| 1 | J Neural Transm (Vienna) 2007 Feb 114: 249-54 |
|---|---|
| PMID | 16897606 |
| Title | No association between the genetic polymorphisms in the RTN4R gene and schizophrenia in the Chinese population. |
| Abstract | The RTN4R gene is located in the 22q11 region and it encodes a subunit of the receptor complex (RTN4R-p75NTR) which results in neuronal growth inhibitory signals in response to Nogo-66, MAG orOMGsignaling. Previous studies have suggested that RTN4R might act as a potential candidate forschizophreniasusceptibility loci. We genotyped four SNPs within the gene and conducted a case-control study and TDT analysis, involving 707schizophrenicpatients, 689 controls and 372 unrelated small nuclear families withschizophrenicoffspring in the Chinese population. We examined allele and genotype frequencies and haplotype distributions in both family- and nonfamily-based samples. Our results suggest that there is no significant association between the genetic polymorphisms andschizophreniain the Han Chinese population. |
| SCZ Keywords | schizophrenia, schizophrenic |
| 2 | J Neural Transm (Vienna) 2007 Feb 114: 249-54 |
| PMID | 16897606 |
| Title | No association between the genetic polymorphisms in the RTN4R gene and schizophrenia in the Chinese population. |
| Abstract | The RTN4R gene is located in the 22q11 region and it encodes a subunit of the receptor complex (RTN4R-p75NTR) which results in neuronal growth inhibitory signals in response to Nogo-66, MAG orOMGsignaling. Previous studies have suggested that RTN4R might act as a potential candidate forschizophreniasusceptibility loci. We genotyped four SNPs within the gene and conducted a case-control study and TDT analysis, involving 707schizophrenicpatients, 689 controls and 372 unrelated small nuclear families withschizophrenicoffspring in the Chinese population. We examined allele and genotype frequencies and haplotype distributions in both family- and nonfamily-based samples. Our results suggest that there is no significant association between the genetic polymorphisms andschizophreniain the Han Chinese population. |
| SCZ Keywords | schizophrenia, schizophrenic |
| 3 | Am. J. Med. Genet. B Neuropsychiatr. Genet. 2011 Jul 156B: 581-92 |
| PMID | 21563301 |
| Title | Association study of Nogo-related genes with schizophrenia in a Japanese case-control sample. |
| Abstract | Many studies have suggested that myelin dysfunction may be causally involved in the pathogenesis ofschizophrenia. Nogo (RTN4), myelin-associated glycoprotein (MAG) and oligodendrocyte myelin glycoprotein (OMG) all bind to the common receptor, Nogo-66 receptor 1 (RTN4R). We examined 68 single nucleotide polymorphisms (SNPs) (51 with genotyping and 17 with imputation analysis) from these four genes for genetic association withschizophrenia,使用2120病例对照样本e Japanese population. Allelic tests showed nominally significant association of two RTN4 SNPs (P = 0.047 and 0.037 for rs11894868 and rs2968804, respectively) and two MAG SNPs (P = 0.034 and 0.029 for rs7249617 and rs16970218, respectively) withschizophrenia. The MAG SNP rs7249617 also showed nominal significance in a genotypic test (P = 0.017). In haplotype analysis, the MAG haplotype block including rs7249617 and rs16970218 showed nominal significance (P = 0.008). These associations did not remain significant after correction for multiple testing, possibly due to their small genetic effect. In the imputation analysis of RTN4, the untyped SNP rs2972090 showed nominally significant association (P = 0.032) and several imputed SNPs showed marginal associations. Moreover, in silico analysis (PolyPhen) of a missense variant (rs11677099: Asp357Val), which is in strong linkage disequilibrium with rs11894868, predicted a deleterious effect on Nogo protein function. Despite a failure to detect robust associations in this Japanese cohort, our nominally positive signals, taken together with previously reported biological and genetic findings, add further support to the "disturbed myelin system theory ofschizophrenia" across different populations. |
| SCZ Keywords | schizophrenia, schizophrenic |