| Abstract |
Recently, ubiquitin-specific peptidase 46 (USP46) has been identified as a quantitative trait gene responsible for immobility in the tail suspension test and forced swimming test in mice. Mice with 3-bp deletion inUSP46exhibited loss of 'behavioral despair' under inescapable stresses in addition to abnormalities in circadian behavioral rhythms and the GABAergic system. Considering the face and construct validity as an animal model for bipolar disorder, we explored an association ofUSP46and bipolar disorder in a Japanese population. We also examined an association ofUSP46andschizophrenia。We found nominal evidence for an association of rs12646800 andschizophrenia。这种关联并不显著的房颤ter correction for multiple testing. No significant association was detected for bipolar disorder. In conclusion, our data argue against the presence of any strong genetic susceptibility factors for bipolar disorder orschizophreniain the regionUSP46。 |