| 1 | Psychiatr. Genet. 2003 Dec 13: 205-9 |
|---|---|
| PMID | 14639047 |
| Title | NQO2基因和精神分裂症的插入/缺失多态性之间的可能关联。 |
| Abstract | Glutathione-S-transferases, NAD(P)H: quinone oxidoreductase1 (NQO1) and NRH: quinone oxidoreductase2 (NQO2) provide important cellular defences against the neurotoxicity induced by catecholamine-derived o-quinones and oxidative stress during redox cycling. In this study, we investigated the association between polymorphisms of theNQO2基因和精神分裂症。 我们分析了启动子和编码区域NQO2102例患者的基因精神分裂症对于234个对照，使用单链构象变化多态性和PCR直接序列分析以及RNA浓度NQO2在从外周血分离的白细胞中。 We identified 12 variants including the insertion/deletion (I/D) polymorphism of the 29 base pair nucleotide sequence in the promoter region. The frequency of the D allele was significantly higher in the精神分裂症组比对照组（p = 0.0109）。特别是，在具有剧本类型的病例指定的患者中，该值非常显着（p = 0.0016），而在Bonferroni校正后，显着性仍然存在。29个碱基对核苷酸序列包含SP1结合顺式元素的假定核心序列的四个重复序列，这对基因表达的激活很重要。我们的初步数据，尽管样本量还不够，但表明RNA的浓度NQO2in white blood cells isolated from peripheral blood was higher in individuals homozygous (II) for the I allele than in those heterozygous (ID) or homozygous (DD) for the D allele. 目前的数据表明，在启动子区域中删除了29个碱基对序列的个体NQO2基因可能会赋予某种形式的敏感性精神分裂症。 |
| SCZ Keywords | 精神分裂症, schizophrenic |
| 2 | Tissue Antigens 2003 12月62日：483-91 |
| PMID | 14617031 |
| Title | NQO2基因与氯氮平诱导的粒细胞增多症有关。 |
| Abstract | 氯氮平是一种具有非典型药理和临床特征的二苯并二氮卓类神经肽。该药物的治疗可能会因农业细胞增多症（AGR）而复杂。有缺陷的氧化机制可能是AGR的原因。候选基因，二氢膦酰胺核苷（NRH）喹酮氧化还原酶2（NQO2), which is involved in detoxification of drugs, was selected. This gene has been mapped to the short arm of chromosome six. The gene was studied by single-strand conformation polymorphism analysis and direct sequencing in 98精神分裂症接受氯氮平治疗的患者。这些患者中有十八位出现了AGR。发现编码区域中的十种多态性，内含子1和启动子区域中，其中两个是新颖的。AGR患者和对照组中第一个内含子中多态性的比较表明该部位可能与AGR有关。定量逆转录酶 - 聚合酶链反应分析表明，NQO2mRNA is low in AGR patients compared with the control group. Such a reduction in message suggests that theNQO2基因可能参与氯氮平诱导的AGR的发展。 |
| SCZ Keywords | 精神分裂症, schizophrenic |
| 3 | Psychiatr. Genet. 2003 Dec 13: 205-9 |
| PMID | 14639047 |
| Title | NQO2基因和精神分裂症的插入/缺失多态性之间的可能关联。 |
| Abstract | Glutathione-S-transferases, NAD(P)H: quinone oxidoreductase1 (NQO1) and NRH: quinone oxidoreductase2 (NQO2) provide important cellular defences against the neurotoxicity induced by catecholamine-derived o-quinones and oxidative stress during redox cycling. In this study, we investigated the association between polymorphisms of theNQO2基因和精神分裂症。 我们分析了启动子和编码区域NQO2102例患者的基因精神分裂症对于234个对照，使用单链构象变化多态性和PCR直接序列分析以及RNA浓度NQO2在从外周血分离的白细胞中。 We identified 12 variants including the insertion/deletion (I/D) polymorphism of the 29 base pair nucleotide sequence in the promoter region. The frequency of the D allele was significantly higher in the精神分裂症组比对照组（p = 0.0109）。特别是，在具有剧本类型的病例指定的患者中，该值非常显着（p = 0.0016），而在Bonferroni校正后，显着性仍然存在。29个碱基对核苷酸序列包含SP1结合顺式元素的假定核心序列的四个重复序列，这对基因表达的激活很重要。我们的初步数据，尽管样本量还不够，但表明RNA的浓度NQO2in white blood cells isolated from peripheral blood was higher in individuals homozygous (II) for the I allele than in those heterozygous (ID) or homozygous (DD) for the D allele. 目前的数据表明，在启动子区域中删除了29个碱基对序列的个体NQO2基因可能会赋予某种形式的敏感性精神分裂症。 |
| SCZ Keywords | 精神分裂症, schizophrenic |
| 4 | Tijdschr Psychiatr 2006 -1 48: 295-302 |
| PMID | 16955993 |
| Title | [氯氮平诱导的农业细胞增多症：遗传危险因素和免疫学解释模型]。 |
| Abstract | 氯氮平，一种用于治疗难治性的非典型抗精神病药精神分裂症, causes agranulocytosis in 0.8% of patients. The risk factors for clozapine-induced agranulocytosis (CIA) and the underlying mechanisms are unclear. 确定遗传和免疫的风险ctors for CIA, and on the basis of these findings to construct an explanatory model for CIA. 我们使用Medline（从1966年至2004年5月）回顾了文献，并使用搜索术语“氯氮平”和“ Agranulocytosis”（从1980年到2004年5月）进行了筛选（从1980年至2004年5月）。 We found 8 case-control studies that fulfilled our selection criteria. In精神分裂症患者中，CIA似乎与HLA（人白细胞抗原）基因的某些单倍型与TNF的4B，3D微卫星等位基因（肿瘤坏死因子），具有HSP 70（热休克蛋白），以及与HSP 70（热休克蛋白）的变异基因相关。NQO2（二氢膦酰胺核苷喹酮氧化还原酶）基因多态性。这些遗传发现大多数是相互关联的。这种基因异常可能在CIA中起重要的病因作用，并可能为CIA的免疫毒性解释模型提供基础。 似乎可以根据遗传和免疫毒性因素来解释中央情报局。该模型应帮助我们了解如何由各种抗精神病药以及如何治疗来引起肿瘤细胞增多症。但是，尚无法确定特别有CIA风险的患者。 |
| SCZ Keywords | 精神分裂症, schizophrenic |
| 5 | Schizophr Bull 2009 11月35日：1163-82 |
| PMID | 18552348 |
| Title | 精神分裂症易感基因直接与病原体生命周期有关：巨细胞病毒，流感，单纯疱疹，风疹和弓形虫弓形虫。 |
| Abstract | 许多基因涉及精神分裂症可以与谷氨酸能传播和神经塑性，少突胶质细胞功能以及其他与神经生物学和神经生物学和其他家庭有关精神分裂症表型。其他人似乎似乎参与了与该疾病有关的病原体的生命周期。例如，天冬氨酸葡萄糖苷酶（AGA），PLA2，SIAT8B，GALNT7或B3GAT1代谢化学配体与流感病毒，单纯疱疹，巨细胞病毒（CMV），Rubella，Rubella，Rubella，或Toxoplasma Gondii结合到这些化学配体。CMV使用表皮生长因子受体（EGR/EGFR）进入细胞，并且CMV基因代码用于白介素（IL-10）模拟于结合宿主同源受体IL10R的模拟物。单纯疱疹使用成纤维细胞生长因子受体（FGFR1）。KPNA3和RANBP5控制流感病毒的核进口。破坏了精神分裂症1(DISC1) controls the microtubule network that is used by viruses as a route to the nucleus, while DTNBP1, MUTED, and BLOC1S3 regulate endosomal to lysosomal routing that is also important in viral traffic. Neuregulin 1 activates ERBB receptors releasing a factor, EBP1, known to inhibit the influenza virus transcriptase. Other viral or bacterial components bind to genes or proteins encoded by CALR, FEZ1, FYN, HSPA1B, IL2, HTR2A, KPNA3, MED12, MED15, MICB,NQO2, PAX6, PIK3C3, RANBP5, or TP53, while the cerebral infectivity of the herpes simplex virus is modified by Apolipoprotein E (APOE). Genes encoding for proteins related to the innate immune response, including cytokine related (CCR5, CSF2RA, CSF2RB, IL1B, IL1RN, IL2, IL3, IL3RA, IL4, IL10, IL10RA, IL18RAP, lymphotoxin-alpha, tumor necrosis factor alpha [TNF]), human leukocyte antigen (HLA) antigens (HLA-A10, HLA-B, HLA-DRB1), and genes involved in antigen processing (angiotensin-converting enzyme and tripeptidyl peptidase 2) are all concerned with defense against invading pathogens. Human microRNAs (Hsa-mir-198 and Hsa-mir-206) are predicted to bind to influenza, rubella, or poliovirus genes. Certain genes associated with精神分裂症, including those also concerned with neurophysiology, are intimately related to the life cycles of the pathogens implicated in the disease. Several genes may affect pathogen virulence, while the pathogens in turn may affect genes and processes relevant to the neurophysiology of精神分裂症。对于此类基因，遗传研究中的关联强度可能是由病原体的存在来调节的，病原体在不同时间在不同人群中有所不同，这可能解释了困扰着这种研究的异质性。这种情况还表明，旨在消除与如此清晰相互作用的病原体的药物或疫苗精神分裂症易感基因可能会对疾病的发生产生巨大影响。 |
| SCZ Keywords | 精神分裂症, schizophrenic |