1 J PERS评估2007年2月88日:74-80
PMID 17266417
Title 在寻求辩证行为疗法的患者中,人格评估库存量表的同时有效性。
Abstract The purpose of this study was to explore the usefulness of the Personality Assessment Inventory (PAI; Morey, 1991) Borderline full scale (BOR) and subscales in the assessment of patients being evaluated for dialectical behavior therapy (DBT;Linehan,1993)。我们管理了67名精神障碍的PAI和诊断和统计手册(第四版;美国精神病学协会,1994年),结构化Axis II疾病的临床访谈(SCID-II; First,Spitzer,Spitzer,Gibbon,Williams,Williams,&Benjamin,&Benjamin,&Benjamin,&Benjamin,&Benjamin,&Benjamin,&Benjamin,&Benjamin,&Benjamin,&Benjamin,&1997)。点双相关性显示出边界人格障碍(BPD)的存在与BOR的分数之间存在显着关系。精神分裂症(SCZ)鳞片。回归分析表明,ong the BOR subscales, those measuring identity disturbance, self-harming behavior, and negative relationships were significantly related to the total number of SCID-II BPD criteria. Diagnostic efficiency statistics between the BOR scale and the number of SCID-II BPD criteria indicated that a T score cutoff of 65 optimally differentiates patients who do and do not meet criteria for BPD. The relationship between BOR and SCID-II BPD demonstrates the concurrent validity of the PAI and shows its usefulness in this setting.
SCZ Keywords 精神分裂症
2 Harefuah 2011 3月150日:269-74,302
PMID 21574364
Title [心理治疗 - 以色列的循证护理政策指南和指南]。
Abstract 心理治疗是心理健康领域的主要治疗方法之一。对文献的评论表明,某些形式的心理治疗是基于证据的。数百种荟萃分析研究的发现表明,心理治疗通常可以实现临床上有意义的结果,也可能有助于节省成本。这篇综述包含与主要心理治疗方法有关的发现:心理动力,认知行为(CBT)和辩证行为(DBT)。研究结果表明,有足够的证据表明CBT在治疗各种精神障碍中的有效性。还有大量的证据表明,短期心理动力学心理疗法可有效治疗精神障碍,除了精神病和精神病和精神分裂症. On the other hand, there are only preliminary findings supporting the effectiveness ofDBT关于这种劳动密集型治疗技术的成本效益仍然存在问题。同样,只有初步的结果表明,长期心理动力心理治疗有效地治疗复杂的精神障碍。回顾了心理治疗结果的最新技术进步。这些包括在整个治疗过程中跟踪变化的方法以及旨在为治疗师提供持续反馈的计算机辅助程序。这些技术旨在通过将心理治疗集中在明确定义的目标上,并使用旨在减少治疗的负面反应并降低客户过早终止治疗的风险来改善结果。作者通过为以色列的基于公共部门的门诊心理治疗提出了基于循证护理政策的准则来总结。
SCZ Keywords 精神分裂症
3 Psychodyn精神病学2015年9月43日:423-61
PMID 26301761
Title 当代认知行为疗法:理论,历史和证据的回顾。
Abstract Cognitive behavior therapy (CBT) has come to be a widely practiced psychotherapy throughout the world. The present article reviews theory, history, and evidence for CBT. It is meant as an effort to summarize the forms and scope of CBT to date for the uninitiated. Elements of CBT such as cognitive therapy, behavior therapy, and so-called "third wave" CBT, such as dialectical behavior therapy (DBT)以及接受和承诺疗法(法案)。审查了CBT对各种疾病功效的证据,包括抑郁症,焦虑症,人格障碍,饮食失调,滥用药物,精神分裂症,慢性疼痛,失眠和儿童/青少年疾病。还简要考虑了药物和CBT或其组合的相对功效。提出了未来的研究和治疗开发方向。beplay苹果手机能用吗
SCZ Keywords 精神分裂症
4 欧元。J. Nucl。医学摩尔。成像2016年3月43日:537-47
PMID 26455500
Title PET imaging evaluation of [(18)F]DBT-10, a novel radioligand specific to ?7 nicotinic acetylcholine receptors, in nonhuman primates.
Abstract 正电子发射断层扫描(PET)适用于?7种烟碱乙酰胆碱受体(NACHR)的放射性物体,可为这种受体的体内成像,用于诸如阿尔茨海默氏病,例如阿尔茨海默氏病,精神分裂症和药物滥用。这项工作旨在表征?7-nACHR特异性放射线的动力学特性,7-(1,4-二氮扎下氮杂方[3.2.2] nonan-4-yl)-2 - [(18)f] -fluorodibenzo [b] -fluorodibenzo [b,d]噻吩5,5-二氧化物([(18)F]DBT-10), in nonhuman primates.
[(18)f]DBT-10是通过硝基辅助者的亲核取代产生的。[(18)F]成像了四个Macaca mulatta受试者DBT-10 PET,测量[(18)F]DBT-10动脉等离子体中的母体浓度和代谢。所有受试者都获得了基线PET扫描。进行一次扫描后,对脑组织进行了离体分析,以检查脑中的放射性标记的代谢物。还获得了三个阻断扫描,并获得了0.69和1.24 mg/kg的?7-nACHR特异性配体ASEM,以评估[(18)F]的剂量依赖性阻断DBT-10 binding. Kinetic analysis of PET data was performed using the metabolite-corrected input function to calculate the parent fraction corrected total distribution volume (V T/f P).
[(18)f]DBT-10 was produced within 90 min at high specific activities of 428?�?436 GBq/?mol at end of synthesis. Metabolism of [(18)F]DBT-10在受试者之间有所不同,注射后120分钟的母体分数为15-55%。吸收[(18)f]DBT-10 in brain occurred rapidly, reaching peak standardized uptake values (SUVs) of 2.9-3.7 within 30 min. The plasma-free fraction was 18.8?�?3.4%. No evidence for radiolabeled [(18)F]DBT-10 metabolites was found in ex vivo brain tissue samples. Kinetic analysis of PET data was best described by the two-tissue compartment model. Estimated V T/f P values were 193-376 ml/cm(3) across regions, with regional rank order of thalamus?>?frontal cortex?>?striatum?>?hippocampus?>?occipital cortex?>?cerebellum?>?pons. Dose-dependent blockade of [(18)F]DBT-10在整个大脑中观察到结构类似ASEM的结合,占用图的v nd/f p估计为20?????16 mL/cm(3)。
这些结果表明[(18)F]的合适动力学特性DBT-10用于非人类灵长类动物中7-NACHR结合的体内定量。
SCZ Keywords 精神分裂症
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