| 1 | 精神分裂。res。2009年4月109日：113-20 |
|---|---|
| PMID | 19195843 |
| 标题 | Elevated delta-6 desaturase (FADS2) expression in the postmortem prefrontal cortex of schizophrenic patients: relationship with fatty acid composition. |
| Abstract | Although emerging evidence suggests thatschizophrenia（SZ）与外周和中央多不饱和脂肪酸（PUFA）缺陷有关，目前对介导SZ患者PUFA生物合成的基因表达一无所知。在这里，我们确定了delta5去饱和酶（FADS1），delta6去饱和酶（FADS2），力酶（Helo1 [Elovl5]），过氧化物酶体（PEX19）和delta9 desatyase（stearoyl-CoA desaturase，scd）mRNA表达和相关脂肪酸产物：前体的含量：作为前体的估计，在enzyme的活性中估计。SZ患者（n = 20）和非精神病对照（n = 20）的患者的前额叶前皮层（PFC）。校正多次比较后，相对于对照组，SZ患者的FADS2 mRNA表达显着更大（+36％，p = 0.002），并且发现有阳性趋势FADS1(+26%, p=0.15). No differences were found for HELO1 (+10%, p=0.44), PEX19 (+12%, p=0.44), or SCD (-6%, p=0.85). Both male (+34%, p=0.02) and female (+42%, p=0.02) SZ patients exhibited greater FADS2 mRNA expression relative to same-gender controls. Drug-free SZ patients (+37%, p=0.02), and SZ patients treated with typical (+40%, p=0.002) or atypical (+31%, p=0.04) antipsychotics, exhibited greater FADS2 mRNA expression relative to controls. Consistent with increased Delta6 desaturase activity, SZ patients exhibited a greater 20:3/18:2 ratio (+20%, p=0.03) and a positive trend was found for 20:4/18:2 (+13%, p=0.07). These data demonstrate abnormal, potentially compensatory, elevations in Delta6 desaturase (FADS2) expression in the PFC of SZ patients that are independent of gender and antipsychotic medications. Greater Delta6 desaturase expression and activity could have implications for central prostaglandin synthesis and proinflammatory signaling. |
| SCZ关键字 | 精神分裂症，精神分裂症 |
| 2 | 精神分裂。res。2009年4月109日：113-20 |
| PMID | 19195843 |
| 标题 | Elevated delta-6 desaturase (FADS2) expression in the postmortem prefrontal cortex of schizophrenic patients: relationship with fatty acid composition. |
| Abstract | Although emerging evidence suggests thatschizophrenia（SZ）与外周和中央多不饱和脂肪酸（PUFA）缺陷有关，目前对介导SZ患者PUFA生物合成的基因表达一无所知。在这里，我们确定了delta5去饱和酶（FADS1），delta6去饱和酶（FADS2），力酶（Helo1 [Elovl5]），过氧化物酶体（PEX19）和delta9 desatyase（stearoyl-CoA desaturase，scd）mRNA表达和相关脂肪酸产物：前体的含量：作为前体的估计，在enzyme的活性中估计。SZ患者（n = 20）和非精神病对照（n = 20）的患者的前额叶前皮层（PFC）。校正多次比较后，相对于对照组，SZ患者的FADS2 mRNA表达显着更大（+36％，p = 0.002），并且发现有阳性趋势FADS1(+26%, p=0.15). No differences were found for HELO1 (+10%, p=0.44), PEX19 (+12%, p=0.44), or SCD (-6%, p=0.85). Both male (+34%, p=0.02) and female (+42%, p=0.02) SZ patients exhibited greater FADS2 mRNA expression relative to same-gender controls. Drug-free SZ patients (+37%, p=0.02), and SZ patients treated with typical (+40%, p=0.002) or atypical (+31%, p=0.04) antipsychotics, exhibited greater FADS2 mRNA expression relative to controls. Consistent with increased Delta6 desaturase activity, SZ patients exhibited a greater 20:3/18:2 ratio (+20%, p=0.03) and a positive trend was found for 20:4/18:2 (+13%, p=0.07). These data demonstrate abnormal, potentially compensatory, elevations in Delta6 desaturase (FADS2) expression in the PFC of SZ patients that are independent of gender and antipsychotic medications. Greater Delta6 desaturase expression and activity could have implications for central prostaglandin synthesis and proinflammatory signaling. |
| SCZ关键字 | 精神分裂症，精神分裂症 |
| 3 | Wei Sheng Yan Jiu 2011 Mar 40: 154-7 |
| PMID | 21560298 |
| 标题 | [A case-control study between gene polymorphisms of polyunsaturated fatty acids metabolic rate-limiting enzymes and paranoid schizophrenia of Han ethnicity in Jilin Province]. |
| Abstract | To investigate an association between gene polymorphisms of FADS 1 (fatty acid desaturase 1) , FADS2 (fatty acid desaturase 2) and ELOVL2 (elongation of very long chain fatty acids (FEN1/ Elo2, SUR4/Elo3, yeast) -like 2) and paranoidschizophreniaof the Han ethnicity in Jilin province of China. We genotyped 3 single nucleotide polymorphisms from 3 candidate genes in 100 paranoidschizophrenia使用聚合酶链反应限制片段长度多态性方法的病例和95个健康对照。所有样本均来自中国吉林省的汉族。 The genotype distributions of rs174556 inFADS1gene and rs174617 in FADS2 gene showed no significant difference between case and control groups (P > 0.05). The genotype distribution of rs3756963 in ELOVL2 gene showed significant difference between case group and control group (P < 0.05). The distribution proportion of allele T carriers in case group was higher than that in control group. Trans-phase gene interaction analysis showed that the distribution proportion of combined genotypes included rs3756963 (T/T) was higher in case group than that in control group (P < 0.05). rs174556 inFADS1gene and rs174617 in FADS2 gene may not be associated with paranoidschizophrenia. rs3756963 in ELOVL2 gene may be associated with paranoidschizophrenia. |
| SCZ关键字 | 精神分裂症，精神分裂症 |
| 4 | Cardiovasc Psychiatry Neurol 2013 -1 2013: 596945 |
| PMID | 24455201 |
| 标题 | 精神分裂症和双极患者服用抗精神病药的脂肪酸去饱和酶基因多态性和代谢措施。 |
| Abstract | 非典型抗精神病药物已经成为通信n therapeutic option in bothschizophreniaand bipolar disorder. However, these medications come with a high risk of metabolic side effects, particularly dyslipidemia and insulin resistance. Therefore, identification of patients who are at increased risk for metabolic side effects is of great importance. The genetics of fatty acid metabolism is one area of research that may help identify such patients. Therefore, in this present study, we aimed to determine the effect of one commonly studied genetic polymorphism from both fatty acid desaturase 1 (FADS1) and FADS2 gene on a surrogate measure of insulin resistance and lipid levels in a metabolically high-risk population of patients largely exposed to atypical antipsychotics. This study used a cross-sectional design, fasting blood draws, and genetic analysis to investigate associations between polymorphisms, haplotypes, and metabolic measures. A total of 320 subjects withschizophrenia（n = 226）或躁郁症（n = 94）包括在本研究中。人口的平均年龄为42.5岁，男性为45％。之间的重要关联FADS1and FADS2 haplotypes was found with insulin resistance while controlling for confounders. Further investigation is required to replicate this finding. |
| SCZ关键字 | 精神分裂症，精神分裂症 |
| 5 | Mol. Neurobiol. 2016 Apr 53: 2065-81 |
| PMID | 25902861 |
| 标题 | Hippocampal Pruning as a New Theory of Schizophrenia Etiopathogenesis. |
| Abstract | 有人建议将神经元修剪参与schizophrenia's (SKZ) etiopathogenesis in recent biological, imaging, and genetic studies. We investigated the impact of protein-coding genes known to be involved in pruning, collected by a systematic literature research, in shaping the risk for SKZ in a case-control sample of 9,490 subjects (Psychiatric Genomics Consortium). Moreover, their modifications through evolution (humans, chimpanzees, and rats) and subcellular localization (as indicative of their biological function) were also investigated. We also performed a biological pathways (Gene Ontology) analysis. Genetics analyses found four genes (DLG1, NOS1, THBS4, andFADS1）和17条途径在先前的文献发现中与修剪和SKZ强烈涉及与所分析样本显着相关。对亚细胞定位的分析发现，分泌的基因及其调节性基因是通过进化而保守的，也是与SKZ相关的最不保守的。他们的细胞系和区域脑表达分析发现，他们的主要表达区域分别是神经和海马。从我们的全部知识上，我们第一次能够从单个生物学过程开始描述SKZ神经发育假设。我们还可以假设在修剪精细的调节和编排中的变化与进化最新（更敏感）的分泌蛋白质密切相关，可能与海马特别相关。这种早期的改变可能导致神经连通性的误解，从而导致脑部改变了SKZ患者的不同。 |
| SCZ关键字 | 精神分裂症，精神分裂症 |