| 1 | Neurosci. Res. 2005 Sep 53: 8-13 |
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| PMID | 15963589 |
| Title | Polymorphisms of heat shock protein 70 gene (HSPA1A, HSPA1B and HSPA1L) and schizophrenia. |
| Abstract | The heat shock protein 70 (HSP70) is believed to be involved in the pathogenesis ofschizophrenia关于神经发育。一个差the HSP70 has been proposed inschizophreniapatients, suggesting that it is a candidate gene forschizophrenia. This study aimed to investigate the association between the three polymorphisms of HSP70-1 (HSPA1A), HSP70-hom (HSPA1L) and HSP70-2 (HSPA1B) andschizophrenia. One hundred and sixty-one patients withschizophreniaand 165 controls were enrolled in the study. A polymerase chain reaction (PCR) with a restriction fragment length enzyme (RFLP) was used to genotype the HSPA1A,HSPA1Land HSPA1B polymorphisms. There were no significant differences in the allelic or genotype frequencies of the HSPA1A andHSPA1Lpolymorphisms between theschizophreniapatients and the controls, while there was a marginal difference in the genotype frequency of the HSPA1B polymorphisms, and a significant difference in the allelic frequency of the HSPA1B polymorphisms between theschizophreniapatients and the controls. There was no evidence of an association between the clinical variables andschizophreniaacross the genotypes among the three HSP70 gene polymorphisms. These results suggest that a HSPA1B polymorphism might be related to the pathogenesis ofschizophreniaat least in the Korean population. Therefore, larger studies from different ethnic groups should be performed to confirm these results. |
| SCZ Keywords | schizophrenia, schizophrenic |
| 2 | Eur Arch Psychiatry Clin Neurosci 2008 Jun 258: 239-44 |
| PMID | 18299791 |
| Title | Association analysis of heat shock protein 70 gene polymorphisms in schizophrenia. |
| Abstract | Heat shock proteins (HSPs) are a promising candidate gene inschizophreniaas they are believed to play a protective role in the central nervous system. An alteration in the titers of antibodies to the HSPs inschizophreniapatients has been suggested. Association between the three polymorphisms of HSP70-1 (HSPA1A), HSP70-hom (HSPA1L) and HSP70-2 (HSPA1B) andschizophreniahas been reported. Therefore, this study investigated the association between an enlarged set of SNPs at HSP70 gene andschizophrenia. Two hundred and ninety-four patients withschizophreniaand 287 controls were enrolled in the study. Genotypings of 5 SNPs of HSP70 were performed using pyrosequencing method. Haploview 3.2 was used to generate a linkage disequilibrium map and to test for Hardy-Weinberg equilibrium. Single locus and haplotype-based associations were tested. Tests for associations using and multi-marker haplotypes were performed by using a COCAPHASE v2.403. Association of SNP markers and clinical variables were analyzed by analysis of variance. 重要的协会是维etected at rs2075799 (allele A, X2 = 8.03, df = 1, P = 0.0046), but not at rs2227956 (P = 0.28), rs1043618 (P = 0.88), rs562047 (P = 0.47) or rs539689 (P = 0.32). In fact, the rs2075799*G/A genotype was more represented in patients withschizophreniathan in controls (X2 = 8.23, df= 1, P = 0.0041). Haplotype based associations were also detected (global P value 0.000003); the T-A-C-C-G haplotype was more prevalent among the patients (odds ratio, OR 5.95). Sliding windows analysis revealed a major contribution from rs2227956 and rs2075799 (global-P value 0.0075), with T-A haplotype significantly associated withschizophrenia. There was no evidence of an association between the clinical variables andschizophreniaacross the genotypes. Our results raise the possibility that HSP70 gene (i.e., haplotypes of rs2075799) might be implicated in the development ofschizophrenia, although limited by rare haplotypic association with the disease. Hence further studies from different ethnics should be performed to confirm these results. |
| SCZ Keywords | schizophrenia, schizophrenic |
| 3 | Neuropsychobiology 2009 -1 59: 135-41 |
| PMID | 19439993 |
| Title | The impact of heat shock protein 70 gene variations on clinical presentation and outcome in schizophrenic inpatients. |
| Abstract | We previously investigated a group of single-nucleotide polymorphisms of a set of genes coding for heat shock proteins (HSPA1A, HSPA1B andHSPA1L) and found a significant association between one HSPA1B variation andschizophrenia(SZ). We now report an association between a set of variations (rs2227956, rs2075799, rs1043618, rs562047 and rs539689) within the same genes and a larger sample ofschizophrenicinpatients. A single variation, rs539689 (HSPA1B), was found to be marginally associated with Positive and Negative Syndrome Scale (PANSS) positive scores at discharge, and haplotype analysis revealed a significant association between improvement in PANSS scores with both A-C-G-G and A-C-G-G haplotypes. These findings further support a role of heat shock proteins in the pathophysiology of SZ. |
| SCZ Keywords | schizophrenia, schizophrenic |
| 4 | Neuropsychobiology 2009 -1 59: 135-41 |
| PMID | 19439993 |
| Title | The impact of heat shock protein 70 gene variations on clinical presentation and outcome in schizophrenic inpatients. |
| Abstract | We previously investigated a group of single-nucleotide polymorphisms of a set of genes coding for heat shock proteins (HSPA1A, HSPA1B andHSPA1L) and found a significant association between one HSPA1B variation andschizophrenia(SZ). We now report an association between a set of variations (rs2227956, rs2075799, rs1043618, rs562047 and rs539689) within the same genes and a larger sample ofschizophrenicinpatients. A single variation, rs539689 (HSPA1B), was found to be marginally associated with Positive and Negative Syndrome Scale (PANSS) positive scores at discharge, and haplotype analysis revealed a significant association between improvement in PANSS scores with both A-C-G-G and A-C-G-G haplotypes. These findings further support a role of heat shock proteins in the pathophysiology of SZ. |
| SCZ Keywords | schizophrenia, schizophrenic |
| 5 | Cell Stress Chaperones 2014 Mar 19: 205-15 |
| PMID | 23893339 |
| Title | Heat shock protein 70 gene polymorphisms are associated with paranoid schizophrenia in the Polish population. |
| Abstract | HSP70 genes have been considered as promisingschizophreniacandidate genes based on their protective role in the central nervous system under stress conditions. In this study, we analyzed the potential implication of HSPA1A +190G/C, HSPA1B +1267A/G, andHSPA1L+2437T/C polymorphisms in the susceptibility to paranoidschizophreniain a homogenous Caucasian Polish population. In addition, we investigated the association of the polymorphisms with the clinical variables of the disease. Two hundred and three patients with paranoidschizophreniaand 243 healthy controls were enrolled in the study. Polymorphisms of HSPA1A, -1B, and -1L genes were genotyped using the PCR-RFLP technique. Analyses were conducted in entire groups and in subgroups that were stratified according to gender. There were significant differences in the genotype and allele frequencies of HSPA1A polymorphism between the patients and controls. The +190CC genotype and +190C allele were over-represented in the patients and significantly increased the risk for developingschizophrenia(OR?=?3.45 and OR?=?1.61, respectively). Interestingly, such a risk was higher for females with the +190CC genotype than for males with the +190CC genotype (OR?=?5.78 vs. OR?=?2.76). We also identified the CGT haplotype as a risk haplotype forschizophreniaand demonstrated the effects of HSPA1A and HSPA1B genotypes on the psychopathology and age of onset. Our study provided the first evidence that the HSPA1A polymorphism may potentially increase the risk of developing paranoidschizophrenia. Further independent analyses in different populations to evaluate the role of gender are needed to replicate these results. |
| SCZ Keywords | schizophrenia, schizophrenic |