤醒的感知。在简单的视觉检测中，adra2aC-1291G G-Allele会导致对高度唤醒的面（scheming）的检测较慢，该脸部受到每种其他COMT Val158met Met-Allele的调节，男性性别预测速度更快。G-Allele，Met-Allele和男性性别的结合也预测了悲伤的面孔中更高的感知消极情绪。C-1291G，Val158met和性别没有对言语情绪识别的影响。应用发现在情绪感知障碍中研究儿茶酚胺-O-甲基转移酶活性和2A受体之间的相互作用（例如ADHD，自闭症和精神分裂症）在男女中，将是了解情感感知中个体差异的下一步。 |
| SCZ关键字 | 精神分裂症，精神分裂症，精神分裂症患者 |