| 1 | Mol. Psychiatry 2010 Jan 15: 29-37 |
|---|---|
| PMID | 19844207 |
| Title | Replication of association between schizophrenia and ZNF804A in the Irish Case-Control Study of Schizophrenia sample. |
| Abstract | A recent genome-wide association study reported association between精神分裂症and the ZNF804A gene on chromosome 2q32.1. We attempted to replicate these findings in our Irish Case-Control Study of精神分裂症(ICCSS) sample (N=1021 cases, 626 controls). Following consultation with the original investigators, we genotyped three of the most promising single-nucleotide polymorphisms (SNPs) from the Cardiff study. We replicate association with rs1344706 (trend test one-tailed P=0.0113 with the previously associated A allele) in ZNF804A. We detect no evidence of association with rs6490121 in NOS1 (one-tailed P=0.21), and only a trend with rs9922369 in RGRIP1L (one-tailed P=0.0515). On the basis of these results, we completed genotyping of 11 additional linkage disequilibrium-tagging SNPs in ZNF804A. Of 12 SNPs genotyped, 11 pass quality control criteria and 4 are nominally associated, with our most significant evidence of association at rs7597593 (P=0.0013) followed by rs1344706. We observe no evidence of differential association in ZNF804A on the basis of family history or sex of case. The associated SNP rs1344706 lies in approximately 30 bp of conserved mammalian sequence, and the associated A allele is predicted to maintain binding sites for the brain-expressed transcription factors MYT1l andPOU3F1/OCT-6. In controls, expression is significantly increased from the A allele of rs1344706 compared with the C allele. Expression is increased in精神分裂症cases compared with controls, but this difference does not achieve statistical significance. This study replicates the original reported association of ZNF804A with精神分裂症and suggests that there is a consistent link between the A allele of rs1344706, increased expression of ZNF804A and risk for精神分裂症. |
| SCZ Keywords | 精神分裂症, schizophrenic |
| 2 | Mol. Psychiatry 2010 Jan 15: 29-37 |
| PMID | 19844207 |
| Title | Replication of association between schizophrenia and ZNF804A in the Irish Case-Control Study of Schizophrenia sample. |
| Abstract | A recent genome-wide association study reported association between精神分裂症and the ZNF804A gene on chromosome 2q32.1. We attempted to replicate these findings in our Irish Case-Control Study of精神分裂症(ICCSS) sample (N=1021 cases, 626 controls). Following consultation with the original investigators, we genotyped three of the most promising single-nucleotide polymorphisms (SNPs) from the Cardiff study. We replicate association with rs1344706 (trend test one-tailed P=0.0113 with the previously associated A allele) in ZNF804A. We detect no evidence of association with rs6490121 in NOS1 (one-tailed P=0.21), and only a trend with rs9922369 in RGRIP1L (one-tailed P=0.0515). On the basis of these results, we completed genotyping of 11 additional linkage disequilibrium-tagging SNPs in ZNF804A. Of 12 SNPs genotyped, 11 pass quality control criteria and 4 are nominally associated, with our most significant evidence of association at rs7597593 (P=0.0013) followed by rs1344706. We observe no evidence of differential association in ZNF804A on the basis of family history or sex of case. The associated SNP rs1344706 lies in approximately 30 bp of conserved mammalian sequence, and the associated A allele is predicted to maintain binding sites for the brain-expressed transcription factors MYT1l andPOU3F1/OCT-6. In controls, expression is significantly increased from the A allele of rs1344706 compared with the C allele. Expression is increased in精神分裂症cases compared with controls, but this difference does not achieve statistical significance. This study replicates the original reported association of ZNF804A with精神分裂症and suggests that there is a consistent link between the A allele of rs1344706, increased expression of ZNF804A and risk for精神分裂症. |
| SCZ Keywords | 精神分裂症, schizophrenic |