| 1 | Prog. Neuropsychopharmacol. Biol. Psychiatry 2009 Nov 33: 1491-5 |
|---|---|
| PMID | 19703508 |
| Title | Positive association between ALDH1A2 and schizophrenia in the Chinese population. |
| Abstract | Vitamin A (retinol), in the biologically active form of retinoic acid (RA), has been proposed as involved in the pathogenesis of精神分裂症. We hypothesized that genetic basis of genes encoding RA metabolism enzymes, which control the cellular RA level, might be associated with this disease. This cascade genetic association model, using markers in genes of synthesis and degradation enzymes within the retinoid cascade, would better fit the biological character of the retinoid hypothesis than the single gene strategy. In the present study we chose to investigate 7 genes involved in the synthesis, degradation and transportation of RA, ALDH1A1, ALDH1A2, ALDH1A3,CYP26A1, CYP26B1, CYP26C1 and Transthyretin (TTR), for their roles in the development of精神分裂症. We genotyped 18 single nucleotide polymorphisms (SNPs) in the regulatory and coding regions of these 7 genes using LDR technology in the 617 Chinese Han subjects. Case-control analyses were performed to detect association of these 7 genes with精神分裂症. Association analyses using both allelic and genotypic single-locus tests revealed no significant association between the risk for each of investigated gene and精神分裂症. However, analyses of multiple-locus haplotypes indicated that the overall frequency of rs4646642-rs4646580 of ALDH1A2 gene showed significant difference between patients and control subjects (p=0.0055). We also employed multifactor dimensionality reduction method to detect multilocus effects. In summary, in this work we show multiple candidate genes involved in retinoid cascade in精神分裂症s. In addition, our results suggest a positive association between ALDH1A2 and精神分裂症s in the Chinese population and support the retinoid hypothesis of精神分裂症. |
| SCZ Keywords | 精神分裂症, schizophrenics |
| 2 | Prog. Neuropsychopharmacol. Biol. Psychiatry 2009 Nov 33: 1491-5 |
| PMID | 19703508 |
| Title | Positive association between ALDH1A2 and schizophrenia in the Chinese population. |
| Abstract | Vitamin A (retinol), in the biologically active form of retinoic acid (RA), has been proposed as involved in the pathogenesis of精神分裂症. We hypothesized that genetic basis of genes encoding RA metabolism enzymes, which control the cellular RA level, might be associated with this disease. This cascade genetic association model, using markers in genes of synthesis and degradation enzymes within the retinoid cascade, would better fit the biological character of the retinoid hypothesis than the single gene strategy. In the present study we chose to investigate 7 genes involved in the synthesis, degradation and transportation of RA, ALDH1A1, ALDH1A2, ALDH1A3,CYP26A1, CYP26B1, CYP26C1 and Transthyretin (TTR), for their roles in the development of精神分裂症. We genotyped 18 single nucleotide polymorphisms (SNPs) in the regulatory and coding regions of these 7 genes using LDR technology in the 617 Chinese Han subjects. Case-control analyses were performed to detect association of these 7 genes with精神分裂症. Association analyses using both allelic and genotypic single-locus tests revealed no significant association between the risk for each of investigated gene and精神分裂症. However, analyses of multiple-locus haplotypes indicated that the overall frequency of rs4646642-rs4646580 of ALDH1A2 gene showed significant difference between patients and control subjects (p=0.0055). We also employed multifactor dimensionality reduction method to detect multilocus effects. In summary, in this work we show multiple candidate genes involved in retinoid cascade in精神分裂症s. In addition, our results suggest a positive association between ALDH1A2 and精神分裂症s in the Chinese population and support the retinoid hypothesis of精神分裂症. |
| SCZ Keywords | 精神分裂症, schizophrenics |