| 1 | Am. J. Med. Genet. B Neuropsychiatr. Genet. 2008 Apr 147: 351-5 |
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| PMID | 17948900 |
| Title | Is MYO9B the missing link between schizophrenia and celiac disease? |
| Abstract | There has long been discussion on the correlation betweenschizophreniaand autoimmune diseases (especially celiac disease), which makes the recently discovered celiac disease risk factor,MYO9B, an attractive functional and positional candidate gene forschizophrenia. To test this hypothesis we compared allele frequencies of threeMYO9Btag SNPs in 315schizophreniacases and 1,624 healthy controls in a genetic association study. Highly significant differences in allele frequencies betweenschizophrenia例和健康对照组观察for SNP rs2305767 in intron 14 ofMYO9B(P = 1.16 x 10(-4); OR 1.41, 95% CI 1.18-1.67). We demonstrate significant association of allelic variants inMYO9Bwithschizophrenia. To our knowledge, this is the first molecular genetic evidence for a correlation between autoimmune diseases and the risk of developingschizophrenia. |
| SCZ Keywords | schizophrenia |
| 2 | Am. J. Med. Genet. B Neuropsychiatr. Genet. 2011 Sep 156B: 709-19 |
| PMID | 21688385 |
| Title | No association observed between schizophrenia and non-HLA coeliac disease genes: integration with the initial MYO9B association with coeliac disease. |
| Abstract | schizophreniais a severe psychotic illness with a heterogeneous presentation and a devastating impact on social and occupational function. Worldwide variations inschizophreniaincidence rates suggest that local conditions may modify disease risk. The human leukocyte antigen (HLA) region has been confirmed to be associated withschizophreniaby genome-wide association studies in populations across the world. While the presence of autoimmune processes in a subgroup ofschizophreniacases is contentious, the immune system could allow environmental exposures to lead toschizophreniaby generating improper immune response. To investigate this topic, we reviewed the current evidence of the relationship betweenschizophreniaand coeliac disease. Based on this review, we performed genetic analysis of theMYO9Bgene and the IL-2/IL-21 locus by genotyping SNPs that have been previously associated with coeliac disease orschizophreniain 223 families, 108 unrelated individuals withschizophreniaand 120 controls. Finding no evidence for association with these two loci in our study samples, we applied meta-analytic techniques to combine our findings with previous reports. This synthesis, in light of our review of previous reports, suggests a differing developmental trajectory forschizophreniaand coeliac disease. It is possible that these two conditions do not share any functional overlap. |
| SCZ Keywords | schizophrenia |
| 3 | Psychiatr. Genet. 2015 Apr 25: 97 |
| PMID | 25710847 |
| Title | Lack of genetic association between the MYO9B locus and schizophrenia in a Chinese population. |
| Abstract | Jungerius et al. (2008) have reported that the myosin IXB (MYO9B) gene is strongly associated with susceptibility toschizophreniain a Dutch population. However, this initial work failed to be replicated in a British population (Law et al., 2011). The present study was then undertaken to examine whether the association ofMYO9Bwithschizophreniacould be replicated in a Chinese population. |
| SCZ Keywords | schizophrenia |