| Abstract |
schizophreniais a severe psychiatric disorder with lifetime prevalence of ~1% worldwide. A genotyping study was conducted using a custom panel of Illumina 1536 SNPs in 840schizophreniacases and 876 controls (351 patients and 385 controls from North India; and 436 patients, 401 controls and 143 familial samples with 53 probands containing 37 complete and 16 incomplete trios from South India). Meta-analysis of this population of Indo-European and Dravidian ancestry identified three strongly associated variants withschizophrenia:STT3A(rs548181, p = 1.47�10 (5)),NRG1 (rs17603876, p=8.66�10(-5)) and GRM7 (rs3864075, p=4.06�10(-3)). Finally, a meta-analysis was conducted comparing our data with data from theschizophreniaPsychiatric Genome-Wide Association Study Consortium (PGC-SCZ) that supported rs548181 (p=1.39�10(-7)). In addition, combined analysis of sporadic case-control association and a transmission disequilibrium test in familial samples from South Indian population identified three associations: rs1062613 (p=3.12�10(-3)), a functional promoter variant of HTR3A; rs6710782 (p=3.50�10(-3)), an intronic variant of ERBB4; and rs891903 (p=1.05�10(-2)), an intronic variant of EBF1. The results support the risk variants observed in the earlier published work and suggest a potential role of neurodevelopmental genes in theschizophreniapathogenesis. |