| 1 | Neurosci. Lett. 2013 Sep 552: 120-3 |
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| PMID | 23933155 |
| Title | Lack of association between MPC2 variants and schizophrenia in a replication study of Han Chinese. |
| Abstract | 精神分裂症(SCZ) is a common, complex and severe psychiatric disorder associated with many different risk factors, both genetic and environmental. A recent genome-wide association study (GWAS) of Han Chinese identified a single-nucleotide polymorphism (SNP, rs10489202) in the mitochondrial pyruvate carrier 2 gene (MPC2, also known as BRP44) as a possible susceptibility locus for精神分裂症. Hoping to validate this finding, we conducted a case-control study of Han Chinese with 1093精神分裂症cases and 1022 healthy controls, using the LDR-PCR method to genotype polymorphisms (rs10489202 and a TagSNP rs203861) in theMPC2gene. However, we found no significant difference (P>0.05) in either allele or genotype frequency in the SNPs between patients and controls. These results did not support the previous finding suggesting the further study by using a large-scale association analysis in the future should be warranted in Han Chinese populations. |
| SCZ Keywords | 精神分裂症 |
| 2 | Schizophr. Res. 2016 Apr 172: 75-7 |
| PMID | 26899211 |
| Title | Replication of Han Chinese GWAS loci for schizophrenia via meta-analysis of four independent samples. |
| Abstract | 精神分裂症is a highly heritable psychiatric disorder with unclear aetiology. Recent genome-wide association studies (GWAS) in European populations have reported numerous susceptibility variants, while GWAS in East Asians also identified several risk loci but with fewer independent replications. Here we focus on nine single nucleotide polymorphisms (SNPs) which have shown genome-wide significant associations with精神分裂症in previous Han Chinese GWAS, and we tend to replicate the associations in four independent samples of East Asian origin including a total of 3977 cases and 5589 controls. The results showed that rs10489202 inMPC2(BRP44) is significantly associated with精神分裂症in these East Asian replication samples (one-tailed P=5.75�10(-3), OR=1.12), and further meta-analysis after including previous GWAS data yielded a genome-wide significant association (two-tailed P=1.11�10(-10), OR=1.19), adding further support for the involvement of this locus in the genetic risk of精神分裂症,future studies regarding the underlying molecular mechanisms of the risk association are necessary. |
| SCZ Keywords | 精神分裂症 |