| 1 | int。J. Neuropsychopharmacol。2010年7月13日：793-8 |
|---|---|
| PMID | 20196918 |
| Title | 精神分裂症的严重程度和氯氮平治疗结果与催产基因的关联。 |
| Abstract | 抗精神病药是症状治疗患者的最佳方法schizophrenia; however, there is a significant variability in clinical response to these psychotropic medications. Previous findings connect oxytocin (OXT) withschizophrenia和抗精神病药作用。因此，我们评估了oxt和oxt受体（Oxtr）基因可能在症状严重程度和氯氮平治疗反应中起作用schizophrenia主题。OXT基因中的RS2740204变体与治疗反应显着相关（1000个排列后P = 0.042），并在我们样本中名义上与负面症状相关。此外，在Oxtrwere nominally associated with severity of overall symptoms accessed using the Brief Psychiatric Rating Scale (rs237885, rs237887) as well as on the improvement of the positive symptoms (rs11706648, rs4686301, rs237899). Additional association studies in independent samples will be able evaluate whether OXT andOxtr基因在氯氮平治疗结果中真正发挥了作用。 |
| SCZ Keywords | schizophrenia, schizophrenic |
| 2 | J Affect Disord 2010 Dec 127: 31-7 |
| PMID | 20488544 |
| Title | The association between oxytocin receptor gene (OXTR) polymorphisms and affective temperaments, as measured by TEMPS-A. |
| Abstract | Oxytocin is associated with social interaction, trust, and affectivity. Affective temperaments are traits based on Kraepelin's typological definition of the "fundamental states" of manic-depressive illness. These states can be measured by the Temperament Evaluation of Memphis, Pisa, Paris and San Diego-Autoquestionnaire version (TEMPS-A). The objective of this study is to assess the association between oxytocin receptor gene (Oxtr) polymorphisms and affective temperaments. 参与者由493个遗传无关的，非临床的日本受试者（307名男性和186名女性）组成。迷你国际神经精神访谈（MINI）用于筛查和排除那些终身诊断的人schizophreniaor other psychotic disorders. FifteenOxtrtag single nucleotide polymorphisms (SNPs) were genotyped using TaqMan� or direct sequencing. The Haploview 4.1. software determined the haplotype block structure. Haplotype-based quantitative trait association analysis with Bonferroni correction using PLINK 1.06 software was used to assess the association between haplotypes and the following affective temperaments: depressive, cyclothymic, hyperthymic, irritable, and anxious. Two haplotype blocks were identified on theOxtr。抑郁气质与最频繁的单倍型GGGTGTC（RS11131149/RS2243370/RS2243369/RS13316193/RS22554298/RS22268493/RS2268491）（校正P <0.05）。 这项研究由公司的参与者组成，效果大小很小。 调查结果表明Oxtrhaplotype is associated with a discrete depressive temperament. Clarification of the biological basis of this temperamental trait may help to elucidate the pathophysiology of depressive disorder. |
| SCZ Keywords | schizophrenia, schizophrenic |
| 3 | 精神病学临床。Neurosci。2012年12月66日：622 |
| PMID | 23252931 |
| Title | Oxytocin receptor (OXTR) gene and risk of schizophrenia: case-control and family-based analyses and meta-analysis in a Japanese population. |
| Abstract | -1 |
| SCZ Keywords | schizophrenia, schizophrenic |
| 4 | PLoS ONE 2012 -1 7: e51882 |
| PMID | 23284802 |
| Title | Association between oxytocin receptor gene polymorphisms and self-rated 'empathic concern' in schizophrenia. |
| Abstract | 非肽催产素（OXT）及其受体（Oxtr）与人类的社会认知，同理心，情感和压力调节有关。先前的研究报告了OXT和Oxtrgenetic polymorphisms and risk for disorders characterized by impaired socio-emotional functioning, such asschizophrenia和自闭症。在这里，我们研究了两种单核苷酸多态性（SNP）的影响Oxtrgene on a measure of socio-emotional functioning inschizophrenic患者。OxtrSNPs that were previously investigated in other studies were genotyped in 145 patients diagnosed withschizophrenia根据DSM-IV和145个健康对照，年龄和性别匹配。人际反应指数（IRI）用于评估认知（“透视视图”），情感（“移情关注”）和自我相关（“个人困扰”）的同理心方面。没有观察到基因型频率的群体差异。Mancova揭示了重要的主（F [1,282]？=？10.464; P <0.01）和相互作用效应（诊断基因型：F [1,282]？=？4.329; P <0.05）OxtrSNP RS2254298（a> gg）具有“同理心关注”。在schizophrenia组，线性回归分析确定Oxtrrs2254298 genotype, PANSS negative and general symptom score, and age of disease onset as being significantly associated with 'empathic concern'.Oxtrrs2254298 significantly impacted PANSS general psychopathology scores. No associations were found forOxtrRS53576，IRI“视角获取”或“个人遇险”评级。我们的初步发现支持有关参与的假设Oxtrrs2254298 in emotional empathy inschizophrenicand healthy individuals, warranting independent replication. |
| SCZ Keywords | schizophrenia, schizophrenic |
| 5 | PLoS ONE 2012 -1 7: e51882 |
| PMID | 23284802 |
| Title | Association between oxytocin receptor gene polymorphisms and self-rated 'empathic concern' in schizophrenia. |
| Abstract | 非肽催产素（OXT）及其受体（Oxtr）与人类的社会认知，同理心，情感和压力调节有关。先前的研究报告了OXT和Oxtrgenetic polymorphisms and risk for disorders characterized by impaired socio-emotional functioning, such asschizophrenia和自闭症。在这里，我们研究了两种单核苷酸多态性（SNP）的影响Oxtrgene on a measure of socio-emotional functioning inschizophrenic患者。OxtrSNPs that were previously investigated in other studies were genotyped in 145 patients diagnosed withschizophrenia根据DSM-IV和145个健康对照，年龄和性别匹配。人际反应指数（IRI）用于评估认知（“透视视图”），情感（“移情关注”）和自我相关（“个人困扰”）的同理心方面。没有观察到基因型频率的群体差异。Mancova揭示了重要的主（F [1,282]？=？10.464; P <0.01）和相互作用效应（诊断基因型：F [1,282]？=？4.329; P <0.05）OxtrSNP RS2254298（a> gg）具有“同理心关注”。在schizophrenia组，线性回归分析确定Oxtrrs2254298 genotype, PANSS negative and general symptom score, and age of disease onset as being significantly associated with 'empathic concern'.Oxtrrs2254298 significantly impacted PANSS general psychopathology scores. No associations were found forOxtrRS53576，IRI“视角获取”或“个人遇险”评级。我们的初步发现支持有关参与的假设Oxtrrs2254298 in emotional empathy inschizophrenicand healthy individuals, warranting independent replication. |
| SCZ Keywords | schizophrenia, schizophrenic |
| 6 | World J. Biol. Psychiatry 2013 Sep 14: 500-8 |
| PMID | 22651577 |
| Title | Oxytocin and oxytocin receptor gene polymorphisms and risk for schizophrenia: a case-control study. |
| Abstract | Dysfunctions of the "social brain" belong to the core features ofschizophrenia。神经激素催产素（OXT），通过其特定受体介导（Oxtr），参与了社会行为和社会认知的调节。先前的研究表明，Obeplay苹果手机能用吗XT系统基因在社会互惠障碍中的作用。初步证据指出了外围OXT水平以及oxt和oxt的关联Oxtr具有精神病症状和治疗反应的基因多态性schizophrenia。这项研究旨在确定OXT和Oxtr遗传变异schizophreniasusceptibility. Using n = 406 individuals diagnosed withschizophreniaaccording to DSM-IV and n = 406 healthy controls matched for age and gender in a case-control design, two single nucleotide polymorphisms (SNPs) within the OXT gene (rs2740204, rs2740210) and four SNPs within theOxtrgene (rs53576, rs237880, rs237885, rs237902) that were previously investigated in other studies were genotyped. CHI（2）测试暗示了有关的显着关联OxtrSNP RS53576（A> G）（P = 0.008）和RS237885（T> G）（P = 0.025），诊断为schizophrenia。事后ANCOVA揭示了重大的关联OxtrSNP rs53576具有一般心理病理学和RS237902，具有负症状分数schizophrenic患者。 我们的发现支持关于催产毒素能基因变异的假设schizophrenia脆弱性和保证独立复制。 |
| SCZ Keywords | schizophrenia, schizophrenic |
| 7 | World J. Biol. Psychiatry 2013 Sep 14: 500-8 |
| PMID | 22651577 |
| Title | Oxytocin and oxytocin receptor gene polymorphisms and risk for schizophrenia: a case-control study. |
| Abstract | Dysfunctions of the "social brain" belong to the core features ofschizophrenia。神经激素催产素（OXT），通过其特定受体介导（Oxtr），参与了社会行为和社会认知的调节。先前的研究表明，Obeplay苹果手机能用吗XT系统基因在社会互惠障碍中的作用。初步证据指出了外围OXT水平以及oxt和oxt的关联Oxtr具有精神病症状和治疗反应的基因多态性schizophrenia。这项研究旨在确定OXT和Oxtr遗传变异schizophreniasusceptibility. Using n = 406 individuals diagnosed withschizophreniaaccording to DSM-IV and n = 406 healthy controls matched for age and gender in a case-control design, two single nucleotide polymorphisms (SNPs) within the OXT gene (rs2740204, rs2740210) and four SNPs within theOxtrgene (rs53576, rs237880, rs237885, rs237902) that were previously investigated in other studies were genotyped. CHI（2）测试暗示了有关的显着关联OxtrSNP RS53576（A> G）（P = 0.008）和RS237885（T> G）（P = 0.025），诊断为schizophrenia。事后ANCOVA揭示了重大的关联OxtrSNP rs53576具有一般心理病理学和RS237902，具有负症状分数schizophrenic患者。 我们的发现支持关于催产毒素能基因变异的假设schizophrenia脆弱性和保证独立复制。 |
| SCZ Keywords | schizophrenia, schizophrenic |
| 8 | Expert Opin Ther Pat 2014 Jan 24: 29-46 |
| PMID | 24094047 |
| Title | Novel oxytocin receptor agonists and antagonists: a patent review (2002 - 2013). |
| Abstract | Oxytocin is a nine amino acid cyclic peptide hormone with a high degree of uterotonic activity. The oxytocin receptor (Oxtr) is most strongly expressed in the uterus and mammary gland, but can also be found in regions of the brain, showing a neurotransmitter-like activity. TheOxtr淘汰小鼠在生育或性行为上没有明显的缺陷，但表现出异常的社会行为。所有这些都表明Oxtrmay become an important therapeutic target for the treatment of a wide range of conditions. 本文将强调发现和发展的重大进展Oxtragonists and antagonists in the patent literature between January 2002 and May 2013. 在过去的十年中，累积证据支持了激活的观念Oxtr可以对人类认知和社会行为产生积极影响。作者认为，新的激动剂和拮抗剂可能在治疗诸如焦虑，自闭症或schizophrenia。甚至可能年龄较大Oxtr用来克服与劳动有关的功能障碍的激动剂和拮抗剂也可能对人类的社会行为产生重大影响。 |
| SCZ Keywords | schizophrenia, schizophrenic |
| 9 | Psychoneuroendocrinology 2014年7月45日：128-41 |
| PMID | 24845184 |
| Title | The neuroanatomical distribution of oxytocin receptor binding and mRNA in the male rhesus macaque (Macaca mulatta). |
| Abstract | 恒河猕猴(解剖)是一个文件夹内t primate model for social cognition, and recent studies have begun to explore the impact of oxytocin on social cognition and behavior. Macaques have great potential for elucidating the neural mechanisms by which oxytocin modulates social cognition, which has implications for oxytocin-based pharmacotherapies for psychiatric disorders such as autism andschizophrenia。Previous attempts to localize oxytocin receptors (Oxtr) in the rhesus macaque brain have failed due to reduced selectivity of radioligands, which in primates bind to bothOxtrand the structurally similar vasopressin 1a receptor (AVPR1A). We have developed a pharmacologically-informed competitive binding autoradiography protocol that selectively revealsOxtrand AVPR1A binding sites in primate brain sections. Using this protocol, we describe the neuroanatomical distribution ofOxtr在猕猴。最后，我们使用原位杂交来本地化OxtrmRNA. Our results demonstrate thatOxtrexpression in the macaque brain is much more restricted than AVPR1A.Oxtris largely limited to the nucleus basalis of Meynert, pedunculopontine tegmental nucleus, the superficial gray layer of the superior colliculus, the trapezoid body, and the ventromedial hypothalamus. These regions are involved in a variety of functions relevant to social cognition, including modulating visual attention, processing auditory and multimodal sensory stimuli, and controlling orienting responses to visual stimuli. These results provide insights into the neural mechanisms by which oxytocin modulates social cognition and behavior in this species, which, like humans, uses vision and audition as the primary modalities for social communication. |
| SCZ Keywords | schizophrenia, schizophrenic |
| 10 | 精神分裂。res。2014年11月159日：353-7 |
| PMID | 25244972 |
| Title | 催产素受体基因型与精神分裂症患者的社会认知表现之间的关联。 |
| Abstract | Individuals withschizophreniaoften show substantial deficits in social cognitive abilities, which are strongly associated with social functioning. To advance our understanding of the genetic variation that is associated with social cognitive deficits inschizophrenia，我们基因分型74schizophreniaoutpatients who completed social cognitive performance measures assessing mentalizing, social perception, and emotional intelligence, as well as clinical symptoms. We assessed seven single nucleotide polymorphisms (SNPs) of the oxytocin receptor (Oxtr）以前发现与社会情感过程显示可复制的关联。对于七个SNP之一，RS2268493，“ T”等位基因与复合社会认知指数的性能较差以及对心理和社会知觉的特定测试显着相关。SNP均与临床症状有关。尽管样本量很小，但这些发现为参与遗传变异的初始支持提供了最初的支持Oxtr在社会认知障碍中schizophrenia。 |
| SCZ Keywords | schizophrenia, schizophrenic |
| 11 | 基因脑行为。2014年1月13日：104-17 |
| PMID | 23927712 |
| Title | Theory of mind and the social brain: implications for understanding the genetic basis of schizophrenia. |
| Abstract | 全基因组关联研究schizophrenia最近，我们对这种疾病的复杂遗传结构的理解取得了重大进展。已经确定了许多遗传基因座，现在需要功能研究。一种方法涉及研究它们与神经影像和神经认知性内表型的相关性。心理理论（汤姆）缺陷已经很好地确定schizophreniaand they appear to fulfill criteria for being considered an endophenotype. We aim to review the behavioral and neuroimaging-based studies of ToM inschizophrenia, assess its suitability as an endophenotype, discuss current findings, and propose future research directions. Suitable research articles were sourced from a comprehensive literature search and from references identified through other studies. ToM deficits are repeatable, stable, and heritable: First-episode patients, those in remission and unaffected relatives all show deficits. Activation and structural differences in brain regions believed important for ToM are also consistently reported inschizophrenia患者处于疾病的各个阶段，尽管迄今为止尚未研究未受影响的亲戚。beplay苹果手机能用吗使用TOM作为内表型的研究提供了与单核苷酸多态性（SNP）和特定拷贝数变化（CNV）（例如22Q11.2缺失综合征）的有趣遗传关联。我们得出的结论是，汤姆是在未来的研究中考虑的重要认知内表型，以解决复杂的遗传结构schizophrenia, and may help identify more homogeneous clinical sub-types for further study. |
| SCZ Keywords | schizophrenia, schizophrenic |
| 12 | Psychoneuroendocrinology 2014 Apr 42：225-36 |
| PMID | 24636519 |
| Title | 慢性中枢输注催产素对焦虑，催产素受体结合和与应力相关参数的剂量依赖性作用。 |
| Abstract | 慢性社会心理压力是各种情感和躯体疾病的公认危险因素。在已建立的慢性社会心理压力的鼠模型中，暴露于慢性下属菌落外壳（CSC）导致生理，行为，神经内分泌和免疫学参数的改变，包括焦虑，肾上腺肥大和乳腺癌的持续增长。基于啮齿动物和人类急性给药后催产素（OXT）的压力保护性和抗焦虑特性，我们研究的主要目的是评估OXT剂量的长期给药是否依赖性地依赖性地影响雄性小鼠的行为和生理学，以至于在人类中的治疗用途，将主要使用慢性治疗方法。此外，我们研究了CSC期间长期给药是否阻止应力引起的后果。我们的结果表明，在高（10ng/h）下对OXT（15天）输注慢性脑室（ICV），但在低（1ng/h）剂量下却不会诱导抗焦虑观表型，并伴随着Oxt受体的同时减少（Oxtr）结合隔膜内，基底外侧和内侧杏仁核以及中间raphe核。此外，我们证明了在19天的CSC暴露期间慢性ICV输注OXT（1NG/H）可防止过度焦虑，胸腺萎缩，肾上腺肥大和降低体外肾上腺ACTH敏感性。因此，鉴于在慢性OXT治疗后同时看到的两种负面效果，似乎是剂量依赖性的，需要对持久治疗效果进行更深入的了解，然后才能考虑将OXT考虑用于长期治疗用于治疗心理病理，例如自闭症，schizophreniaor anxiety-disorders. |
| SCZ Keywords | schizophrenia, schizophrenic |
| 13 | Front Hum Neurosci 2015 -1 9：9 |
| PMID | 25667571 |
| Title | 催产素受体基因中的遗传变异与情绪戒断之间的关联，而不是催产素途径基因与精神病诊断之间的关联。 |
| Abstract | Social dysfunction is common in patients with psychotic disorders. Oxytocin is a neuropeptide with a central role in social behavior. This study aims to explore the relationship between oxytocin pathway genes and symptoms related to social dysfunction in patients with psychotic disorders. We performed association analyses between four oxytocin pathway genes (OXT,Oxtr, AVP, and CD38) and four areas of social behavior-related psychopathology as measured by Positive and Negative Syndrome Scale. For this purpose, we used both a polygenic risk score (PGRS) and singleOxtr候选单核苷酸多态性先前在文献中报道（RS53576，RS237902和RS2254298）。总共包括734名患有DSM-IV精神病谱系障碍和420个健康对照的受试者。催产素途径PGRS是根据独立的精神基因组学联盟研究样本计算的。情绪戒断的症状与先前报道的症状之间存在显着关联Oxtr在53576卢比中冒险a。催产素途径基因变异与精神病疾病的诊断之间没有显着关联。我们的发现表明，虽然催产素途径基因似乎并不有助于对精神病的易感性，但在Oxtrgene might play a role in the development of impaired social behavior. |
| SCZ Keywords | schizophrenia, schizophrenic |
| 14 | 是。J. Med。基因。B Neuropsychiatr。基因。2015年10月168日：609-16 |
| PMID | 26174935 |
| Title | Oxytocin system social function impacts in children with attention-deficit/hyperactivity disorder. |
| Abstract | 调查变形之间的关系isms and social functioning of children with Attention Deficit/Hyperactivity Disorder (ADHD), according to the polymorphism of three oxytocin receptor (Oxtr）基因（RS53576，RS13316193和RS2268493）。在同一中学和中学中，共有198名儿童学习，并在年龄和性别方面进行匹配（99 ADHD，99个控制） - 本研究中包括。情感障碍的时间表和schizophrenia为了建立临床诊断，用于学龄儿童和终身版本。应用社会互惠量表（SRS）用于评估社会功能。从颊粘膜样品中分离出总基因组DNA。根据RS2268493，RS13316193和RS53576基因型分布（P = 0.078，P = 0.330，P = 0.330和P = 0.149），ADHD和对照组之间没有明显差异。但是，对照组T等位基因频率Oxtr单核苷酸多态性（SNP）RS2268493显着高于ADHD组（P = 0.024）。与对照组相比，ADHD组在SRS量表上的得分较高（SRS总数； Z =？ - 21,135，P <0.001）。ADHD组中T/T基因型和C等位基因的儿童之间的SRS量表得分没有显着差异（SRS总数； Z =？ - 0.543，p = 0.587）。等位基因分布Oxtr与对照组相比，ADHD组的基因SNP RS2268493在ADHD组中有显着差异。该观察结果对于了解多动症中的潜在生物基础设施和发展治疗方式很重要。 |
| SCZ Keywords | schizophrenia, schizophrenic |
| 15 | Biol. Psychiatry 2016 Feb 79: 174-84 |
| PMID | 26392129 |
| Title | 催产素途径基因：影响人类隶属关系，社会性和心理病理学的进化古代系统。 |
| Abstract | 催产素（OT）是源自祖先肽的非肽信号分子，出现在所有脊椎动物和几种无脊椎动物物种的不同变体中。在整个动物进化过程中，神经抑制剂信号已通过生物体调节对迅速变化的环境的反应进行了调整。OT样分子家族会影响与繁殖，稳态和能量平衡有关的外围组织，以及从线虫到人类到人类的社会行为，压力调节和社会学习的神经调节。在描述了OT信号途径之后，我们回顾了对人类最广泛研究的三个基因的研究：OT受体（beplay苹果手机能用吗Oxtr), the structural gene for OT (OXT/neurophysin-I), and CD38. Consistent with the notion that sociality should be studied from the perspective of social life at the species level, we address human social functions in relation to OT-pathway genes, including parenting, empathy, and using social relationships to manage stress. We then describe associations between OT-pathway genes with psychopathologies involving social dysfunctions such as autism, depression, orschizophrenia。人类研究特别beplay苹果手机能用吗强调了两个Oxtrsingle nucleotide polymorphisms (rs53576, rs2254298) with fewer studies focusing on otherOxtr(rs7632287, rs1042778, rs2268494, rs2268490), OXT (rs2740210, rs4813627, rs4813625), and CD38 (rs3796863, rs6449197) single nucleotide polymorphisms.总体而言，研究提供了证据证明OT-Pathway基因参与人类社会功能，但也表明诸如性别，文化和早期环境等因素经常混淆尝试复制第一发现的尝试。最后，我们通过讨论表观遗传学，在进化观点中的概念含义以及未来的方向，尤其是需要完善表型，仔细表征早期环境并纳入生态环境中社会行为的观察结果。 |
| SCZ Keywords | schizophrenia, schizophrenic |
| 16 | Biol Psychiatry Cogn Neurosci Neuroimaging 2016 Mar 1: 141-151 |
| PMID | 26977453 |
| Title | 性别和诊断与情绪处理以及精神病性疾病中的颞叶和额叶脑体积之间的性别与催产素受体基因的DNA甲基化之间的特定关联。 |
| Abstract | The oxytocin (OT) system, including receptor epigenetic mechanisms, has been shown to influence emotion processing, especially in females. Whether OT receptor (Oxtr）与疾病相关的社会认知和大脑解剖结构中与疾病相关的障碍有关的精神疾病的表观遗传改变尚不清楚。 Participants with affective and nonaffective psychotic disorders (92 women, 75 men) and healthy controls (38 women, 37 men) from the Chicago site of the BSNIP study completed the Penn Emotion Recognition Test (ER-40), a facial emotion recognition task. We measured cytosine methylation at site -934 upstream of theOxtrstart codon in DNA from whole blood, and for the first time their relationship with plasma OT levels assessed by enzyme-immunoassay. Volumes of brain regions supporting social cognition were measured from MRI scans using FreeSurfer. 具有原型的患者schizophrenia比具有概念性双极特征的特征显示出更高的DNA甲基化水平。女性的甲基化高于男性，并且与女性患者和对照组的情绪识别较差有关。较大的甲基化与先前与社会认知相关的颞叶和额叶区域中的少量与较小的体积有关，但仅在健康的女性和女性中schizophrenia。 DNA methylation of theOxtrsite -934 was higher inschizophrenia频谱比双极患者。在患者中，它与社会认知和神经解剖结构的行为缺陷有关，仅在schizophrenia频谱个体。 |
| SCZ Keywords | schizophrenia, schizophrenic |