| Abstract |
Our recent microarray study reported altered mRNA expression of several low density lipoprotein receptor-related proteins (LRP) associated with the first 4 years following diagnosis withschizophrenia。Whilst this finding is novel, apolipoprotein E (APOE), which mediates its activity through LRPs, has been reported by several studies to be altered in brains of subjects withschizophrenia。我们使用qPCR测量the expression of LRP2,LRP4, LRP6, LRP8, LRP10 and LRP12 mRNA in Brodmann's area (BA) 46 of the dorsolateral prefrontal cortex in 15 subjects with short duration of illnessschizophrenia(SDS) and 15 pair matched controls. We also used Western blotting to measure APOE protein expression in BA46 from these subjects. Amongst the LRPs examined, LRP10 expression was significantly increased (P?=?0.03) and LRP12 was significantly decreased (P?schizophreniaand adds weight to the hypothesis that aberrant apolipoprotein signaling is involved in the early stages ofschizophrenia。 |