| 1 | J. Hum。基因。2010年2月55日：127-30 |
|---|---|
| PMID | 20057506 |
| 标题 | Polymorphism screening of brain-expressed FABP7, 5 and 3 genes and association studies in autism and schizophrenia in Japanese subjects. |
| Abstract | 脂肪酸结合蛋白(FABP)基因全家ly encode fatty acid-binding proteins and consist of at least 12 members, of which FABP7, 5 and 3 are expressed in the brain. We previously showed that FABP7 is associated with精神分裂症和躁郁症。最近，自闭症与精神分裂症已经被报告了。因此，在这项研究中，我们着手研究脑表达的Fabps在自闭症中的可能作用，主要关注潜在的功能多态性（即错过多态性）。首先，我们使用285个自闭症样本重新占了这三个基因。我们确定了13种多态性，其中7种是新颖的。在新型的单核苷酸多态性（SNP）中，有两个是错义突变，即FabP7中的376G> C（Val126Leu）和Fabp5中的340G> C（Gly114arg）。其次，我们测试了四个失误SNP与自闭症的遗传关联和精神分裂症，但未能检测到重大结果。最后，作为基于Web的算法预测，8a> g（asp3gly; rs17848124）Fabp3is 'probably damaging', we estimated the possible impact of this SNP, and found that the loss of charge and salt bridge, caused by the Asp3-to-Gly3, may affect stability of theFabp3protein. Future searches for associated phenotypes with missense SNPs using larger samples are highly warranted. |
| SCZ关键字 | 精神分裂症，精神分裂症 |
| 2 | 是。J. Med。基因。B Neuropsychiatr。基因。2010年3月153b：484-93 |
| PMID | 19554614 |
| 标题 | 脑表达的脂肪酸结合蛋白（FABP）基因与精神分裂症和双相情感障碍之间的关联分析。 |
| Abstract | 抑制前抑制作用（PPI）是精神病的生物学标志物，例如精神分裂症和躁郁症。To unravel PPI-controlling mechanisms, we previously performed quantitative trait loci (QTL) analysis in mice, and identified Fabp7, that encodes a brain-type fatty acid binding protein (Fabp), as a causative gene. In that study, human FABP7 showed genetic association with精神分裂症。Fabps构成了一个基因家族，其中Fabp5成员和Fabp3are also expressed in the brain. These FABP proteins are molecular chaperons for polyunsaturated fatty acids (PUFAs) such as arachidonic and docosahexaenoic acids. Additionally, the involvement of PUFAs has been documented in the pathophysiology of精神分裂症和情绪障碍。因此，在这项研究中，我们检查了Fabp5和3在精神分裂症（n = 1,900与对照组合）和躁郁症中的FabP7、5和3（在病例对照组中n = 1,762）。FABP7的三个单核苷酸多态性（SNP）与双相情感障碍相关性，同一基因的单倍型也显示出与躁郁症的经验关联，即使在校正了多个测试后。由于缺乏信息的SNP，我们无法对FabP5进行关联研究。Fabp3displayed no association with either disease. Each FABP is relatively small and it is assumed that there are multiple regulatory elements that control gene expression. Therefore, future identification of unknown regulatory elements will be necessary to make a more detailed analysis of their genetic contribution to mental illnesses. |
| SCZ关键字 | 精神分裂症，精神分裂症 |
| 3 | Pharmacopsychiatry 2011 Jan 44: 15-20 |
| PMID | 20821366 |
| 标题 | 精神分裂症患者的能量稳态基因和抗精神病药诱导的体重增加的关联研究。 |
| Abstract | Marked inter-individual variation has been observed with respect to the risk of weight gain and related metabolic disturbances during antipsychotic treatment, which in part could be explained by heritability. Such adverse effects have been proposed to occur through drug-induced mechanisms involving both the central nervous system and different peripheral tissues. 我们在几个基因中基因分型标记（Adipoq，prkaa1，prkaa2，prkab1，prkag1，prkag1，prkag2，prkag2，prkag3，prkag3，fto和ftoFabp3）调节脂质和能量稳态，以使其可能与抗精神病药诱导的体重增加相关。 在160名德国血统患者的样本中精神分裂症对体重的监测，我们发现BMI与抗精神病药相关的变化与脂联素基因（Adipoq）的6个标记之间有明显的关联。 这些发现支持先前的观察结果（在患者的血清中），即脂联素参与抗精神病药介导的代谢不良反应。 |
| SCZ关键字 | 精神分裂症，精神分裂症 |
| 4 | Nihon Shinkei Seishin Yakurigaku Zasshi 2011年6月31日：125-30 |
| PMID | 21800703 |
| 标题 | [多巴胺D2受体作为心脏型脂肪酸结合蛋白的新型靶标分子]。 |
| Abstract | 长链多不饱和脂肪酸（LCPUFA）的基本作用已在较高的大脑功能中记录在包括情绪，学习和记忆中。几项临床研究表明，口服eicosapentaenoic（EPA）和二十六烯酸（DHA）可以改善情绪和认知功能障碍精神分裂症患者。同样，补充花生四烯酸可以改善人类神经退行性疾病（例如阿尔茨海默氏病）中的认知功能障碍。由于LCPUFA在水性细胞环境中不溶于溶解，因此脂肪酸结合蛋白（FABPS）对于充当LCPUFA的细胞内转运至关重要。在各种Fabps中，心型脂肪酸结合蛋白（H-FABP，Fabp3）在成熟大脑的神经元中高度表达。我们先前证明了H-FABP在体外与多巴胺D2受体长同工型（D2LR）有关。此外，我们证明了H-FABP敲除小鼠表现出多巴胺D2受体功能障碍。这些结果表明，LCPUFA的给药通过大脑中的H-FABP调节多巴胺D2受体的功能。 |
| SCZ关键字 | 精神分裂症，精神分裂症 |
| 5 | 哼。摩尔。基因。2014 Dec 23: 6495-511 |
| PMID | 25027319 |
| 标题 | 在精神分裂症和自闭症谱系障碍和小鼠行为研究中鉴定的FABP3，5和7基因变体的功能表征。 |
| Abstract | 脂质代谢的障碍与精神病有关。我们先前报道了脂肪酸结合蛋白7（FabP7）的基因之间的关联和精神分裂症。Furthermore, we identified and reported several rare non-synonymous polymorphisms of the brain-expressed genesFabp3，Fabp5和Fabp7来自精神分裂症和自闭症谱系障碍（ASD），已知可以分散遗传结构的疾病。在这里，我们进行了进一步的研究，以更好地了解这些基因对精神分裂症and ASD. In postmortem brains, we detected altered mRNA expression levels of FABP5 in精神分裂症，在ASD中的FabP7和外周淋巴细胞中的FABP5改变。使用患者队列，全面的突变筛选确定了三个FABP基因的六个错义和两个移码变体。两个移码蛋白，Fabp3E132fs and FABP7 N80fs, formed cellular aggregates and were unstable when expressed in cultured cells. The four missense mutants with predicted possible damaging outcomes showed no changes in intracellular localization. Examining ligand binding properties, FABP7 S86G and FABP7 V126L lost their preference for docosahexaenoic acid to linoleic acid. Finally, mice deficient inFabp3, Fabp5 and Fabp7 were evaluated in a systematic behavioral test battery. TheFabp3敲除（KO）小鼠的社交记忆和寻求新颖性显示出降低，Fabp7 KO小鼠表现出多动和焦虑相关的表型，而FabP5 KO小鼠没有明显的表型。总之，脑表达的Fabps的干扰可以代表一种基本的疾病机制精神分裂症and ASD sufferers. |
| SCZ关键字 | 精神分裂症，精神分裂症 |
| 6 | 哼。摩尔。基因。2015年4月24日：2409 |
| PMID | 25655139 |
| 标题 | 在精神分裂症和自闭症谱系障碍和小鼠行为研究中鉴定的FABP3，5和7基因变体的功能表征。 |
| Abstract | -1 |
| SCZ关键字 | 精神分裂症，精神分裂症 |
| 7 | 大脑行为。免疫。2016年2月52日：178-86 |
| PMID | 26541453 |
| 标题 | 脂肪酸处理蛋白H-FABP和CD36的预处理水平预测了最近发作的精神分裂症患者对奥氮平的反应。 |
| Abstract | 传统的精神分裂症pharmacotherapy remains a subjective trial and error process involving administration, titration and switching of drugs multiple times until an adequate response is achieved. Despite this time-consuming and costly process, not all patients show an adequate response to treatment. As a consequence, relapse is a common occurrence and early intervention is hampered. Here, we have attempted to identify candidate blood biomarkers associated with drug response in 121 initially antipsychotic-free recent-onset精神分裂症接受广泛使用的抗精神病药治疗的患者，即奥氮平（n = 40），喹硫平（n = 23），利培酮（n = 30）和这些药物的混合物（n = 28）。招募患者并作为两个单独的同类人群进行调查，以允许生物标志物验证。数据分析表明，心脏型脂肪酸结合蛋白（H-FABP）的预处理水平和对奥氮平的反应之间的关系最显着（p = 0.008，f = 8.6，？= 70.4，在发现同龄人中，p = 0.003，f = 15.2，？= 24.4在验证队列中，针对相关的混杂变量进行了调整）。在对该发现的功能性随访分析中，我们测试了10名用奥氮平治疗的10例患者的独立队列，发现血浆H-FABP的基线水平以及H-FABP的结合伴侣的表达H-FABP，脂肪酸易位酶（CD36），，CD36），，，在单核细胞上预测了精神病症状的减少（p = 0.040，f = 6.0，？= 116.3和p = 0.012，f = 11.9，？= -0.0054）。我们还确定了用抗精神病药（尤其是奥氮平）治疗后一组血清分子发生了变化。这些分子主要参与细胞发育和代谢。综上所述，我们的发现表明，参与脂肪酸代谢的生物标志物与对奥氮平的反应之间的关联，而其他蛋白质可能是与药物疗效和副作用相关的替代标记。 |
| SCZ关键字 | 精神分裂症，精神分裂症 |
| 8 | 精神分裂。res。2016年3月171日：225-32 |
| PMID | 26792082 |
| 标题 | Fatty acid composition and fatty acid binding protein expression in the postmortem frontal cortex of patients with schizophrenia: A case-control study. |
| Abstract | N-3多不饱和脂肪酸（PUFAS），尤其是Docosahexaenoic酸（DHA）的水平异常精神分裂症。Altered mRNA expression of fatty acid binding protein (FABP) 5 and FABP7 has likewise been reported. 这项研究调查了额叶皮层中的PUFA [Brodmann地区（BA）8]和mRNA表达是否Fabp3, 5, and 7 were different between patients with精神分裂症(n=95) and unaffected controls (n=93). In contrast to previous studies, no significant differences were found in DHA between the groups. Although arachidonic acid (AA) levels were significantly decreased in the精神分裂症小组，在AA和精神分裂症on logistic regression analysis. OnlyFabp3表达显着降低精神分裂症group than in the control group. Significant inverse associations were seen between only two saturated fatty acids, behenic acid and lignoceric acid, andFabp3表达。 We found no evidence that major PUFA levels in BA8 are involved in the etiology of精神分裂症。虽然Fabp3expression was not correlated with any of the major PUFAs, it might play a novel role in the pathology of BA8 in a subset of patients with精神分裂症。 |
| SCZ关键字 | 精神分裂症，精神分裂症 |
| 9 | Neurosci. Res. 2016 Jan 102: 47-55 |
| PMID | 25205626 |
| 标题 | 脂肪酸结合蛋白和神经系统：它们对精神状况的影响。 |
| Abstract | 大脑富含脂质和脂肪分子。在这篇评论文章中，我们专注于与脂肪酸（如花生四烯酸和二十二烷二十二烷酸）结合的脂肪酸结合蛋白（FABP），并将这些脂质配体转移到细胞质中。在Fabp家族分子中，Fabp3，Fabp5和FabP7以细胞类型的特异性方式专门定位在神经/祖细胞，神经元和神经胶质细胞中。定量性状基因座分析表明，FABP7与使用作为精神病的内表型（例如，精神分裂症。Fabp5 and Fabp7 play important roles on neurogenesis and differentially regulate acoustic startle response and PPI. However, other behavior performances including spatial memory, anxiety-like behavior, and diurnal changes in general activity were not different in mice deficient for Fabp7 or Fabp5. Considering the importance of fatty acids in neurogenesis, we would like to emphasize that lipid nutrition and its dynamism via Fabps play significant roles in mental conditions. This might provide a good example of how nutritional environment can affect psychiatric conditions at the molecular level. |
| SCZ关键字 | 精神分裂症，精神分裂症 |