| 1 | Psychiatr. Genet. 2012 Feb 22: 1-14 |
|---|---|
| PMID | 21970977 |
| Title | Multiple genes in the 15q13-q14 chromosomal region are associated with schizophrenia. |
| Abstract | The chromosomal region, 15q13-q14, including the ?7 nicotinic acetylcholine receptor gene, CHRNA7, is a replicated region for精神分裂症. This study fine-mapped genes at 15q13-q14 to determine whether the association is unique to CHRNA7. Family-based and case-control association studies were performed on Caucasian-non-Hispanic and African-American individuals from 120 families as well as 468 individual patients with精神分裂症and 144 well-characterized controls. Single-nucleotide polymorphism (SNP) markers were genotyped, and association analyses carried out for the outcomes of精神分裂症, smoking, and smoking in精神分裂症. Three genes were associated with精神分裂症in both ethnic populations: TRPM1,KLF13, and RYR3. Two SNPs in CHRNA7 were associated with精神分裂症in African-Americans, and a second SNP in CHRNA7 was significant for an association with smoking and smoking in精神分裂症在白种人。 Results of these studies support association of the 15q13-q14 region with精神分裂症. The broad positive association suggests that more than one 15q gene may be contributing to the disorder, either in combination or through a regulatory mechanism. |
| SCZ Keywords | 精神分裂症 |