| Abstract |
外围车辆od mononuclear cells (PBMCs) represent an accessible tissue source for gene expression profiling inschizophreniathat could provide insight into the molecular basis of the disorder. This study used the Illumina HT_12 microarray platform and quantitative real time PCR (QPCR) to perform mRNA�expression profiling on 114 patients withschizophreniaor schizoaffective disorder and 80 non-psychiatric controls from the AustralianschizophreniaResearch Bank (ASRB). Differential expression analysis revealed altered expression of 164 genes (59 up-regulated and 105 down-regulated) in the PBMCs from patients withschizophreniacompared to controls. Bioinformatic analysis indicated significant enrichment of differentially expressed genes known to be involved or associated with immune function and regulating the immune response. The differential expression of 6 genes, EIF2C2 (Ago 2), MEF2D, EVL, PI3, S100A12 andDEFA4was confirmed by QPCR. Genome-wide expression analysis of PBMCs from individuals withschizophreniawas characterized by the alteration of genes with immune system function, supporting the hypothesis that the disorder has a significant immunological component in its etiology. |