| 1 | Prostaglandins Leukot. Essent. Fatty Acids 2005 Dec 73: 441-5 |
|---|---|
| PMID | 16181776 |
| Title | A study of the combined effect of the CLDN5 locus and the genes for the phospholipid metabolism pathway in schizophrenia. |
| Abstract | The present study attempts to test the combined effect of the CLDN5 gene and those for the phospholipid metabolism pathway, includingPTGS1, PTGS2, PLA2G4A and PLA2G4C. We detected five single nucleotide polymorphisms (SNPs) present in these genes among 131 British family trios of精神分裂症patients. The transmission disequilibrium test (TDT) showed that BanI-SNP located in the 5'-flanking region of the PLA2G4A gene was associated with精神分裂症(chi(2) = 5.16, P = 0.023) although the others failed to show such allelic associations. The global P-value was 0.150 for 1000 permutations with the TDT analysis. The conditioning on genotype test, but not on allele test, revealed a strong association for the combination of the CLDN5 gene with the PLA2G4A gene (chi(2) = 10.17, df = 2, P = 0.006). The present results suggest that the PLA2G4A locus may be involved in精神分裂症and its combination with the CLDN5 gene may increase further the risk for the illness. |
| SCZ Keywords | 精神分裂症, schizophrenic |
| 2 | Prostaglandins Leukot. Essent. Fatty Acids 2005 Dec 73: 441-5 |
| PMID | 16181776 |
| Title | A study of the combined effect of the CLDN5 locus and the genes for the phospholipid metabolism pathway in schizophrenia. |
| Abstract | The present study attempts to test the combined effect of the CLDN5 gene and those for the phospholipid metabolism pathway, includingPTGS1, PTGS2, PLA2G4A and PLA2G4C. We detected five single nucleotide polymorphisms (SNPs) present in these genes among 131 British family trios of精神分裂症patients. The transmission disequilibrium test (TDT) showed that BanI-SNP located in the 5'-flanking region of the PLA2G4A gene was associated with精神分裂症(chi(2) = 5.16, P = 0.023) although the others failed to show such allelic associations. The global P-value was 0.150 for 1000 permutations with the TDT analysis. The conditioning on genotype test, but not on allele test, revealed a strong association for the combination of the CLDN5 gene with the PLA2G4A gene (chi(2) = 10.17, df = 2, P = 0.006). The present results suggest that the PLA2G4A locus may be involved in精神分裂症and its combination with the CLDN5 gene may increase further the risk for the illness. |
| SCZ Keywords | 精神分裂症, schizophrenic |
| 3 | Psychiatry Res 2012 Apr 196: 201-6 |
| PMID | 22397921 |
| Title | Differential age- and disease-related effects on the expression of genes related to the arachidonic acid signaling pathway in schizophrenia. |
| Abstract | We have previously identified differential effects of age on global brain gene expression profiles in subjects with精神分裂症compared to normal controls. Here, we have focused on age-related effects of genes associated with the arachidonic acid-related inflammation pathway. Linear correlation analysis of published microarray expression data reveal strong age- and cell-type- specific-effects on the expression of genes related to the arachidonic acid signaling pathway, which differed in control subjects compared to those with精神分裂症. Using real-time qPCR analysis, we validated age and disease effects of arachidonic acid-related genes in a large cohort of subjects with精神分裂症and matched controls (n=76 subjects in total). We found that levels of prostaglandin-endoperoxide synthase 1 (PTGS1; aka COX-1) and prostaglandin-endoperoxide receptor 3 (PTGER3) mRNA are increased, and levels of prostaglandin-endoperoxide synthase 2 (PTGS2; aka COX-2) mRNA are decreased, in older subjects with精神分裂症(> 40years of age) compared to matched normal controls or younger subjects with精神分裂症(< 40years of age). These findings contribute to the accumulating evidence suggesting that inflammatory processes in the CNS contribute to pathophysiology of精神分裂症and further suggest that age may be an important factor in the potential use of anti-inflammatory therapies. |
| SCZ Keywords | 精神分裂症, schizophrenic |