| 1 | 是。J. Med。基因。2000年12月96日：725-7 |
|---|---|
| PMID | 11121169 |
| 标题 | Support for an association between HLA-DR1 and schizophrenia in the Japanese population. |
| Abstract | An increase of HLA-DR1在精神分裂症patients from the Japanese population. A decrease of DR4, which was reported in Caucasian patients, has also been found in some of the Japanese studies. This small study further investigated frequencies of HLA-DR1和DR4 in unrelated Japanese patients with精神分裂症（n = 45）和健康的比较对象（n = 117）。拥有的患者人数DR1was higher (10 of 45, 22%) compared with the comparison group (11 of 117, 9.4%, P = 0.03). This may support the previous observation of an increasedDR1日本患者的频率。当目前的数据与先前的三项研究结合在一起时，日本受试者的比例与DR1是588中的98精神分裂症patients (16.7%) vs. 93 of 942 comparison subjects (9.9%). However, no difference was observed in DR4 frequencies between the patients (51%) and comparison subjects (44%). Am. J. Med. Genet. (Neuropsychiatr. Genet.) 96:725-727, 2000. |
| SCZ关键字 | 精神分裂症，精神分裂症，精神分裂症患者 |
| 2 | Am J Psychiatry 2000 Jul 157：1173-5 |
| PMID | 10873932 |
| 标题 | 人类白细胞抗原,在日本出生的季节anese patients with schizophrenia. |
| Abstract | Five Japanese studies, to the authors' knowledge, without exception, have consistently shown an increased frequency of human leukocyte antigen (HLA)-DR1in patients with精神分裂症。这表明hla-之间存在关联DR1和精神分裂症in the Japanese population. The mechanism of the association is unknown; however, prenatal infections may be involved. The present study explored factors, including winter birth, that might correlate with this mechanism. Age at onset and gender were also studied. 比较了日本患者的因素精神分裂症with and in those without HLA-DR1（n = 60和n = 307）。 A significantly higher incidence of births in February and March was observed in patients with (31.7%) than those without (15. 6%) HLA-DR1。No association was found between the presence of HLA-DR1和other variables. 尽管该结果是初步的，但它可能表明HLA与冬季出生之间的相互作用精神分裂症in the Japanese population. |
| SCZ关键字 | 精神分裂症，精神分裂症，精神分裂症患者 |
| 3 | 精神分裂。res。2001年4月49日：73-8 |
| PMID | 11343866 |
| 标题 | 使用来自汉族中国人口的家庭三重奏，对精神分裂症中HLA II类DRB1，DQA1，DQB1和DPB1多态性的传播不平衡分析。 |
| Abstract | Our goal was to evaluate the role of HLA in the risk of developing精神分裂症，在中国人口中。在日本的几项研究中，有证据表明DR1和精神分裂症。在其他人群中已经报道了各种其他关联，包括与DQBETA（*）0602的负相关以及与DR1（*）0101。使用序列特异性寡核苷酸，我们在165个族三重奏中基因分型了四个HLA标记（DRB1，DQA1，DQB1和DPB1），由汉族中文组成精神分裂症subjects and their parents. Individual markers were analysed for transmission distortion in the trios using the transmission disequilibrium test. Multiple haplotype transmission was performed using the program TRANSMIT v2.5. The four markers were in strong linkage disequilibrium with each other (P value from 0.002 to 0). There was no evidence of overall transmission disequilibrium for each of the four loci. For DRB1, we did not find transmission distortion for the DRB1(*)04 and DRB1(*)08 alleles, as reported previously, but the DRB1(*)03 allele was preferentially not transmitted (P=0.009), and the DRB1(*)13 allele was preferentially transmitted from parents to精神分裂症offspring (P=0.041). Using haplotypes of pairs of markers, a significant global P value of 0.019 was achieved when using DRB1 and DQA1, mainly as a result of the excess transmission of DRB1(*)13-DQA1(*)01 (P=0.012) and a deficit in transmission of DRB1(*)03-DQA1(*)05 (P=0.002). In summary, we did not confirm any of the specific HLA allelic associations reported previously in Japanese or other populations. However, our results are compatible with the view that this region of HLA might contain a susceptibility gene which is in linkage disequilibrium with DRB1 and DQA1 genes. |
| SCZ关键字 | 精神分裂症，精神分裂症，精神分裂症患者 |
| 4 | 精神分裂。res。2001年4月49日：73-8 |
| PMID | 11343866 |
| 标题 | 使用来自汉族中国人口的家庭三重奏，对精神分裂症中HLA II类DRB1，DQA1，DQB1和DPB1多态性的传播不平衡分析。 |
| Abstract | Our goal was to evaluate the role of HLA in the risk of developing精神分裂症，在中国人口中。在日本的几项研究中，有证据表明DR1和精神分裂症。在其他人群中已经报道了各种其他关联，包括与DQBETA（*）0602的负相关以及与DR1（*）0101。使用序列特异性寡核苷酸，我们在165个族三重奏中基因分型了四个HLA标记（DRB1，DQA1，DQB1和DPB1），由汉族中文组成精神分裂症subjects and their parents. Individual markers were analysed for transmission distortion in the trios using the transmission disequilibrium test. Multiple haplotype transmission was performed using the program TRANSMIT v2.5. The four markers were in strong linkage disequilibrium with each other (P value from 0.002 to 0). There was no evidence of overall transmission disequilibrium for each of the four loci. For DRB1, we did not find transmission distortion for the DRB1(*)04 and DRB1(*)08 alleles, as reported previously, but the DRB1(*)03 allele was preferentially not transmitted (P=0.009), and the DRB1(*)13 allele was preferentially transmitted from parents to精神分裂症offspring (P=0.041). Using haplotypes of pairs of markers, a significant global P value of 0.019 was achieved when using DRB1 and DQA1, mainly as a result of the excess transmission of DRB1(*)13-DQA1(*)01 (P=0.012) and a deficit in transmission of DRB1(*)03-DQA1(*)05 (P=0.002). In summary, we did not confirm any of the specific HLA allelic associations reported previously in Japanese or other populations. However, our results are compatible with the view that this region of HLA might contain a susceptibility gene which is in linkage disequilibrium with DRB1 and DQA1 genes. |
| SCZ关键字 | 精神分裂症，精神分裂症，精神分裂症患者 |
| 5 | Prog. Neuropsychopharmacol. Biol. Psychiatry 2006 May 30: 423-8 |
| PMID | 16412545 |
| 标题 | 日本和土耳其精神分裂症患者的人白细胞抗原DR1。 |
| Abstract | The main focus of this review has been to discuss the probable causes of the higher frequency of HLADR1antigen in patients with精神分裂症来自日本和土耳其，也看看属于乌拉尔语言群体是否存在影响。一般的Medline搜索HLA和精神分裂症被用作确定患有HLA研究的方法精神分裂症。Most of the findings were inconsistent regarding the increased or decreased frequencies of different Class I and II antigens. However, there were interesting results, which have been consistently repeated in several Japanese studies and in a Turkish study. HLADR1日本和土耳其患者的抗原在统计学上显着增加精神分裂症。As Japanese and Turkish languages belong to the Ural-Altaic language group, HLADR1antigen might have a specific association with精神分裂症在日本和土耳其患者中。搜索HLA的频率DR1antigen in patients with精神分裂症in other members of Ural-Altaic language group is necessary to support this hypothesis. Other language groups (e.g. Indo-European) should be assessed as well. |
| SCZ关键字 | 精神分裂症，精神分裂症，精神分裂症患者 |
| 6 | Neurosci. Res. 2009 Sep 65: 53-63 |
| PMID | 19465068 |
| 标题 | 多巴胺受体亚型与大鼠脑中多巴胺和cAMP调节的磷蛋白（DARPP-32）的共定位。 |
| Abstract | 在本研究中，使用间接免疫荧光免疫组织化学，共免疫沉淀和蛋白质印迹分析我们确定了多巴胺受体1-5和多巴胺和cAMP调节的磷酸蛋白（DARPP-32）在大鼠脑皮质和纹状体中的共定位。所有五个DR亚型和DARPP-32均在大鼠脑皮层和纹状体中表达。DARPP-32阳性神经元显示出与DR1-5. In cingulate cortex, the colocalization of DR subtypes was greatly different from frontal or temporal cortex. D1R is one of the most predominant subtypes which colocalized with DARPP-32 in cortex as well as striatum and followed by D2R, D3R, D4R and D5R. Amongst all DR subtypes D5R was coexpressed the least with DARPP-32 positive neurons. Consistent with immunohistochemical data, western blot analysis also reveals comparable distribution of DR subtypes and DARPP-32 in cortex and striatum. Colocalization studies were also supported by using co-immunoprecipitate assay displaying DARPP-32 expression in DR immunoprecipitate from tissue lysate prepared from cortex and striatum. Taken together our data support receptor specific association of DARPP-32 with DR subtypes that might shed new information in drugs of abuse and pathophysiology of neurodegenerative diseases as well as neuropsychiatric disorders such as精神分裂症。 |
| SCZ关键字 | 精神分裂症，精神分裂症，精神分裂症患者 |