| 1 | Schizophr Bull 2012 Mar 38: 285-94 |
|---|---|
| PMID | 20595202 |
| Title | Schizophrenic patients and their unaffected siblings share increased resting-state connectivity in the task-negative network but not its anticorrelated task-positive network. |
| Abstract | Abnormal connectivity of the anticorrelated intrinsic networks, the task-negative network (TNN), task-positive网络(TPN)is implicated inschizophrenia. Comparisons betweenschizophrenicpatients and their unaffected siblings enable further understanding of illness susceptibility and pathophysiology. We examined the resting-state connectivity differences in the intrinsic networks betweenschizophrenicpatients, their unaffected siblings, and healthy controls. Resting-state functional magnetic resonance images were obtained from 25 individuals in each subject group. The posterior cingulate cortex/precuneus and right dorsolateral prefrontal cortex were used as seed regions to identify theTNNand TPN through functional connectivity analysis. Interregional connectivity strengths were analyzed using overlapped intrinsic networks composed of regions common to all subject groups. schizophrenicpatients and their unaffected siblings showed increased connectivity in theTNNbetween the bilateral inferior temporal gyri. By contrast,schizophrenicpatients alone demonstrated increased connectivity between the posterior cingulate cortex/precuneus and left inferior temporal gyrus and between the ventral medial prefrontal cortex and right lateral parietal cortex in theTNN.schizophrenicpatients exhibited increased connectivity between the left dorsolateral prefrontal cortex and right inferior frontal gyrus in the TPN relative to their unaffected siblings, though this trend only approached statistical significance in comparison to healthy controls. Resting-state hyperconnectivity of the intrinsic networks may disrupt network coordination and thereby contribute to the pathophysiology ofschizophrenia. Similar, though milder, hyperconnectivity of theTNNin unaffected siblings ofschizophrenicpatients may contribute to the identification ofschizophreniaendophenotypes and ultimately to the determination ofschizophreniarisk genes. |
| SCZ Keywords | schizophrenia, schizophrenic |
| 2 | Schizophr Bull 2012 Mar 38: 285-94 |
| PMID | 20595202 |
| Title | Schizophrenic patients and their unaffected siblings share increased resting-state connectivity in the task-negative network but not its anticorrelated task-positive network. |
| Abstract | Abnormal connectivity of the anticorrelated intrinsic networks, the task-negative network (TNN), task-positive网络(TPN)is implicated inschizophrenia. Comparisons betweenschizophrenicpatients and their unaffected siblings enable further understanding of illness susceptibility and pathophysiology. We examined the resting-state connectivity differences in the intrinsic networks betweenschizophrenicpatients, their unaffected siblings, and healthy controls. Resting-state functional magnetic resonance images were obtained from 25 individuals in each subject group. The posterior cingulate cortex/precuneus and right dorsolateral prefrontal cortex were used as seed regions to identify theTNNand TPN through functional connectivity analysis. Interregional connectivity strengths were analyzed using overlapped intrinsic networks composed of regions common to all subject groups. schizophrenicpatients and their unaffected siblings showed increased connectivity in theTNNbetween the bilateral inferior temporal gyri. By contrast,schizophrenicpatients alone demonstrated increased connectivity between the posterior cingulate cortex/precuneus and left inferior temporal gyrus and between the ventral medial prefrontal cortex and right lateral parietal cortex in theTNN.schizophrenicpatients exhibited increased connectivity between the left dorsolateral prefrontal cortex and right inferior frontal gyrus in the TPN relative to their unaffected siblings, though this trend only approached statistical significance in comparison to healthy controls. Resting-state hyperconnectivity of the intrinsic networks may disrupt network coordination and thereby contribute to the pathophysiology ofschizophrenia. Similar, though milder, hyperconnectivity of theTNNin unaffected siblings ofschizophrenicpatients may contribute to the identification ofschizophreniaendophenotypes and ultimately to the determination ofschizophreniarisk genes. |
| SCZ Keywords | schizophrenia, schizophrenic |