| 1 |
点。105年j .地中海,麝猫。2001年4月:246 - 9 |
| PMID |
11353443 |
| 标题 |
Lack of association between schizophrenia and the phospholipase-A(2) genes cPLA2 and sPLA2. |
| 摘要 |
The well-established role of genetic factors in the etiology ofschizophreniatogether with reports of allelic association with cPLA2, a phospholipase-A(2) gene, a reported increase of phospholipase-A(2) activity, and the phospholipase-A(2) hypothesis of Horrobin et al. [1995: Med Hypotheses 45:605-613] strongly support cPLA2 (PLA2G4A) and sPLA2 (PLA2G1B) as candidate genes forschizophrenia。In search for allelic association between these phospholipase-A(2) genes andschizophrenia, two samples of Chinese and European origins, in total 328 unrelatedschizophrenicpatients and their parents, were investigated using Falk and Rubinstein's haplotype relative risk method. Both genes showed marginally significant evidence for association in the total sample (P
schizophrenia。Additional studies will be necessary to rule out a possible confounding effect of niacin sensitivity as postulated by Hudson et al. [1999: Biol Psychiatr 46:401-405]. |
| SCZ关键字 |
schizophrenia, schizophrenic |
| 2 |
点。105年j .地中海,麝猫。2001年4月:246 - 9 |
| PMID |
11353443 |
| 标题 |
Lack of association between schizophrenia and the phospholipase-A(2) genes cPLA2 and sPLA2. |
| 摘要 |
The well-established role of genetic factors in the etiology ofschizophreniatogether with reports of allelic association with cPLA2, a phospholipase-A(2) gene, a reported increase of phospholipase-A(2) activity, and the phospholipase-A(2) hypothesis of Horrobin et al. [1995: Med Hypotheses 45:605-613] strongly support cPLA2 (PLA2G4A) and sPLA2 (PLA2G1B) as candidate genes forschizophrenia。In search for allelic association between these phospholipase-A(2) genes andschizophrenia, two samples of Chinese and European origins, in total 328 unrelatedschizophrenicpatients and their parents, were investigated using Falk and Rubinstein's haplotype relative risk method. Both genes showed marginally significant evidence for association in the total sample (P
schizophrenia。Additional studies will be necessary to rule out a possible confounding effect of niacin sensitivity as postulated by Hudson et al. [1999: Biol Psychiatr 46:401-405]. |
| SCZ关键字 |
schizophrenia, schizophrenic |
| 3 |
Prostaglandins Leukot。当然。Fatty Acids 2004 Dec 71: 405-8 |
| PMID |
15519500 |
| 标题 |
No association between the PTGS2/PLA2G4A locus and schizophrenia in a Chinese population. |
| 摘要 |
The present study was undertaken to replicate an association between the PTGS2/PLA2G4A轨迹和schizophreniaamong a Chinese population. We recruited 168 Chinese parent-offspring trios of Han descent, consisting of fathers, mothers and affected offspring withschizophrenia。Of 3 informative SNPs genotyped, no one showed allelic association withschizophrenia;the haplotype analysis also failed to capture a haplotypic association with the illness. Because the frequencies of alleles and genotypes of SNPs analyzed differ in the Chinese population as compared with a British population that initially showed the genetic association between the PTGS2/PLA2G4A轨迹和schizophrenia, the ethnic background may be a major reason for poor replication of the initial finding. |
| SCZ关键字 |
schizophrenia, schizophrenic |
| 4 |
Prostaglandins Leukot。当然。脂肪酸2004年4月70日：413-5 |
| PMID |
15041036 |
| 标题 |
A study of a genetic association between the PTGS2/PLA2G4A locus and schizophrenia. |
| 摘要 |
Six single nucleotide polymorphisms (SNPs) present in the PTGS2/PLA2G4A在118个英国家庭中发现了基因座schizophreniapatients. The transmission disequilibrium test showed that SNP4 located in the 5'-flanking region of thePLA2G4Agene was associated withschizophreniaand that the haplotype analysis also showed a genetic association between the PTGS2 gene andschizophrenia。Because these two genes are arranged in a head-to-head configuration and separated by just about 149kb of DNA, they may have a combined effect on susceptibility toschizophreniain some cases. |
| SCZ关键字 |
schizophrenia, schizophrenic |
| 5 |
Prostaglandins Leukot。当然。Fatty Acids 2005 Dec 73: 419-22 |
| PMID |
16213696 |
| 标题 |
A family based study of the genetic association between the PLA2G4D gene and schizophrenia. |
| 摘要 |
The present study detected two single nucleotide polymorphisms (SNPs) at the PLA2G4D locus, rs2459692 and rs4924618, to investigate a genetic association between the PLA2G4D gene andschizophrenia。总共招募了236个中国父母三下的han下降三重奏进行遗传分析。传输不平衡测试（TDT）未显示rs2459692（CHI（2）= 0.217，p = 0.641）或RS4924618（CHI（2）= 0.663，P = 0.416）的等位基因关联。为了查看PLA2G4D基因座与其他三个PLA2G4基因的综合作用，我们将上述两个SNP应用于条件标记，以测试疾病关联的配对组合。等位基因（COA）测试的条件显示RS2459692-的关联较弱PLA2G4Acombination (chi(2) = 6.03, df = 2, P = 0.049), the rs2459692-PLA2G4B combination (chi(2) = 7.16, df = 3, P = 0.028) and the rs4924618-PLA2G4C combination (chi(2) = 7.01, df = 2, P = 0.03), whereas the conditioning on genotype (COG) test showed a weak association only for the rs4924618-PLA2G4C combination (chi(2) = 8.52, df = 3, P = 0.036). Because we performed a multi-locus analysis in this study, the weak association shown by the conditional tests could make little biological sense. In conclusion, the PLA2G4D gene may not be involved in a susceptibility toschizophrenia。 |
| SCZ关键字 |
schizophrenia, schizophrenic |
| 6 |
Prostaglandins Leukot。当然。Fatty Acids 2005 Dec 73: 441-5 |
| PMID |
16181776 |
| 标题 |
A study of the combined effect of the CLDN5 locus and the genes for the phospholipid metabolism pathway in schizophrenia. |
| 摘要 |
本研究试图测试CLDN5基因和对于磷脂代谢途径的综合作用，包括PTGS1，PTGS2，PTGS2，PLA2G4Aand PLA2G4C. We detected five single nucleotide polymorphisms (SNPs) present in these genes among 131 British family trios ofschizophrenicpatients. The transmission disequilibrium test (TDT) showed that BanI-SNP located in the 5'-flanking region of thePLA2G4Agene was associated withschizophrenia（CHI（2）= 5.16，p = 0.023）尽管其他人未能显示这种等位基因关联。通过TDT分析，1000个排列的全局P值为0.150。基因型测试的条件，但没有等位基因测试，发现CLDN5基因与PLA2G4Agene (chi(2) = 10.17, df = 2, P = 0.006). The present results suggest that thePLA2G4A基因座可能参与schizophrenia它与CLDN5基因的结合可能会增加疾病的风险。 |
| SCZ关键字 |
schizophrenia, schizophrenic |
| 7 |
Prostaglandins Leukot。当然。Fatty Acids 2005 Dec 73: 441-5 |
| PMID |
16181776 |
| 标题 |
A study of the combined effect of the CLDN5 locus and the genes for the phospholipid metabolism pathway in schizophrenia. |
| 摘要 |
本研究试图测试CLDN5基因和对于磷脂代谢途径的综合作用，包括PTGS1，PTGS2，PTGS2，PLA2G4Aand PLA2G4C. We detected five single nucleotide polymorphisms (SNPs) present in these genes among 131 British family trios ofschizophrenicpatients. The transmission disequilibrium test (TDT) showed that BanI-SNP located in the 5'-flanking region of thePLA2G4Agene was associated withschizophrenia（CHI（2）= 5.16，p = 0.023）尽管其他人未能显示这种等位基因关联。通过TDT分析，1000个排列的全局P值为0.150。基因型测试的条件，但没有等位基因测试，发现CLDN5基因与PLA2G4Agene (chi(2) = 10.17, df = 2, P = 0.006). The present results suggest that thePLA2G4A基因座可能参与schizophrenia它与CLDN5基因的结合可能会增加疾病的风险。 |
| SCZ关键字 |
schizophrenia, schizophrenic |
| 8 |
点。J. Med。基因。B Neuropsychiatr。基因。2005年8月137b：56-8 |
| PMID |
15999343 |
| 标题 |
Cytosolic PLA2 genes possibly contribute to the etiology of schizophrenia. |
| 摘要 |
The present study detected three single nucleotide polymorphisms (SNPs), BanISNP at thePLA2G4APLA2G4B基因座的rs1648833和PLA2G4C基因座的RS1549637，以研究胞质PLA2（CPLA2）基因与基因之间的遗传关联schizophrenia。A total of 240 Chinese parent-offspring trios of Han descent were recruited for the genetic analysis. The transmission disequilibrium test (TDT) showed allelic association for rs1549637 (chi(2) = 5.68, uncorrected P = 0.017), but not for BanISNP and rs1648833. The conditioning on genotype (COG) test revealed a disease association for the BanISNP-rs1648833 combination (chi(2) = 12.54, df = 3, P = 0.0057) and for the BanISNP-rs1549637 combination (chi(2) = 9.72, df = 2, P = 0.021), but the conditioning on allele (COA) test did not show such an association for the above two combinations. Neither the COA test nor the COG showed a disease association for the rs1648833-rs1549637 combination. In the combination of all three SNPs, the COG test, but not the COA test, showed a strong association (chi(2) = 22.93, df = 6, P = 0.0008). These findings suggest that these three cPLA2 genes may all be involved in contributing to the etiology ofschizophreniaalthough their effect size appears to be relatively small. |
| SCZ关键字 |
schizophrenia, schizophrenic |
| 9 |
精神病。基因。2007年6月17日：205 |
| PMID |
17417066 |
| 标题 |
A case-control study of genetic association of the PLA2G4A gene with schizophrenia in a Chinese population. |
| 摘要 |
-1 |
| SCZ关键字 |
schizophrenia, schizophrenic |
| 10 |
Eur Arch Psychiatry Clin Neurosci 2007 Sep 257: 340-3 |
| PMID |
17629734 |
| 标题 |
Association between BanI genotype and increased phospholipase A2 activity in schizophrenia. |
| 摘要 |
Phospholipases A2 (PLA2) are a family of key enzymes in the metabolism of membrane phospholipids. Several studies reported on increased blood and brain PLA2 activity inschizophrenia, which suggest a disordered phospholipid metabolism in the disease. In addition, a genetic variant of a cytosolic PLA2 gene has been reported to be associated withschizophrenia。These data indicate that variants of PLA2 encoding genes are plausible candidates for increasing the susceptibility forschizophrenia。在这项研究中，我们研究了血小板中的PLA2活性与BANI在PLA2（第4A组）基因1q25中的BANI的多态性位点之间的可能关联。七十五schizophrenicpatients (DSM-IV) and 68 healthy controls were recruited and the PCR assays were performed. A radioenzymatic assay for the cytosolic PLA2 activity in platelets was used. The allele A2 and the genotype A2A2 were more frequent inschizophrenicpatients than in controls (p<0.005 and p<0.05 respectively). When we assorted the subjects according to their genotypes, we found that PLA2 activity was significantly higher in patients with the A2A2 genotype (29.6+/-5.1 pMol/mg protein/min) than in those with the A1A2 (20.8+/-3.6 pMol/mg protein/min, p<0.001) or A1A1 genotype (15.9+/-5.1 pMol/mg protein/min, p<0.001). Also in controls, carriers of the A2 allele (A1A2 and A2A2) had higher PLA2 activity than the A1A1 group (p=0.004 for both). Our data suggest an association between BanI genotype andPLA2G4Aactivity in platelets and that the presence of the allele A2 may increase risk forschizophrenia通过pla2活性的增加。 |
| SCZ关键字 |
schizophrenia, schizophrenic |
| 11 |
Eur Arch Psychiatry Clin Neurosci 2007 Sep 257: 340-3 |
| PMID |
17629734 |
| 标题 |
Association between BanI genotype and increased phospholipase A2 activity in schizophrenia. |
| 摘要 |
Phospholipases A2 (PLA2) are a family of key enzymes in the metabolism of membrane phospholipids. Several studies reported on increased blood and brain PLA2 activity inschizophrenia, which suggest a disordered phospholipid metabolism in the disease. In addition, a genetic variant of a cytosolic PLA2 gene has been reported to be associated withschizophrenia。These data indicate that variants of PLA2 encoding genes are plausible candidates for increasing the susceptibility forschizophrenia。在这项研究中，我们研究了血小板中的PLA2活性与BANI在PLA2（第4A组）基因1q25中的BANI的多态性位点之间的可能关联。七十五schizophrenicpatients (DSM-IV) and 68 healthy controls were recruited and the PCR assays were performed. A radioenzymatic assay for the cytosolic PLA2 activity in platelets was used. The allele A2 and the genotype A2A2 were more frequent inschizophrenicpatients than in controls (p<0.005 and p<0.05 respectively). When we assorted the subjects according to their genotypes, we found that PLA2 activity was significantly higher in patients with the A2A2 genotype (29.6+/-5.1 pMol/mg protein/min) than in those with the A1A2 (20.8+/-3.6 pMol/mg protein/min, p<0.001) or A1A1 genotype (15.9+/-5.1 pMol/mg protein/min, p<0.001). Also in controls, carriers of the A2 allele (A1A2 and A2A2) had higher PLA2 activity than the A1A1 group (p=0.004 for both). Our data suggest an association between BanI genotype andPLA2G4Aactivity in platelets and that the presence of the allele A2 may increase risk forschizophrenia通过pla2活性的增加。 |
| SCZ关键字 |
schizophrenia, schizophrenic |
| 12 |
Prostaglandins Leukot。当然。脂肪酸2008年6月78日：351-60 |
| PMID |
18562188 |
| 标题 |
BanI polymorphism of cytosolic phospholipase A2 gene is associated with age at onset in male patients with schizophrenia and schizoaffective disorder. |
| 摘要 |
The enzymes phospholipases A2 are believed to be involved in the pathology ofschizophrenia。我们研究了等位基因和基因型频率PLA2G4ACroatian的PLA2G6A中的Bani多态性和RS4375schizophrenicpatients (n=81) and controls (n=182), using PCR/RFLP. Genotype and allelic frequencies of both loci, alone or in combination did not show significant difference (chi2-test). Allele-wise and genotype-wise meta-analyses of BanI polymorphism in case-control and family-based studies also revealed no significant association withschizophrenia。多个逻辑回归分析揭示了PANSS一般心理病理学量表与BANI多态性的几个项目之间具有统计学意义的关联PLA2G4A。BANI多态性进一步显示出对男性疾病发作的平均年龄的重大影响（betaa1 = 0.351，p = 0.021; Spearman's RA1 = 0.391，p = 0.010）表明在纯合子A2A2雄性中，平均年龄较低。 |
| SCZ关键字 |
schizophrenia, schizophrenic |
| 13 |
Prostaglandins Leukot。当然。脂肪酸2008年6月78日：351-60 |
| PMID |
18562188 |
| 标题 |
BanI polymorphism of cytosolic phospholipase A2 gene is associated with age at onset in male patients with schizophrenia and schizoaffective disorder. |
| 摘要 |
The enzymes phospholipases A2 are believed to be involved in the pathology ofschizophrenia。我们研究了等位基因和基因型频率PLA2G4ACroatian的PLA2G6A中的Bani多态性和RS4375schizophrenicpatients (n=81) and controls (n=182), using PCR/RFLP. Genotype and allelic frequencies of both loci, alone or in combination did not show significant difference (chi2-test). Allele-wise and genotype-wise meta-analyses of BanI polymorphism in case-control and family-based studies also revealed no significant association withschizophrenia。多个逻辑回归分析揭示了PANSS一般心理病理学量表与BANI多态性的几个项目之间具有统计学意义的关联PLA2G4A。BANI多态性进一步显示出对男性疾病发作的平均年龄的重大影响（betaa1 = 0.351，p = 0.021; Spearman's RA1 = 0.391，p = 0.010）表明在纯合子A2A2雄性中，平均年龄较低。 |
| SCZ关键字 |
schizophrenia, schizophrenic |
| 14 |
Prostaglandins Leukot。当然。Fatty Acids 2009 Oct 81: 273-7 |
| PMID |
19560328 |
| 标题 |
No association between the PPARG gene and schizophrenia in a British population. |
| 摘要 |
It has consistently been reported that patients withschizophrenia患有2型糖尿病的风险增加。为了研究这两种疾病之间的遗传联系，PLA2G4A, PTGS2 and PPARG genes were tested among 221 British nuclear families consisting of fathers, mothers and affected offspring withschizophrenia。共有10个单核苷酸polymorphisms (SNPs) were tested and the likelihood-based association analysis for nuclear families was used to analyse the genotyping data. Eight SNPs detected across the PPARG gene did not show allelic association withschizophrenia;在PTGS2基因座（CHI2 = 4.19，P = 0.041）和RS10798059中，在RS2745557上检测到弱关联。PLA2G4Alocus (chi2=4.28, p=0.039) but these associations did not survive after 10,000 permutations to correct the p-value (global p=0.246). The gene-gene interaction test did not show any evidence of either cis-phase interactions for thePLA2G4Aand PTGS2 combinations or a trans-phase interaction for thePLA2G4Aand PPARG combinations. The PPARG gene has been reported to be strongly associated with type-2 diabetes, but the present study did not support the hypothesis that the PPARG gene may also play an important role in the development ofschizophrenia。 |
| SCZ关键字 |
schizophrenia, schizophrenic |
| 15 |
Prostaglandins Leukot。当然。脂肪酸2013年2月88日：185-90 |
| PMID |
23219238 |
| 标题 |
PLA2G4A和PTGS2基因多态性以及红细胞PUFAS缺陷对精神分裂症患者的烟酸皮肤冲洗反应的影响。 |
| 摘要 |
We investigated the etiology of the attenuated niacin skin flush response inschizophreniapatients. Skin response to topical niacin of 0.1M, 0.01 M, 0.001 M, and 0.0001 M concentrations was rated using method of volumetric niacin response (VNR) and correlated to two functional A/G polymorphisms in genes: phospholipase A2 group IVA (BanI of thePLA2G4A), and rs689466 of the prostaglandin synthase-2 (PTGS2). We further tested the possible correlation between niacin response and fatty acid (FA) content of red blood cells (RBCs). We detected statistically significant but weak impact of both polymorphisms on niacin flush response inschizophreniapatients. The dosage of the G alleles of both polymorphisms was associated with higher VNR values, although each polymorphic variant accounted for only 1% of the overall flush response variability. Regarding FA content, both n-3 and n-6 polyunsaturated FAs (PUFAs) were significantly reduced in the patient group, but an association with niacin sensitivity was not detected. |
| SCZ关键字 |
schizophrenia, schizophrenic |