| 1 | Psychiatr. Genet. 2013 Feb 23: 11-9 |
|---|---|
| PMID | 23142968 |
| Title | Whole-genome-wide association study in the Bulgarian population reveals HHAT as schizophrenia susceptibility gene. |
| Abstract | schizophrenia, the most common major psychiatric disorder (or group of disorders), entails severe decline of higher functions, principally with alterations in cognitive functioning and reality perception. Both genetic and environmental factors are involved in its pathogenesis; however, its genetic background still needs to be clarified. The objective of the study was to reveal genetic markers associated withschizophreniain the Bulgarian population. We have conducted a genome-wide association study using 554 496 single nucleotide polymorphisms (SNPs) in 188 affected and 376 unaffected Bulgarian individuals. Subsequently, the 100 candidate SNPs that revealed the smallest P-values were further evaluated in an additional set of 99 case and 328 control samples. We found a significant association betweenschizophreniaand the intronic SNP rs7527939 in theHHATgene (P-value of 6.49�10 with an odds ratio of 2.63, 95% confidence interval of 1.89-3.66). We also genotyped additional SNPs within a 58-kb linkage disequilibrium block surrounding the landmark SNP. We suggest rs7527939 to be the strongest indicator of susceptibility toschizophrenia在th保加利亚人口eHHATlocus. |
| SCZ Keywords | schizophrenia |