| 1 | Schizophr. Res. 2010 Aug 121: 213-7 |
|---|---|
| PMID | 20591628 |
| Title | LEP和LEPR基因的多态性，延长氯氮平施用后的代谢特征以及对抗糖尿病二甲双胍的反应。 |
| 抽象的 | 在非典型antipsychotic-induc瘦素的作用ed metabolic dysfunction was explored by assessing the anthropometric and metabolic profile and the response to metformin (MET) of clozapine- (CLZ) treatedschizophrenia患者根据瘦素启动子（LEP2548/GA）和瘦素受体（LEP2548/GA）中的单核苷酸多态性（SNP）（SNP）（SNP）（SNP）（LEPRQ223R) genes. Phase 1. Body mass index (BMI), waist circumference, serum glucose, HbA1C, lipids, leptin, cortisol, insulin resistance index (HOMA-IR), metabolic syndrome and the frequencies of SNPs were assessed in 56 CLZ-treated patients (78.6% males). Phase 2. Fifty two phase 1 subjects were randomly assigned to MET XR (n=23) (1000 mg/day) or placebo (n=29) for 14 weeks. Changes in anthropometric and biochemical variables were compared between the SNPs. Phase 1. The QQ group displayed the lowest triglyceride levels (p<0.05). No other significant difference was observed. Phase 2. Change in anthropometric variables did not differ between the genotypes in any treatment group. After MET, glucose levels significantly increased in the GG group (p<0.05), whereas the HOMA-IR and the low density cholesterol significantly decreased in the QQ- but not in the (QR+RR) group (p<0.05). No differences were observed after placebo. BW对CLZ的反应与LEP和LEPR-SNPs. The GG and (QR+RR) genotypes showed an unexpectedly opposite and blunted response to MET administration respectively. |
| SCZ Keywords | schizophrenia, schizophrenic |
| 2 | Schizophr. Res. 2011 Feb 125: 187-93 |
| PMID | 21050724 |
| Title | Clock genes and body composition in patients with schizophrenia under treatment with antipsychotic drugs. |
| 抽象的 | In the healthy population, several pathways are known to exert an effect on basal metabolic factors. Previous studies have found associations between single nucleotide polymorphisms in clock genes or downstream hormone receptors such as the leptin receptor (LEPR)或糖皮质激素受体(NR3C1)和肥胖n the healthy population, but this association remains to be examined in patients withschizophreniatreated with antipsychotics. To assess anthropomorphic parameters in patients taking second-generation antipsychotics (SGA) as a function of nine polymorphisms in three core genes of the clock pathway, and two genes of downstream hormone receptors. Clinical parameters were evaluated in 261 patients withschizophreniaspectrum disorder. Polymorphisms inLEPR, MC3R, NR3C1, PER2 and SDC3 were genotyped. In order to control for multiple testing, permutation tests were used to generate corrected empirical p-values using the Max(T) procedure in PLINK. A significant effect of the rs6196 polymorphism in the NR3C1 on weight (?=-4.18; SE=2.02; p=0.018), BMI (?=-1.88; SE=0.64; p=0.004), waist (?=-5.77; SE=1.75; p=0.001) and waist/hip ratio (?=-0.03; SE=0.012; p=0.009) was found. Permutation tests confirmed the findings for BMI (p=0.037) and waist (p=0.024). Carriers of the G allele consistently displayed better parameters than patients with the wild type allele. A weak effect of rs4949184 in SDC3 on BMI was found, but this did not sustain permutation testing (?=-1.27; SE=0.58; p=0.030, p=0.270 after permutations). Variations in genes implicated in circadian regulation or its related downstream pathways may be important in the regulation of antropomorphic parameters in patients withschizophrenia在长期治疗SGA期间。 |
| SCZ Keywords | schizophrenia, schizophrenic |
| 3 | J Clin Psychopharmacol 2011 Dec 31: 705-11 |
| PMID | 22020349 |
| Title | Polymorphisms of INSIG2, MC4R, and LEP are associated with obesity- and metabolic-related traits in schizophrenic patients. |
| 抽象的 | schizophrenicpatients have a high prevalence of metabolic adversities. Previous studies have suggested some candidate genes for obesity- and metabolic-related traits, including the insulin-induced gene (INSIG2), melanocortin 4 receptor gene (MC4R), and leptin and leptin receptor genes (LEP andLEPR）。我们旨在研究这些基因与患者的代谢紊乱之间的关联schizophreniain Taiwan. 有诊断的患者schizophrenia或根据精神障碍的诊断和统计手册，第四版的诊断和统计手册是从台北的36个社区精神病康复中心或医院招募的。总共招募了650名受试者，遗传分析中包括577名受试者。人体测量学（体重指数，腰围[WC]和血压）和生化测量（禁食血浆葡萄糖，胰岛素，甘油三酸酯，高密度脂蛋白胆固醇和评估的储基模型 - 胰岛素耐药性index index [HOMA-IR] [HOMA-IR]）被评估。使用标准Taqman分析对4个基因中的七个基因座进行了基因分型。进行了遗传关联分析，以对前提到的性状进行二元和定量测量。肥胖患者schizophrenia比非肥胖患者表现出更多的代谢障碍。 我们的数据表明，Insig2与空腹血浆葡萄糖显着相关（对于RS17587100，p <0.0001），MC4R与WC相关（对于RS2229616，P = 0.005），而LEP与体重指数和WC相关（对于RS77999039，RS7799039和WC<0.01）。此外，这些基因座显示出与包括高密度脂蛋白胆固醇和甘油三酸酯，代谢综合征，胰岛素水平和HOMA-IR指数在内的特征的暗示性关联（P = 0.05）。除了抗精神病药和不健康的生活方式的影响外，遗传因素还有助于肥胖症和代谢障碍的高流行。schizophrenia, especially genes involved in metabolic-related pathways. |
| SCZ Keywords | schizophrenia, schizophrenic |
| 4 | J Clin Psychopharmacol 2011 Dec 31: 705-11 |
| PMID | 22020349 |
| Title | Polymorphisms of INSIG2, MC4R, and LEP are associated with obesity- and metabolic-related traits in schizophrenic patients. |
| 抽象的 | schizophrenicpatients have a high prevalence of metabolic adversities. Previous studies have suggested some candidate genes for obesity- and metabolic-related traits, including the insulin-induced gene (INSIG2), melanocortin 4 receptor gene (MC4R), and leptin and leptin receptor genes (LEP andLEPR）。我们旨在研究这些基因与患者的代谢紊乱之间的关联schizophreniain Taiwan. 有诊断的患者schizophrenia或根据精神障碍的诊断和统计手册，第四版的诊断和统计手册是从台北的36个社区精神病康复中心或医院招募的。总共招募了650名受试者，遗传分析中包括577名受试者。人体测量学（体重指数，腰围[WC]和血压）和生化测量（禁食血浆葡萄糖，胰岛素，甘油三酸酯，高密度脂蛋白胆固醇和评估的储基模型 - 胰岛素耐药性index index [HOMA-IR] [HOMA-IR]）被评估。使用标准Taqman分析对4个基因中的七个基因座进行了基因分型。进行了遗传关联分析，以对前提到的性状进行二元和定量测量。肥胖患者schizophrenia比非肥胖患者表现出更多的代谢障碍。 我们的数据表明，Insig2与空腹血浆葡萄糖显着相关（对于RS17587100，p <0.0001），MC4R与WC相关（对于RS2229616，P = 0.005），而LEP与体重指数和WC相关（对于RS77999039，RS7799039和WC<0.01）。此外，这些基因座显示出与包括高密度脂蛋白胆固醇和甘油三酸酯，代谢综合征，胰岛素水平和HOMA-IR指数在内的特征的暗示性关联（P = 0.05）。除了抗精神病药和不健康的生活方式的影响外，遗传因素还有助于肥胖症和代谢障碍的高流行。schizophrenia, especially genes involved in metabolic-related pathways. |
| SCZ Keywords | schizophrenia, schizophrenic |
| 5 | prog。神经心理药物。生物。精神病学2012年8月38日：134-41 |
| PMID | 22426215 |
| Title | Association study of polymorphisms in leptin and leptin receptor genes with antipsychotic-induced body weight gain. |
| 抽象的 | Antipsychotic-induced weight gain (AIWG) is a serious side-effect of antipsychotic medication leading to metabolic syndrome and increased cardiovascular morbidity. Unfortunately, there are still no valid predictors to assess an individual's risk to gain weight. Previous studies have indicated an impact of genetic variation in the genes encoding leptin, LEP, and leptin receptor,LEPR, on AIWG, but results have not been conclusive. Thus, we investigated polymorphisms in both genes for an association with AIWG. A total of 181schizophrenicand schizoaffective patients treated with various antipsychotics were included. In a small subset of patients, leptin plasma levels were additionally obtained. Five polymorphisms in LEP andLEPR(LEP: rs7799039 (-2548G/A polymorphism), rs10954173, rs3828942;LEPR: rs1327120, rs1137101 (Q223R polymorphism) were genotyped using TaqMan assays. Statistical association with % weight change from baseline weight was performed using ANCOVA with baseline weight as covariate. ANCOVA显示出RS7799039标记的基因型关联的趋势（p = .068）。其他LEP没有显着关联LEPRSNPs with AIWG was detected. However, we found a significant association between a haplotype of LEP rs7799039G-rs10954173G-rs3828942G (p=.035) and AIWG. The rs7799039 G-allele (p=.042) and G-allele of rs3828942 (p=.032) were associated with higher weight gain. 我们的研究支持LEP基因变异对AIWG的影响的假设。我们研究的局限性包括异质样本，短期治疗持续时间和多重比较。我们的发现与以前的研究进行了详细比较，以便为读者提供更结论性的图片。但是，有必要进行进一步的研究，包括更多的基因变异和与瘦素 - 甲状腺皮质素途径的其他基因的相互作用分析。 |
| SCZ Keywords | schizophrenia, schizophrenic |
| 6 | Pharmacogenomics 2014 Mar 15: 477-85 |
| PMID | 24624915 |
| Title | Association of FTO, LEPR and MTHFR gene polymorphisms with metabolic syndrome in schizophrenia patients receiving antipsychotics. |
| 抽象的 | The occurrence of metabolic syndrome (MS) inschizophrenia接受长期抗精神病药（AP）的患者有助于高死亡率。我们旨在确定在我们的研究人群中，已鉴定出的候选基因的遗传多态性是否与MS相关。 We recruited 206schizophreniapatients receiving AP treatment for at least a year. Cross-sectional measurements of weight, height, blood pressure, waist and hip circumference, and other lipid profiles were recorded. Patient DNA was genotyped for 16 candidate gene polymorphisms. 在这些患者中，发现59.7％的患者患有MS，而40.3％的患者没有。两组之间的所有代谢参数均显着差异。研究的16个多态性中只有三个显示与MS显着相关。FTO基因的RS9939609赋予了MS的风险（优势比[OR]：1.73，95％CI：1.07-2.78，P = 0.026），而RS1137101LEPRgene (OR: 0.47, 95% CI: 0.28-0.80, p = 0.005) and rs1801133 of the MTHFR gene (OR: 0.59, 95% CI: 0.35-0.99, p = 0.049) are protective against MS. Polymorphisms of the FTO,LEPRMTHFR基因可能在马来西亚的MS中发挥作用schizophrenia接受AP长期治疗的患者。 |
| SCZ Keywords | schizophrenia, schizophrenic |
| 7 | Psychiatry Res 2015 Jul 228: 177-8 |
| PMID | 25841316 |
| Title | Effects of LEP, LEPR, ADIPOQ, MC4R and FTO polymorphisms on dyslipidemia in Korean patients with schizophrenia who are taking clozapine. |
| 抽象的 | -1 |
| SCZ Keywords | schizophrenia, schizophrenic |
| 8 | Schizophr. Res. 2016 Jan 170: 1-17 |
| PMID | 26621002 |
| Title | A systematic review of genetic variants associated with metabolic syndrome in patients with schizophrenia. |
| 抽象的 | 代谢综合征（METS）是一群因素，增加了心血管疾病（CVD）的风险，这是患者死亡率的主要原因之一schizophrenia。患者的Mets发病率明显更高schizophrenia与普通人群相比。几个因素导致这种高合并症。这项系统评价的重点是遗传因素，并询问与与MetS发展有关的基因研究的数据schizophrenia。We aimed to identify variants that potentially contribute to the high comorbidity between these disorders. PubMed, Web of Science and Scopus databases were accessed and a systematic review of published studies was conducted. Several genes showed strong evidence for an association with MetS in patients withschizophrenia, including the fat mass and obesity associated gene (FTO), leptin and leptin receptor genes (LEP,LEPR），甲基四氢叶酸还原酶（MTHFR）基因和5-羟色胺受体2C基因（HTR2C）。这些疾病的多因素性质使对复杂疾病的遗传关联研究使合并症的研究更加复杂。未来研究的建议包括评估较大样本，包括健康对照，纵向而不是横断面研究设计，详细捕获有关疾病的混杂变量的数据以及其他人群中重大发现的验证。将来，大基因组数据集可能允许计算多基因风险评分，以预测患者的MetS风险预测schizophrenia。这最终可能促进早期，精确和患者特异性的药理和非药理学干预措施，以最大程度地减少CVD相关的发病率和死亡率。 |
| SCZ Keywords | schizophrenia, schizophrenic |