| 1 | Rehabilitation (Stuttg) 2004 Dec 43: 368-74 |
|---|---|
| PMID | 15565538 |
| 标题 | [针对精神病患者的Osnabruck工作能力概况（O-AFP）：精神分裂症患者的概念，发展和测试]。 |
| 抽象的 | 本文的目的是介绍库存，以评估精神病患者在治疗和康复过程中的基本能力和职业行为。“ Osnabruck的工作能力配置文件”（O-AFP）是由员工填写的工具，由三个量表组成，其中包括十个项目，测量“学习能力”，“社交沟通能力”和“适应”。在提出的研究中，通过194年数据的因素分析证实了这些量表schizophrenicpatients. Test analyses yielded good item and scale characteristics. The only exception to this are elevated item difficulty scores of the third scale (adaptation). This was attributed to specific effects of selecting the sample of patients. Furthermore, low or insignificant correlations with the patients' symptom scores indicate the discriminant validity of the scales. It is concluded that the O-AFPis well suited for application with different forms of occupational therapy. |
| SCZ关键字 | 精神分裂症，精神分裂症 |
| 2 | Fortschr Neurol Psychiatr 2005 Nov 73: 674-80 |
| PMID | 16283611 |
| 标题 | [Which schizophrenic patients improve under work therapy, which ones don't?]. |
| 抽象的 | This investigation is part of a multicenter study, where only small effects and no superiority compared to creative ergotherapy was found for four weeks of inpatient work therapy. The criteria were three scales of the Osnabr�ck-Working Capabilities Profile (O-AFP) assessing basic learning ability, social communication ability and adaptation at the work place. The goal of this investigation is to identify subgroups of patients within the work therapy group, which differ in their course of ability level during the intervention. Three subgroups were identified for each scale. Subgroups with improvements comprise 24 % (learning ability) and 15 % (social communication) of the sample. Adaptation level decreases in a group of 9 % of the patients. The remaining clusters show constancy of abilities at different levels. Comparison of the clusters with neurocognitive, symptom and motivational variables shows that for learning ability mainly neurocognitive variables yield salient differences, whereas for social communication abilities, symptoms and motivation, together with a specific aspect of memory, seem to be characteristic. Only positive symptoms are related to adaptation. Also, there are hints for variables that specifically characterize patients with improvement of ability level. The discussion deals with issues of assessment and prognosis in rehabilitation, contributions to the neurocognitive theory ofschizophreniaand to the development of person-centered interventions. |
| SCZ关键字 | 精神分裂症，精神分裂症 |
| 3 | Fortschr Neurol Psychiatr 2005 Nov 73: 674-80 |
| PMID | 16283611 |
| 标题 | [Which schizophrenic patients improve under work therapy, which ones don't?]. |
| 抽象的 | This investigation is part of a multicenter study, where only small effects and no superiority compared to creative ergotherapy was found for four weeks of inpatient work therapy. The criteria were three scales of the Osnabr�ck-Working Capabilities Profile (O-AFP) assessing basic learning ability, social communication ability and adaptation at the work place. The goal of this investigation is to identify subgroups of patients within the work therapy group, which differ in their course of ability level during the intervention. Three subgroups were identified for each scale. Subgroups with improvements comprise 24 % (learning ability) and 15 % (social communication) of the sample. Adaptation level decreases in a group of 9 % of the patients. The remaining clusters show constancy of abilities at different levels. Comparison of the clusters with neurocognitive, symptom and motivational variables shows that for learning ability mainly neurocognitive variables yield salient differences, whereas for social communication abilities, symptoms and motivation, together with a specific aspect of memory, seem to be characteristic. Only positive symptoms are related to adaptation. Also, there are hints for variables that specifically characterize patients with improvement of ability level. The discussion deals with issues of assessment and prognosis in rehabilitation, contributions to the neurocognitive theory ofschizophreniaand to the development of person-centered interventions. |
| SCZ关键字 | 精神分裂症，精神分裂症 |
| 4 | Psychiatr Prax 2006 Nov 33: 383-9 |
| PMID | 17128396 |
| 标题 | [精神分裂症的职业疗法：仅与某些患者以及哪些患者作用？]。 |
| 抽象的 | 在先前的研究中，使用OSNABR.CK的工作能力（O-）评估了职业疗法的有效性（O-AFP). No or only minor effects were detected. The goal of this reanalysis is to identify distinct responder groups. O-的分层聚类分析AFP-scores before and after treatment, anovas, t-statistics as well as regression and discriminant analyses were applied to specify the clusters. For each of the O-AFP- 可以确定尺度（学习能力，社交沟通能力，适应）的三个子组在水平和能力的斜率上不同。检测到具有中等至高效果的改进，以获得社会沟通能力（34％）和学习能力（14％的患者），在30％的患者适应性中发现了恶化。可以在症状学的帮助下描述亚组。可以通过判别和回归分析来预测更多变量和亚组成员身份。 有针对性的一个d more appropriate design of vocational therapy seems necessary. |
| SCZ关键字 | 精神分裂症，精神分裂症 |
| 5 | Eur Child Adolesc Psychiatry 2015 Dec 24: 1447-59 |
| PMID | 25726022 |
| 标题 | Functional deterioration from the premorbid period to 2 years after the first episode of psychosis in early-onset psychosis. |
| 抽象的 | 该研究的目的是分析精神病（FEP）第一集（FEP）的功能调整的变化。schizophreniaspectrum disorders (SSD) and affective psychoses (AFP）以及良好或中间的病前调整。我们跟随106名青少年（年龄12-17岁），在招募后2年以FEP进行了FEP。在98例儿童期刺激前调节量表（C-PAS）的儿童期患者中，评估了儿童期的病前调整。在FEP之后2年，使用儿童全球评估量表（C-GAS）或功能量表（GAF）的全球功能评估全球功能。功能恶化定义为从童年到FEP后2年的功能调整水平的下降。在良好或中间前调整的患者中，在28.2％中观察到功能恶化（占26.5％AFPgroup, 29.4 % of the SSD group). Longer duration of untreated psychosis (Beta = 0.01; P = 0.01) and higher symptom severity at the FEP, as measured with the Clinical Global Impression Scale (Beta = 1.12; P = 0.02), significantly predicted the presence of functional deterioration, accounting for 21.4 % of the variance. Irrespective of diagnosis (SSD orAFP), almost one-third of adolescents with FEP and good or intermediate premorbid adjustment showed functional deterioration from the premorbid period to 2 years after the FEP. |
| SCZ关键字 | 精神分裂症，精神分裂症 |
| 6 | Schizophr Bull 2016 Mar 42: 344-57 |
| PMID | 26371339 |
| 标题 | Age at First Episode Modulates Diagnosis-Related Structural Brain Abnormalities in Psychosis. |
| 抽象的 | Brain volume and thickness abnormalities have been reported in first-episode psychosis (FEP). However, it is unclear if and how they are modulated by brain developmental stage (and, therefore, by age at FEP as a proxy). This is a multicenter cross-sectional case-control brain magnetic resonance imaging (MRI) study. Patients with FEP (n = 196), 65.3% males, with a wide age at FEP span (12-35 y), and healthy controls (HC) (n = 157), matched for age, sex, and handedness, were scanned at 6 sites. Gray matter volume and thickness measurements were generated for several brain regions using FreeSurfer software. The nonlinear relationship between age at scan (a proxy for age at FEP in patients) and volume and thickness measurements was explored in patients withschizophreniaspectrum disorders (SSD), affective psychoses (AFP）和HC。早期的SSD病例（即15-20 y之前的FEP）在额叶中显示出明显的体积和厚度缺陷，颞叶的体积缺陷以及心室系统和基底神经节中的体积扩大。第一集AFP患者仅在FEP时（18-20 y之前）才有较小的扣带回皮质体积和较厚的颞皮层。这AFPgroup also had age-constant (12-35-y age span) volume enlargements in the frontal and parietal lobe. Our study suggests that age at first episode modulates the structural brain abnormalities found in FEP patients in a nonlinear and diagnosis-dependent manner. Future MRI studies should take these results into account when interpreting samples with different ages at onset and diagnosis. |
| SCZ关键字 | 精神分裂症，精神分裂症 |