| 1 | Mol. Psychiatry 2007 Jun 12: 562-71 |
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| PMID | 17211438 |
| Title | 慢性奥氮平治疗期间，大鼠脂肪细胞中脂质代谢和基因表达的改变。 |
| Abstract | Although antipsychotics are established drugs in精神分裂症众所周知，他们众所周知，它们会诱导副作用，这有利于肥胖症的发作并恶化其并发症。尽管组胺受体拮抗作用或其他神经递质系统的潜在参与，但未阐明抗精神病药增加体重的机制。本研究的目的是研究慢性抗精神病药物是否可以直接改变对白脂肪组织的两个主要功能的调节：脂解和葡萄糖利用。将经典抗精神病药（氟哌啶醇）的影响与两种非典型抗精神病药（一种已知有利于体重增加（Olanzapine））的影响，另一种不是（Ziprasidone）。细胞大小，脂解能力和葡萄糖转运活性在接受这些抗精神病药的5周口服治疗的大鼠的白色脂肪细胞中测定。参与葡萄糖转运或脂肪储存和动员的脂肪细胞蛋白的基因表达，例如葡萄糖转运蛋白（GLUT1和GLUT4），瘦素，基质金属蛋白酶9（MMP9), hormone-sensitive lipase (HSL) and fatty acid synthase (FAS) was also evaluated. Adipocytes from chronic olanzapine-treated rats exhibited decreased lipolytic activity, lowered HSL expression and increased FAS expression. These changes were concomitant to enlarged fat deposition and adipocyte size. Alterations were observed in adipocytes from olanzapine-treated rats whereas the other antipsychotics did not induce any notable disorder. Our results therefore show evidence of an effect of chronic antipsychotic treatment on rat adipocyte metabolism. Thus, impairment of fat cell lipolysis should be considered as a side effect of certain antipsychotics, leading, along with the already documented hyperphagia, to the excessive weight gain observed in patients under prolonged treatment.. |
| SCZ Keywords | 精神分裂症, schizophrenic |
| 2 | 心理精神病学神经2009 -1 2009：904836 |
| PMID | 20037727 |
| Title | 基质金属蛋白酶9（MMP9） - 心血管疾病，癌症和神经精神疾病中的介导酶。 |
| Abstract | Matrix metalloproteinase-9 (MMP9) has been implicated in numerous somatic illnesses, including cardiovascular disorders and cancer. Recently,MMP9已显示在中枢神经系统活动的几个方面越来越重要。此外，在这种神经精神疾病中已经提出了这种酶的致病作用精神分裂症，躁郁症和多发性硬化症。在本文中，生化和分子遗传学研究的结果MMP9that have been performed in these pathological conditions will be summarized. Furthermore, I hypothesize that theMMP9如功能-1562 C/T多态性研究所示的基因可能正在介导神经精神疾病的关系（精神分裂症，双相情绪障碍，多发性硬化症）与心血管疾病和癌症合并。 |
| SCZ Keywords | 精神分裂症, schizophrenic |
| 3 | Psychiatry Res 2011 May 187: 341-6 |
| PMID | 20510460 |
| Title | Expression of anti-cardiolipin antibodies and inflammatory associated factors in patients with schizophrenia. |
| Abstract | 许多研究暗示了精神分裂症和自身免疫性疾病。但是，精确的关系和基本机制仍然晦涩难懂。进一步确定自身免疫性疾病与精神分裂症, the mRNA expressions of various cytokines and Toll-like receptors (TLRs) in monocytes are examined by using RT-PCR. Additionally, ELISA and zymography were performed to determine the anti-cardiolipin antibody (aCL) andMMP9activity in serum form精神分裂症患者。值得注意的是，在精神分裂症患者，检测到TLR-3和TLR-5 mRNA的显着降低。此外，ACL抗体的水平显着升高，正阳性频率更高MMP9在患者的血清中检测到活性精神分裂症。Meanwhile, no significant association was found between each of the medications and aCL activity. These findings demonstrated autoimmune-related phenomena in精神分裂症患者并进一步提出精神分裂症和自身免疫性疾病。 |
| SCZ Keywords | 精神分裂症, schizophrenic |
| 4 | Psychiatry Res 2011 May 187: 341-6 |
| PMID | 20510460 |
| Title | Expression of anti-cardiolipin antibodies and inflammatory associated factors in patients with schizophrenia. |
| Abstract | 许多研究暗示了精神分裂症和自身免疫性疾病。但是，精确的关系和基本机制仍然晦涩难懂。进一步确定自身免疫性疾病与精神分裂症, the mRNA expressions of various cytokines and Toll-like receptors (TLRs) in monocytes are examined by using RT-PCR. Additionally, ELISA and zymography were performed to determine the anti-cardiolipin antibody (aCL) andMMP9activity in serum form精神分裂症患者。值得注意的是，在精神分裂症患者，检测到TLR-3和TLR-5 mRNA的显着降低。此外，ACL抗体的水平显着升高，正阳性频率更高MMP9在患者的血清中检测到活性精神分裂症。Meanwhile, no significant association was found between each of the medications and aCL activity. These findings demonstrated autoimmune-related phenomena in精神分裂症患者并进一步提出精神分裂症和自身免疫性疾病。 |
| SCZ Keywords | 精神分裂症, schizophrenic |
| 5 | Pharmacol Rep 2015 67：442-5 |
| PMID | 25933951 |
| Title | 基质金属蛋白酶-9（MMP9）基因的功能性多态性与精神分裂症及其缺陷亚型无关。 |
| Abstract | The deficit subtype of精神分裂症假设构成一个病理生理上不同的亚组精神分裂症patients suffering from enduring, idiopathic negative symptoms and various neuropsychological deficits. Matrix metalloproteinases (MMPs) are extracellularly acting endopeptidases the substrates of which are matrix and adhesion molecules. Recently,MMP9has been shown to be involved in various forms of synaptic plasticity, learning and memory consolidation. The primary aim of the present study was to evaluate associations between the functional MMP-9 -1562C/T gene polymorphism and the deficit and non-deficit subtypes of精神分裂症。 The study was conducted between 2009 and 2012. Deficit精神分裂症使用SDS诊断。该样本由468位患者，高加索人，是波兰下降，ICD 10诊断为精神分裂症：189 [51％男性]包括在非缺乏亚组中，279例患者[53％男性]被包括在赤字亚组中。对照组由532名受试者，即高加索人，是波兰下降[51％男性]。MMP -9 -1562C/T基因多态性使用荧光共振能量转移（FRET）方法和轻型循环器系统2.0进行基因分型。 The frequencies of genotypes and alleles did not differ between the精神分裂症患者和对照组。在基因型和等位基因频率方面，赤字和非缺乏患者没有差异。赤字患者与对照组以及非缺陷患者与对照组之间的基因型和等位基因频率没有发现差异。 我们没有发现证据表明功能性MMP-9 -1562C/T基因多态性与缺陷/非缺乏亚型之间的关联精神分裂症。 |
| SCZ Keywords | 精神分裂症, schizophrenic |
| 6 | Oncol. Rep. 2016 Feb 35: 999-1005 |
| PMID | 26719016 |
| Title | CHRNA7通过PI3K/AKT信号传导抑制LOVO人结肠直肠癌细胞的细胞侵袭和转移。 |
| Abstract | ？7神经元烟碱受体基因（CHRNA7）在大脑和周围都广泛表达，而其编码蛋白的编码蛋白（？7NACHR）属于烟碱乙酰胆碱受体家族。大量证据表明，7NACHR在慢性炎症和神经性疼痛信号传导中起重要作用，因此已被提出是治疗患者认知缺陷的潜在靶标精神分裂症注意缺陷多动障碍(ADHD)and Alzheimer's disease. The aim of the present study was to determine the role of endogenous ?7nAChR signaling in human colorectal cancer growth and metastasis. pLVX?CHRNA7 encoding the full length of CHRNA7 was constructed and transfected into LoVo human colorectal cancer cells. Cell proliferation was measured by Cell Counting Kit?8 (CCK?8), and cell migration and invasion were detected by Transwell chamber assays. Expression and activity of metastasis?related metalloproteinases (MMPs) were analyzed by western blotting and gelatin zymography, respectively. Activation of metastasis-related signaling molecules was detected by western blotting. LY294002 was used to specifically block the phosphatidylinositol 3?kinase/v?akt murine thymoma viral oncogene homologue (PI3K/Akt) pathway. We showed that concomitantly with an increase in ?7nAChR expression after transfection, LoVo cells presented reduced abilities for migration and invasion, which was accompanied by reduced expression levels of MMP?1 and MMP?9 as well as activation of the PI3K/Akt signaling pathway. The application of LY294002 restored the migration and invasion abilities of the LoVo cells bearing CHRNA7. Collectively, we conclude that overexpression of CHRNA7 negatively controls colorectal cancer LoVo cell invasion and metastasis via PI3K/Akt pathway activation and may serve as either a diagnostic marker or a therapeutic target for colorectal cancer metastasis. |
| SCZ Keywords | 精神分裂症, schizophrenic |