| 1 | Schizophr. Res. 2008 Jul 102: 352-5 |
|---|---|
| PMID | 18486454 |
| Title | Patients with schizophrenia show raised serum levels of the pro-inflammatory chemokine CCL2: association with the metabolic syndrome in patients? |
| 抽象的 | -1 |
| SCZ Keywords | 精神分裂症，精神分裂症 |
| 2 | Prog. Neuropsychopharmacol. Biol. Psychiatry 2008 Apr 32: 710-4 |
| PMID | 18096286 |
| Title | 精神分裂症中CCL11/Eotaxin的血清水平升高。 |
| 抽象的 | Inflammatory and immune alterations occur and may be relevant in patients with精神分裂症。趋化因子是细胞因子的亚组，在确定的白细胞子集募集到组织中起主要作用。迄今为止，尚无研究评估患者的趋化因子水平是否改变精神分裂症。 To evaluate serum levels of CC and CXC chemokines of精神分裂症患者以及年龄和性别匹配的对照。 四十个男性制度化精神分裂症patients (mean+/-SD age, 52.3+/-9.9) and 20 asymptomatic matched controls were recruited for this study. Severity of symptoms was assessed using BPRS, PANSS and AIMS. All patients were under typical antipsychotic treatment. Serum concentrations of chemokines were measured by ELISA. 血清水平没有统计学差异CCL2，ccl3，CCL2对照和患者之间的4，CXCL9和CXCL10。CCL11的血清水平增加精神分裂症与对照组相比，患者。趋化因子的血清水平与疾病或住院时间的长度以及非自愿运动，正和/或阴性症状的严重程度无关。 CCL11是CCR3的配体，它是在Th2淋巴细胞，肥大细胞和嗜酸性粒细胞上优先表达的受体。CCL11的血清水平较高精神分裂症reinforce the view that this disease may be associated with a Th1/Th2 imbalance with a shift toward a Th2 immune response. |
| SCZ Keywords | 精神分裂症，精神分裂症 |
| 3 | Prog. Neuropsychopharmacol. Biol. Psychiatry 2008 Apr 32: 710-4 |
| PMID | 18096286 |
| Title | 精神分裂症中CCL11/Eotaxin的血清水平升高。 |
| 抽象的 | Inflammatory and immune alterations occur and may be relevant in patients with精神分裂症。趋化因子是细胞因子的亚组，在确定的白细胞子集募集到组织中起主要作用。迄今为止，尚无研究评估患者的趋化因子水平是否改变精神分裂症。 To evaluate serum levels of CC and CXC chemokines of精神分裂症患者以及年龄和性别匹配的对照。 四十个男性制度化精神分裂症patients (mean+/-SD age, 52.3+/-9.9) and 20 asymptomatic matched controls were recruited for this study. Severity of symptoms was assessed using BPRS, PANSS and AIMS. All patients were under typical antipsychotic treatment. Serum concentrations of chemokines were measured by ELISA. 血清水平没有统计学差异CCL2，ccl3，CCL2对照和患者之间的4，CXCL9和CXCL10。CCL11的血清水平增加精神分裂症与对照组相比，患者。趋化因子的血清水平与疾病或住院时间的长度以及非自愿运动，正和/或阴性症状的严重程度无关。 CCL11是CCR3的配体，它是在Th2淋巴细胞，肥大细胞和嗜酸性粒细胞上优先表达的受体。CCL11的血清水平较高精神分裂症reinforce the view that this disease may be associated with a Th1/Th2 imbalance with a shift toward a Th2 immune response. |
| SCZ Keywords | 精神分裂症，精神分裂症 |
| 4 | J Affect Disord 2010 10月126日：312-6 |
| PMID | 20451256 |
| Title | 挪威个体躁郁症的全基因组疾病研究，然后在冰岛样本中复制。 |
| 抽象的 | In the present study we investigated genetic variants associated with bipolar disorder in a homogenous Norwegian sample, and potential genetic overlap with精神分裂症, using the Affymetrix 6.0 array. 我们通过基因分型620 390单核苷酸多态性（SNP）进行了全基因组关联研究（GWAS），这是在挪威起源的病例对照样本中（最高研究），包括双相情感障碍（n = 194）（n = 194），健康对照（N= 336）和精神分裂症（n = 230），然后在遗传上一致的冰岛疾病样本（n = 435）和健康对照（n = 10,258）中进行复制和联合分析。 我们选择了1000个标记在顶部发现GWAS中的P值最低的标记，并在冰岛复制样本中测试了这些标记（或它们的替代物）。在复制样本中，证实了与双相情感障碍（标称P值<0.05；未对多次测试校正）证实了35个基因座的多态性。最重要的标记位于dleu2，gucy1b2，pkia，CCL2，CNTNAP5，DPP10和FBN1。组合的组精神分裂症and bipolar disorder compared to controls did not provide additional significant findings. 相对较少的样品。 We detected weak but reproducible association with markers in several genes, in proximity to susceptibility loci found in previous GWAS studies of bipolar disorder. Further work is required to study their localization, expression, and regulation and international meta-analytic efforts will help to further elucidate their role. |
| SCZ Keywords | 精神分裂症，精神分裂症 |
| 5 | Psychoneuroendocrinology 2012 12月37日：1901-11 |
| PMID | 22541717 |
| Title | 精神分裂症患者的血清细胞因子，趋化因子和脂肪因子的水平升高与疾病和代谢综合征有关。 |
| 抽象的 | 目前有很强的迹象表明精神分裂症(SZ), diabetes and the metabolic syndrome (metS). In this study we focus on an aberrantly activated monocyte/macrophage system as the shared factor. We measured in SZ patients (n=144), the serum levels of monocyte/macrophage cytokines/chemokines/adipokinesCCL2，CCL4，IL-1？，tnf-？，6，PTX3，瘦素，脂联素，PAI-1，OPG和ICAM-1，并将这些水平与健康对照（HC）进行了比较（hc）（n = 138）。使用多变量分析，我们研究了疾病SZ的存在，包括BMI在内的Mets的成分，脂质水平（HDL胆固醇和甘油三酸酯（TG）），糖尿病（高血糖）以及使用抗精神病药物的使用这些免疫化合物的血清水平。我们发现所有测量的免疫化合物，除了PAI-1和OPG以外，SZ患者人群的升高。多变量分析表明，高程与性别（ICAM-1，瘦素，TNF-？和脂联蛋白）有关，BMI（瘦素，脂联素），高血糖/糖尿病（CCL4和OPG）增加，HDL-胆固醇或增加的水平TG（脂联素和PTX3）或Mets（CCL2, leptin and adiponectin). IL-1? and IL-6 were the only immune compounds raised in the serum of patients not affected by any of the included factors. Although many of the immune compounds were found linked to (components of) the metS, the most dominant linkage was found with the disease精神分裂症早些时候,确认报告增加单核细胞/macrophage activation as a key component for understanding the pathogenesis of精神分裂症。 |
| SCZ Keywords | 精神分裂症，精神分裂症 |
| 6 | Prog. Neuropsychopharmacol. Biol. Psychiatry 2014 Jun 51: 153-8 |
| PMID | 24495780 |
| Title | A pharmacogenetic study of risperidone on chemokine (C-C motif) ligand 2 (CCL2) in Chinese Han schizophrenia patients. |
| 抽象的 | 先前观察到趋化因子（C-C基序）配体的病理生理分布和药理特征2（CCL2）表明其在抗精神病药作用中的潜在作用。有关药物遗传学的更多信息CCL2因此，可能有助于开发个性化疗法。但是，据我们所知，在该领域有罕见的研究。该调查试图澄清是否是否CCL2多态性可能会影响利培酮的功效。我们基于四个SNP（RS4795893，RS1024611，RS4586和RS2857657），分布在整个过程中CCL2基因并使用正面和阴性综合征量表（PANSS）得分在两个独立的中国人群中进行了检查精神分裂症在8周的利培酮单一疗法之后，来自两个不同地理区域的患者（n = 208）。我们发现所有基因分型SNP都与利培酮治疗显着相关（rs4795893：p = 1.66e-04，rs4586：p = 0.001，rs2857657：p = 0.004：p = 0.004，在第4周，在ANOVA）。我们的结果表明，差异可能会产生一定的影响CCL2gene on therapeutic efficacy of risperidone, and the associated polymorphisms may be a potential genetic marker for predicting the therapeutic effect of risperidone. |
| SCZ Keywords | 精神分裂症，精神分裂症 |
| 7 | Prog. Neuropsychopharmacol. Biol. Psychiatry 2014 Jun 51: 153-8 |
| PMID | 24495780 |
| Title | A pharmacogenetic study of risperidone on chemokine (C-C motif) ligand 2 (CCL2) in Chinese Han schizophrenia patients. |
| 抽象的 | 先前观察到趋化因子（C-C基序）配体的病理生理分布和药理特征2（CCL2）表明其在抗精神病药作用中的潜在作用。有关药物遗传学的更多信息CCL2因此，可能有助于开发个性化疗法。但是，据我们所知，在该领域有罕见的研究。该调查试图澄清是否是否CCL2多态性可能会影响利培酮的功效。我们基于四个SNP（RS4795893，RS1024611，RS4586和RS2857657），分布在整个过程中CCL2基因并使用正面和阴性综合征量表（PANSS）得分在两个独立的中国人群中进行了检查精神分裂症在8周的利培酮单一疗法之后，来自两个不同地理区域的患者（n = 208）。我们发现所有基因分型SNP都与利培酮治疗显着相关（rs4795893：p = 1.66e-04，rs4586：p = 0.001，rs2857657：p = 0.004：p = 0.004，在第4周，在ANOVA）。我们的结果表明，差异可能会产生一定的影响CCL2gene on therapeutic efficacy of risperidone, and the associated polymorphisms may be a potential genetic marker for predicting the therapeutic effect of risperidone. |
| SCZ Keywords | 精神分裂症，精神分裂症 |
| 8 | 翻译精神病学2014 -1 4：E406 |
| PMID | 24984193 |
| Title | 慢性双相情感障碍患者的M1/降低M2特征和Th1/Th2转移的迹象，但在精神分裂症患者中没有增加。 |
| 抽象的 | 我们在这里介绍有关趋化因子，趋化因子受体，细胞因子和调节性T细胞（T-REG）标志物的免疫基因表达的数据精神分裂症(SCZ, N = 20)或双相情感障碍(BD = 20),而with healthy controls (HCs, N=20). We extracted RNA from peripheral blood mononuclear cells and performed real-time (RT)-PCR to measure mRNA levels of chemokines, chemokine receptors, cytokines and T-reg markers. All the analyses were Bonferroni-corrected. The classical monocyte activation (M1) markers il6, ccl3 were significantly increased in BD as compared with both HC and SCZ patients (P=0.03 and P=0.002; P=0.024 and P=0.021, respectively), whereas markers of alternative (M2) monocyte activation ccl1,CCL22and il10 were coherently decreased (controls: P=0.01, P=0.001 and P=0.09; SCZ subjects: P=0.02, P=0.05 and P=0.011, respectively). Concerning T-cell markers, BD patients had compared with HC downregulated ccr5 (P=0.02) and upregulated il4 (P=0.04) and compared with both healthy and SCZ individuals downregulatedCCL2(P=0.006 and P=0.003) and tgf? (P=0.004 and P=0.007, respectively). No significant associations were found between any immune gene expression and clinical variables (prior hospitalizations, Brief Psychiatric Rating Scale, medications' dosages and lifetime administration). Although some markers are expressed by different immune cell types, these findings suggest a coherent increased M1/decrease M2 signature in the peripheral blood of BD patients with potential Th1/Th2 shift. In contrast, all the explored immune marker levels were preserved in SCZ. Further larger studies are needed to investigate the relevance of inflammatory response in BD, trying to correlate it to psychopathology, treatment and outcome measures and, possibly, to brain connectivity. |
| SCZ Keywords | 精神分裂症，精神分裂症 |
| 9 | J神经炎症2014 -1 11：128 |
| PMID | 25069615 |
| Title | 在大脑中Munc18-1a诱导的精神分裂症小鼠模型中的细胞因子途径破坏。 |
| 抽象的 | An accumulating body of evidence points to the significance of neuroinflammation and immunogenetics in精神分裂症，并且已经提出中枢神经系统（CNS）中细胞因子的失衡与该疾病有关。MUNC18过表达的小鼠（Munc18-OE）为研究的改变提供了模型精神分裂症。The aim of the present study was to elucidate the involvement of neuroinflammation and cytokine imbalance in this model. Cytokines were evaluated in the cortex and the striatum of Munc18-OE and wild-type (WT) mice by enzyme-linked immunosorbent assay (ELISA). Protein levels of specific microglia and macrophage, astrocytic and neuroinflammation markers were quantified by western blot in the cortex and the striatum of Munc18-OE and WT mice. 每种评估的细胞因子（干扰素 - γ（IFN-？），肿瘤坏死因子-Alpha（TNF-？），白介素2（IL-2）和CCL2在Munc18-OE小鼠的纹状体中，趋化因子在较高的水平上存在于WT。皮质TNF-？MUNC18-OE小鼠的IL-2水平明显低于WT小鼠。Munc18-Oe小鼠皮质中的小胶质细胞和巨噬细胞标记CD11b低于WT，但在纹状体中未观察到差异。两组之间的神经胶质原纤维酸性蛋白（GFAP）和核因子-kappab（NF-？b）p65水平没有差异。白介素-1beta（IL-1？）和IL-6水平在检测极限之下。 发现在MUNC18-OE小鼠大脑中检测到的细胞因子的干扰水平与临床报告相似，并认可对这种类型的研究，以分析该疾病的这一方面。皮质中的CD11b表达较低，但在Munc18-OE小鼠的纹状体中不显示生理活性的差异。在Munc18-OE小鼠中观察到的细胞因子表达模式类似于先前公布的模型精神分裂症由母体免疫激活引起。总之，这些数据表明免疫失衡在这种疾病中可能起作用。 |
| SCZ Keywords | 精神分裂症，精神分裂症 |
| 10 | Neurosci Biobehav Rev 2014年5月42日：93-115 |
| PMID | 24513303 |
| Title | 情绪障碍，精神分裂症和认知障碍中的趋化因子和趋化因子受体：生物标志物研究的系统评价。 |
| 抽象的 | The search for immune biomarkers in psychiatric disorders has primarily focused on pro-inflammatory cytokines. Other immune proteins including chemokines have been relatively neglected in such studies. Recent evidence has implicated chemokines in many neurobiological processes potentially relevant to psychiatric disorders, beyond their classical chemotactic functions. These may include neuromodulator effects, neurotransmitter-like effects, and direct/indirect regulation of neurogenesis. This systematic review presents the existing early evidence which supports an association of many chemokines with the psychiatric disorders: depression, bipolar disorder,精神分裂症，轻度认知障碍和阿尔茨海默氏病。包括CXCL8（IL-8），包括CXCL8（IL-8）的非特异性趋化因子关联CCL2(MCP-1), CCL3 (MIP-1?) and CCL5 (RANTES) with these disorders across diagnostic categories implies a generalised involvement of many chemokine systemic with psychiatric disease. Additional chemokines with great mechanistic relevance including CXCL12 (SDF-1) and CX3CL1 (fractalkine) have been rarely reported in the existing human literature and should be included in future clinical studies. The potential utility of these proteins as pathologically relevant biomarkers or therapeutic targets should be considered by future clinical and translational research. |
| SCZ Keywords | 精神分裂症，精神分裂症 |
| 11 | 前细胞Neurosci 2015 -1 9：357 |
| PMID | 26441528 |
| Title | 趋化因子与精神疾病的神经生物学相关性的系统评价。 |
| 抽象的 | 精神疾病是高度普遍的公共卫生相关性的严重疾病。最近的许多研究集中在细胞beplay苹果手机能用吗因子在精神疾病的病理生理学中的作用。但是，相关的免疫蛋白指定趋化因子的家族已相对忽略。趋化因子最初被鉴定为在免疫细胞上具有趋化功能。然而，最近的证据已经开始阐明这些蛋白质的新颖，大脑特异性功能与精神疾病机制相关。对PubMed和Google Scholar数据库中的人类和动物文献进行了系统的综述。应用了所有包含和排除标准后，仍有157个参考文献进行审查。一些早期的机械证据确实将某些趋化因子与神经生物学过程相关联，包括神经发生，神经炎症反应的调节，下丘脑 - 垂体 - 肾上腺肾上腺轴的调节以及神经递质系统的调节。然而，这一早期证据并未清楚地证明对某种精神疾病的任何特异性，而是与跨疾病共享的机制有关。值得注意的例外包括最近已证明在衰老中损害海马功能的CCL11？精神分裂症。促炎性趋化因子，例如CCL2，CCL7，CCL8，CCL12和CCL13已被证明可驱动促炎细胞的趋化细胞趋化或受伤的CNS。同样，CX3CL与促进神经胶质细胞的激活，促炎细胞因子分泌，ICAM-1的表达以及在神经炎症过程中将CD4+ T细胞募集到CNS中。通过进一步的转化研究，趋化因子可能会呈现精神疾病中的新beplay苹果手机能用吗型诊断和/或治疗靶标。 |
| SCZ Keywords | 精神分裂症，精神分裂症 |
| 12 | Mol Genet Genomic Med 2016 Jan 4: 18-27 |
| PMID | 26788534 |
| Title | Evaluation of genetic association of neurodevelopment and neuroimmunological genes with antipsychotic treatment response in schizophrenia in Indian populations. |
| 抽象的 | 神经发育和神经免疫学基因严格调节抗精神病药物治疗结果。我们报告了742中抗精神病药反应的遗传关联精神分裂症来自印度 - 欧洲和德拉维血统的印度人口的患者，被疾病严重程度隔离。比较确定的两个人群的荟萃分析CCL2[RS4795893：OR（95％CI）=�1.79（1.27-2.52），p = -7.62。10（-4）;RS4586：OR（95％CI）=�=�1.74（1.24-2.43），p = =�1.13.13.10（-3）]和Gria4 [rs2513265：OR（95％CI）在低严重性组中，，p =�1.44.10（-3）]；并且，ADCY2 [RS1544938：OR（95％CI）= .0.36（0.19-0.65），p = = 3.7.68.10（-4）]和NRG1 [RS132509750.23-0.79），p。=�6.81。10（-3）;rs17716295，或（95％CI）=�1.78（1.15-2.75），p = -8.71。10（-3）]在高严重性组中，对抗精神病药的反应不完全。据我们所知，这是第一个确定与抗精神病药物治疗功效相关的遗传多态性的研究精神分裂症patients from two major India populations. |
| SCZ Keywords | 精神分裂症，精神分裂症 |